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Search results 1901 to 2000 out of 3475 for Clock

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Categories

Category: Publication
Type Details Score
Publication
First Author: Yan L
Year: 2006
Journal: J Neurosci
Title: DARPP-32 involvement in the photic pathway of the circadian system.
Volume: 26
Issue: 37
Pages: 9434-8
Publication
First Author: Franken P
Year: 2000
Journal: J Neurosci
Title: The transcription factor DBP affects circadian sleep consolidation and rhythmic EEG activity.
Volume: 20
Issue: 2
Pages: 617-25
Publication  
First Author: Campbell JR
Year: 2020
Journal: Endocrinology
Title: Essential Role of Syntaxin-Binding Protein-1 in the Regulation of Glucagon-Like Peptide-1 Secretion.
Volume: 161
Issue: 5
Publication  
First Author: Ling Z
Year: 2024
Journal: Neuropharmacology
Title: Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration.
Volume: 246
Pages: 109834
Publication
First Author: Sundaram S
Year: 2019
Journal: Sci Rep
Title: Inhibition of casein kinase 1δ/εimproves cognitive-affective behavior and reduces amyloid load in the APP-PS1 mouse model of Alzheimer's disease.
Volume: 9
Issue: 1
Pages: 13743
Publication
First Author: Young ME
Year: 2014
Journal: J Biol Rhythms
Title: Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heart.
Volume: 29
Issue: 4
Pages: 257-76
Publication
First Author: Schroder EA
Year: 2013
Journal: Am J Physiol Cell Physiol
Title: The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility.
Volume: 304
Issue: 10
Pages: C954-65
Publication
First Author: Mia S
Year: 2020
Journal: Am J Physiol Heart Circ Physiol
Title: Differential effects of REV-ERBα/β agonism on cardiac gene expression, metabolism, and contractile function in a mouse model of circadian disruption.
Volume: 318
Issue: 6
Pages: H1487-H1508
Publication  
First Author: Li H
Year: 2022
Journal: Front Cardiovasc Med
Title: SR9009 improves heart function after pressure overload independent of cardiac REV-ERB.
Volume: 9
Pages: 952114
Publication
First Author: Morton AJ
Year: 2005
Journal: J Neurosci
Title: Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease.
Volume: 25
Issue: 1
Pages: 157-63
Publication
First Author: Pallier PN
Year: 2007
Journal: J Neurosci
Title: Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease.
Volume: 27
Issue: 29
Pages: 7869-78
Publication  
First Author: Ouk K
Year: 2019
Journal: eNeuro
Title: Abnormal Photic Entrainment to Phase-Delaying Stimuli in the R6/2 Mouse Model of Huntington's Disease, despite Retinal Responsiveness to Light.
Volume: 6
Issue: 6
Publication
First Author: Yi SA
Year: 2022
Journal: Exp Mol Med
Title: S6K1 controls adiponectin expression by inducing a transcriptional switch: BMAL1-to-EZH2.
Volume: 54
Issue: 3
Pages: 324-333
Publication
First Author: Mouland JW
Year: 2019
Journal: Curr Biol
Title: Cones Support Alignment to an Inconsistent World by Suppressing Mouse Circadian Responses to the Blue Colors Associated with Twilight.
Volume: 29
Issue: 24
Pages: 4260-4267.e4
Publication  
First Author: Ma Z
Year: 2022
Journal: Neurobiol Dis
Title: Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms.
Volume: 168
Pages: 105690
Publication  
First Author: Partington HS
Year: 2021
Journal: Behav Brain Res
Title: Nurr1 deficiency shortens free running period, enhances photoentrainment to phase advance, and disrupts circadian cycling of the dopamine neuron phenotype.
Volume: 411
Pages: 113347
Publication
First Author: Suzuki T
Year: 2001
Journal: Mamm Genome
Title: Quantitative trait locus analysis of abnormal circadian period in CS mice.
Volume: 12
Issue: 4
Pages: 272-7
Publication  
First Author: Ko FC
Year: 2023
Journal: Bone
Title: Colon epithelial cell-specific Bmal1 deletion impairs bone formation in mice.
Volume: 168
Pages: 116650
Publication
First Author: Um JH
Year: 2011
Journal: PLoS One
Title: AMPK regulates circadian rhythms in a tissue- and isoform-specific manner.
Volume: 6
Issue: 3
Pages: e18450
Publication
First Author: Ait-Hmyed Hakkari O
Year: 2016
Journal: FASEB J
Title: Rev-Erbα modulates retinal visual processing and behavioral responses to light.
Volume: 30
Issue: 11
Pages: 3690-3701
Publication
First Author: Lee J
Year: 2020
Journal: Aging Cell
Title: Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer's disease.
Volume: 19
Issue: 2
Pages: e13078
Publication  
First Author: Sato S
Year: 2014
Journal: ScientificWorldJournal
Title: Direct and indirect suppression of interleukin-6 gene expression in murine macrophages by nuclear orphan receptor REV-ERBα.
Volume: 2014
Pages: 685854
Publication
First Author: Jager J
Year: 2014
Journal: Mol Endocrinol
Title: Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erbα.
Volume: 28
Issue: 4
Pages: 490-8
Publication  
First Author: Chen R
Year: 2023
Journal: Brain Behav Immun
Title: Microglia depletion ameliorates neuroinflammation, anxiety-like behavior, and cognitive deficits in a sex-specific manner in Rev-erbα knockout mice.
Volume: 114
Pages: 287-298
Publication
First Author: Berthier A
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBα complex.
Volume: 115
Issue: 47
Pages: E11033-E11042
Publication
First Author: Mrosovsky N
Year: 2003
Journal: Chronobiol Int
Title: Impaired masking responses to light in melanopsin-knockout mice.
Volume: 20
Issue: 6
Pages: 989-99
Publication  
First Author: Tam SKE
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Dim light in the evening causes coordinated realignment of circadian rhythms, sleep, and short-term memory.
Volume: 118
Issue: 39
Publication
First Author: Stein RM
Year: 2020
Journal: Nature
Title: Virtual discovery of melatonin receptor ligands to modulate circadian rhythms.
Volume: 579
Issue: 7800
Pages: 609-614
Publication
First Author: Owino S
Year: 2016
Journal: PLoS One
Title: Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks.
Volume: 11
Issue: 1
Pages: e0148214
Publication
First Author: Delezie J
Year: 2012
Journal: FASEB J
Title: The nuclear receptor REV-ERBα is required for the daily balance of carbohydrate and lipid metabolism.
Volume: 26
Issue: 8
Pages: 3321-35
Publication  
First Author: Delezie J
Year: 2016
Journal: Sci Rep
Title: Rev-erbα in the brain is essential for circadian food entrainment.
Volume: 6
Pages: 29386
Publication
First Author: Paerewijck O
Year: 2017
Journal: Sci Rep
Title: Interleukin-17 receptor A (IL-17RA) as a central regulator of the protective immune response against Giardia.
Volume: 7
Issue: 1
Pages: 8520
Publication  
First Author: Pastore N
Year: 2019
Journal: EMBO J
Title: Nutrient-sensitive transcription factors TFEB and TFE3 couple autophagy and metabolism to the peripheral clock.
Volume: 38
Issue: 12
Publication
First Author: Imamura K
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: ASK family kinases mediate cellular stress and redox signaling to circadian clock.
Volume: 115
Issue: 14
Pages: 3646-3651
Publication  
First Author: Schroder EA
Year: 2021
Journal: Front Physiol
Title: Cardiomyocyte Deletion of Bmal1 Exacerbates QT- and RR-Interval Prolongation in Scn5a +/ΔKPQ Mice.
Volume: 12
Pages: 681011
Publication  
First Author: Crislip GR
Year: 2022
Journal: Biomolecules
Title: Apparent Absence of BMAL1-Dependent Skeletal Muscle-Kidney Cross Talk in Mice.
Volume: 12
Issue: 2
Publication
First Author: Schroeder A
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Circadian regulation of cardiovascular function: a role for vasoactive intestinal peptide.
Volume: 300
Issue: 1
Pages: H241-50
Publication
First Author: Brown TM
Year: 2007
Journal: J Neurophysiol
Title: Disrupted neuronal activity rhythms in the suprachiasmatic nuclei of vasoactive intestinal polypeptide-deficient mice.
Volume: 97
Issue: 3
Pages: 2553-8
Publication
First Author: Dragich JM
Year: 2010
Journal: Eur J Neurosci
Title: The role of the neuropeptides PACAP and VIP in the photic regulation of gene expression in the suprachiasmatic nucleus.
Volume: 31
Issue: 5
Pages: 864-75
Publication
First Author: Vieira E
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle.
Volume: 295
Issue: 5
Pages: E1032-7
Publication
First Author: Yamaguchi Y
Year: 2022
Journal: Biol Pharm Bull
Title: Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity.
Volume: 45
Issue: 8
Pages: 1172-1179
Publication
First Author: Riedel CS
Year: 2020
Journal: PLoS One
Title: Altered light induced EGR1 expression in the SCN of PACAP deficient mice.
Volume: 15
Issue: 5
Pages: e0232748
Publication  
First Author: Hablitz LM
Year: 2020
Journal: eNeuro
Title: Cannabinoid Signaling Recruits Astrocytes to Modulate Presynaptic Function in the Suprachiasmatic Nucleus.
Volume: 7
Issue: 1
Publication
First Author: Kudo T
Year: 2011
Journal: Exp Neurol
Title: Circadian dysfunction in a mouse model of Parkinson's disease.
Volume: 232
Issue: 1
Pages: 66-75
Publication
First Author: Hughes AT
Year: 2004
Journal: J Neurosci
Title: Aberrant gating of photic input to the suprachiasmatic circadian pacemaker of mice lacking the VPAC2 receptor.
Volume: 24
Issue: 14
Pages: 3522-6
Publication
First Author: Sheward WJ
Year: 2010
Journal: PLoS One
Title: Circadian control of mouse heart rate and blood pressure by the suprachiasmatic nuclei: behavioral effects are more significant than direct outputs.
Volume: 5
Issue: 3
Pages: e9783
Publication
First Author: Cao R
Year: 2013
Journal: Eur J Neurosci
Title: Mitogen- and stress-activated protein kinase 1 modulates photic entrainment of the suprachiasmatic circadian clock.
Volume: 37
Issue: 1
Pages: 130-40
Publication  
First Author: Ono M
Year: 2022
Journal: Int J Mol Sci
Title: Uterine Deletion of Bmal1 Impairs Placental Vascularization and Induces Intrauterine Fetal Death in Mice.
Volume: 23
Issue: 14
Publication
First Author: Chatterjee S
Year: 2020
Journal: BMC Biol
Title: The CBP KIX domain regulates long-term memory and circadian activity.
Volume: 18
Issue: 1
Pages: 155
Publication
First Author: Paul JR
Year: 2017
Journal: Eur J Neurosci
Title: Glycogen synthase kinase 3 regulates photic signaling in the suprachiasmatic nucleus.
Volume: 45
Issue: 8
Pages: 1102-1110
Publication
First Author: Deery MJ
Year: 2009
Journal: Curr Biol
Title: Proteomic analysis reveals the role of synaptic vesicle cycling in sustaining the suprachiasmatic circadian clock.
Volume: 19
Issue: 23
Pages: 2031-6
Publication
First Author: Li JD
Year: 2006
Journal: J Neurosci
Title: Attenuated circadian rhythms in mice lacking the prokineticin 2 gene.
Volume: 26
Issue: 45
Pages: 11615-23
Publication
First Author: Girardet C
Year: 2013
Journal: Glia
Title: Brain-derived neurotrophic factor/TrkB signaling regulates daily astroglial plasticity in the suprachiasmatic nucleus: electron-microscopic evidence in mouse.
Volume: 61
Issue: 7
Pages: 1172-7
Publication  
First Author: Peng Y
Year: 2022
Journal: Front Physiol
Title: Cell Type-Specific Genetic Manipulation and Impaired Circadian Rhythms in Vip (tTA) Knock-In Mice.
Volume: 13
Pages: 895633
Publication
First Author: Yamaguchi Y
Year: 2021
Journal: Sci Rep
Title: Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock.
Volume: 11
Issue: 1
Pages: 22406
Publication
First Author: Rohde K
Year: 2017
Journal: J Neurochem
Title: A modulatory role of the Rax homeobox gene in mature pineal gland function: Investigating the photoneuroendocrine circadian system of a Rax conditional knockout mouse.
Volume: 143
Issue: 1
Pages: 100-111
Publication
First Author: Nadimpalli HP
Year: 2024
Journal: Genome Biol
Title: Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms.
Volume: 25
Issue: 1
Pages: 128
Publication
First Author: Yang S
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Tissue-specific FAH deficiency alters sleep-wake patterns and results in chronic tyrosinemia in mice.
Volume: 116
Issue: 44
Pages: 22229-22236
Publication  
First Author: Deans JR
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver.
Volume: 14
Pages: 1266527
Publication
First Author: Watanabe N
Year: 2015
Journal: Development
Title: Hbp1 regulates the timing of neuronal differentiation during cortical development by controlling cell cycle progression.
Volume: 142
Issue: 13
Pages: 2278-90
Publication
First Author: Singh M
Year: 2018
Journal: Oncotarget
Title: i3 signaling is associated with sexual dimorphic expression of the clock-controlled output gene Dbp in murine liver.
Volume: 9
Issue: 54
Pages: 30213-30224
Publication
First Author: Liu Y
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Loss of BMAL1 in ovarian steroidogenic cells results in implantation failure in female mice.
Volume: 111
Issue: 39
Pages: 14295-300
Publication
First Author: Moraes MN
Year: 2017
Journal: Biochim Biophys Acta
Title: Cold-sensing TRPM8 channel participates in circadian control of the brown adipose tissue.
Volume: 1864
Issue: 12
Pages: 2415-2427
Publication
First Author: Zhu P
Year: 2022
Journal: Genes Dev
Title: BMAL1 drives muscle repair through control of hypoxic NAD+ regeneration in satellite cells.
Volume: 36
Issue: 3-4
Pages: 149-166
Publication
First Author: Mereness AL
Year: 2016
Journal: Endocrinology
Title: Conditional Deletion of Bmal1 in Ovarian Theca Cells Disrupts Ovulation in Female Mice.
Volume: 157
Issue: 2
Pages: 913-27
Publication
First Author: Mermet J
Year: 2021
Journal: PLoS Genet
Title: Oscillating and stable genome topologies underlie hepatic physiological rhythms during the circadian cycle.
Volume: 17
Issue: 2
Pages: e1009350
Publication  
First Author: Clemenzi MN
Year: 2020
Journal: Mol Cell Endocrinol
Title: Analysis of Western diet, palmitate and BMAL1 regulation of neuropeptide Y expression in the murine hypothalamus and BMAL1 knockout cell models.
Volume: 507
Pages: 110773
Publication
First Author: Barca-Mayo O
Year: 2020
Journal: Glia
Title: Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice.
Volume: 68
Issue: 6
Pages: 1131-1147
Publication
First Author: Bhatwadekar AD
Year: 2017
Journal: Am J Pathol
Title: Conditional Deletion of Bmal1 Accentuates Microvascular and Macrovascular Injury.
Volume: 187
Issue: 6
Pages: 1426-1435
Publication
First Author: Yu X
Year: 2014
Journal: Curr Biol
Title: Circadian factor BMAL1 in histaminergic neurons regulates sleep architecture.
Volume: 24
Issue: 23
Pages: 2838-44
Publication  
First Author: Nakano JJ
Year: 2016
Journal: Sci Rep
Title: SCOP/PHLPP1β in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior.
Volume: 6
Pages: 33500
Publication
First Author: Froy O
Year: 2006
Journal: Am J Physiol Endocrinol Metab
Title: Long-lived alphaMUPA transgenic mice exhibit pronounced circadian rhythms.
Volume: 291
Issue: 5
Pages: E1017-24
Publication
First Author: Froy O
Year: 2008
Journal: Neuroscience
Title: The suprachiasmatic nuclei are involved in determining circadian rhythms during restricted feeding.
Volume: 155
Issue: 4
Pages: 1152-9
Publication
First Author: Froy O
Year: 2009
Journal: Mech Ageing Dev
Title: Effect of intermittent fasting on circadian rhythms in mice depends on feeding time.
Volume: 130
Issue: 3
Pages: 154-60
Publication
First Author: Schilperoort M
Year: 2020
Journal: FASEB J
Title: Circadian disruption by shifting the light-dark cycle negatively affects bone health in mice.
Volume: 34
Issue: 1
Pages: 1052-1064
Publication
First Author: In Het Panhuis W
Year: 2022
Journal: Aging (Albany NY)
Title: Aging attenuates diurnal lipid uptake by brown adipose tissue.
Volume: 14
Issue: 19
Pages: 7734-7751
Publication
First Author: Sulli G
Year: 2018
Journal: Nature
Title: Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence.
Volume: 553
Issue: 7688
Pages: 351-355
Publication
First Author: Purrier N
Year: 2014
Journal: PLoS One
Title: Mice deficient of glutamatergic signaling from intrinsically photosensitive retinal ganglion cells exhibit abnormal circadian photoentrainment.
Volume: 9
Issue: 10
Pages: e111449
Publication  
First Author: Moldavan MG
Year: 2018
Journal: eNeuro
Title: Circadian Behavioral Responses to Light and Optic Chiasm-Evoked Glutamatergic EPSCs in the Suprachiasmatic Nucleus of ipRGC Conditional vGlut2 Knock-Out Mice.
Volume: 5
Issue: 3
Publication
First Author: Barrett P
Year: 2006
Journal: J Endocrinol
Title: Photoperiodic regulation of cellular retinol binding protein, CRBP1 [corrected] and nestin in tanycytes of the third ventricle ependymal layer of the Siberian hamster.
Volume: 191
Issue: 3
Pages: 687-98
Publication
First Author: Wisor JP
Year: 2007
Journal: Sleep
Title: A novel quantitative trait locus on mouse chromosome 18, "era1," modifies the entrainment of circadian rhythms.
Volume: 30
Issue: 10
Pages: 1255-63
Publication  
First Author: Skoda J
Year: 2022
Journal: Biochem Pharmacol
Title: Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized mice.
Volume: 197
Pages: 114905
Publication
First Author: West AC
Year: 2017
Journal: Nat Commun
Title: Misalignment with the external light environment drives metabolic and cardiac dysfunction.
Volume: 8
Issue: 1
Pages: 417
Publication
First Author: Bussi IL
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Expression of the vesicular GABA transporter within neuromedin S(+) neurons sustains behavioral circadian rhythms.
Volume: 120
Issue: 49
Pages: e2314857120
Publication
First Author: Drouyer E
Year: 2010
Journal: J Comp Neurol
Title: Specializations of gastrin-releasing peptide cells of the mouse suprachiasmatic nucleus.
Volume: 518
Issue: 8
Pages: 1249-63
Publication
First Author: Butler MP
Year: 2012
Journal: Endocrinology
Title: Dose-dependent effects of androgens on the circadian timing system and its response to light.
Volume: 153
Issue: 5
Pages: 2344-52
Publication
First Author: Karatsoreos IN
Year: 2004
Journal: J Neurosci
Title: Phenotype matters: identification of light-responsive cells in the mouse suprachiasmatic nucleus.
Volume: 24
Issue: 1
Pages: 68-75
Publication
First Author: Watanabe T
Year: 2009
Journal: PLoS One
Title: Genetic and molecular analysis of wild-derived arrhythmic mice.
Volume: 4
Issue: 1
Pages: e4301
Publication
First Author: Park N
Year: 2015
Journal: PLoS One
Title: A Novel Bmal1 Mutant Mouse Reveals Essential Roles of the C-Terminal Domain on Circadian Rhythms.
Volume: 10
Issue: 9
Pages: e0138661
Publication  
First Author: Uetani N
Year: 2017
Journal: JCI Insight
Title: PRL2 links magnesium flux and sex-dependent circadian metabolic rhythms.
Volume: 2
Issue: 13
Publication
First Author: LeSauter J
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Stomach ghrelin-secreting cells as food-entrainable circadian clocks.
Volume: 106
Issue: 32
Pages: 13582-7
Publication
First Author: Hirao A
Year: 2010
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Combination of starvation interval and food volume determines the phase of liver circadian rhythm in Per2::Luc knock-in mice under two meals per day feeding.
Volume: 299
Issue: 5
Pages: G1045-53
Publication
First Author: Haraguchi A
Year: 2018
Journal: Sci Rep
Title: Night eating model shows time-specific depression-like behavior in the forced swimming test.
Volume: 8
Issue: 1
Pages: 1081
Publication
First Author: Oishi K
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice.
Volume: 412
Issue: 2
Pages: 396-400
Publication
First Author: Aryal DK
Year: 2022
Journal: Genes Brain Behav
Title: Mice lacking proSAAS display alterations in emotion, consummatory behavior and circadian entrainment.
Volume: 21
Issue: 7
Pages: e12827
Publication
First Author: Basse AL
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: NAMPT-dependent NAD(+) biosynthesis controls circadian metabolism in a tissue-specific manner.
Volume: 120
Issue: 14
Pages: e2220102120
Publication
First Author: Zhang C
Year: 2009
Journal: PLoS One
Title: Efferent projections of prokineticin 2 expressing neurons in the mouse suprachiasmatic nucleus.
Volume: 4
Issue: 9
Pages: e7151
Publication
First Author: Kim SM
Year: 2018
Journal: FASEB J
Title: Shift work cycle-induced alterations of circadian rhythms potentiate the effects of high-fat diet on inflammation and metabolism.
Volume: 32
Issue: 6
Pages: 3085-3095
Publication
First Author: Hayasaka N
Year: 2011
Journal: PLoS One
Title: Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice.
Volume: 6
Issue: 3
Pages: e17655
Publication
First Author: Tremblay F
Year: 2012
Journal: Endocrinology
Title: Loss of coiled-coil domain containing 80 negatively modulates glucose homeostasis in diet-induced obese mice.
Volume: 153
Issue: 9
Pages: 4290-303