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Search results 201 to 300 out of 5246 for App

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Category: Publication
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Type Details Score
Publication
23274884 | J:199052
First Author: Niedowicz DM
Year: 2013
Journal: Biochim Biophys Acta
Title: Leptin regulates amyloid β production via the γ-secretase complex.
Volume: 1832
Issue: 3
Pages: 439-44
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Publication
10412057 | J:58050
First Author: Lamb BT
Year: 1999
Journal: Nat Neurosci
Title: Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.
Volume: 2
Issue: 8
Pages: 695-7
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Publication
32455709 | J:304191
 
First Author: Park SY
Year: 2020
Journal: Cells
Title: SPON1 Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer's Disease Mouse Model.
Volume: 9
Issue: 5
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Publication
23580652 | J:199624
First Author: Sagare AP
Year: 2013
Journal: J Biol Chem
Title: A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain.
Volume: 288
Issue: 21
Pages: 15154-66
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Publication
19118188 | J:239203
First Author: Puzzo D
Year: 2008
Journal: J Neurosci
Title: Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus.
Volume: 28
Issue: 53
Pages: 14537-45
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Publication
28826672 | J:271996
First Author: Wang ZH
Year: 2017
Journal: Mol Cell
Title: Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.
Volume: 67
Issue: 5
Pages: 812-825.e5
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Publication
31439589 | J:284845
 
First Author: Pervolaraki E
Year: 2019
Journal: Dis Model Mech
Title: Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, affecting anxiety-related behaviours.
Volume: 12
Issue: 9
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Publication
8635459 | J:32213
First Author: Moechars D
Year: 1996
Journal: EMBO J
Title: Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.
Volume: 15
Issue: 6
Pages: 1265-74
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Publication
32321771 | J:289167
 
First Author: Maezono SEB
Year: 2020
Journal: eNeuro
Title: Progressive Changes in Sleep and Its Relations to Amyloid-β Distribution and Learning in Single App Knock-In Mice.
Volume: 7
Issue: 2
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Publication
36104602 | J:340078
First Author: Shang Y
Year: 2022
Journal: Acta Neuropathol
Title: A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.
Volume: 144
Issue: 5
Pages: 911-938
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Publication
9117892 | J:80782
First Author: Borchelt DR
Year: 1996
Journal: Genet Anal
Title: A vector for expressing foreign genes in the brains and hearts of transgenic mice.
Volume: 13
Issue: 6
Pages: 159-63
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Publication
11032903 | J:65205
First Author: Marcinkiewicz M
Year: 2000
Journal: J Neurochem
Title: Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain.
Volume: 75
Issue: 5
Pages: 2133-43
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Publication
22958823 | J:325329
First Author: Yoon SO
Year: 2012
Journal: Neuron
Title: JNK3 perpetuates metabolic stress induced by Aβ peptides.
Volume: 75
Issue: 5
Pages: 824-37
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Publication
39427315 | J:358090
First Author: Miller SR
Year: 2024
Journal: Cell Rep
Title: Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models.
Volume: 43
Issue: 11
Pages: 114870
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Publication
28980867 | J:311253
First Author: Yang C
Year: 2017
Journal: Autophagy
Title: NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models.
Volume: 13
Issue: 12
Pages: 2028-2040
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Publication
31932477 | J:291599
 
First Author: Uruno A
Year: 2020
Journal: Mol Cell Biol
Title: Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer's Disease Model Mice.
Volume: 40
Issue: 6
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Publication
24821909 | J:213119
First Author: Ahn HJ
Year: 2014
Journal: J Exp Med
Title: A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice.
Volume: 211
Issue: 6
Pages: 1049-62
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Publication
31759806 | J:283375
First Author: Bassil F
Year: 2020
Journal: Neuron
Title: Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology.
Volume: 105
Issue: 2
Pages: 260-275.e6
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Publication
17258906 | J:119002
First Author: Ohno M
Year: 2007
Journal: Neurobiol Dis
Title: BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice.
Volume: 26
Issue: 1
Pages: 134-45
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Publication
24305806 | J:255339
First Author: Herskowitz JH
Year: 2013
Journal: J Neurosci
Title: Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model.
Volume: 33
Issue: 49
Pages: 19086-98
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Publication
11485902 | J:70861
First Author: Sigurdsson EM
Year: 2001
Journal: Am J Pathol
Title: Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice.
Volume: 159
Issue: 2
Pages: 439-47
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Publication
11162243 | J:67764
First Author: Cha JH
Year: 2001
Journal: Neurobiol Dis
Title: Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein.
Volume: 8
Issue: 1
Pages: 90-102
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Publication
11493029 | J:71189
First Author: Steinhoff T
Year: 2001
Journal: Neurobiol Dis
Title: Increased cystatin C in astrocytes of transgenic mice expressing the K670N-M671L mutation of the amyloid precursor protein and deposition in brain amyloid plaques.
Volume: 8
Issue: 4
Pages: 647-54
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Publication
36765071 | J:333392
First Author: Cao R
Year: 2023
Journal: Nat Commun
Title: Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals.
Volume: 14
Issue: 1
Pages: 744
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Publication
29229786 | J:272179
First Author: Ziegler-Waldkirch S
Year: 2018
Journal: EMBO J
Title: Seed-induced Aβ deposition is modulated by microglia under environmental enrichment in a mouse model of Alzheimer's disease.
Volume: 37
Issue: 2
Pages: 167-182
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Publication
15347685 | J:94996
First Author: Lee JH
Year: 2004
Journal: J Biol Chem
Title: The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice.
Volume: 279
Issue: 47
Pages: 49099-104
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Publication
20971852 | J:167567
First Author: Wirths O
Year: 2010
Journal: J Biol Chem
Title: Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis.
Volume: 285
Issue: 53
Pages: 41517-24
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Publication
23820808 | J:263411
First Author: Kandalepas PC
Year: 2013
Journal: Acta Neuropathol
Title: The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques.
Volume: 126
Issue: 3
Pages: 329-52
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Publication
26080426 | J:223748
First Author: Corbett GT
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP.
Volume: 112
Issue: 27
Pages: 8445-50
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Publication
21412423 | J:171451
First Author: Adlard PA
Year: 2011
Journal: PLoS One
Title: Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease.
Volume: 6
Issue: 3
Pages: e17669
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Publication
11880515 | J:75098
First Author: Westerman MA
Year: 2002
Journal: J Neurosci
Title: The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.
Volume: 22
Issue: 5
Pages: 1858-67
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Publication
11839594 | J:74500
First Author: Gau JT
Year: 2002
Journal: Am J Pathol
Title: Stable beta-secretase activity and presynaptic cholinergic markers during progressive central nervous system amyloidogenesis in Tg2576 mice.
Volume: 160
Issue: 2
Pages: 731-8
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Publication
21709248 | J:174392
First Author: Bedrosian TA
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice.
Volume: 108
Issue: 28
Pages: 11686-91
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Publication
36064300 | J:350549
First Author: Bocharova OV
Year: 2023
Journal: Brain Pathol
Title: Aβ plaques do not protect against HSV-1 infection in a mouse model of familial Alzheimer's disease, and HSV-1 does not induce Aβ pathology in a model of late onset Alzheimer's disease.
Volume: 33
Issue: 1
Pages: e13116
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Publication
33607163 | J:307357
 
First Author: Locci A
Year: 2021
Journal: Behav Brain Res
Title: Comparison of memory, affective behavior, and neuropathology in APPNLGF knock-in mice to 5xFAD and APP/PS1 mice.
Volume: 404
Pages: 113192
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Publication
26993139 | J:313426
First Author: Sadleir KR
Year: 2016
Journal: Acta Neuropathol
Title: Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease.
Volume: 132
Issue: 2
Pages: 235-256
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Publication
20180882 | J:159907
First Author: Ajmo JM
Year: 2010
Journal: J Neurochem
Title: Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw.
Volume: 113
Issue: 3
Pages: 784-95
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Publication
25261995 | J:227827
First Author: Minami SS
Year: 2014
Journal: Nat Med
Title: Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.
Volume: 20
Issue: 10
Pages: 1157-64
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Publication
25716857 | J:219846
First Author: Ayton S
Year: 2015
Journal: J Neurosci
Title: Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein.
Volume: 35
Issue: 8
Pages: 3591-7
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Publication
16708023 | J:109150
First Author: Valla J
Year: 2006
Journal: Neuroreport
Title: Nonprogressive transgene-related callosal and hippocampal changes in PDAPP mice.
Volume: 17
Issue: 8
Pages: 829-32
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Publication
34215298 | J:324340
First Author: Sharoar MG
Year: 2021
Journal: Mol Neurodegener
Title: Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains.
Volume: 16
Issue: 1
Pages: 45
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Publication
25937280 | J:228470
First Author: Yamamoto K
Year: 2015
Journal: Cell Rep
Title: Chronic optogenetic activation augments aβ pathology in a mouse model of Alzheimer disease.
Volume: 11
Issue: 6
Pages: 859-865
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Publication
12586551 | J:127925
First Author: Weiss C
Year: 2002
Journal: Neurobiol Dis
Title: Impaired eyeblink conditioning and decreased hippocampal volume in PDAPP V717F mice.
Volume: 11
Issue: 3
Pages: 425-33
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Publication
10643895 | J:60044
First Author: Dodart JC
Year: 1999
Journal: Neurosci Lett
Title: Early regional cerebral glucose hypometabolism in transgenic mice overexpressing the V717F beta-amyloid precursor protein.
Volume: 277
Issue: 1
Pages: 49-52
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Publication
8220418 | J:80947
First Author: Lamb BT
Year: 1993
Journal: Nat Genet
Title: Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected].
Volume: 5
Issue: 1
Pages: 22-30
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Publication
25217641 | J:217754
First Author: Bolós M
Year: 2014
Journal: J Biol Chem
Title: Neurogenin 2 mediates amyloid-β precursor protein-stimulated neurogenesis.
Volume: 289
Issue: 45
Pages: 31253-61
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Publication
29894726 | J:272721
 
First Author: Hurwitz SN
Year: 2018
Journal: J Neurosci Methods
Title: An optimized method for enrichment of whole brain-derived extracellular vesicles reveals insight into neurodegenerative processes in a mouse model of Alzheimer's disease.
Volume: 307
Pages: 210-220
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Publication
29107146 | J:274302
First Author: Jang JY
Year: 2018
Journal: Biochim Biophys Acta Gen Subj
Title: NABi, a novel β-sheet breaker, inhibits Aβ aggregation and neuronal toxicity: Therapeutic implications for Alzheimer's disease.
Volume: 1862
Issue: 1
Pages: 71-80
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Publication
36549605 | J:350551
 
First Author: Plachez C
Year: 2023
Journal: Neuroscience
Title: Amyloid Deposition and Dendritic Complexity of Corticocortical Projection Cells in Five Familial Alzheimer's Disease Mouse.
Volume: 512
Pages: 85-98
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Publication
33298560 | J:304416
 
First Author: Ghosh A
Year: 2020
Journal: Sci Transl Med
Title: An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease.
Volume: 12
Issue: 573
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Publication
37437821 | J:339354
 
First Author: Yang Y
Year: 2023
Journal: Brain Behav Immun
Title: LPS priming before plaque deposition impedes microglial activation and restrains Aβ pathology in the 5xFAD mouse model of Alzheimer's disease.
Volume: 113
Pages: 228-247
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Publication
22267726 | J:182761
First Author: Wittnam JL
Year: 2012
Journal: J Biol Chem
Title: Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease.
Volume: 287
Issue: 11
Pages: 8154-62
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Publication
37551444 | J:346663
First Author: Keramidis I
Year: 2023
Journal: Brain
Title: Restoring neuronal chloride extrusion reverses cognitive decline linked to Alzheimer's disease mutations.
Volume: 146
Issue: 12
Pages: 4903-4915
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Publication
38497356 | J:348220
First Author: Palko SI
Year: 2024
Journal: Glia
Title: ER-stress response in retinal Müller glia occurs significantly earlier than amyloid pathology in the Alzheimer's mouse brain and retina.
Volume: 72
Issue: 6
Pages: 1067-1081
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37710351 | J:340550
First Author: Upadhyay A
Year: 2023
Journal: Mol Neurodegener
Title: Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity.
Volume: 18
Issue: 1
Pages: 61
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Publication
31964863 | J:301698
First Author: Yan T
Year: 2020
Journal: Nat Commun
Title: FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease.
Volume: 11
Issue: 1
Pages: 411
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39837326 | J:361225
     
First Author: Sasmita AO
Year: 2025
Journal: Neuron
Title: Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer's disease.
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17409228 | J:119403
First Author: Zhao J
Year: 2007
Journal: J Neurosci
Title: Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.
Volume: 27
Issue: 14
Pages: 3639-49
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Publication
22033930 | J:178748
First Author: Sclip A
Year: 2011
Journal: J Biol Chem
Title: c-Jun N-terminal kinase regulates soluble Aβ oligomers and cognitive impairment in AD mouse model.
Volume: 286
Issue: 51
Pages: 43871-80
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Publication
21148560 | J:169481
First Author: Jawhar S
Year: 2011
Journal: J Biol Chem
Title: Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.
Volume: 286
Issue: 6
Pages: 4454-60
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10408445 | J:56166
First Author: Schenk D
Year: 1999
Journal: Nature
Title: Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.
Volume: 400
Issue: 6740
Pages: 173-7
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Publication
20451588 | J:165233
First Author: Lee KJ
Year: 2010
Journal: Neuroscience
Title: Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines.
Volume: 169
Issue: 1
Pages: 344-56
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17705508 | J:124967
First Author: Van Vickle GD
Year: 2007
Journal: Biochemistry
Title: TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation.
Volume: 46
Issue: 36
Pages: 10317-27
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27094130 | J:236998
First Author: Kim BM
Year: 2016
Journal: Hum Mol Genet
Title: Inhibition of death-associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein.
Volume: 25
Issue: 12
Pages: 2498-2513
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Publication
38937583 | J:359459
First Author: Kedia S
Year: 2024
Journal: Nat Neurosci
Title: T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.
Volume: 27
Issue: 8
Pages: 1468-1474
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33768250 | J:354270
 
First Author: Owen JE
Year: 2021
Journal: Sleep
Title: Late-in-life neurodegeneration after chronic sleep loss in young adult mice.
Volume: 44
Issue: 8
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31113487 | J:289681
First Author: Stephen TL
Year: 2019
Journal: Acta Neuropathol Commun
Title: APOE genotype and sex affect microglial interactions with plaques in Alzheimer's disease mice.
Volume: 7
Issue: 1
Pages: 82
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23060451 | J:193422
First Author: Youmans KL
Year: 2012
Journal: J Biol Chem
Title: APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.
Volume: 287
Issue: 50
Pages: 41774-86
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Publication
28361984 | J:272779
 
First Author: Colié S
Year: 2017
Journal: Sci Rep
Title: Neuronal p38α mediates synaptic and cognitive dysfunction in an Alzheimer's mouse model by controlling β-amyloid production.
Volume: 7
Pages: 45306
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Publication
29200205 | J:311456
First Author: He Z
Year: 2018
Journal: Nat Med
Title: Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation.
Volume: 24
Issue: 1
Pages: 29-38
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Publication
34426734 | J:345178
 
First Author: Estfanous S
Year: 2021
Journal: Front Immunol
Title: Elevated Expression of MiR-17 in Microglia of Alzheimer's Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation.
Volume: 12
Pages: 705581
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22745485 | J:185647
First Author: Kook SY
Year: 2012
Journal: J Neurosci
Title: Aβ₁₋₄₂-RAGE interaction disrupts tight junctions of the blood-brain barrier via Ca²⁺-calcineurin signaling.
Volume: 32
Issue: 26
Pages: 8845-54
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Publication
36635496 | J:348189
First Author: van Lengerich B
Year: 2023
Journal: Nat Neurosci
Title: A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
Volume: 26
Issue: 3
Pages: 416-429
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Publication
32966798 | J:311228
First Author: Yao J
Year: 2020
Journal: Cell Rep
Title: Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation.
Volume: 32
Issue: 12
Pages: 108169
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Publication
28698220 | J:330075
 
First Author: Park D
Year: 2017
Journal: Sci Signal
Title: Activation of CaMKIV by soluble amyloid-β1-42 impedes trafficking of axonal vesicles and impairs activity-dependent synaptogenesis.
Volume: 10
Issue: 487
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Publication
36982771 | J:334837
 
First Author: Tun X
Year: 2023
Journal: Int J Mol Sci
Title: Integrin β3-Mediated Cell Senescence Associates with Gut Inflammation and Intestinal Degeneration in Models of Alzheimer's Disease.
Volume: 24
Issue: 6
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Publication
26522221 | J:233202
First Author: Jin Y
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Amyloid-β peptide increases cell surface localization of α7 ACh receptor to protect neurons from amyloid β-induced damage.
Volume: 468
Issue: 1-2
Pages: 157-60
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Publication
27091843 | J:233314
First Author: Wang Y
Year: 2016
Journal: J Exp Med
Title: TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques.
Volume: 213
Issue: 5
Pages: 667-75
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Publication
29803828 | J:269675
 
First Author: Giralt A
Year: 2018
Journal: Exp Neurol
Title: PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease.
Volume: 307
Pages: 62-73
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Publication
31980612 | J:283770
First Author: Tanaka H
Year: 2020
Journal: Nat Commun
Title: YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology.
Volume: 11
Issue: 1
Pages: 507
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Publication
23850592 | J:207047
 
First Author: Shukla M
Year: 2013
Journal: Neuroscience
Title: Reduced expression of pain mediators and pain sensitivity in amyloid precursor protein over-expressing CRND8 transgenic mice.
Volume: 250
Pages: 92-101
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Publication
27084579 | J:246510
First Author: Kurkinen KM
Year: 2016
Journal: J Cell Sci
Title: SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.
Volume: 129
Issue: 11
Pages: 2224-38
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Publication
24898256 | J:216007
First Author: Cheng F
Year: 2014
Journal: J Biol Chem
Title: Amyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate.
Volume: 289
Issue: 30
Pages: 20871-8
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Publication
14715132 | J:87453
First Author: Ohno M
Year: 2004
Journal: Neuron
Title: BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease.
Volume: 41
Issue: 1
Pages: 27-33
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Publication
35431893 | J:323890
 
First Author: Blume T
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