|  Help  |  About  |  Contact Us

Search our database by keyword

- or -

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 300 out of 838 for Ins1

Category restricted to Publication (x)

0.239s

Categories

Category: Publication
Type Details Score
Publication
First Author: Withers DJ
Year: 1999
Journal: Nat Genet
Title: Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.
Volume: 23
Issue: 1
Pages: 32-40
Publication
First Author: Xia P
Year: 2015
Journal: J Exp Med
Title: Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages.
Volume: 212
Issue: 13
Pages: 2305-21
Publication
First Author: Seymour PA
Year: 2012
Journal: Development
Title: A Sox9/Fgf feed-forward loop maintains pancreatic organ identity.
Volume: 139
Issue: 18
Pages: 3363-72
Publication
First Author: Diaferia GR
Year: 2013
Journal: Development
Title: β1 integrin is a crucial regulator of pancreatic β-cell expansion.
Volume: 140
Issue: 16
Pages: 3360-72
Publication
First Author: Win PW
Year: 2020
Journal: Cell Tissue Res
Title: Beta-cell β1 integrin deficiency affects in utero development of islet growth and vascularization.
Volume: 381
Issue: 1
Pages: 163-175
Publication    
First Author: Tixi W
Year: 2023
Journal: Elife
Title: Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation.
Volume: 12
Publication
First Author: Boj SF
Year: 2012
Journal: Cell
Title: Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.
Volume: 151
Issue: 7
Pages: 1595-607
Publication
First Author: Reinert RB
Year: 2013
Journal: Diabetes
Title: Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets.
Volume: 62
Issue: 12
Pages: 4154-64
Publication
First Author: Brissova M
Year: 2006
Journal: Diabetes
Title: Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function.
Volume: 55
Issue: 11
Pages: 2974-85
Publication  
First Author: Marchant C
Year: 2020
Journal: Development
Title: Vessel-derived angiocrine IGF1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis.
Volume: 147
Issue: 11
Publication
First Author: Reinert RB
Year: 2014
Journal: Development
Title: Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding.
Volume: 141
Issue: 7
Pages: 1480-91
Publication
First Author: Asayesh A
Year: 2006
Journal: Genes Dev
Title: Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice.
Volume: 20
Issue: 16
Pages: 2208-13
Publication
First Author: Sussel L
Year: 1998
Journal: Development
Title: Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
Volume: 125
Issue: 12
Pages: 2213-21
Publication  
First Author: Kordowich S
Year: 2011
Journal: BMC Dev Biol
Title: Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage.
Volume: 11
Pages: 52
Publication
First Author: Suissa Y
Year: 2013
Journal: PLoS One
Title: Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas.
Volume: 8
Issue: 8
Pages: e70397
Publication
First Author: Chao CS
Year: 2007
Journal: Dev Biol
Title: Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells.
Volume: 312
Issue: 2
Pages: 523-32
Publication
First Author: Wang J
Year: 2004
Journal: Dev Biol
Title: The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation.
Volume: 266
Issue: 1
Pages: 178-89
Publication
First Author: Doyle MJ
Year: 2007
Journal: Development
Title: Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.
Volume: 134
Issue: 3
Pages: 515-23
Publication
First Author: Mastracci TL
Year: 2011
Journal: Dev Biol
Title: Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression.
Volume: 359
Issue: 1
Pages: 1-11
Publication    
First Author: Churchill AJ
Year: 2017
Journal: Elife
Title: Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development.
Volume: 6
Publication
First Author: Prado CL
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development.
Volume: 101
Issue: 9
Pages: 2924-9
Publication
First Author: Perez SE
Year: 2005
Journal: Diabetes
Title: Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.
Volume: 54
Issue: 3
Pages: 694-701
Publication
First Author: Miyatsuka T
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a.
Volume: 108
Issue: 1
Pages: 185-90
Publication
First Author: Chesnokova V
Year: 2009
Journal: Endocrinology
Title: Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence.
Volume: 150
Issue: 6
Pages: 2603-10
Publication
First Author: Kredo-Russo S
Year: 2012
Journal: Development
Title: Pancreas-enriched miRNA refines endocrine cell differentiation.
Volume: 139
Issue: 16
Pages: 3021-31
Publication
First Author: Magenheim J
Year: 2011
Journal: Dev Biol
Title: Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium.
Volume: 359
Issue: 1
Pages: 26-36
Publication      
First Author: Dudek KD
Year: 2021
Journal: G3 (Bethesda)
Title: Insm1, Neurod1, and Pax6 promote murine pancreatic endocrine cell development through overlapping yet distinct RNA transcription and splicing programs.
Publication
First Author: Kuo TL
Year: 2016
Journal: Oncogene
Title: APC haploinsufficiency coupled with p53 loss sufficiently induces mucinous cystic neoplasms and invasive pancreatic carcinoma in mice.
Volume: 35
Issue: 17
Pages: 2223-34
Publication
First Author: Zhang Y
Year: 2017
Journal: Dev Biol
Title: Monitoring p53 by MDM2 and MDMX is required for endocrine pancreas development and function in a spatio-temporal manner.
Volume: 423
Issue: 1
Pages: 34-45
Publication  
First Author: Uhlemeyer C
Year: 2023
Journal: Mol Metab
Title: Selective ablation of P53 in pancreatic beta cells fails to ameliorate glucose metabolism in genetic, dietary and pharmacological models of diabetes mellitus.
Volume: 67
Pages: 101650
Publication
First Author: Cai EP
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate.
Volume: 110
Issue: 36
Pages: 14723-8
Publication
First Author: Fulgenzi G
Year: 2020
Journal: Nat Commun
Title: Novel metabolic role for BDNF in pancreatic β-cell insulin secretion.
Volume: 11
Issue: 1
Pages: 1950
Publication
First Author: Valtat B
Year: 2011
Journal: Diabetologia
Title: Genetic evidence of the programming of beta cell mass and function by glucocorticoids in mice.
Volume: 54
Issue: 2
Pages: 350-9
Publication
First Author: Arnaud-Dabernat S
Year: 2007
Journal: Diabetes
Title: FGFR3 is a negative regulator of the expansion of pancreatic epithelial cells.
Volume: 56
Issue: 1
Pages: 96-106
Publication
First Author: Kilic G
Year: 2006
Journal: Dev Dyn
Title: Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice.
Volume: 235
Issue: 6
Pages: 1659-67
Publication      
First Author: Malenczyk K
Year: 2018
Journal: Mol Metab
Title: Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification.
Publication
First Author: Denis RG
Year: 2015
Journal: Cell Metab
Title: Palatability Can Drive Feeding Independent of AgRP Neurons.
Volume: 22
Issue: 4
Pages: 646-57
Publication
First Author: Talchai C
Year: 2012
Journal: Nat Genet
Title: Generation of functional insulin-producing cells in the gut by Foxo1 ablation.
Volume: 44
Issue: 4
Pages: 406-12, S1
Publication
First Author: Talchai SC
Year: 2015
Journal: Diabetes
Title: Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult β-Cell Mass and Function.
Volume: 64
Issue: 8
Pages: 2868-79
Publication
First Author: Muñoz-Bravo JL
Year: 2013
Journal: Development
Title: GDNF is required for neural colonization of the pancreas.
Volume: 140
Issue: 17
Pages: 3669-79
Publication
First Author: Pauerstein PT
Year: 2017
Journal: Development
Title: A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis.
Volume: 144
Issue: 20
Pages: 3744-3754
Publication
First Author: Chu K
Year: 2005
Journal: Diabetes
Title: Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion.
Volume: 54
Issue: 4
Pages: 1064-73
Publication
First Author: Baumgartner BK
Year: 2014
Journal: Dev Biol
Title: Distinct requirements for beta-catenin in pancreatic epithelial growth and patterning.
Volume: 391
Issue: 1
Pages: 89-98
Publication
First Author: Murtaugh LC
Year: 2005
Journal: Development
Title: Beta-catenin is essential for pancreatic acinar but not islet development.
Volume: 132
Issue: 21
Pages: 4663-74
Publication
First Author: Gong Y
Year: 2023
Journal: Dev Cell
Title: Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma.
Volume: 58
Issue: 3
Pages: 192-210.e11
Publication
First Author: Soggia A
Year: 2014
Journal: Diabetologia
Title: von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulation.
Volume: 57
Issue: 11
Pages: 2348-56
Publication
First Author: Lin X
Year: 2016
Journal: PLoS Genet
Title: MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice.
Volume: 12
Issue: 10
Pages: e1006308
Publication
First Author: Tao J
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: SEC23B is required for the maintenance of murine professional secretory tissues.
Volume: 109
Issue: 29
Pages: E2001-9
Publication
First Author: Fujitani Y
Year: 2006
Journal: Genes Dev
Title: Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.
Volume: 20
Issue: 2
Pages: 253-66
Publication
First Author: Chakravarthy MV
Year: 2008
Journal: Diabetes
Title: Decreased fetal size is associated with beta-cell hyperfunction in early life and failure with age.
Volume: 57
Issue: 10
Pages: 2698-707
Publication
First Author: Carbe C
Year: 2012
Journal: Dev Biol
Title: The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development.
Volume: 363
Issue: 1
Pages: 320-9
Publication
First Author: Beucher A
Year: 2022
Journal: Nat Cell Biol
Title: The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A.
Volume: 24
Issue: 10
Pages: 1528-1540
Publication
First Author: Carpenter AC
Year: 2010
Journal: Genesis
Title: Generation of mice with a conditional null allele for Wntless.
Volume: 48
Issue: 9
Pages: 554-8
Publication
First Author: Pan FC
Year: 2015
Journal: Development
Title: Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing β-cells to a δ-like fate and reveals a facultative proliferative capacity in aged β-cells.
Volume: 142
Issue: 21
Pages: 3637-48
Publication  
First Author: Khoriaty R
Year: 2016
Journal: Sci Rep
Title: Pancreatic SEC23B deficiency is sufficient to explain the perinatal lethality of germline SEC23B deficiency in mice.
Volume: 6
Pages: 27802
Publication
First Author: Dessimoz J
Year: 2005
Journal: Curr Biol
Title: Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development.
Volume: 15
Issue: 18
Pages: 1677-83
Publication  
First Author: Wells JM
Year: 2007
Journal: BMC Dev Biol
Title: Wnt/beta-catenin signaling is required for development of the exocrine pancreas.
Volume: 7
Pages: 4
Publication
First Author: Cras-Méneur C
Year: 2009
Journal: Genes Dev
Title: Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.
Volume: 23
Issue: 17
Pages: 2088-101
Publication
First Author: Jonsson J
Year: 1994
Journal: Nature
Title: Insulin-promoter-factor 1 is required for pancreas development in mice.
Volume: 371
Issue: 6498
Pages: 606-9
Publication
First Author: Ahlgren U
Year: 1996
Journal: Development
Title: The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice.
Volume: 122
Issue: 5
Pages: 1409-16
Publication
First Author: Edfalk S
Year: 2008
Journal: Diabetes
Title: Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion.
Volume: 57
Issue: 9
Pages: 2280-7
Publication
First Author: Oliver-Krasinski JM
Year: 2009
Journal: J Clin Invest
Title: The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice.
Volume: 119
Issue: 7
Pages: 1888-98
Publication
First Author: Spence JR
Year: 2009
Journal: Dev Cell
Title: Sox17 regulates organ lineage segregation of ventral foregut progenitor cells.
Volume: 17
Issue: 1
Pages: 62-74
Publication
First Author: Sumazaki R
Year: 2004
Journal: Nat Genet
Title: Conversion of biliary system to pancreatic tissue in Hes1-deficient mice.
Volume: 36
Issue: 1
Pages: 83-7
Publication
First Author: Larsen BM
Year: 2015
Journal: Development
Title: Mesenchymal Hox6 function is required for mouse pancreatic endocrine cell differentiation.
Volume: 142
Issue: 22
Pages: 3859-68
Publication
First Author: Lioubinski O
Year: 2003
Journal: Dev Dyn
Title: Expression of Sox transcription factors in the developing mouse pancreas.
Volume: 227
Issue: 3
Pages: 402-8
Publication
First Author: Ealey KN
Year: 2008
Journal: Int J Cancer
Title: Colon carcinogenesis in liver-specific IGF-I-deficient (LID) mice.
Volume: 122
Issue: 2
Pages: 472-6
Publication
First Author: Pulkkinen MA
Year: 2003
Journal: Mech Dev
Title: The IIIb isoform of fibroblast growth factor receptor 2 is required for proper growth and branching of pancreatic ductal epithelium but not for differentiation of exocrine or endocrine cells.
Volume: 120
Issue: 2
Pages: 167-75
Publication
First Author: Martín J
Year: 2003
Journal: Oncogene
Title: Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number.
Volume: 22
Issue: 34
Pages: 5261-9
Publication
First Author: Kim SY
Year: 2011
Journal: Development
Title: The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors.
Volume: 138
Issue: 10
Pages: 1903-12
Publication
First Author: Kong KC
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1.
Volume: 107
Issue: 49
Pages: 21181-6
Publication
First Author: Kim JH
Year: 2001
Journal: Genomics
Title: Genetic analysis of a new mouse model for non-insulin-dependent diabetes.
Volume: 74
Issue: 3
Pages: 273-86
Publication
First Author: Zhang X
Year: 2006
Journal: Dev Biol
Title: Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.
Volume: 300
Issue: 2
Pages: 748-57
Publication
First Author: Kim SK
Year: 2002
Journal: Nat Genet
Title: Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus.
Volume: 30
Issue: 4
Pages: 430-5
Publication
First Author: Gu Y
Year: 2011
Journal: Diabetes
Title: Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size.
Volume: 60
Issue: 3
Pages: 827-37
Publication
First Author: Stiles BL
Year: 2006
Journal: Mol Cell Biol
Title: Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes.
Volume: 26
Issue: 7
Pages: 2772-81
Publication
First Author: Wong C
Year: 2020
Journal: Cell Death Differ
Title: Two well-differentiated pancreatic neuroendocrine tumor mouse models.
Volume: 27
Issue: 1
Pages: 269-283
Publication
First Author: Georgia S
Year: 2013
Journal: Genes Dev
Title: DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis.
Volume: 27
Issue: 4
Pages: 372-7
Publication
First Author: Parveen N
Year: 2023
Journal: Diabetes
Title: DNA Methylation-Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-Cell Heterogeneity.
Volume: 72
Issue: 5
Pages: 575-589
Publication
First Author: Goulley J
Year: 2007
Journal: Cell Metab
Title: BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.
Volume: 5
Issue: 3
Pages: 207-19
Publication
First Author: Jiang FX
Year: 2017
Journal: Stem Cells Dev
Title: Transient Impairment of Islet Architectural Development in Pancreas-Specific Bmpr1a-Deleted Prenatal Mice Involves Reduced Expression of E-Cadherin.
Volume: 26
Issue: 23
Pages: 1706-1714
Publication
First Author: Wang S
Year: 2007
Journal: Mech Dev
Title: Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse.
Volume: 124
Issue: 11-12
Pages: 898-910
Publication
First Author: Madhusudhan T
Year: 2017
Journal: Blood
Title: Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.
Volume: 130
Issue: 12
Pages: 1445-1455
Publication
First Author: Juhl K
Year: 2008
Journal: Diabetes
Title: Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse.
Volume: 57
Issue: 10
Pages: 2755-61
Publication
First Author: Sojoodi M
Year: 2016
Journal: Diabetologia
Title: The zinc finger transcription factor PW1/PEG3 restrains murine beta cell cycling.
Volume: 59
Issue: 7
Pages: 1474-1479
Publication
First Author: Mellitzer G
Year: 2010
Journal: J Clin Invest
Title: Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival.
Volume: 120
Issue: 5
Pages: 1708-21
Publication
First Author: Piccand J
Year: 2014
Journal: Diabetes
Title: Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice.
Volume: 63
Issue: 1
Pages: 203-15
Publication
First Author: Serafimidis I
Year: 2011
Journal: Mol Cell Biol
Title: G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesis.
Volume: 31
Issue: 22
Pages: 4442-53
Publication
First Author: Lindahl M
Year: 2014
Journal: Cell Rep
Title: MANF is indispensable for the proliferation and survival of pancreatic β cells.
Volume: 7
Issue: 2
Pages: 366-75
Publication
First Author: Pakarinen E
Year: 2022
Journal: Cell Mol Life Sci
Title: CDNF and MANF regulate ER stress in a tissue-specific manner.
Volume: 79
Issue: 2
Pages: 124
Publication
First Author: Petzold KM
Year: 2013
Journal: Development
Title: Rho signalling restriction by the RhoGAP Stard13 integrates growth and morphogenesis in the pancreas.
Volume: 140
Issue: 1
Pages: 126-35
Publication
First Author: Hammerle CM
Year: 2020
Journal: PLoS Genet
Title: Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function.
Volume: 16
Issue: 10
Pages: e1009069
Publication
First Author: Seymour PA
Year: 2008
Journal: Dev Biol
Title: A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation.
Volume: 323
Issue: 1
Pages: 19-30
Publication
First Author: Mitchell RK
Year: 2016
Journal: Mol Endocrinol
Title: Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance.
Volume: 30
Issue: 1
Pages: 77-91
Publication
First Author: Wei FY
Year: 2011
Journal: J Clin Invest
Title: Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice.
Volume: 121
Issue: 9
Pages: 3598-608
Publication
First Author: Chamberlain CE
Year: 2014
Journal: J Clin Invest
Title: Menin determines K-RAS proliferative outputs in endocrine cells.
Volume: 124
Issue: 9
Pages: 4093-101
Publication
First Author: Tsai MJ
Year: 2014
Journal: Endocrinology
Title: TCTP is essential for β-cell proliferation and mass expansion during development and β-cell adaptation in response to insulin resistance.
Volume: 155
Issue: 2
Pages: 392-404
Publication  
First Author: Navarro G
Year: 2018
Journal: JCI Insight
Title: Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes.
Volume: 3
Issue: 12
Publication
First Author: Yang Y
Year: 2017
Journal: Endocrinology
Title: Differential Gene Dosage Effects of Diabetes-Associated Gene GLIS3 in Pancreatic β Cell Differentiation and Function.
Volume: 158
Issue: 1
Pages: 9-20
Publication
First Author: Li H
Year: 2018
Journal: J Biol Chem
Title: Hepatitis B X-interacting protein promotes the formation of the insulin gene-transcribing protein complex Pdx-1/Neurod1 in animal pancreatic β-cells.
Volume: 293
Issue: 6
Pages: 2053-2065