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Search results 201 to 300 out of 453 for Tsc2

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Category: Publication
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Type Details Score
Publication
24632604 | J:218622
First Author: Yang J
Year: 2015
Journal: Oncogene
Title: Renal tumours in a Tsc2(+/-) mouse model do not show feedback inhibition of Akt and are effectively prevented by rapamycin.
Volume: 34
Issue: 7
Pages: 922-31
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Publication
19395652 | J:148013
First Author: Blando J
Year: 2009
Journal: Am J Pathol
Title: PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth.
Volume: 174
Issue: 5
Pages: 1869-79
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Publication
32023468 | J:287482
First Author: Wilson JL
Year: 2020
Journal: Cell Rep
Title: Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation.
Volume: 30
Issue: 5
Pages: 1542-1552.e7
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Publication
37018657 | J:337940
First Author: Sukhbaatar N
Year: 2023
Journal: Blood
Title: Duodenal macrophages control dietary iron absorption via local degradation of transferrin.
Volume: 141
Issue: 23
Pages: 2878-2890
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Publication
10677526 | J:68331
First Author: Kim K
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Polycystin 1 is required for the structural integrity of blood vessels.
Volume: 97
Issue: 4
Pages: 1731-6
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Publication
25893604 | J:222700
First Author: Pollizzi KN
Year: 2015
Journal: J Clin Invest
Title: mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation.
Volume: 125
Issue: 5
Pages: 2090-108
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Publication
36423280 | J:331924
First Author: Bernard C
Year: 2022
Journal: Science
Title: Cortical wiring by synapse type-specific control of local protein synthesis.
Volume: 378
Issue: 6622
Pages: eabm7466
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Publication
30910408 | J:277302
 
First Author: Pita-Thomas W
Year: 2019
Journal: Exp Neurol
Title: HDAC5 promotes optic nerve regeneration by activating the mTOR pathway.
Volume: 317
Pages: 271-283
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Publication
35584673 | J:325096
First Author: Schrötter S
Year: 2022
Journal: Cell Rep
Title: The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth.
Volume: 39
Issue: 7
Pages: 110824
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Publication
9072957 | J:38919
First Author: Burmeister M
Year: 1997
Journal: Mamm Genome
Title: The trefoil gene maps to mouse chromosome 17.
Volume: 8
Issue: 3
Pages: 223-4
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Publication
17355907 | J:123206
First Author: Yasui S
Year: 2007
Journal: Mol Cell Neurosci
Title: The TSC1 gene product hamartin interacts with NADE.
Volume: 35
Issue: 1
Pages: 100-8
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Publication
17942919 | J:125965
First Author: Finlay GA
Year: 2007
Journal: Cancer Res
Title: Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.
Volume: 67
Issue: 20
Pages: 9878-86
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Publication
19068483 | J:147633
First Author: Wang W
Year: 2009
Journal: J Biol Chem
Title: The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis.
Volume: 284
Issue: 6
Pages: 3521-8
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Publication
20042714 | J:177809
First Author: Barnes EA
Year: 2010
Journal: Am J Respir Cell Mol Biol
Title: The loss of tuberin promotes cell invasion through the ß-catenin pathway.
Volume: 43
Issue: 5
Pages: 617-27
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Publication
23508953 | J:198599
First Author: La P
Year: 2013
Journal: J Biol Chem
Title: Mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation stabilizes ISCU protein: implications for iron metabolism.
Volume: 288
Issue: 18
Pages: 12901-9
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Publication
25533187 | J:219761
First Author: Kim YM
Year: 2015
Journal: Mol Cell
Title: mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.
Volume: 57
Issue: 2
Pages: 207-18
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Publication
20453062 | J:161320
First Author: Aguado C
Year: 2010
Journal: Hum Mol Genet
Title: Laforin, the most common protein mutated in Lafora disease, regulates autophagy.
Volume: 19
Issue: 14
Pages: 2867-76
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Publication
22343943 | J:182149
First Author: Settembre C
Year: 2012
Journal: EMBO J
Title: A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.
Volume: 31
Issue: 5
Pages: 1095-108
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Publication
24096482 | J:214352
First Author: Chen Z
Year: 2014
Journal: Oncogene
Title: mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression.
Volume: 33
Issue: 37
Pages: 4548-57
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Publication
30679017 | J:271893
First Author: Antoine MW
Year: 2019
Journal: Neuron
Title: Increased Excitation-Inhibition Ratio Stabilizes Synapse and Circuit Excitability in Four Autism Mouse Models.
Volume: 101
Issue: 4
Pages: 648-661.e4
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Publication
23778976 | J:238448
First Author: Chen N
Year: 2013
Journal: Autophagy
Title: IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway.
Volume: 9
Issue: 8
Pages: 1214-27
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Publication
29056426 | J:248911
First Author: Valvezan AJ
Year: 2017
Journal: Cancer Cell
Title: mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.
Volume: 32
Issue: 5
Pages: 624-638.e5
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Publication
23425014 | J:218147
First Author: Caccamo A
Year: 2013
Journal: Aging Cell
Title: mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies.
Volume: 12
Issue: 3
Pages: 370-80
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Publication
23966835 | J:201589
First Author: Potter WB
Year: 2013
Journal: PLoS Biol
Title: Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling.
Volume: 11
Issue: 8
Pages: e1001627
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37804836 | J:358028
First Author: Fritsch SD
Year: 2023
Journal: Cell Metab
Title: Metabolic support by macrophages sustains colonic epithelial homeostasis.
Volume: 35
Issue: 11
Pages: 1931-1943.e8
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37042477 | J:335768
 
First Author: Minor BMN
Year: 2023
Journal: Endocrinology
Title: Estradiol Augments Tumor-Induced Neutrophil Production to Promote Tumor Cell Actions in Lymphangioleiomyomatosis Models.
Volume: 164
Issue: 6
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Publication
21737790 | J:186597
First Author: Zhai P
Year: 2011
Journal: Circ Res
Title: Differential roles of GSK-3β during myocardial ischemia and ischemia/reperfusion.
Volume: 109
Issue: 5
Pages: 502-11
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Publication
27064374 | J:260621
First Author: Pollizzi KN
Year: 2016
Journal: Nat Immunol
Title: Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation.
Volume: 17
Issue: 6
Pages: 704-11
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Publication
37450596 | J:338613
First Author: Wang Y
Year: 2023
Journal: Sci Adv
Title: Overexpression of Nfe2l1 increases proteasome activity and delays vision loss in a preclinical model of human blindness.
Volume: 9
Issue: 28
Pages: eadd5479
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Publication
19255143 | J:148419
First Author: Distefano G
Year: 2009
Journal: Mol Cell Biol
Title: Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.
Volume: 29
Issue: 9
Pages: 2359-71
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Publication
24737317 | J:315936
First Author: Cho Y
Year: 2014
Journal: J Biol Chem
Title: Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration.
Volume: 289
Issue: 22
Pages: 15820-32
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30514904 | J:298778
First Author: Deng L
Year: 2019
Journal: Cell Res
Title: Ubiquitination of Rheb governs growth factor-induced mTORC1 activation.
Volume: 29
Issue: 2
Pages: 136-150
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Publication
23858058 | J:204748
First Author: Chakrabarti P
Year: 2013
Journal: Mol Cell Biol
Title: Insulin inhibits lipolysis in adipocytes via the evolutionarily conserved mTORC1-Egr1-ATGL-mediated pathway.
Volume: 33
Issue: 18
Pages: 3659-66
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Publication
24161930 | J:208097
First Author: Liu P
Year: 2013
Journal: Nat Cell Biol
Title: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Volume: 15
Issue: 11
Pages: 1340-50
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17470459 | J:125107
First Author: Rosner M
Year: 2007
Journal: Hum Mol Genet
Title: p27Kip1 localization depends on the tumor suppressor protein tuberin.
Volume: 16
Issue: 13
Pages: 1541-56
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18411301 | J:137317
First Author: Huang J
Year: 2008
Journal: Mol Cell Biol
Title: The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.
Volume: 28
Issue: 12
Pages: 4104-15
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23102618 | J:190892
First Author: Bayeva M
Year: 2012
Journal: Cell Metab
Title: mTOR regulates cellular iron homeostasis through tristetraprolin.
Volume: 16
Issue: 5
Pages: 645-57
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25043031 | J:217111
First Author: Zhang Y
Year: 2014
Journal: Nature
Title: Coordinated regulation of protein synthesis and degradation by mTORC1.
Volume: 513
Issue: 7518
Pages: 440-3
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28512249 | J:242570
First Author: Lam HC
Year: 2017
Journal: Cancer Res
Title: p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.
Volume: 77
Issue: 12
Pages: 3255-3267
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Publication
12783884 | J:85181
First Author: Yang ZZ
Year: 2003
Journal: J Biol Chem
Title: Protein kinase B alpha/Akt1 regulates placental development and fetal growth.
Volume: 278
Issue: 34
Pages: 32124-31
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Publication
21383064 | J:172815
First Author: Wolff NC
Year: 2011
Journal: Mol Cell Biol
Title: Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.
Volume: 31
Issue: 9
Pages: 1870-84
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Publication
21795849 | J:314079
First Author: Jung CH
Year: 2011
Journal: Autophagy
Title: ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.
Volume: 7
Issue: 10
Pages: 1212-21
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Publication
30237867 | J:308760
 
First Author: Brown EA
Year: 2018
Journal: Mol Autism
Title: Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models.
Volume: 9
Pages: 48
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Publication
21896734 | J:176586
First Author: Banerjee S
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.
Volume: 108
Issue: 38
Pages: 15996-6001
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21746920 | J:174534
First Author: Parkhitko A
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent.
Volume: 108
Issue: 30
Pages: 12455-60
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Publication
25175012 | J:274167
 
First Author: Zhu L
Year: 2014
Journal: Nat Commun
Title: TSC1 controls macrophage polarization to prevent inflammatory disease.
Volume: 5
Pages: 4696
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Publication
24931163 | J:221262
First Author: Dodd KM
Year: 2015
Journal: Oncogene
Title: mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3.
Volume: 34
Issue: 17
Pages: 2239-50
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Publication
27080031 | J:266755
 
First Author: Petrinovic MM
Year: 2016
Journal: Sci Rep
Title: A novel anesthesia regime enables neurofunctional studies and imaging genetics across mouse strains.
Volume: 6
Pages: 24523
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27593484 | J:333623
First Author: Yang T
Year: 2016
Journal: Cell Mol Immunol
Title: TSC1 controls IL-1β expression in macrophages via mTORC1-dependent C/EBPβ pathway.
Volume: 13
Issue: 5
Pages: 640-50
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Publication
23228442 | J:196914
First Author: Yang J
Year: 2013
Journal: Eur J Cancer
Title: Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin.
Volume: 49
Issue: 6
Pages: 1479-90
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Publication
28763796 | J:260078
 
First Author: Lee PY
Year: 2017
Journal: Sci Immunol
Title: The metabolic regulator mTORC1 controls terminal myeloid differentiation.
Volume: 2
Issue: 11
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Publication
22916036 | J:188124
First Author: Tanwar PS
Year: 2012
Journal: PLoS Genet
Title: Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1.
Volume: 8
Issue: 8
Pages: e1002906
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Publication
31527310 | J:293727
First Author: Asrani K
Year: 2019
Journal: J Clin Invest
Title: mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulation.
Volume: 129
Issue: 12
Pages: 5584-5599
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Publication
23142078 | J:193986
First Author: Kim SG
Year: 2013
Journal: Mol Cell
Title: Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.
Volume: 49
Issue: 1
Pages: 172-85
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Publication
28013293 | J:241435
First Author: Jin F
Year: 2017
Journal: Hum Mol Genet
Title: Deficient TSC1/TSC2-complex suppression of SOX9-osteopontin-AKT signalling cascade constrains tumour growth in tuberous sclerosis complex.
Volume: 26
Issue: 2
Pages: 407-419
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23274085 | J:195093
First Author: Bae SH
Year: 2013
Journal: Cell Metab
Title: Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
Volume: 17
Issue: 1
Pages: 73-84
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18344980 | J:133950
First Author: Lim KH
Year: 2008
Journal: Nature
Title: Tumour maintenance is mediated by eNOS.
Volume: 452
Issue: 7187
Pages: 646-9
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18373617 | J:137320
First Author: Kiebish MA
Year: 2008
Journal: J Neurochem
Title: Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria.
Volume: 106
Issue: 1
Pages: 299-312
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23315073 | J:193238
First Author: Katholnig K
Year: 2013
Journal: J Immunol
Title: p38α senses environmental stress to control innate immune responses via mechanistic target of rapamycin.
Volume: 190
Issue: 4
Pages: 1519-27
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17015619 | J:114498
First Author: Gan B
Year: 2006
Journal: J Cell Biol
Title: Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways.
Volume: 175
Issue: 1
Pages: 121-33
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24209762 | J:205532
First Author: Wang S
Year: 2013
Journal: Cell Stem Cell
Title: Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency.
Volume: 13
Issue: 5
Pages: 617-25
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32807950 | J:334054
First Author: Babetto E
Year: 2020
Journal: Nat Neurosci
Title: A glycolytic shift in Schwann cells supports injured axons.
Volume: 23
Issue: 10
Pages: 1215-1228
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21436046 | J:171212
First Author: Williams T
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress.
Volume: 108
Issue: 14
Pages: 5849-54
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35645731 | J:325114
 
First Author: Serra I
Year: 2022
Journal: Front Mol Neurosci
Title: Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum.
Volume: 15
Pages: 831687
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23275438 | J:315254
First Author: Zurashvili T
Year: 2013
Journal: Mol Cell Biol
Title: Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.
Volume: 33
Issue: 5
Pages: 1027-40
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15249583 | J:91846
First Author: Harrington LS
Year: 2004
Journal: J Cell Biol
Title: The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.
Volume: 166
Issue: 2
Pages: 213-23
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8945939 | J:36847
First Author: Soonpaa MH
Year: 1996
Journal: Am J Physiol
Title: Cardiomyocyte DNA synthesis and binucleation during murine development.
Volume: 271
Issue: 5 Pt 2
Pages: H2183-9
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19620286 | J:152599
First Author: Bhaskar PT
Year: 2009
Journal: Mol Cell Biol
Title: mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition.
Volume: 29
Issue: 18
Pages: 5136-47
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19398581 | J:149890
First Author: Saiga T
Year: 2009
Journal: Mol Cell Biol
Title: Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.
Volume: 29
Issue: 13
Pages: 3529-43
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9226367 | J:41656
First Author: Brinkmeier ML
Year: 1997
Journal: Genomics
Title: Localization of somatostatin receptor genes on mouse chromosomes 2, 11, 12, 15, and 17: correlation with growth QTLs.
Volume: 43
Issue: 1
Pages: 9-14
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27050589 | J:235088
First Author: de la Torre-Ubieta L
Year: 2016
Journal: Nat Med
Title: Advancing the understanding of autism disease mechanisms through genetics.
Volume: 22
Issue: 4
Pages: 345-61
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25273085 | J:217495
First Author: Ka M
Year: 2014
Journal: Development
Title: mTOR regulates brain morphogenesis by mediating GSK3 signaling.
Volume: 141
Issue: 21
Pages: 4076-86
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20665729 | J:164696
First Author: Tan Y
Year: 2010
Journal: Genesis
Title: Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development.
Volume: 48
Issue: 9
Pages: 531-9
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20399730 | J:160624
First Author: Kim S
Year: 2010
Journal: Neuron
Title: The apical complex couples cell fate and cell survival to cerebral cortical development.
Volume: 66
Issue: 1
Pages: 69-84
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34242585 | J:308686
First Author: Tiu GC
Year: 2021
Journal: Dev Cell
Title: A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies.
Volume: 56
Issue: 14
Pages: 2089-2102.e11
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28069738 | J:244710
 
First Author: Yamauchi T
Year: 2017
Journal: Mol Cell Biol
Title: FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.
Volume: 37
Issue: 8
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21238928 | J:168571
First Author: Zou J
Year: 2011
Journal: Dev Cell
Title: Rheb1 is required for mTORC1 and myelination in postnatal brain development.
Volume: 20
Issue: 1
Pages: 97-108
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27416896 | J:240829
 
First Author: Jiang M
Year: 2016
Journal: Nat Commun
Title: Regulation of PERK-eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes.
Volume: 7
Pages: 12185
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27582005 | J:235788
First Author: Nagy II
Year: 2016
Journal: BMC Dev Biol
Title: Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis.
Volume: 16
Issue: 1
Pages: 30
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28671696 | J:249721
First Author: Li J
Year: 2017
Journal: Nat Neurosci
Title: Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
Volume: 20
Issue: 8
Pages: 1150-1161
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16452087 | J:263376
First Author: Trinidad JC
Year: 2006
Journal: Mol Cell Proteomics
Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.
Volume: 5
Issue: 5
Pages: 914-22
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29950673 | J:266104
First Author: Choi JH
Year: 2018
Journal: Nat Commun
Title: mTORC1 accelerates retinal development via the immunoproteasome.
Volume: 9
Issue: 1
Pages: 2502
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Publication
37494420 | J:344559
First Author: Hughes CHK
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve.
Volume: 120
Issue: 32
Pages: e2220849120
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25211037 | J:263419
First Author: Distler U
Year: 2014
Journal: Proteomics
Title: In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics.
Volume: 14
Issue: 21-22
Pages: 2607-13
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- | J:342612
       
First Author: UniProt curators
Year: 2014
Title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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