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Search results 201 to 300 out of 462 for Xbp1

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Category: Publication
Type Details Score
Publication
First Author: Clauss IM
Year: 1993
Journal: Dev Dyn
Title: In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis.
Volume: 197
Issue: 2
Pages: 146-56
Publication
First Author: Ijuin T
Year: 2016
Journal: Mol Cell Biol
Title: Phosphatidylinositol 3,4,5-Trisphosphate Phosphatase SKIP Links Endoplasmic Reticulum Stress in Skeletal Muscle to Insulin Resistance.
Volume: 36
Issue: 1
Pages: 108-18
Publication
First Author: Ozcan L
Year: 2009
Journal: Cell Metab
Title: Endoplasmic reticulum stress plays a central role in development of leptin resistance.
Volume: 9
Issue: 1
Pages: 35-51
Publication
First Author: Lee J
Year: 2011
Journal: Nat Med
Title: p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis.
Volume: 17
Issue: 10
Pages: 1251-60
Publication  
First Author: Lee J
Year: 2018
Journal: Mol Metab
Title: PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism.
Volume: 7
Pages: 119-131
Publication
First Author: Sha H
Year: 2014
Journal: Diabetes
Title: Adipocyte spliced form of X-box-binding protein 1 promotes adiponectin multimerization and systemic glucose homeostasis.
Volume: 63
Issue: 3
Pages: 867-79
Publication
First Author: Bartelt A
Year: 2018
Journal: Nat Med
Title: Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.
Volume: 24
Issue: 3
Pages: 292-303
Publication
First Author: Oikawa D
Year: 2010
Journal: FEBS Lett
Title: Positive contribution of the IRE1alpha-XBP1 pathway to placental expression of CEA family genes.
Volume: 584
Issue: 5
Pages: 1066-70
Publication
First Author: Hu CC
Year: 2009
Journal: EMBO J
Title: XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells.
Volume: 28
Issue: 11
Pages: 1624-36
Publication
First Author: Cissé M
Year: 2017
Journal: Mol Psychiatry
Title: The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model.
Volume: 22
Issue: 11
Pages: 1562-1575
Publication
First Author: Benhamron S
Year: 2014
Journal: Eur J Immunol
Title: Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells.
Volume: 44
Issue: 3
Pages: 867-76
Publication
First Author: Uemura T
Year: 2009
Journal: Mol Cell Biol
Title: p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival.
Volume: 29
Issue: 7
Pages: 1869-81
Publication
First Author: Xu L
Year: 2020
Journal: Nat Cell Biol
Title: Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions.
Volume: 22
Issue: 10
Pages: 1162-1169
Publication
First Author: Wang X
Year: 2018
Journal: Cell Death Differ
Title: Glucose-regulated protein 78 is essential for cardiac myocyte survival.
Volume: 25
Issue: 12
Pages: 2181-2194
Publication
First Author: Tsuchiya Y
Year: 2018
Journal: J Cell Biol
Title: IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells.
Volume: 217
Issue: 4
Pages: 1287-1301
Publication
First Author: Huang H
Year: 2017
Journal: Cell Death Dis
Title: Neuroprotection by eIF2α-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss.
Volume: 8
Issue: 7
Pages: e2936
Publication  
First Author: Shao M
Year: 2014
Journal: Nat Commun
Title: Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.
Volume: 5
Pages: 3528
Publication
First Author: Tschurtschenthaler M
Year: 2017
Journal: J Exp Med
Title: Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.
Volume: 214
Issue: 2
Pages: 401-422
Publication
First Author: Schwärzler J
Year: 2022
Journal: Gastroenterology
Title: PUFA-Induced Metabolic Enteritis as a Fuel for Crohn's Disease.
Volume: 162
Issue: 6
Pages: 1690-1704
Publication
First Author: Novosyadlyy R
Year: 2008
Journal: Cell Death Differ
Title: Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum.
Volume: 15
Issue: 8
Pages: 1304-17
Publication
First Author: Love KT
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Lipid-like materials for low-dose, in vivo gene silencing.
Volume: 107
Issue: 5
Pages: 1864-9
Publication
First Author: Wang W
Year: 2010
Journal: J Immunol
Title: Hemokinin-1 activates the MAPK pathway and enhances B cell proliferation and antibody production.
Volume: 184
Issue: 7
Pages: 3590-7
Publication
First Author: Liu L
Year: 2013
Journal: Am J Pathol
Title: Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization.
Volume: 182
Issue: 4
Pages: 1412-24
Publication
First Author: Sun S
Year: 2019
Journal: Genes Dev
Title: The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation.
Volume: 33
Issue: 15-16
Pages: 1083-1094
Publication
First Author: ten Berge D
Year: 1998
Journal: Dev Biol
Title: Mouse Alx3: an aristaless-like homeobox gene expressed during embryogenesis in ectomesenchyme and lateral plate mesoderm.
Volume: 199
Issue: 1
Pages: 11-25
Publication
First Author: Zhang K
Year: 2006
Journal: Cell
Title: Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response.
Volume: 124
Issue: 3
Pages: 587-99
Publication
First Author: Chen S
Year: 2019
Journal: Cell Metab
Title: Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction.
Volume: 30
Issue: 6
Pages: 1141-1151.e5
Publication
First Author: Grootjans J
Year: 2019
Journal: Science
Title: Epithelial endoplasmic reticulum stress orchestrates a protective IgA response.
Volume: 363
Issue: 6430
Pages: 993-998
Publication
First Author: Adolph TE
Year: 2013
Journal: Nature
Title: Paneth cells as a site of origin for intestinal inflammation.
Volume: 503
Issue: 7475
Pages: 272-6
Publication
First Author: Benhamron S
Year: 2015
Journal: Mol Cell Biol
Title: mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion.
Volume: 35
Issue: 1
Pages: 153-66
Publication
First Author: Luo S
Year: 2006
Journal: Mol Cell Biol
Title: GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development.
Volume: 26
Issue: 15
Pages: 5688-97
Publication
First Author: Moloughney JG
Year: 2016
Journal: Mol Cell
Title: mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1.
Volume: 63
Issue: 5
Pages: 811-26
Publication
First Author: Madhusudhan T
Year: 2017
Journal: Blood
Title: Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.
Volume: 130
Issue: 12
Pages: 1445-1455
Publication
First Author: Mann MJ
Year: 2012
Journal: PLoS One
Title: UPR-induced resistance to etoposide is downstream of PERK and independent of changes in topoisomerase IIα levels.
Volume: 7
Issue: 10
Pages: e47931
Publication
First Author: Peña J
Year: 2011
Journal: J Biol Chem
Title: Dengue virus modulates the unfolded protein response in a time-dependent manner.
Volume: 286
Issue: 16
Pages: 14226-36
Publication
First Author: Kanekura K
Year: 2015
Journal: Sci Signal
Title: IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions.
Volume: 8
Issue: 382
Pages: ra62
Publication      
First Author: Duan J
Year: 2023
Journal: Immunity
Title: Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut.
Publication
First Author: Aden K
Year: 2018
Journal: J Exp Med
Title: ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.
Volume: 215
Issue: 11
Pages: 2868-2886
Publication
First Author: Mao C
Year: 2006
Journal: J Biol Chem
Title: In vivo regulation of Grp78/BiP transcription in the embryonic heart: role of the endoplasmic reticulum stress response element and GATA-4.
Volume: 281
Issue: 13
Pages: 8877-87
Publication
First Author: Francisco AB
Year: 2010
Journal: J Biol Chem
Title: Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality.
Volume: 285
Issue: 18
Pages: 13694-703
Publication
First Author: Hasbold J
Year: 2004
Journal: Nat Immunol
Title: Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation.
Volume: 5
Issue: 1
Pages: 55-63
Publication
First Author: Zhang Y
Year: 2012
Journal: PLoS One
Title: Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking.
Volume: 7
Issue: 11
Pages: e48587
Publication
First Author: Nikaido T
Year: 2001
Journal: Histochem Cell Biol
Title: Expression of the novel transcription factor OASIS, which belongs to the CREB/ATF family, in mouse embryo with special reference to bone development.
Volume: 116
Issue: 2
Pages: 141-8
Publication
First Author: Firtina Z
Year: 2011
Journal: Gene Expr Patterns
Title: Unfolded Protein Response (UPR) is activated during normal lens development.
Volume: 11
Issue: 1-2
Pages: 135-43
Publication
First Author: Reneker LW
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Activation of unfolded protein response in transgenic mouse lenses.
Volume: 52
Issue: 5
Pages: 2100-8
Publication
First Author: Duplan E
Year: 2013
Journal: J Cell Sci
Title: ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1.
Volume: 126
Issue: Pt 9
Pages: 2124-33
Publication
First Author: Reimold AM
Year: 2000
Journal: Genes Dev
Title: An essential role in liver development for transcription factor XBP-1.
Volume: 14
Issue: 2
Pages: 152-7
Publication
First Author: Saito A
Year: 2014
Journal: Mol Cell
Title: Chondrocyte proliferation regulated by secreted luminal domain of ER stress transducer BBF2H7/CREB3L2.
Volume: 53
Issue: 1
Pages: 127-39
Publication
First Author: de Reuver R
Year: 2021
Journal: Cell Rep
Title: ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation.
Volume: 36
Issue: 6
Pages: 109500
Publication
First Author: Zhang X
Year: 2007
Journal: Int J Dev Neurosci
Title: Endoplasmic reticulum stress during the embryonic development of the central nervous system in the mouse.
Volume: 25
Issue: 7
Pages: 455-63
Publication
First Author: Hao L
Year: 2009
Journal: Biol Reprod
Title: The unfolded protein response contributes to preimplantation mouse embryo death in the DDK syndrome.
Volume: 80
Issue: 5
Pages: 944-53
Publication
First Author: Rainger J
Year: 2013
Journal: PLoS Genet
Title: A trans-acting protein effect causes severe eye malformation in the Mp mouse.
Volume: 9
Issue: 12
Pages: e1003998
Publication
First Author: Li X
Year: 2013
Journal: Diabetes
Title: c-Jun NH2-terminal kinase 1/2 and endoplasmic reticulum stress as interdependent and reciprocal causation in diabetic embryopathy.
Volume: 62
Issue: 2
Pages: 599-608
Publication
First Author: Mao M
Year: 2017
Journal: Dis Model Mech
Title: Genetic dissection of anterior segment dysgenesis caused by a Col4a1 mutation in mouse.
Volume: 10
Issue: 4
Pages: 475-485
Publication
First Author: Yamaguchi H
Year: 2022
Journal: Dev Dyn
Title: Disruption of Trip11 in cranial neural crest cells is associated with increased ER and Golgi stress contributing to skull defects in mice.
Volume: 251
Issue: 7
Pages: 1209-1222
Publication
First Author: Liang G
Year: 2014
Journal: PLoS One
Title: Endoplasmic reticulum stress-unfolding protein response-apoptosis cascade causes chondrodysplasia in a col2a1 p.Gly1170Ser mutated mouse model.
Volume: 9
Issue: 1
Pages: e86894
Publication
First Author: Mirigian LS
Year: 2016
Journal: J Bone Miner Res
Title: Osteoblast Malfunction Caused by Cell Stress Response to Procollagen Misfolding in α2(I)-G610C Mouse Model of Osteogenesis Imperfecta.
Volume: 31
Issue: 8
Pages: 1608-1616
Publication
First Author: Zhang B
Year: 2011
Journal: Blood
Title: Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin.
Volume: 118
Issue: 12
Pages: 3384-91
Publication
First Author: Posey KL
Year: 2012
Journal: Am J Pathol
Title: Chop (Ddit3) is essential for D469del-COMP retention and cell death in chondrocytes in an inducible transgenic mouse model of pseudoachondroplasia.
Volume: 180
Issue: 2
Pages: 727-37
Publication
First Author: Neupane S
Year: 2021
Journal: Glycobiology
Title: Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ.
Volume: 31
Issue: 8
Pages: 988-1004
Publication
First Author: Ariyasu D
Year: 2019
Journal: Endocrinology
Title: Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly Inherited GH Deficiency in Humanized GH1 Mouse Models.
Volume: 160
Issue: 11
Pages: 2673-2691
Publication
First Author: Park S
Year: 2020
Journal: Nat Commun
Title: The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates.
Volume: 11
Issue: 1
Pages: 1914
Publication  
First Author: Beauchamp MC
Year: 2022
Journal: Int J Mol Sci
Title: Craniofacial Defects in Embryos with Homozygous Deletion of Eftud2 in Their Neural Crest Cells Are Not Rescued by Trp53 Deletion.
Volume: 23
Issue: 16
Publication
First Author: Tao J
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: SEC23B is required for the maintenance of murine professional secretory tissues.
Volume: 109
Issue: 29
Pages: E2001-9
Publication
First Author: Patra D
Year: 2014
Journal: PLoS One
Title: Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.
Volume: 9
Issue: 8
Pages: e105674
Publication
First Author: Lindahl M
Year: 2014
Journal: Cell Rep
Title: MANF is indispensable for the proliferation and survival of pancreatic β cells.
Volume: 7
Issue: 2
Pages: 366-75
Publication  
First Author: Pakarinen E
Year: 2020
Journal: eNeuro
Title: MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System.
Volume: 7
Issue: 1
Publication
First Author: Fakruddin M
Year: 2018
Journal: Cell Rep
Title: Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease.
Volume: 22
Issue: 2
Pages: 482-496
Publication  
First Author: Xiang J
Year: 2023
Journal: Cells
Title: ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment.
Volume: 12
Issue: 22
Publication
First Author: Firtina Z
Year: 2009
Journal: J Biol Chem
Title: Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract.
Volume: 284
Issue: 51
Pages: 35872-84
Publication
First Author: Deneault E
Year: 2009
Journal: Cell
Title: A functional screen to identify novel effectors of hematopoietic stem cell activity.
Volume: 137
Issue: 2
Pages: 369-79
Publication
First Author: Ramsdell CM
Year: 2006
Journal: Mamm Genome
Title: Development of a deer mouse whole-genome radiation hybrid panel and comparative mapping of Mus chromosome 11 loci.
Volume: 17
Issue: 1
Pages: 37-48
Publication
First Author: Shi H
Year: 2016
Journal: Development
Title: Gestational stress induces the unfolded protein response, resulting in heart defects.
Volume: 143
Issue: 14
Pages: 2561-72
Publication  
First Author: Yang R
Year: 2019
Journal: Development
Title: CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development.
Volume: 146
Issue: 2
Publication
First Author: Yan D
Year: 2016
Journal: Cell Rep
Title: STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation.
Volume: 16
Issue: 11
Pages: 2914-2927
Publication
First Author: Grigaravicius P
Year: 2016
Journal: Cell Death Differ
Title: Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain.
Volume: 23
Issue: 3
Pages: 454-68
Publication      
First Author: Moyon S
Year: 2016
Journal: Cell Rep
Title: Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage.
Publication
First Author: Wang B
Year: 2018
Journal: J Clin Invest
Title: The COPII cargo adapter SEC24C is essential for neuronal homeostasis.
Volume: 128
Issue: 8
Pages: 3319-3332
Publication
First Author: Pakarinen E
Year: 2022
Journal: Cell Mol Life Sci
Title: CDNF and MANF regulate ER stress in a tissue-specific manner.
Volume: 79
Issue: 2
Pages: 124
Publication
First Author: Yang P
Year: 2019
Journal: Nat Commun
Title: Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy.
Volume: 10
Issue: 1
Pages: 282
Publication  
First Author: Jiang M
Year: 2016
Journal: Nat Commun
Title: Regulation of PERK-eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes.
Volume: 7
Pages: 12185
Publication
First Author: Moon JH
Year: 2020
Journal: Diabetes
Title: Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.
Volume: 69
Issue: 2
Pages: 205-214
Publication  
First Author: Zhu M
Year: 2015
Journal: Sci Rep
Title: Neural tube opening and abnormal extraembryonic membrane development in SEC23A deficient mice.
Volume: 5
Pages: 15471
Publication  
First Author: Wang F
Year: 2017
Journal: Nat Commun
Title: Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy.
Volume: 8
Pages: 15182
Publication
First Author: Borisova E
Year: 2024
Journal: Nat Commun
Title: Protein translation rate determines neocortical neuron fate.
Volume: 15
Issue: 1
Pages: 4879
Publication  
First Author: Zheng C
Year: 2019
Journal: EBioMedicine
Title: Suppressing UPR-dependent overactivation of FGFR3 signaling ameliorates SLC26A2-deficient chondrodysplasias.
Volume: 40
Pages: 695-709
Publication
First Author: Wang DY
Year: 2014
Journal: J Am Heart Assoc
Title: Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects.
Volume: 3
Issue: 5
Pages: e001018
Publication  
First Author: Danilova T
Year: 2019
Journal: Front Endocrinol (Lausanne)
Title: Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function.
Volume: 10
Pages: 765
Publication
First Author: Chu VT
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.
Volume: 113
Issue: 44
Pages: 12514-12519
Publication
First Author: Yan W
Year: 2024
Journal: Commun Biol
Title: Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy.
Volume: 7
Issue: 1
Pages: 94
Publication
First Author: Roma G
Year: 2007
Journal: Genome Res
Title: A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells.
Volume: 17
Issue: 7
Pages: 1051-60
Publication
First Author: Jazwiec PA
Year: 2022
Journal: Biol Reprod
Title: Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism†.
Volume: 107
Issue: 2
Pages: 574-589
Publication
First Author: Jerome-Majewska LA
Year: 2010
Journal: Dev Biol
Title: The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta.
Volume: 341
Issue: 1
Pages: 154-66
Publication
First Author: Song B
Year: 2008
Journal: J Clin Invest
Title: Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.
Volume: 118
Issue: 10
Pages: 3378-89
Publication  
First Author: Liakath-Ali K
Year: 2014
Journal: Nat Commun
Title: Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.
Volume: 5
Pages: 3540
Publication
First Author: Cobo I
Year: 2023
Journal: Nat Commun
Title: NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation.
Volume: 14
Issue: 1
Pages: 3761
Publication  
First Author: Neupane S
Year: 2022
Journal: Matrix Biol
Title: O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development.
Volume: 107
Pages: 77-96
Publication
First Author: Wang F
Year: 2015
Journal: Am J Physiol Endocrinol Metab
Title: ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development.
Volume: 309
Issue: 5
Pages: E487-99
Publication      
First Author: Xu L
Year: 2024
Journal: Cell Stem Cell
Title: Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells.
Publication
First Author: Flodby P
Year: 2016
Journal: Am J Respir Cell Mol Biol
Title: The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development.
Volume: 55
Issue: 1
Pages: 135-49