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Search results 2301 to 2400 out of 2744 for H2-Ab1

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Category: Publication
Type Details Score
Publication
First Author: Takenaka E
Year: 2018
Journal: Sci Rep
Title: Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation.
Volume: 8
Issue: 1
Pages: 15180
Publication
First Author: Kandasamy M
Year: 2016
Journal: PLoS Pathog
Title: RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection.
Volume: 12
Issue: 7
Pages: e1005754
Publication
First Author: Rapp M
Year: 2019
Journal: J Exp Med
Title: CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes.
Volume: 216
Issue: 5
Pages: 1170-1181
Publication
First Author: Holl EK
Year: 2012
Journal: PLoS One
Title: Plexin-B2 and Plexin-D1 in dendritic cells: expression and IL-12/IL-23p40 production.
Volume: 7
Issue: 8
Pages: e43333
Publication
First Author: Pulendran B
Year: 2001
Journal: J Immunol
Title: Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo.
Volume: 167
Issue: 9
Pages: 5067-76
Publication
First Author: Facciotti F
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6+B helper T cells in systemic lupus erythematosus.
Volume: 117
Issue: 13
Pages: 7305-7316
Publication
First Author: Sirois J
Year: 2015
Journal: Immunology
Title: The atypical MAPK ERK3 controls positive selection of thymocytes.
Volume: 145
Issue: 1
Pages: 161-9
Publication
First Author: Álvarez-Salamero C
Year: 2020
Journal: PLoS Biol
Title: IL-23 signaling regulation of pro-inflammatory T-cell migration uncovered by phosphoproteomics.
Volume: 18
Issue: 3
Pages: e3000646
Publication
First Author: Ooi JD
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis.
Volume: 109
Issue: 39
Pages: E2615-24
Publication
First Author: Jaiswal AK
Year: 2022
Journal: Lung
Title: ADAMTS7 Attenuates House Dust Mite-Induced Airway Inflammation and Th2 Immune Responses.
Volume: 200
Issue: 3
Pages: 305-313
Publication
First Author: Canonigo-Balancio AJ
Year: 2009
Journal: J Immunol
Title: SLAT/Def6 plays a critical role in the development of Th17 cell-mediated experimental autoimmune encephalomyelitis.
Volume: 183
Issue: 11
Pages: 7259-67
Publication
First Author: Kallikourdis M
Year: 2013
Journal: Blood
Title: The CXCR4 mutations in WHIM syndrome impair the stability of the T-cell immunologic synapse.
Volume: 122
Issue: 5
Pages: 666-73
Publication
First Author: O'Connell RM
Year: 2010
Journal: Immunity
Title: MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development.
Volume: 33
Issue: 4
Pages: 607-19
Publication
First Author: Kölsch U
Year: 2006
Journal: Mol Cell Biol
Title: Normal T-cell development and immune functions in TRIM-deficient mice.
Volume: 26
Issue: 9
Pages: 3639-48
Publication
First Author: Nish SA
Year: 2017
Journal: J Exp Med
Title: CD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions.
Volume: 214
Issue: 1
Pages: 39-47
Publication
First Author: Xia Y
Year: 2018
Journal: Cell
Title: The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.
Volume: 175
Issue: 4
Pages: 1059-1073.e21
Publication
First Author: Tao J
Year: 2006
Journal: J Leukoc Biol
Title: Aspergillus fumigatus extract differentially regulates antigen-specific CD4+ and CD8+ T cell responses to promote host immunity.
Volume: 80
Issue: 3
Pages: 529-37
Publication
First Author: Dillon TJ
Year: 2013
Journal: Int Immunol
Title: B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells.
Volume: 25
Issue: 4
Pages: 259-69
Publication
First Author: Batal I
Year: 2014
Journal: J Leukoc Biol
Title: The mechanisms of up-regulation of dendritic cell activity by oxidative stress.
Volume: 96
Issue: 2
Pages: 283-93
Publication
First Author: Mendelsohn AC
Year: 2020
Journal: Am J Physiol Cell Physiol
Title: From initial segment to cauda: a regional characterization of mouse epididymal CD11c+ mononuclear phagocytes based on immune phenotype and function.
Volume: 319
Issue: 6
Pages: C997-C1010
Publication
First Author: Joffre OP
Year: 2010
Journal: Eur J Immunol
Title: Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A.
Volume: 40
Issue: 5
Pages: 1255-65
Publication
First Author: Chow MT
Year: 2010
Journal: Eur J Immunol
Title: H2-M3-restricted CD8+ T cells augment CD4+ T-cell responses by promoting DC maturation.
Volume: 40
Issue: 5
Pages: 1408-17
Publication
First Author: Wang Q
Year: 2017
Journal: Sci Rep
Title: Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability.
Volume: 7
Issue: 1
Pages: 6086
Publication
First Author: Farkas AM
Year: 2013
Journal: J Immunol
Title: Antigen choice determines vaccine-induced generation of immunogenic versus tolerogenic dendritic cells that are marked by differential expression of pancreatic enzymes.
Volume: 190
Issue: 7
Pages: 3319-27
Publication
First Author: Jinushi M
Year: 2009
Journal: J Exp Med
Title: Milk fat globule epidermal growth factor-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms.
Volume: 206
Issue: 6
Pages: 1317-26
Publication
First Author: Jacobsen EA
Year: 2008
Journal: J Exp Med
Title: Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells.
Volume: 205
Issue: 3
Pages: 699-710
Publication
First Author: Shao X
Year: 2023
Journal: Cell Insight
Title: A role for Hes1 in constraining germinal center B cell formation.
Volume: 2
Issue: 2
Pages: 100078
Publication
First Author: Missy K
Year: 2008
Journal: Mol Cell Biol
Title: AlphaPIX Rho GTPase guanine nucleotide exchange factor regulates lymphocyte functions and antigen receptor signaling.
Volume: 28
Issue: 11
Pages: 3776-89
Publication  
First Author: Oriss TB
Year: 2017
Journal: JCI Insight
Title: IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice.
Volume: 2
Issue: 10
Publication
First Author: Kanemaru H
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages.
Volume: 114
Issue: 35
Pages: E7331-E7340
Publication    
First Author: Zhang TT
Year: 2017
Journal: Elife
Title: Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help.
Volume: 6
Publication
First Author: Turner JS
Year: 2018
Journal: Cell Rep
Title: B Cell Receptor Crosslinking Augments Germinal Center B Cell Selection when T Cell Help Is Limiting.
Volume: 25
Issue: 6
Pages: 1395-1403.e4
Publication
First Author: Boukhaled GM
Year: 2016
Journal: Cell Rep
Title: The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence.
Volume: 16
Issue: 7
Pages: 1829-37
Publication
First Author: Meibers HE
Year: 2023
Journal: Cell Rep
Title: Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells.
Volume: 42
Issue: 10
Pages: 113180
Publication
First Author: Kim MY
Year: 2005
Journal: J Immunol
Title: OX40 signals during priming on dendritic cells inhibit CD4 T cell proliferation: IL-4 switches off OX40 signals enabling rapid proliferation of Th2 effectors.
Volume: 174
Issue: 3
Pages: 1433-7
Publication
First Author: Nair MG
Year: 2008
Journal: J Immunol
Title: Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation.
Volume: 181
Issue: 7
Pages: 4709-15
Publication
First Author: Oertli M
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Helicobacter pylori γ-glutamyl transpeptidase and vacuolating cytotoxin promote gastric persistence and immune tolerance.
Volume: 110
Issue: 8
Pages: 3047-52
Publication
First Author: Causton B
Year: 2015
Journal: J Immunol
Title: CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation.
Volume: 195
Issue: 2
Pages: 683-94
Publication  
First Author: Lee BR
Year: 2016
Journal: Sci Rep
Title: Combination of TLR1/2 and TLR3 ligands enhances CD4(+) T cell longevity and antibody responses by modulating type I IFN production.
Volume: 6
Pages: 32526
Publication  
First Author: Yu J
Year: 2017
Journal: J Autoimmun
Title: The differential organogenesis and functionality of two liver-draining lymph nodes in mice.
Volume: 84
Pages: 109-121
Publication
First Author: Dunlock VE
Year: 2022
Journal: Cell Rep
Title: Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function.
Volume: 39
Issue: 13
Pages: 111006
Publication
First Author: Bromley SK
Year: 2005
Journal: Nat Immunol
Title: Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics.
Volume: 6
Issue: 9
Pages: 895-901
Publication  
First Author: Göbel K
Year: 2012
Journal: J Neuroinflammation
Title: CD4(+) CD25(+) FoxP3(+) regulatory T cells suppress cytotoxicity of CD8(+) effector T cells: implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level.
Volume: 9
Pages: 41
Publication
First Author: Brennan TV
Year: 2011
Journal: J Surg Res
Title: Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts.
Volume: 169
Issue: 1
Pages: e69-75
Publication
First Author: Ouchi T
Year: 2016
Journal: J Invest Dermatol
Title: EpCAM Expressed by Murine Epidermal Langerhans Cells Modulates Immunization to an Epicutaneously Applied Protein Antigen.
Volume: 136
Issue: 8
Pages: 1627-35
Publication
First Author: Kim JH
Year: 2016
Journal: Nat Immunol
Title: CD1a on Langerhans cells controls inflammatory skin disease.
Volume: 17
Issue: 10
Pages: 1159-66
Publication
First Author: Lodygin D
Year: 2013
Journal: Nat Med
Title: A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity.
Volume: 19
Issue: 6
Pages: 784-90
Publication
First Author: Wang H
Year: 2019
Journal: Nat Commun
Title: Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation.
Volume: 10
Issue: 1
Pages: 1898
Publication
First Author: Oliveira TY
Year: 2024
Journal: Cell Rep
Title: Quantitative trait loci mapping provides insights into the genetic regulation of dendritic cell numbers in mouse tissues.
Volume: 43
Issue: 6
Pages: 114296
Publication  
First Author: Chen J
Year: 2018
Journal: Front Immunol
Title: Interleukin-33 Contributes to the Induction of Th9 Cells and Antitumor Efficacy by Dectin-1-Activated Dendritic Cells.
Volume: 9
Pages: 1787
Publication  
First Author: Manna S
Year: 2015
Journal: Nat Commun
Title: Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation.
Volume: 6
Pages: 8152
Publication  
First Author: Limper CB
Year: 2023
Journal: Front Immunol
Title: Effective differentiation of double negative thymocytes requires high fidelity replication of mitochondrial DNA in an age dependent manner.
Volume: 14
Pages: 1128626
Publication
First Author: Liu R
Year: 2019
Journal: Biochem Biophys Res Commun
Title: TIPE2 in dendritic cells inhibits the induction of pTregs in the gut mucosa.
Volume: 509
Issue: 4
Pages: 911-917
Publication
First Author: Pilon-Thomas S
Year: 2016
Journal: Cancer Res
Title: Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy.
Volume: 76
Issue: 6
Pages: 1381-90
Publication
First Author: Heymann F
Year: 2009
Journal: J Clin Invest
Title: Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury.
Volume: 119
Issue: 5
Pages: 1286-97
Publication
First Author: Li H
Year: 2019
Journal: PLoS One
Title: CD5 on dendritic cells regulates CD4+ and CD8+ T cell activation and induction of immune responses.
Volume: 14
Issue: 9
Pages: e0222301
Publication
First Author: Hänninen A
Year: 2007
Journal: Am J Pathol
Title: Islet beta-cell-specific T cells can use different homing mechanisms to infiltrate and destroy pancreatic islets.
Volume: 170
Issue: 1
Pages: 240-50
Publication
First Author: Patzak IM
Year: 2010
Journal: Eur J Immunol
Title: HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion.
Volume: 40
Issue: 11
Pages: 3220-5
Publication
First Author: Wang J
Year: 2021
Journal: Nat Commun
Title: Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling.
Volume: 12
Issue: 1
Pages: 6198
Publication
First Author: Nishimura T
Year: 2020
Journal: Eur J Immunol
Title: SIRPα on CD11c+ cells induces Th17 cell differentiation and subsequent inflammation in the CNS in experimental autoimmune encephalomyelitis.
Volume: 50
Issue: 10
Pages: 1560-1570
Publication  
First Author: Maulloo CD
Year: 2021
Journal: Front Immunol
Title: Lymph Node-Targeted Synthetically Glycosylated Antigen Leads to Antigen-Specific Immunological Tolerance.
Volume: 12
Pages: 714842
Publication
First Author: Mackenzie KJ
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Effector and central memory T helper 2 cells respond differently to peptide immunotherapy.
Volume: 111
Issue: 8
Pages: E784-93
Publication
First Author: Massoud AH
Year: 2017
Journal: J Immunol
Title: Peripherally Generated Foxp3+ Regulatory T Cells Mediate the Immunomodulatory Effects of IVIg in Allergic Airways Disease.
Volume: 198
Issue: 7
Pages: 2760-2771
Publication
First Author: Rydström A
Year: 2007
Journal: J Immunol
Title: Monocyte recruitment, activation, and function in the gut-associated lymphoid tissue during oral Salmonella infection.
Volume: 178
Issue: 9
Pages: 5789-801
Publication
First Author: Hütter J
Year: 2014
Journal: PLoS One
Title: Role of the C-type lectin receptors MCL and DCIR in experimental colitis.
Volume: 9
Issue: 7
Pages: e103281
Publication
First Author: Alloatti A
Year: 2017
Journal: J Exp Med
Title: Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity.
Volume: 214
Issue: 8
Pages: 2231-2241
Publication
First Author: Yoshida M
Year: 2006
Journal: J Clin Invest
Title: Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.
Volume: 116
Issue: 8
Pages: 2142-2151
Publication
First Author: Dunkel J
Year: 2014
Journal: Eur J Immunol
Title: Endothelial amine oxidase AOC3 transiently contributes to adaptive immune responses in the airways.
Volume: 44
Issue: 11
Pages: 3232-9
Publication
First Author: Hu W
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation.
Volume: 112
Issue: 45
Pages: 13994-9
Publication
First Author: Jung JW
Year: 2018
Journal: Oncoimmunology
Title: Clinically-Relevant Rapamycin Treatment Regimens Enhance CD8+ Effector Memory T Cell Function In The Skin and Allow their Infiltration into Cutaneous Squamous Cell Carcinoma.
Volume: 7
Issue: 9
Pages: e1479627
Publication
First Author: Harris TL
Year: 2015
Journal: PLoS One
Title: Drak2 Does Not Regulate TGF-β Signaling in T Cells.
Volume: 10
Issue: 5
Pages: e0123650
Publication
First Author: Takebe T
Year: 2018
Journal: Biochem Biophys Res Commun
Title: A novel mouse model for tracking the fate of CXCR5-expressing T cells.
Volume: 495
Issue: 2
Pages: 1642-1647
Publication
First Author: Dudziak D
Year: 2007
Journal: Science
Title: Differential antigen processing by dendritic cell subsets in vivo.
Volume: 315
Issue: 5808
Pages: 107-11
Publication  
First Author: Monaghan KL
Year: 2023
Journal: Front Immunol
Title: Tetramerization of STAT5 regulates monocyte differentiation and the dextran sulfate sodium-induced colitis in mice.
Volume: 14
Pages: 1117828
Publication
First Author: Akkaya B
Year: 2019
Journal: Nat Immunol
Title: Regulatory T cells mediate specific suppression by depleting peptide-MHC class II from dendritic cells.
Volume: 20
Issue: 2
Pages: 218-231
Publication
First Author: Chen HH
Year: 2015
Journal: PLoS One
Title: Eosinophils from Murine Lamina Propria Induce Differentiation of Naïve T Cells into Regulatory T Cells via TGF-β1 and Retinoic Acid.
Volume: 10
Issue: 11
Pages: e0142881
Publication
First Author: Ghadially H
Year: 2013
Journal: Eur J Immunol
Title: NKp46 regulates allergic responses.
Volume: 43
Issue: 11
Pages: 3006-16
Publication
First Author: Choi UY
Year: 2014
Journal: PLoS One
Title: Tripartite motif-containing protein 30 modulates TCR-activated proliferation and effector functions in CD4+ T cells.
Volume: 9
Issue: 4
Pages: e95805
Publication
First Author: Saveljeva S
Year: 2022
Journal: Cell Metab
Title: A purine metabolic checkpoint that prevents autoimmunity and autoinflammation.
Volume: 34
Issue: 1
Pages: 106-124.e10
Publication
First Author: Torralba D
Year: 2018
Journal: Nat Commun
Title: Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts.
Volume: 9
Issue: 1
Pages: 2658
Publication
First Author: Misumi I
Year: 2013
Journal: J Immunol
Title: Differential T cell responses to residual viral antigen prolong CD4+ T cell contraction following the resolution of infection.
Volume: 191
Issue: 11
Pages: 5655-68
Publication
First Author: Wan S
Year: 2007
Journal: J Immunol
Title: IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+CD25+ T cell regulatory functions.
Volume: 178
Issue: 1
Pages: 271-9
Publication
First Author: Bueno SM
Year: 2010
Journal: Immunology
Title: Salmonella pathogenicity island 1 differentially modulates bacterial entry to dendritic and non-phagocytic cells.
Volume: 130
Issue: 2
Pages: 273-87
Publication
First Author: Tay CS
Year: 2013
Journal: PLoS One
Title: Cis-acting pathways selectively enforce the non-immunogenicity of shed placental antigen for maternal CD8 T cells.
Volume: 8
Issue: 12
Pages: e84064
Publication
First Author: Unsinger J
Year: 2009
Journal: J Leukoc Biol
Title: Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury.
Volume: 85
Issue: 3
Pages: 382-90
Publication
First Author: Huang TY
Year: 2023
Journal: Cell Rep
Title: Phosphoenolpyruvate regulates the Th17 transcriptional program and inhibits autoimmunity.
Volume: 42
Issue: 3
Pages: 112205
Publication
First Author: Janss T
Year: 2016
Journal: Eur J Immunol
Title: Interferon response factor-3 promotes the pro-Th2 activity of mouse lung CD11b+ conventional dendritic cells in response to house dust mite allergens.
Volume: 46
Issue: 11
Pages: 2614-2628
Publication
First Author: Read KA
Year: 2023
Journal: Nat Commun
Title: Aiolos represses CD4(+) T cell cytotoxic programming via reciprocal regulation of T(FH) transcription factors and IL-2 sensitivity.
Volume: 14
Issue: 1
Pages: 1652
Publication
First Author: Martin-Blanco N
Year: 2016
Journal: Int Immunol
Title: CD3ε recruits Numb to promote TCR degradation.
Volume: 28
Issue: 3
Pages: 127-37
Publication  
First Author: Zheng T
Year: 2018
Journal: Sci Signal
Title: p38α signaling in Langerhans cells promotes the development of IL-17-producing T cells and psoriasiform skin inflammation.
Volume: 11
Issue: 521
Publication
First Author: Kool M
Year: 2011
Journal: J Leukoc Biol
Title: Facilitated antigen uptake and timed exposure to TLR ligands dictate the antigen-presenting potential of plasmacytoid DCs.
Volume: 90
Issue: 6
Pages: 1177-90
Publication
First Author: Barber DL
Year: 2010
Journal: Blood
Title: Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice.
Volume: 116
Issue: 18
Pages: 3485-93
Publication
First Author: Imai T
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection.
Volume: 115
Issue: 45
Pages: E10662-E10671
Publication
First Author: Swiecki M
Year: 2010
Journal: Immunity
Title: Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual.
Volume: 33
Issue: 6
Pages: 955-66
Publication
First Author: Wu W
Year: 2016
Journal: Eur J Immunol
Title: Commensal A4 bacteria inhibit intestinal Th2-cell responses through induction of dendritic cell TGF-β production.
Volume: 46
Issue: 5
Pages: 1162-7
Publication
First Author: Wallace RP
Year: 2024
Journal: Cell Rep Med
Title: Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics.
Volume: 5
Issue: 1
Pages: 101345
Publication
First Author: Westritschnig K
Year: 2013
Journal: Mol Immunol
Title: Antigen processing and presentation by dendritic cells is independent of coronin 1.
Volume: 53
Issue: 4
Pages: 379-86
Publication
First Author: Erlich Z
Year: 2019
Journal: Nat Immunol
Title: Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model.
Volume: 20
Issue: 4
Pages: 397-406
Publication  
First Author: Wannemacher R
Year: 2023
Journal: Front Immunol
Title: Ovalbumin-specific CD4(+) and CD8(+) T cells contribute to different susceptibility for Theiler's murine encephalomyelitis virus persistence.
Volume: 14
Pages: 1194842
Publication  
First Author: Jin H
Year: 2023
Journal: J Clin Invest
Title: Antigen-presenting aged neutrophils induce CD4+ T cells to exacerbate inflammation in sepsis.
Volume: 133
Issue: 14