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Search results 2601 to 2700 out of 7744 for Cd4

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Category: Publication
Type Details Score
Publication
First Author: Bracamonte-Baran W
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance.
Volume: 114
Issue: 5
Pages: 1099-1104
Publication
First Author: Manjunath N
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: A transgenic mouse model to analyze CD8(+) effector T cell differentiation in vivo.
Volume: 96
Issue: 24
Pages: 13932-7
Publication
First Author: Cohen JL
Year: 1998
Journal: Transgenic Res
Title: Fertile homozygous transgenic mice expressing a functional truncated herpes simplex thymidine kinase delta TK gene.
Volume: 7
Issue: 5
Pages: 321-30
Publication
First Author: Łyszkiewicz M
Year: 2019
Journal: PLoS Biol
Title: miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity.
Volume: 17
Issue: 3
Pages: e2006716
Publication
First Author: Leung BL
Year: 1999
Journal: J Immunol
Title: TCR alpha beta-independent CD28 signaling and costimulation require non-CD4-associated Lck.
Volume: 163
Issue: 3
Pages: 1334-41
Publication
First Author: Wang D
Year: 2012
Journal: Nat Immunol
Title: Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.
Volume: 13
Issue: 6
Pages: 560-8
Publication
First Author: Theisen DJ
Year: 2018
Journal: Science
Title: WDFY4 is required for cross-presentation in response to viral and tumor antigens.
Volume: 362
Issue: 6415
Pages: 694-699
Publication
First Author: Deng J
Year: 2021
Journal: Nat Commun
Title: The metabolic hormone leptin promotes the function of T(FH) cells and supports vaccine responses.
Volume: 12
Issue: 1
Pages: 3073
Publication
First Author: Liang B
Year: 2008
Journal: J Immunol
Title: Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II.
Volume: 180
Issue: 9
Pages: 5916-26
Publication
First Author: Suzukawa M
Year: 2012
Journal: J Immunol
Title: Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.
Volume: 189
Issue: 7
Pages: 3641-52
Publication
First Author: Wang W
Year: 2018
Journal: Cancer Cell
Title: RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.
Volume: 34
Issue: 5
Pages: 757-774.e7
Publication
First Author: LaCasse CJ
Year: 2011
Journal: J Immunol
Title: Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
Volume: 187
Issue: 12
Pages: 6310-7
Publication
First Author: Venuprasad K
Year: 2006
Journal: J Clin Invest
Title: Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation.
Volume: 116
Issue: 4
Pages: 1117-26
Publication
First Author: Koch MA
Year: 2012
Journal: Immunity
Title: T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor β2.
Volume: 37
Issue: 3
Pages: 501-10
Publication
First Author: Schorer M
Year: 2020
Journal: Nat Commun
Title: Rapid expansion of Treg cells protects from collateral colitis following a viral trigger.
Volume: 11
Issue: 1
Pages: 1522
Publication
First Author: David C
Year: 2023
Journal: J Am Heart Assoc
Title: Impact of NKG2D Signaling on Natural Killer and T-Cell Function in Cerebral Ischemia.
Volume: 12
Issue: 12
Pages: e029529
Publication
First Author: Wang Y
Year: 2023
Journal: Nat Commun
Title: The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells.
Volume: 14
Issue: 1
Pages: 6639
Publication
First Author: Calzada-Fraile D
Year: 2023
Journal: Nat Commun
Title: Immune synapse formation promotes lipid peroxidation and MHC-I upregulation in licensed dendritic cells for efficient priming of CD8(+) T cells.
Volume: 14
Issue: 1
Pages: 6772
Publication
First Author: Ahmed KA
Year: 2012
Journal: J Leukoc Biol
Title: Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling.
Volume: 92
Issue: 2
Pages: 289-300
Publication
First Author: Weber JP
Year: 2015
Journal: J Exp Med
Title: ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2.
Volume: 212
Issue: 2
Pages: 217-33
Publication
First Author: Morris AB
Year: 2020
Journal: Immunity
Title: Signaling through the Inhibitory Fc Receptor FcγRIIB Induces CD8+ T Cell Apoptosis to Limit T Cell Immunity.
Volume: 52
Issue: 1
Pages: 136-150.e6
Publication
First Author: Mantegazza AR
Year: 2012
Journal: Immunity
Title: Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4(+) T cells.
Volume: 36
Issue: 5
Pages: 782-94
Publication
First Author: Hao S
Year: 2008
Journal: J Immunol
Title: Antigen specificity acquisition of adoptive CD4+ regulatory T cells via acquired peptide-MHC class I complexes.
Volume: 181
Issue: 4
Pages: 2428-37
Publication
First Author: Zheng X
Year: 2016
Journal: Eur J Immunol
Title: Cardiomyocytes display low mitochondrial priming and are highly resistant toward cytotoxic T-cell killing.
Volume: 46
Issue: 6
Pages: 1415-26
Publication
First Author: Kotov JA
Year: 2019
Journal: J Exp Med
Title: BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors.
Volume: 216
Issue: 6
Pages: 1450-1464
Publication  
First Author: Singh BK
Year: 2019
Journal: Sci Signal
Title: Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms.
Volume: 12
Issue: 597
Publication
First Author: Zhang X
Year: 2010
Journal: J Leukoc Biol
Title: Optimal TLR9 signal converts tolerogenic CD4-8- DCs into immunogenic ones capable of stimulating antitumor immunity via activating CD4+ Th1/Th17 and NK cell responses.
Volume: 88
Issue: 2
Pages: 393-403
Publication
First Author: Park SJ
Year: 2004
Journal: J Immunol
Title: IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation.
Volume: 173
Issue: 6
Pages: 3844-54
Publication
First Author: Mise-Omata S
Year: 2023
Journal: Cell Rep
Title: SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine.
Volume: 42
Issue: 8
Pages: 112940
Publication
First Author: Kim WS
Year: 2016
Journal: Oncotarget
Title: Cisplatin induces tolerogenic dendritic cells in response to TLR agonists via the abundant production of IL-10, thereby promoting Th2- and Tr1-biased T-cell immunity.
Volume: 7
Issue: 23
Pages: 33765-82
Publication
First Author: Kreymborg K
Year: 2007
Journal: J Immunol
Title: IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis.
Volume: 179
Issue: 12
Pages: 8098-104
Publication
First Author: Izumi G
Year: 2021
Journal: Nat Commun
Title: CD11b+ lung dendritic cells at different stages of maturation induce Th17 or Th2 differentiation.
Volume: 12
Issue: 1
Pages: 5029
Publication
First Author: Greter M
Year: 2009
Journal: PLoS Biol
Title: Neo-lymphoid aggregates in the adult liver can initiate potent cell-mediated immunity.
Volume: 7
Issue: 5
Pages: e1000109
Publication
First Author: Bahmani B
Year: 2018
Journal: J Clin Invest
Title: Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival.
Volume: 128
Issue: 11
Pages: 4770-4786
Publication
First Author: Everts B
Year: 2014
Journal: Nat Immunol
Title: TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.
Volume: 15
Issue: 4
Pages: 323-32
Publication
First Author: Morrissey SM
Year: 2021
Journal: Cell Metab
Title: Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming.
Volume: 33
Issue: 10
Pages: 2040-2058.e10
Publication
First Author: Mellor AL
Year: 2004
Journal: Int Immunol
Title: Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase.
Volume: 16
Issue: 10
Pages: 1391-401
Publication
First Author: Iyori M
Year: 2011
Journal: J Immunol
Title: TRAIL/DR5 plays a critical role in NK cell-mediated negative regulation of dendritic cell cross-priming of T cells.
Volume: 187
Issue: 6
Pages: 3087-95
Publication
First Author: Mandula JK
Year: 2024
Journal: Immunity
Title: Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages.
Volume: 57
Issue: 5
Pages: 1124-1140.e9
Publication
First Author: Philip M
Year: 2015
Journal: J Immunol
Title: Heme exporter FLVCR is required for T cell development and peripheral survival.
Volume: 194
Issue: 4
Pages: 1677-85
Publication
First Author: Mortha A
Year: 2014
Journal: Science
Title: Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.
Volume: 343
Issue: 6178
Pages: 1249288
Publication
First Author: Briseño CG
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms.
Volume: 114
Issue: 15
Pages: 3957-3962
Publication
First Author: Liu D
Year: 2013
Journal: J Immunol
Title: Inhibition of CD8+ T cell-derived CD40 signals is necessary but not sufficient for Foxp3+ induced regulatory T cell generation in vivo.
Volume: 191
Issue: 4
Pages: 1957-64
Publication
First Author: Burgdorf S
Year: 2008
Journal: Nat Immunol
Title: Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation.
Volume: 9
Issue: 5
Pages: 558-66
Publication
First Author: Winau F
Year: 2006
Journal: Immunity
Title: Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis.
Volume: 24
Issue: 1
Pages: 105-17
Publication
First Author: Ghoreschi K
Year: 2010
Journal: Nature
Title: Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling.
Volume: 467
Issue: 7318
Pages: 967-71
Publication
First Author: Gommeaux J
Year: 2009
Journal: Eur J Immunol
Title: Thymus-specific serine protease regulates positive selection of a subset of CD4+ thymocytes.
Volume: 39
Issue: 4
Pages: 956-64
Publication    
First Author: Blumenthal D
Year: 2020
Journal: Elife
Title: Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex.
Volume: 9
Publication  
First Author: Rawat K
Year: 2023
Journal: J Exp Med
Title: CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes.
Volume: 220
Issue: 6
Publication
First Author: Fang C
Year: 2011
Journal: Blood
Title: Decay-accelerating factor regulates T-cell immunity in the context of inflammation by influencing costimulatory molecule expression on antigen-presenting cells.
Volume: 118
Issue: 4
Pages: 1008-14
Publication
First Author: Jackson JT
Year: 2011
Journal: EMBO J
Title: Id2 expression delineates differential checkpoints in the genetic program of CD8α+ and CD103+ dendritic cell lineages.
Volume: 30
Issue: 13
Pages: 2690-704
Publication
First Author: Manlove LS
Year: 2015
Journal: J Immunol
Title: Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells.
Volume: 195
Issue: 8
Pages: 4028-37
Publication
First Author: Chikuma S
Year: 2021
Journal: J Immunol
Title: TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus.
Volume: 206
Issue: 7
Pages: 1528-1539
Publication
First Author: Moldenhauer LM
Year: 2010
Journal: J Immunol
Title: GM-CSF is an essential regulator of T cell activation competence in uterine dendritic cells during early pregnancy in mice.
Volume: 185
Issue: 11
Pages: 7085-96
Publication
First Author: DuPage M
Year: 2011
Journal: Cancer Cell
Title: Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression.
Volume: 19
Issue: 1
Pages: 72-85
Publication
First Author: Zhou X
Year: 2021
Journal: Cell Rep
Title: Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity.
Volume: 34
Issue: 1
Pages: 108601
Publication
First Author: Akbari M
Year: 2014
Journal: J Immunol
Title: IRF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major.
Volume: 192
Issue: 5
Pages: 2271-9
Publication    
First Author: Clement M
Year: 2023
Journal: Elife
Title: Inhibitory IL-10-producing CD4(+) T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1.
Volume: 12
Publication
First Author: Baal N
Year: 2019
Journal: J Immunol
Title: ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function.
Volume: 202
Issue: 4
Pages: 1099-1111
Publication  
First Author: Strauss L
Year: 2020
Journal: Sci Immunol
Title: Targeted deletion of PD-1 in myeloid cells induces antitumor immunity.
Volume: 5
Issue: 43
Publication
First Author: Tamoutounour S
Year: 2013
Journal: Immunity
Title: Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin.
Volume: 39
Issue: 5
Pages: 925-38
Publication
First Author: Ho NI
Year: 2017
Journal: J Immunol
Title: C1q-Dependent Dendritic Cell Cross-Presentation of In Vivo-Formed Antigen-Antibody Complexes.
Volume: 198
Issue: 11
Pages: 4235-4243
Publication
First Author: Au-Yeung BB
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
Volume: 111
Issue: 35
Pages: E3679-88
Publication
First Author: Farrand KJ
Year: 2009
Journal: J Immunol
Title: Langerin+ CD8alpha+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens.
Volume: 183
Issue: 12
Pages: 7732-42
Publication
First Author: Bayerl F
Year: 2023
Journal: Immunity
Title: Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses.
Volume: 56
Issue: 6
Pages: 1341-1358.e11
Publication
First Author: Gandhapudi SK
Year: 2013
Journal: PLoS One
Title: TRIF is required for TLR4 mediated adjuvant effects on T cell clonal expansion.
Volume: 8
Issue: 2
Pages: e56855
Publication
First Author: Baratin M
Year: 2015
Journal: Immunity
Title: Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance.
Volume: 42
Issue: 4
Pages: 627-39
Publication
First Author: Thomas DC
Year: 2013
Journal: Diabetes
Title: Protection of islet grafts through transforming growth factor-β-induced tolerogenic dendritic cells.
Volume: 62
Issue: 9
Pages: 3132-42
Publication
First Author: Kamphorst AO
Year: 2010
Journal: J Immunol
Title: Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes.
Volume: 185
Issue: 6
Pages: 3426-35
Publication
First Author: Chalmin F
Year: 2012
Journal: Immunity
Title: Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression.
Volume: 36
Issue: 3
Pages: 362-73
Publication    
First Author: Koike T
Year: 2019
Journal: Elife
Title: The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets.
Volume: 8
Publication  
First Author: Bosteels C
Year: 2020
Journal: Front Immunol
Title: CCR2- and Flt3-Dependent Inflammatory Conventional Type 2 Dendritic Cells Are Necessary for the Induction of Adaptive Immunity by the Human Vaccine Adjuvant System AS01.
Volume: 11
Pages: 606805
Publication
First Author: Laidlaw BJ
Year: 2017
Journal: J Exp Med
Title: The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells.
Volume: 214
Issue: 3
Pages: 639-649
Publication
First Author: Ruane D
Year: 2013
Journal: J Exp Med
Title: Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract.
Volume: 210
Issue: 9
Pages: 1871-88
Publication
First Author: Kamimura Y
Year: 2015
Journal: Cell Rep
Title: Homeostatic control of memory cell progenitors in the natural killer cell lineage.
Volume: 10
Issue: 2
Pages: 280-91
Publication
First Author: Pletneva M
Year: 2009
Journal: Cancer Res
Title: IFN-producing killer dendritic cells are antigen-presenting cells endowed with T-cell cross-priming capacity.
Volume: 69
Issue: 16
Pages: 6607-14
Publication
First Author: Janssen E
Year: 2006
Journal: Immunity
Title: Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway.
Volume: 24
Issue: 6
Pages: 787-99
Publication
First Author: Ali K
Year: 2014
Journal: Nature
Title: Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.
Volume: 510
Issue: 7505
Pages: 407-411
Publication  
First Author: Wang F
Year: 2021
Journal: J Clin Invest
Title: ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells.
Volume: 131
Issue: 19
Publication
First Author: Gmyrek GB
Year: 2013
Journal: Eur J Immunol
Title: Polarity gene discs large homolog 1 regulates the generation of memory T cells.
Volume: 43
Issue: 5
Pages: 1185-94
Publication
First Author: Zheng M
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Protein phosphatase 2A has an essential role in promoting thymocyte survival during selection.
Volume: 116
Issue: 25
Pages: 12422-12427
Publication
First Author: Costello PS
Year: 2004
Journal: Nat Immunol
Title: Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection.
Volume: 5
Issue: 3
Pages: 289-98
Publication
First Author: Terme M
Year: 2009
Journal: Cancer Res
Title: The dendritic cell-like functions of IFN-producing killer dendritic cells reside in the CD11b+ subset and are licensed by tumor cells.
Volume: 69
Issue: 16
Pages: 6590-7
Publication
First Author: Buchwald ZS
Year: 2012
Journal: PLoS One
Title: Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.
Volume: 7
Issue: 6
Pages: e38199
Publication
First Author: Sharma MD
Year: 2009
Journal: Blood
Title: Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes.
Volume: 113
Issue: 24
Pages: 6102-11
Publication
First Author: Taguchi K
Year: 2020
Journal: Mol Cancer Res
Title: Tumor Endothelial Cell-Mediated Antigen-Specific T-cell Suppression via the PD-1/PD-L1 Pathway.
Volume: 18
Issue: 9
Pages: 1427-1440
Publication
First Author: Oh DS
Year: 2019
Journal: Autophagy
Title: Autophagy protein ATG5 regulates CD36 expression and anti-tumor MHC class II antigen presentation in dendritic cells.
Volume: 15
Issue: 12
Pages: 2091-2106
Publication
First Author: Desch AN
Year: 2011
Journal: J Exp Med
Title: CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen.
Volume: 208
Issue: 9
Pages: 1789-97
Publication
First Author: Lancien M
Year: 2021
Journal: J Immunol
Title: Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4+ T Cells.
Volume: 207
Issue: 2
Pages: 421-435
Publication
First Author: Alloatti A
Year: 2017
Journal: J Exp Med
Title: Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity.
Volume: 214
Issue: 8
Pages: 2231-2241
Publication
First Author: Erlich Z
Year: 2019
Journal: Nat Immunol
Title: Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model.
Volume: 20
Issue: 4
Pages: 397-406
Publication
First Author: Takagi H
Year: 2011
Journal: Immunity
Title: Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo.
Volume: 35
Issue: 6
Pages: 958-71
Publication
First Author: van Montfoort N
Year: 2012
Journal: Eur J Immunol
Title: Circulating specific antibodies enhance systemic cross-priming by delivery of complexed antigen to dendritic cells in vivo.
Volume: 42
Issue: 3
Pages: 598-606
Publication
First Author: Saunderson SC
Year: 2014
Journal: Blood
Title: CD169 mediates the capture of exosomes in spleen and lymph node.
Volume: 123
Issue: 2
Pages: 208-16
Publication
First Author: Pelgrom LR
Year: 2022
Journal: Cell Rep
Title: mTORC1 signaling in antigen-presenting cells of the skin restrains CD8(+) T cell priming.
Volume: 40
Issue: 1
Pages: 111032
Publication
First Author: Liu D
Year: 2014
Journal: J Exp Med
Title: 2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses.
Volume: 211
Issue: 2
Pages: 297-311
Publication
First Author: Dolina JS
Year: 2017
Journal: J Immunol
Title: Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.
Volume: 198
Issue: 6
Pages: 2341-2351
Publication
First Author: Bianchi T
Year: 2009
Journal: J Immunol
Title: Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice.
Volume: 182
Issue: 8
Pages: 4665-74
Publication
First Author: Vander Lugt B
Year: 2014
Journal: Nat Immunol
Title: Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation.
Volume: 15
Issue: 2
Pages: 161-7
Publication  
First Author: Kim S
Year: 2023
Journal: J Exp Med
Title: IL-6 selectively suppresses cDC1 specification via C/EBPβ.
Volume: 220
Issue: 10