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Search results 2801 to 2900 out of 7744 for Cd4

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Category: Publication
Type Details Score
Publication
First Author: Wang Y
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function.
Volume: 109
Issue: 6
Pages: E343-52
Publication
First Author: Igyártó BZ
Year: 2011
Journal: Immunity
Title: Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses.
Volume: 35
Issue: 2
Pages: 260-72
Publication
First Author: Kandasamy M
Year: 2013
Journal: PLoS Pathog
Title: Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection.
Volume: 9
Issue: 1
Pages: e1003115
Publication
First Author: Garaude J
Year: 2012
Journal: Sci Transl Med
Title: Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responses.
Volume: 4
Issue: 120
Pages: 120ra16
Publication
First Author: Yang X
Year: 2014
Journal: Cancer Cell
Title: Targeting the tumor microenvironment with interferon-β bridges innate and adaptive immune responses.
Volume: 25
Issue: 1
Pages: 37-48
Publication
First Author: Chen S
Year: 2015
Journal: Cancer Res
Title: Host miR155 promotes tumor growth through a myeloid-derived suppressor cell-dependent mechanism.
Volume: 75
Issue: 3
Pages: 519-31
Publication  
First Author: Takagi H
Year: 2016
Journal: Sci Rep
Title: Plasmacytoid dendritic cells orchestrate TLR7-mediated innate and adaptive immunity for the initiation of autoimmune inflammation.
Volume: 6
Pages: 24477
Publication
First Author: Bachus H
Year: 2019
Journal: Immunity
Title: Impaired Tumor-Necrosis-Factor-α-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in Infants.
Volume: 50
Issue: 1
Pages: 225-240.e4
Publication
First Author: Ardouin L
Year: 2016
Journal: Immunity
Title: Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery.
Volume: 45
Issue: 2
Pages: 305-18
Publication
First Author: Liu X
Year: 2019
Journal: Nature
Title: Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction.
Volume: 567
Issue: 7749
Pages: 525-529
Publication
First Author: Hegde S
Year: 2020
Journal: Cancer Cell
Title: Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer.
Volume: 37
Issue: 3
Pages: 289-307.e9
Publication
First Author: Kilian M
Year: 2023
Journal: Cancer Cell
Title: MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors.
Volume: 41
Issue: 2
Pages: 235-251.e9
Publication
First Author: Hernández-Malmierca P
Year: 2022
Journal: Cell Stem Cell
Title: Antigen presentation safeguards the integrity of the hematopoietic stem cell pool.
Volume: 29
Issue: 5
Pages: 760-775.e10
Publication
First Author: Mazzini E
Year: 2014
Journal: Immunity
Title: Oral tolerance can be established via gap junction transfer of fed antigens from CX3CR1⁺ macrophages to CD103⁺ dendritic cells.
Volume: 40
Issue: 2
Pages: 248-61
Publication
First Author: Vishlaghi N
Year: 2024
Journal: Cell Rep
Title: Vegfc-expressing cells form heterotopic bone after musculoskeletal injury.
Volume: 43
Issue: 4
Pages: 114049
Publication
First Author: De Sá Fernandes C
Year: 2024
Journal: Cell Rep
Title: The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity.
Volume: 43
Issue: 6
Pages: 114308
Publication
First Author: McDonald KG
Year: 2017
Journal: Immunology
Title: CCR6 promotes steady-state mononuclear phagocyte association with the intestinal epithelium, imprinting and immune surveillance.
Volume: 152
Issue: 4
Pages: 613-627
Publication
First Author: Ashayeripanah M
Year: 2024
Journal: Cell Rep
Title: Systemic inflammatory response syndrome triggered by blood-borne pathogens induces prolonged dendritic cell paralysis and immunosuppression.
Volume: 43
Issue: 2
Pages: 113754
Publication
First Author: Johansen KH
Year: 2022
Journal: Sci Signal
Title: A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells.
Volume: 15
Issue: 743
Pages: eabl9169
Publication
First Author: Zhu F
Year: 2023
Journal: Nat Commun
Title: Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4(+) T cell fate.
Volume: 14
Issue: 1
Pages: 3611
Publication
First Author: Nakandakari-Higa S
Year: 2024
Journal: Nature
Title: Universal recording of immune cell interactions in vivo.
Volume: 627
Issue: 8003
Pages: 399-406
Publication  
First Author: Thauland TJ
Year: 2019
Journal: Front Immunol
Title: The Actin-Capping Protein Alpha-Adducin Is Required for T-Cell Costimulation.
Volume: 10
Pages: 2706
Publication      
First Author: Chudnovskiy A
Year: 2022
Journal: bioRxiv
Title: Proximity-dependent labeling identifies dendritic cells that prime the antitumor CD4+ T cell response
Publication
First Author: Chudnovskiy A
Year: 2024
Journal: Sci Immunol
Title: Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4(+) T cell response.
Volume: 9
Issue: 100
Pages: eadq8843
Publication
First Author: Harb H
Year: 2020
Journal: Nat Immunol
Title: A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma.
Volume: 21
Issue: 11
Pages: 1359-1370
Publication
First Author: Soukup K
Year: 2015
Journal: J Immunol
Title: The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis.
Volume: 195
Issue: 2
Pages: 541-52
Publication
First Author: Zhou Q
Year: 2022
Journal: EMBO Mol Med
Title: Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer.
Volume: 14
Issue: 1
Pages: e14502
Publication
First Author: Lança T
Year: 2022
Journal: Immunity
Title: IRF8 deficiency induces the transcriptional, functional, and epigenetic reprogramming of cDC1 into the cDC2 lineage.
Volume: 55
Issue: 8
Pages: 1431-1447.e11
Publication
First Author: Xiao H
Year: 2024
Journal: Nat Commun
Title: Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses.
Volume: 15
Issue: 1
Pages: 3554
Publication
First Author: Vanderkerken M
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells.
Volume: 117
Issue: 49
Pages: 31331-31342
Publication
First Author: Chopin M
Year: 2019
Journal: Immunity
Title: Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT.
Volume: 50
Issue: 1
Pages: 77-90.e5
Publication
First Author: Frentzel S
Year: 2019
Journal: Eur J Immunol
Title: Essential role of IκBNS for in vivo CD4+ T-cell activation, proliferation, and Th1-cell differentiation during Listeria monocytogenes infection in mice.
Volume: 49
Issue: 9
Pages: 1391-1398
Publication
First Author: Au-Yeung BB
Year: 2006
Journal: J Immunol
Title: Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function.
Volume: 176
Issue: 7
Pages: 3895-9
Publication
First Author: Ericsson PO
Year: 1995
Journal: Int Immunol
Title: The protein tyrosine kinase p56lck regulates TCR expression and T cell selection.
Volume: 7
Issue: 4
Pages: 617-24
Publication
First Author: Abe A
Year: 2015
Journal: J Immunol
Title: An Enhancer of the IL-7 Receptor α-Chain Locus Controls IL-7 Receptor Expression and Maintenance of Peripheral T Cells.
Volume: 195
Issue: 7
Pages: 3129-38
Publication
First Author: Yu Q
Year: 2003
Journal: J Exp Med
Title: In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells.
Volume: 197
Issue: 4
Pages: 475-87
Publication
First Author: Zhou J
Year: 2018
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Anti-IL-7 receptor-α treatment ameliorates newly established Sjögren's-like exocrinopathy in non-obese diabetic mice.
Volume: 1864
Issue: 7
Pages: 2438-2447
Publication  
First Author: Li H
Year: 2018
Journal: JCI Insight
Title: Precision DNA demethylation ameliorates disease in lupus-prone mice.
Volume: 3
Issue: 16
Publication
First Author: Thomas SY
Year: 2011
Journal: J Exp Med
Title: PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions.
Volume: 208
Issue: 6
Pages: 1179-88
Publication  
First Author: Cosette J
Year: 2015
Journal: Sci Rep
Title: Single Cell Dynamics Causes Pareto-Like Effect in Stimulated T Cell Populations.
Volume: 5
Pages: 17756
Publication
First Author: Carpio VH
Year: 2020
Journal: iScience
Title: T Helper Plasticity Is Orchestrated by STAT3, Bcl6, and Blimp-1 Balancing Pathology and Protection in Malaria.
Volume: 23
Issue: 7
Pages: 101310
Publication
First Author: Welsh RA
Year: 2020
Journal: PLoS Biol
Title: Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases.
Volume: 18
Issue: 2
Pages: e3000590
Publication
First Author: Verginis P
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression.
Volume: 105
Issue: 9
Pages: 3479-84
Publication
First Author: Wiede F
Year: 2011
Journal: J Clin Invest
Title: T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.
Volume: 121
Issue: 12
Pages: 4758-74
Publication
First Author: Villunger A
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling.
Volume: 101
Issue: 18
Pages: 7052-7
Publication
First Author: Leonard JD
Year: 2017
Journal: Immunity
Title: Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen.
Volume: 47
Issue: 1
Pages: 107-117.e8
Publication
First Author: Liu Z
Year: 2020
Journal: Cell
Title: Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation.
Volume: 183
Issue: 4
Pages: 1117-1133.e19
Publication  
First Author: DiToro D
Year: 2018
Journal: Science
Title: Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells.
Volume: 361
Issue: 6407
Publication
First Author: Muroi S
Year: 2013
Journal: J Immunol
Title: Cutting edge: fine-tuning of Thpok gene activation by an enhancer in close proximity to its own silencer.
Volume: 190
Issue: 4
Pages: 1397-401
Publication
First Author: Abboud G
Year: 2009
Journal: J Immunol
Title: Fc(epsilon)RI and FcgammaRIII/CD16 differentially regulate atopic dermatitis in mice.
Volume: 182
Issue: 10
Pages: 6517-26
Publication
First Author: Cannons JL
Year: 2010
Journal: J Immunol
Title: Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation.
Volume: 185
Issue: 5
Pages: 2819-27
Publication
First Author: Kania G
Year: 2013
Journal: Circulation
Title: Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis.
Volume: 127
Issue: 23
Pages: 2285-94
Publication
First Author: Shibata K
Year: 2008
Journal: J Immunol
Title: Identification of CD25+ gamma delta T cells as fetal thymus-derived naturally occurring IL-17 producers.
Volume: 181
Issue: 9
Pages: 5940-7
Publication
First Author: Schülke S
Year: 2014
Journal: PLoS One
Title: Prevention of intestinal allergy in mice by rflaA:Ova is associated with enforced antigen processing and TLR5-dependent IL-10 secretion by mDC.
Volume: 9
Issue: 2
Pages: e87822
Publication
First Author: Henry CJ
Year: 2008
Journal: J Immunol
Title: IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17.
Volume: 181
Issue: 12
Pages: 8576-84
Publication
First Author: Martínez-Riaño A
Year: 2019
Journal: J Exp Med
Title: RRAS2 shapes the TCR repertoire by setting the threshold for negative selection.
Volume: 216
Issue: 10
Pages: 2427-2447
Publication
First Author: Malchow S
Year: 2013
Journal: Science
Title: Aire-dependent thymic development of tumor-associated regulatory T cells.
Volume: 339
Issue: 6124
Pages: 1219-24
Publication
First Author: Tjota MY
Year: 2013
Journal: J Clin Invest
Title: IL-33-dependent induction of allergic lung inflammation by FcγRIII signaling.
Volume: 123
Issue: 5
Pages: 2287-97
Publication  
First Author: Matheu MP
Year: 2015
Journal: Nat Commun
Title: Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming.
Volume: 6
Pages: 6219
Publication
First Author: Mikhak Z
Year: 2006
Journal: J Immunol
Title: STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells.
Volume: 176
Issue: 8
Pages: 4959-67
Publication
First Author: Zhan Y
Year: 2012
Journal: Eur J Immunol
Title: The inflammatory cytokine, GM-CSF, alters the developmental outcome of murine dendritic cells.
Volume: 42
Issue: 11
Pages: 2889-900
Publication
First Author: Erlebacher A
Year: 2007
Journal: J Clin Invest
Title: Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus.
Volume: 117
Issue: 5
Pages: 1399-411
Publication
First Author: Nakano H
Year: 2009
Journal: Nat Immunol
Title: Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses.
Volume: 10
Issue: 4
Pages: 394-402
Publication
First Author: Toribio-Fernández R
Year: 2018
Journal: Cell Death Dis
Title: Lamin A/C augments Th1 differentiation and response against vaccinia virus and Leishmania major.
Volume: 9
Issue: 1
Pages: 9
Publication
First Author: Spörri R
Year: 2005
Journal: Nat Immunol
Title: Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function.
Volume: 6
Issue: 2
Pages: 163-70
Publication
First Author: Ueda Y
Year: 2016
Journal: J Immunol
Title: Sema3e/Plexin D1 Modulates Immunological Synapse and Migration of Thymocytes by Rap1 Inhibition.
Volume: 196
Issue: 7
Pages: 3019-31
Publication    
First Author: Liu X
Year: 2021
Journal: Elife
Title: Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β-selection.
Volume: 10
Publication
First Author: Xia Y
Year: 2022
Journal: Immunity
Title: BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4+ T cell responses to persistent antigen.
Volume: 55
Issue: 7
Pages: 1200-1215.e6
Publication
First Author: Yang S
Year: 2015
Journal: Science
Title: Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance.
Volume: 348
Issue: 6234
Pages: 589-94
Publication
First Author: Phee H
Year: 2010
Journal: Nat Immunol
Title: Regulation of thymocyte positive selection and motility by GIT2.
Volume: 11
Issue: 6
Pages: 503-11
Publication
First Author: Swee LK
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Sortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes.
Volume: 110
Issue: 4
Pages: 1428-33
Publication
First Author: Navarro MN
Year: 2012
Journal: Biochem J
Title: Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells.
Volume: 442
Issue: 3
Pages: 649-59
Publication
First Author: Dalheimer SL
Year: 2009
Journal: Eur J Immunol
Title: Gads-deficient thymocytes are blocked at the transitional single positive CD4+ stage.
Volume: 39
Issue: 5
Pages: 1395-404
Publication
First Author: Kitamura H
Year: 2010
Journal: J Immunol
Title: Long peptide vaccination can lead to lethality through CD4+ T cell-mediated cytokine storm.
Volume: 185
Issue: 2
Pages: 892-901
Publication
First Author: Zhang W
Year: 2012
Journal: PLoS One
Title: Lymphoma-like T cell infiltration in liver is associated with increased copy number of dominant negative form of TGFβ receptor II.
Volume: 7
Issue: 11
Pages: e49413
Publication  
First Author: Pérez-Mazliah D
Year: 2017
Journal: EBioMedicine
Title: Follicular Helper T Cells are Essential for the Elimination of Plasmodium Infection.
Volume: 24
Pages: 216-230
Publication
First Author: Ribeiro AR
Year: 2013
Journal: J Immunol
Title: Thymocyte selection regulates the homeostasis of IL-7-expressing thymic cortical epithelial cells in vivo.
Volume: 191
Issue: 3
Pages: 1200-9
Publication
First Author: Chitrakar A
Year: 2020
Journal: J Immunol
Title: E3 Ubiquitin Ligase Von Hippel-Lindau Protein Promotes Th17 Differentiation.
Volume: 205
Issue: 4
Pages: 1009-1023
Publication
First Author: Hollister K
Year: 2013
Journal: J Immunol
Title: Insights into the role of Bcl6 in follicular Th cells using a new conditional mutant mouse model.
Volume: 191
Issue: 7
Pages: 3705-11
Publication
First Author: Makar KW
Year: 2004
Journal: J Immunol
Title: DNA methylation is a nonredundant repressor of the Th2 effector program.
Volume: 173
Issue: 7
Pages: 4402-6
Publication
First Author: Shimizu M
Year: 2021
Journal: Sci Rep
Title: T-bet represses collagen-induced arthritis by suppressing Th17 lineage commitment through inhibition of RORγt expression and function.
Volume: 11
Issue: 1
Pages: 17357
Publication  
First Author: Salz A
Year: 2020
Journal: J Cell Sci
Title: Cofilin1-driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus.
Volume: 133
Issue: 5
Publication
First Author: Voss K
Year: 2023
Journal: Sci Immunol
Title: Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus.
Volume: 8
Issue: 79
Pages: eabq0178
Publication
First Author: Thompson JW
Year: 2023
Journal: J Immunol
Title: MicroRNA-155 Plays Selective Cell-Intrinsic Roles in Brain-Infiltrating Immune Cell Populations during Neuroinflammation.
Volume: 210
Issue: 7
Pages: 926-934
Publication
First Author: Hwang SS
Year: 2017
Journal: Biochim Biophys Acta
Title: RHS6-mediated chromosomal looping and nuclear substructure binding is required for Th2 cytokine gene expression.
Volume: 1860
Issue: 3
Pages: 383-391
Publication
First Author: Véron P
Year: 2005
Journal: Blood Cells Mol Dis
Title: Accumulation of MFG-E8/lactadherin on exosomes from immature dendritic cells.
Volume: 35
Issue: 2
Pages: 81-8
Publication
First Author: Khanolkar A
Year: 2010
Journal: J Immunol
Title: T cell epitope specificity and pathogenesis of mouse hepatitis virus-1-induced disease in susceptible and resistant hosts.
Volume: 185
Issue: 2
Pages: 1132-41
Publication
First Author: Woods A
Year: 1994
Journal: J Exp Med
Title: Human major histocompatibility complex class II-restricted T cell responses in transgenic mice.
Volume: 180
Issue: 1
Pages: 173-81
Publication
First Author: Bouchet J
Year: 2011
Journal: Blood
Title: Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody.
Volume: 117
Issue: 13
Pages: 3559-68
Publication
First Author: Martin CE
Year: 2017
Journal: Immunity
Title: Interleukin-7 Availability Is Maintained by a Hematopoietic Cytokine Sink Comprising Innate Lymphoid Cells and T Cells.
Volume: 47
Issue: 1
Pages: 171-182.e4
Publication
First Author: Whitehead GS
Year: 2017
Journal: J Clin Invest
Title: TNF is required for TLR ligand-mediated but not protease-mediated allergic airway inflammation.
Volume: 127
Issue: 9
Pages: 3313-3326
Publication
First Author: Sharma MD
Year: 2010
Journal: Immunity
Title: Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice.
Volume: 33
Issue: 6
Pages: 942-54
Publication
First Author: Mintz MA
Year: 2019
Journal: Immunity
Title: The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis.
Volume: 51
Issue: 2
Pages: 310-323.e7
Publication
First Author: Stephens WZ
Year: 2021
Journal: Cell Rep
Title: Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition.
Volume: 37
Issue: 5
Pages: 109916
Publication
First Author: Burns AM
Year: 2011
Journal: J Immunol
Title: Alloantibodies prevent the induction of transplantation tolerance by enhancing alloreactive T cell priming.
Volume: 186
Issue: 1
Pages: 214-21
Publication
First Author: Kleinschnitz C
Year: 2010
Journal: Blood
Title: Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation.
Volume: 115
Issue: 18
Pages: 3835-42
Publication    
First Author: Li Y
Year: 2023
Journal: Elife
Title: CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance.
Volume: 12
Publication
First Author: Ferris ST
Year: 2020
Journal: Nature
Title: cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity.
Volume: 584
Issue: 7822
Pages: 624-629
Publication
First Author: Liu D
Year: 2019
Journal: Immunity
Title: IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α+ Dendritic Cells Promotes Listeria monocytogenes Infection.
Volume: 51
Issue: 1
Pages: 64-76.e7
Publication
First Author: Sharma MD
Year: 2013
Journal: Immunity
Title: An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos.
Volume: 38
Issue: 5
Pages: 998-1012