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Search results 301 to 400 out of 676 for Ran

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Category: Publication
Type Details Score
Publication  
First Author: Hu X
Year: 2015
Journal: Sci Rep
Title: Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice.
Volume: 5
Pages: 12982
Publication
First Author: Sun Y
Year: 2014
Journal: Mol Genet Metab
Title: Reversal of advanced disease in lysosomal acid lipase deficient mice: a model for lysosomal acid lipase deficiency disease.
Volume: 112
Issue: 3
Pages: 229-41
Publication
First Author: Liang H
Year: 2009
Journal: Free Radic Biol Med
Title: Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria.
Volume: 47
Issue: 3
Pages: 312-20
Publication  
First Author: Chen G
Year: 2018
Journal: Front Immunol
Title: G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis.
Volume: 9
Pages: 2079
Publication
First Author: Tu Z
Year: 2016
Journal: Cell Death Differ
Title: Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice.
Volume: 23
Issue: 1
Pages: 169-81
Publication  
First Author: Wang W
Year: 2021
Journal: Biochem Biophys Res Commun
Title: CX3CR1 deficiency aggravates brain white matter injury and affects expression of the CD36/15LO/NR4A1 signal.
Volume: 549
Pages: 47-53
Publication
First Author: Sun Y
Year: 2010
Journal: Hum Mol Genet
Title: Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits.
Volume: 19
Issue: 6
Pages: 1088-97
Publication
First Author: Lin D
Year: 2014
Journal: Endocrinology
Title: Abnormal response to the anorexic effect of GHS-R inhibitors and exenatide in male Snord116 deletion mouse model for Prader-Willi syndrome.
Volume: 155
Issue: 7
Pages: 2355-62
Publication
First Author: Xiang J
Year: 2021
Journal: J Cell Mol Med
Title: LiCl attenuates impaired learning and memory of APP/PS1 mice, which in mechanism involves α7 nAChRs and Wnt/β-catenin pathway.
Volume: 25
Issue: 22
Pages: 10698-10710
Publication
First Author: Zhi JJ
Year: 2023
Journal: J Neurosci
Title: Insufficient Oligodendrocyte Turnover in Optic Nerve Contributes to Age-Related Axon Loss and Visual Deficits.
Volume: 43
Issue: 11
Pages: 1859-1870
Publication
First Author: Yang Y
Year: 2014
Journal: Cell Res
Title: CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.
Volume: 24
Issue: 11
Pages: 1342-53
Publication
First Author: Yang S
Year: 2021
Journal: J Clin Lab Anal
Title: CYLD deficiency causes auditory neuropathy due to reduced neurite outgrowth.
Volume: 35
Issue: 6
Pages: e23783
Publication  
First Author: Mitra A
Year: 2020
Journal: Front Immunol
Title: CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells.
Volume: 11
Pages: 735
Publication
First Author: Feng J
Year: 2023
Journal: Invest Ophthalmol Vis Sci
Title: Loss of TRPM8 Exacerbate Herpes Simplex Keratitis Infection in Mice by Promoting the Infiltration of CD11b+ Ly6G+ Cells and Increasing the Viral Load in the Cornea.
Volume: 64
Issue: 15
Pages: 24
Publication
First Author: Gelegen C
Year: 2018
Journal: Curr Biol
Title: Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation.
Volume: 28
Issue: 4
Pages: 580-587.e5
Publication
First Author: Jain A
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: CRISPR-Cas9-based treatment of myocilin-associated glaucoma.
Volume: 114
Issue: 42
Pages: 11199-11204
Publication  
First Author: Li Y
Year: 2024
Journal: Biochem Biophys Res Commun
Title: TSHR signaling promotes hippocampal dependent memory formation through modulating Wnt5a/β-catenin mediated neurogenesis.
Volume: 704
Pages: 149723
Publication
First Author: Liu X
Year: 2018
Journal: Eur J Oral Sci
Title: Inactivation of Fam20b in the neural crest-derived mesenchyme of mouse causes multiple craniofacial defects.
Volume: 126
Issue: 5
Pages: 433-436
Publication
First Author: Zhao N
Year: 2021
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Neutrophils-derived Spink7 as one safeguard against experimental murine colitis.
Volume: 1867
Issue: 6
Pages: 166125
Publication
First Author: Li H
Year: 2024
Journal: Nature
Title: AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine lactyltransferases.
Volume: 634
Issue: 8036
Pages: 1229-1237
Publication
First Author: Song T
Year: 2022
Journal: EMBO Rep
Title: ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis.
Volume: 23
Issue: 5
Pages: e54090
Publication
First Author: Li P
Year: 2021
Journal: Aging (Albany NY)
Title: Piccolo is essential for the maintenance of mouse retina but not cochlear hair cell function.
Volume: 13
Issue: 8
Pages: 11678-11695
Publication  
First Author: Lessard CB
Year: 2018
Journal: EMBO Mol Med
Title: High-affinity interactions and signal transduction between Aβ oligomers and TREM2.
Volume: 10
Issue: 11
Publication
First Author: Wang T
Year: 2012
Journal: Am J Pathol
Title: miR-21 regulates skin wound healing by targeting multiple aspects of the healing process.
Volume: 181
Issue: 6
Pages: 1911-20
Publication
First Author: Chen L
Year: 2008
Journal: Aging Cell
Title: Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice.
Volume: 7
Issue: 6
Pages: 866-78
Publication
First Author: Wang J
Year: 2015
Journal: Cardiovasc Res
Title: Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs.
Volume: 107
Issue: 1
Pages: 108-18
Publication
First Author: Li MG
Year: 2018
Journal: J Immunol
Title: Bcl2L12 Contributes to Th2-Biased Inflammation in the Intestinal Mucosa by Regulating CD4+ T Cell Activities.
Volume: 201
Issue: 2
Pages: 725-733
Publication
First Author: Xu ZS
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis.
Volume: 116
Issue: 21
Pages: 10447-10452
Publication
First Author: Zheng PY
Year: 2019
Journal: Theranostics
Title: Regulating Bcl2L12 expression in mast cells inhibits food allergy.
Volume: 9
Issue: 17
Pages: 4982-4992
Publication
First Author: Kitahara A
Year: 2020
Journal: Cell Rep
Title: Generation of Lungs by Blastocyst Complementation in Apneumic Fgf10-Deficient Mice.
Volume: 31
Issue: 6
Pages: 107626
Publication
First Author: Zhou J
Year: 2020
Journal: FASEB J
Title: Hepatocyte nuclear factor 4α negatively regulates connective tissue growth factor during liver regeneration.
Volume: 34
Issue: 4
Pages: 4970-4983
Publication
First Author: Yang C
Year: 2021
Journal: Commun Biol
Title: Melatonin delays ovarian aging in mice by slowing down the exhaustion of ovarian reserve.
Volume: 4
Issue: 1
Pages: 534
Publication  
First Author: Zhang J
Year: 2020
Journal: Mol Immunol
Title: MiR-26a targets EphA2 to resist intracellular Listeria monocytogenes in macrophages.
Volume: 128
Pages: 69-78
Publication  
First Author: das Dores Pereira R
Year: 2021
Journal: Cell Immunol
Title: Role of formyl peptide receptor 2 (FPR2) in modulating immune response and heart inflammation in an experimental model of acute and chronic Chagas disease.
Volume: 369
Pages: 104427
Publication
First Author: Ahn B
Year: 2022
Journal: Aging Cell
Title: Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia.
Volume: 21
Issue: 3
Pages: e13569
Publication
First Author: Lan Q
Year: 2022
Journal: J Thromb Haemost
Title: Renal Klotho safeguards platelet lifespan in advanced chronic kidney disease through restraining Bcl-xL ubiquitination and degradation.
Volume: 20
Issue: 12
Pages: 2972-2987
Publication
First Author: Fujiwara K
Year: 2016
Journal: Genes Cells
Title: Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.
Volume: 21
Issue: 11
Pages: 1176-1194
Publication
First Author: Fatima S
Year: 2017
Journal: Biochim Biophys Acta
Title: Interactome of the inhibitory isoform of the nuclear transporter Importin 13.
Volume: 1864
Issue: 3
Pages: 546-561
Publication  
First Author: Gajewska KA
Year: 2022
Journal: Cells
Title: Nuclear Transporter IPO13 Is Central to Efficient Neuronal Differentiation.
Volume: 11
Issue: 12
Publication  
First Author: Fatima S
Year: 2021
Journal: Biochem Biophys Res Commun
Title: The nuclear transporter importin 13 is critical for cell survival during embryonic stem cell differentiation.
Volume: 534
Pages: 141-148
Publication
First Author: Yan J
Year: 2024
Journal: Cell Rep
Title: Inherent preference for polyunsaturated fatty acids instigates ferroptosis of Treg cells that aggravates high-fat-diet-related colitis.
Volume: 43
Issue: 8
Pages: 114636
Publication
First Author: Luo X
Year: 2024
Journal: Cell Death Differ
Title: Phospholipid peroxidation in macrophage confers tumor resistance by suppressing phagocytic capability towards ferroptotic cells.
Volume: 31
Issue: 9
Pages: 1184-1201
Publication  
First Author: Tokuhiro T
Year: 2021
Journal: Front Cell Dev Biol
Title: Oxidized Phospholipids and Neutrophil Elastase Coordinately Play Critical Roles in NET Formation.
Volume: 9
Pages: 718586
Publication  
First Author: Tu LF
Year: 2023
Journal: J Adv Res
Title: GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS.
Volume: 43
Pages: 205-218
Publication
First Author: Wang Y
Year: 2022
Journal: Nat Immunol
Title: The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis.
Volume: 23
Issue: 2
Pages: 303-317
Publication
First Author: Bressan A
Year: 1991
Journal: Gene
Title: Characterization of the opposite-strand genes from the mouse bidirectionally transcribed HTF9 locus.
Volume: 103
Issue: 2
Pages: 201-9
Publication
First Author: Fu J
Year: 2014
Journal: PLoS Genet
Title: Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration.
Volume: 10
Issue: 10
Pages: e1004579
Publication
First Author: Evdokimov E
Year: 2008
Journal: J Cell Sci
Title: Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3.
Volume: 121
Issue: Pt 24
Pages: 4106-13
Publication    
First Author: He Y
Year: 2021
Journal: Elife
Title: T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.
Volume: 10
Publication
First Author: Kragness S
Year: 2022
Journal: PLoS One
Title: An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.
Volume: 17
Issue: 6
Pages: e0269404
Publication
First Author: Olsson M
Year: 2004
Journal: Exp Cell Res
Title: Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.
Volume: 292
Issue: 2
Pages: 359-70
Publication  
First Author: Khalaf B
Year: 2019
Journal: J Cell Sci
Title: Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.
Volume: 132
Issue: 18
Publication
First Author: Bourne HR
Year: 1991
Journal: Nature
Title: The GTPase superfamily: conserved structure and molecular mechanism.
Volume: 349
Issue: 6305
Pages: 117-27
Publication
First Author: Hayashi N
Year: 1995
Journal: Mol Gen Genet
Title: RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4.
Volume: 247
Issue: 6
Pages: 661-9
Publication
First Author: Gkogkas CG
Year: 2013
Journal: Nature
Title: Autism-related deficits via dysregulated eIF4E-dependent translational control.
Volume: 493
Issue: 7432
Pages: 371-7
Publication
First Author: Li J
Year: 2008
Journal: Dev Cell
Title: Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.
Volume: 14
Issue: 1
Pages: 62-75
Publication
First Author: Bertram MJ
Year: 1999
Journal: Mol Cell Biol
Title: Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes.
Volume: 19
Issue: 2
Pages: 1479-85
Publication
First Author: Nelson CE
Year: 2016
Journal: Science
Title: In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.
Volume: 351
Issue: 6271
Pages: 403-7
Publication
First Author: Tabebordbar M
Year: 2016
Journal: Science
Title: In vivo gene editing in dystrophic mouse muscle and muscle stem cells.
Volume: 351
Issue: 6271
Pages: 407-411
Publication
First Author: Bi X
Year: 2021
Journal: Adv Sci (Weinh)
Title: Mitochondrial Damage-Induced Innate Immune Activation in Vascular Smooth Muscle Cells Promotes Chronic Kidney Disease-Associated Plaque Vulnerability.
Volume: 8
Issue: 5
Pages: 2002738
Publication    
First Author: Chen M
Year: 2017
Journal: Elife
Title: APP modulates KCC2 expression and function in hippocampal GABAergic inhibition.
Volume: 6
Publication
First Author: Pharaoh G
Year: 2020
Journal: Sci Rep
Title: Targeting cPLA2 derived lipid hydroperoxides as a potential intervention for sarcopenia.
Volume: 10
Issue: 1
Pages: 13968
Publication
First Author: Yu J
Year: 2023
Journal: Cell Mol Immunol
Title: The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8(+) T-cell immunity.
Volume: 20
Issue: 12
Pages: 1445-1456
Publication    
First Author: Xie Z
Year: 2021
Journal: Elife
Title: Transcriptomic encoding of sensorimotor transformation in the midbrain.
Volume: 10
Publication
First Author: von Roemeling CA
Year: 2024
Journal: Nat Commun
Title: Adeno-associated virus delivered CXCL9 sensitizes glioblastoma to anti-PD-1 immune checkpoint blockade.
Volume: 15
Issue: 1
Pages: 5871
Publication
First Author: Moore BD
Year: 2018
Journal: J Exp Med
Title: Short Aβ peptides attenuate Aβ42 toxicity in vivo.
Volume: 215
Issue: 1
Pages: 283-301
Publication
First Author: Ding W
Year: 2023
Journal: Nat Commun
Title: The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption.
Volume: 14
Issue: 1
Pages: 6696
Publication
First Author: Moore AR
Year: 2018
Journal: Cell Rep
Title: GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.
Volume: 22
Issue: 9
Pages: 2455-2468
Publication
First Author: Roy S
Year: 2018
Journal: Cancer Res
Title: Macrophage-Derived Neuropilin-2 Exhibits Novel Tumor-Promoting Functions.
Volume: 78
Issue: 19
Pages: 5600-5617
Publication
First Author: Kim TD
Year: 2017
Journal: Sci Rep
Title: MicroRNA-150 modulates intracellular Ca 2+ levels in naïve CD8+ T cells by targeting TMEM20.
Volume: 7
Issue: 1
Pages: 2623
Publication
First Author: Ren J
Year: 2018
Journal: Cell
Title: Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems.
Volume: 175
Issue: 2
Pages: 472-487.e20
Publication
First Author: Moutal A
Year: 2020
Journal: Pain
Title: Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific Nav1.7 regulation in the pathogenesis of chronic neuropathic pain.
Volume: 161
Issue: 11
Pages: 2629-2651
Publication
First Author: Zhang XY
Year: 2013
Journal: Am J Hum Genet
Title: Gain-of-function mutations in SCN11A cause familial episodic pain.
Volume: 93
Issue: 5
Pages: 957-66
Publication
First Author: Park HJ
Year: 2015
Journal: EMBO J
Title: The stress response neuropeptide CRF increases amyloid-β production by regulating γ-secretase activity.
Volume: 34
Issue: 12
Pages: 1674-86
Publication
First Author: Shen S
Year: 2017
Journal: Nat Neurosci
Title: Gut microbiota is critical for the induction of chemotherapy-induced pain.
Volume: 20
Issue: 9
Pages: 1213-1216
Publication
First Author: Peng W
Year: 2019
Journal: FASEB J
Title: Trophoblastic proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia.
Volume: 33
Issue: 5
Pages: 6327-6338
Publication
First Author: Wang S
Year: 2019
Journal: Sci Rep
Title: FOXS1 is regulated by GLI1 and miR-125a-5p and promotes cell proliferation and EMT in gastric cancer.
Volume: 9
Issue: 1
Pages: 5281
Publication
First Author: Wang L
Year: 2020
Journal: Nature
Title: Host-mediated ubiquitination of a mycobacterial protein suppresses immunity.
Volume: 577
Issue: 7792
Pages: 682-688
Publication
First Author: Gomez K
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Identification and targeting of a unique Na(V)1.7 domain driving chronic pain.
Volume: 120
Issue: 32
Pages: e2217800120
Publication
First Author: Yamaguchi T
Year: 2005
Journal: Mol Cell Biol
Title: Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development.
Volume: 25
Issue: 12
Pages: 5171-82
Publication
First Author: Shiroshima T
Year: 2009
Journal: FEBS Lett
Title: Identification of LRP1B-interacting proteins and inhibition of protein kinase Calpha-phosphorylation of LRP1B by association with PICK1.
Volume: 583
Issue: 1
Pages: 43-8
Publication
First Author: Maynard TM
Year: 2002
Journal: Mech Dev
Title: RanBP1, a velocardiofacial/DiGeorge syndrome candidate gene, is expressed at sites of mesenchymal/epithelial induction.
Volume: 111
Issue: 1-2
Pages: 177-80
Publication
First Author: Tamura K
Year: 2010
Journal: Plant Cell
Title: Identification and characterization of nuclear pore complex components in Arabidopsis thaliana.
Volume: 22
Issue: 12
Pages: 4084-97
Publication
First Author: Li P
Year: 2021
Journal: Nat Immunol
Title: Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity.
Volume: 22
Issue: 9
Pages: 1107-1117
Publication
First Author: Jia M
Year: 2020
Journal: Nat Immunol
Title: Redox homeostasis maintained by GPX4 facilitates STING activation.
Volume: 21
Issue: 7
Pages: 727-735
Publication    
First Author: Ide S
Year: 2021
Journal: Elife
Title: Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair.
Volume: 10
Publication
First Author: Jiang Z
Year: 2024
Journal: Adv Sci (Weinh)
Title: Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis.
Volume: 11
Issue: 12
Pages: e2307388
Publication
First Author: Huang Q
Year: 2022
Journal: Cell
Title: The primordial differentiation of tumor-specific memory CD8(+) T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes.
Volume: 185
Issue: 22
Pages: 4049-4066.e25
Publication
First Author: Li Y
Year: 2016
Journal: Immunity
Title: Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment.
Volume: 44
Issue: 2
Pages: 422-37
Publication
First Author: Fu Z
Year: 2014
Journal: Biol Reprod
Title: Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice.
Volume: 90
Issue: 3
Pages: 52
Publication  
First Author: Fedele C
Year: 2021
Journal: J Exp Med
Title: SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling.
Volume: 218
Issue: 1
Publication
First Author: Braunwarth A
Year: 2003
Journal: J Biol Chem
Title: Identification and characterization of a novel RanGTP-binding protein in the yeast Saccharomyces cerevisiae.
Volume: 278
Issue: 17
Pages: 15397-405
Publication
First Author: Ma L
Year: 2009
Journal: PLoS Genet
Title: GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline.
Volume: 5
Issue: 9
Pages: e1000635
Publication
First Author: Tarabay Y
Year: 2017
Journal: J Cell Sci
Title: Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression.
Volume: 130
Issue: 8
Pages: 1463-1474
Publication
First Author: Takahashi H
Year: 2005
Journal: J Biol Chem
Title: Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein.
Volume: 280
Issue: 7
Pages: 5611-21
Publication
First Author: Ide S
Year: 2022
Journal: Cell Rep
Title: Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair.
Volume: 41
Issue: 6
Pages: 111610
Publication
First Author: Liu D
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Mouse models susceptible to HCoV-229E and HCoV-NL63 and cross protection from challenge with SARS-CoV-2.
Volume: 120
Issue: 4
Pages: e2202820120
Publication    
First Author: Yulyaningsih E
Year: 2024
Journal: Elife
Title: DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response.
Volume: 12
Publication
First Author: Xu XM
Year: 2007
Journal: Curr Biol
Title: Anchorage of plant RanGAP to the nuclear envelope involves novel nuclear-pore-associated proteins.
Volume: 17
Issue: 13
Pages: 1157-63
Publication
First Author: Mahajan R
Year: 1997
Journal: Cell
Title: A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.
Volume: 88
Issue: 1
Pages: 97-107