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Search results 401 to 500 out of 570 for Insr

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Category: Publication
Type Details Score
Publication
First Author: Luan B
Year: 2009
Journal: Nature
Title: Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.
Volume: 457
Issue: 7233
Pages: 1146-9
Publication
First Author: Nakae J
Year: 2002
Journal: Nat Genet
Title: Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.
Volume: 32
Issue: 2
Pages: 245-53
Publication
First Author: Bogan JS
Year: 2003
Journal: Nature
Title: Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking.
Volume: 425
Issue: 6959
Pages: 727-33
Publication
First Author: Giovannone B
Year: 2009
Journal: Hum Mol Genet
Title: GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling.
Volume: 18
Issue: 23
Pages: 4629-39
Publication
First Author: Berry DC
Year: 2013
Journal: J Biol Chem
Title: The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye.
Volume: 288
Issue: 34
Pages: 24528-39
Publication  
First Author: Madhusudhan T
Year: 2015
Journal: Nat Commun
Title: Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.
Volume: 6
Pages: 6496
Publication
First Author: Scarlett JM
Year: 2016
Journal: Nat Med
Title: Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.
Volume: 22
Issue: 7
Pages: 800-6
Publication
First Author: Yamashita H
Year: 2003
Journal: Pediatr Res
Title: Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice.
Volume: 53
Issue: 3
Pages: 411-8
Publication
First Author: Pelletier RM
Year: 2020
Journal: Reprod Biol Endocrinol
Title: Glucose, insulin, insulin receptor subunits α and β in normal and spontaneously diabetic and obese ob/ob and db/db infertile mouse testis and hypophysis.
Volume: 18
Issue: 1
Pages: 25
Publication
First Author: Barger JL
Year: 2003
Journal: Exp Gerontol
Title: The retardation of aging by caloric restriction: its significance in the transgenic era.
Volume: 38
Issue: 11-12
Pages: 1343-51
Publication
First Author: Liang H
Year: 2003
Journal: Exp Gerontol
Title: Genetic mouse models of extended lifespan.
Volume: 38
Issue: 11-12
Pages: 1353-64
Publication
First Author: Senokuchi T
Year: 2008
Journal: Diabetes
Title: Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress.
Volume: 57
Issue: 11
Pages: 2967-76
Publication
First Author: Chen S
Year: 2019
Journal: Cell Metab
Title: Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction.
Volume: 30
Issue: 6
Pages: 1141-1151.e5
Publication
First Author: Zhao J
Year: 2017
Journal: Biochem Biophys Res Commun
Title: ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity.
Volume: 486
Issue: 4
Pages: 865-871
Publication
First Author: Muthiah A
Year: 2018
Journal: PLoS One
Title: Biologically anchored knowledge expansion approach uncovers KLF4 as a novel insulin signaling regulator.
Volume: 13
Issue: 9
Pages: e0204100
Publication
First Author: Ferron M
Year: 2010
Journal: Cell
Title: Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism.
Volume: 142
Issue: 2
Pages: 296-308
Publication
First Author: Inoue H
Year: 2006
Journal: Cell Metab
Title: Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.
Volume: 3
Issue: 4
Pages: 267-75
Publication
First Author: Toda G
Year: 2020
Journal: Mol Cell
Title: Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation.
Volume: 79
Issue: 1
Pages: 43-53.e4
Publication
First Author: Kitamura T
Year: 2002
Journal: J Clin Invest
Title: The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.
Volume: 110
Issue: 12
Pages: 1839-47
Publication
First Author: Louvi A
Year: 1997
Journal: Dev Biol
Title: Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development.
Volume: 189
Issue: 1
Pages: 33-48
Publication
First Author: Federici M
Year: 2005
Journal: J Clin Invest
Title: Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha.
Volume: 115
Issue: 12
Pages: 3494-505
Publication
First Author: Dixon-Salazar TJ
Year: 2014
Journal: J Neurosci
Title: MHC class I limits hippocampal synapse density by inhibiting neuronal insulin receptor signaling.
Volume: 34
Issue: 35
Pages: 11844-56
Publication
First Author: Jordan S
Year: 2019
Journal: Cell
Title: Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool.
Volume: 178
Issue: 5
Pages: 1102-1114.e17
Publication
First Author: Riehle C
Year: 2022
Journal: Mol Cell Biol
Title: Insulin and Insulin-Like Growth Factor 1 Signaling Preserves Sarcomere Integrity in the Adult Heart.
Volume: 42
Issue: 10
Pages: e0016322
Publication
First Author: Wiig H
Year: 2013
Journal: J Clin Invest
Title: Immune cells control skin lymphatic electrolyte homeostasis and blood pressure.
Volume: 123
Issue: 7
Pages: 2803-15
Publication
First Author: Rajala A
Year: 2016
Journal: Oncotarget
Title: Activation of oncogenic tyrosine kinase signaling promotes insulin receptor-mediated cone photoreceptor survival.
Volume: 7
Issue: 30
Pages: 46924-46942
Publication
First Author: Rajala A
Year: 2013
Journal: J Biol Chem
Title: Insulin receptor signaling in cones.
Volume: 288
Issue: 27
Pages: 19503-15
Publication
First Author: El Ouaamari A
Year: 2019
Journal: J Biol Chem
Title: Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion.
Volume: 294
Issue: 3
Pages: 1059-1069
Publication
First Author: Copps KD
Year: 2016
Journal: J Biol Chem
Title: Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.
Volume: 291
Issue: 16
Pages: 8602-17
Publication
First Author: Wang L
Year: 2022
Journal: Cell Metab
Title: TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver.
Volume: 34
Issue: 1
Pages: 158-170.e5
Publication
First Author: Stöhr O
Year: 2013
Journal: Age (Dordr)
Title: Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease.
Volume: 35
Issue: 1
Pages: 83-101
Publication
First Author: Oury F
Year: 2013
Journal: J Clin Invest
Title: Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis.
Volume: 123
Issue: 6
Pages: 2421-33
Publication  
First Author: Bhardwaj G
Year: 2021
Journal: Front Physiol
Title: Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors.
Volume: 12
Pages: 779121
Publication
First Author: Fulzele K
Year: 2010
Journal: Cell
Title: Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition.
Volume: 142
Issue: 2
Pages: 309-19
Publication
First Author: Liu Z
Year: 2017
Journal: Neuron
Title: IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning.
Volume: 95
Issue: 1
Pages: 106-122.e5
Publication  
First Author: Garcia-Galiano D
Year: 2017
Journal: JCI Insight
Title: PI3Kα inactivation in leptin receptor cells increases leptin sensitivity but disrupts growth and reproduction.
Volume: 2
Issue: 23
Publication  
First Author: Bhardwaj G
Year: 2021
Journal: J Clin Invest
Title: Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle.
Volume: 131
Issue: 18
Publication
First Author: O'Neill BT
Year: 2016
Journal: J Clin Invest
Title: Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis.
Volume: 126
Issue: 9
Pages: 3433-46
Publication
First Author: Li Y
Year: 2021
Journal: Nat Immunol
Title: Insulin signaling establishes a developmental trajectory of adipose regulatory T cells.
Volume: 22
Issue: 9
Pages: 1175-1185
Publication  
First Author: Dodd GT
Year: 2021
Journal: Sci Adv
Title: Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance.
Volume: 7
Issue: 9
Publication
First Author: Chen Q
Year: 2016
Journal: J Biol Chem
Title: Insulin Is Required to Maintain Albumin Expression by Inhibiting Forkhead Box O1 Protein.
Volume: 291
Issue: 5
Pages: 2371-8
Publication
First Author: Tsuchiya K
Year: 2013
Journal: Diabetes
Title: Liver sinusoidal endothelial cells link hyperinsulinemia to hepatic insulin resistance.
Volume: 62
Issue: 5
Pages: 1478-89
Publication
First Author: Novitskaya T
Year: 2011
Journal: Endocrinology
Title: Organ-specific defects in insulin-like growth factor and insulin receptor signaling in late gestational asymmetric intrauterine growth restriction in Cited1 mutant mice.
Volume: 152
Issue: 6
Pages: 2503-16
Publication
First Author: Lu X
Year: 2006
Journal: Endocrinology
Title: DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling.
Volume: 147
Issue: 6
Pages: 3123-32
Publication
First Author: Frittitta L
Year: 1997
Journal: Breast Cancer Res Treat
Title: The insulin receptor content is increased in breast cancers initiated by three different oncogenes in transgenic mice.
Volume: 45
Issue: 2
Pages: 141-7
Publication
First Author: Uhles S
Year: 2007
Journal: FASEB J
Title: Selective gene activation by spatial segregation of insulin receptor B signaling.
Volume: 21
Issue: 7
Pages: 1609-21
Publication
First Author: Ceci JD
Year: 1990
Journal: Genomics
Title: An interspecific backcross linkage map of mouse chromosome 8.
Volume: 6
Issue: 1
Pages: 72-9
Publication
First Author: Ma NS
Year: 1992
Journal: Cytogenet Cell Genet
Title: Mapping of five human chromosome 19 DNA markers to owl monkey chromosomes.
Volume: 59
Issue: 1
Pages: 57-62
Publication
First Author: Rappolee DA
Year: 1992
Journal: Genes Dev
Title: Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos.
Volume: 6
Issue: 6
Pages: 939-52
Publication
First Author: Wu Z
Year: 1999
Journal: Mol Cell
Title: Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity.
Volume: 3
Issue: 2
Pages: 151-8
Publication  
First Author: Xie L
Year: 2007
Journal: Mol Vis
Title: Elevated insulin signaling disrupts the growth and differentiation pattern of the mouse lens.
Volume: 13
Pages: 397-407
Publication
First Author: Cohen S
Year: 2014
Journal: J Cell Biol
Title: Trim32 reduces PI3K-Akt-FoxO signaling in muscle atrophy by promoting plakoglobin-PI3K dissociation.
Volume: 204
Issue: 5
Pages: 747-58
Publication
First Author: Bera TK
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: A model for obesity and gigantism due to disruption of the Ankrd26 gene.
Volume: 105
Issue: 1
Pages: 270-5
Publication
First Author: Kuo SS
Year: 1991
Journal: Oncogene
Title: Structure, chromosome mapping, and expression of the mouse Lyl-1 gene.
Volume: 6
Issue: 6
Pages: 961-8
Publication
First Author: Ueki K
Year: 2004
Journal: Mol Cell Biol
Title: Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms.
Volume: 24
Issue: 12
Pages: 5434-46
Publication
First Author: Song WJ
Year: 2014
Journal: Cell Metab
Title: Glucagon regulates hepatic kisspeptin to impair insulin secretion.
Volume: 19
Issue: 4
Pages: 667-81
Publication
First Author: Hine C
Year: 2017
Journal: Cell Metab
Title: Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.
Volume: 25
Issue: 6
Pages: 1320-1333.e5
Publication
First Author: Tsuneki H
Year: 2008
Journal: Diabetologia
Title: Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice.
Volume: 51
Issue: 4
Pages: 657-67
Publication
First Author: Stupack J
Year: 2020
Journal: J Neurosci
Title: Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis.
Volume: 40
Issue: 31
Pages: 5908-5921
Publication
First Author: Stojanov T
Year: 2001
Journal: Biol Reprod
Title: In vitro fertilization causes epigenetic modifications to the onset of gene expression from the zygotic genome in mice.
Volume: 64
Issue: 2
Pages: 696-705
Publication
First Author: Telford NA
Year: 1990
Journal: Mol Reprod Dev
Title: Expression of genes for insulin and insulin-like growth factors and receptors in early postimplantation mouse embryos and embryonal carcinoma cells.
Volume: 27
Issue: 2
Pages: 81-92
Publication
First Author: Howard TA
Year: 1991
Journal: Genomics
Title: A linkage map of mouse chromosome 8: further definition of homologous linkage relationships between mouse chromosome 8 and human chromosomes 8, 16, and 19.
Volume: 10
Issue: 1
Pages: 207-13
Publication  
First Author: Jiang A
Year: 2022
Journal: Int J Mol Sci
Title: G6PD Deficiency Is Crucial for Insulin Signaling Activation in Skeletal Muscle.
Volume: 23
Issue: 13
Publication
First Author: Laviola L
Year: 1997
Journal: J Clin Invest
Title: The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.
Volume: 99
Issue: 5
Pages: 830-7
Publication
First Author: Wenger RH
Year: 1993
Journal: J Biol Chem
Title: The heat stable antigen (mouse CD24) gene is differentially regulated but has a housekeeping promoter.
Volume: 268
Issue: 31
Pages: 23345-52
Publication
First Author: Swindell WR
Year: 2009
Journal: Exp Gerontol
Title: Accelerated failure time models provide a useful statistical framework for aging research.
Volume: 44
Issue: 3
Pages: 190-200
Publication
First Author: Lee KY
Year: 2013
Journal: Diabetes
Title: Lessons on conditional gene targeting in mouse adipose tissue.
Volume: 62
Issue: 3
Pages: 864-74
Publication
First Author: Mascarenhas MI
Year: 2009
Journal: Blood
Title: Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profiling.
Volume: 114
Issue: 21
Pages: 4645-53
Publication
First Author: Tseng YH
Year: 2008
Journal: Nature
Title: New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.
Volume: 454
Issue: 7207
Pages: 1000-4
Publication
First Author: Chirivella L
Year: 2012
Journal: Eur J Neurosci
Title: IRS2 signalling is required for the development of a subset of sensory spinal neurons.
Volume: 35
Issue: 3
Pages: 341-52
Publication
First Author: Shimazu J
Year: 2016
Journal: Cell Rep
Title: Smurf1 Inhibits Osteoblast Differentiation, Bone Formation, and Glucose Homeostasis through Serine 148.
Volume: 15
Issue: 1
Pages: 27-35
Publication
First Author: Harrington LS
Year: 2004
Journal: J Cell Biol
Title: The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.
Volume: 166
Issue: 2
Pages: 213-23
Publication
First Author: Fecchi K
Year: 2006
Journal: FASEB J
Title: Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells.
Volume: 20
Issue: 6
Pages: 705-7
Publication
First Author: Larsson-Blomberg L
Year: 1994
Journal: FEBS Lett
Title: Isolation of tyrosine kinase related genes expressed in the early hematopoietic system.
Volume: 348
Issue: 2
Pages: 119-25
Publication  
First Author: Kheirollahi V
Year: 2022
Journal: Cells
Title: Transcriptional Profiling of Insulin-like Growth Factor Signaling Components in Embryonic Lung Development and Idiopathic Pulmonary Fibrosis.
Volume: 11
Issue: 12
Publication      
First Author: RIKEN BioResource Center/RIKEN Genomic Sciences Center
Year: 2008
Journal: PhenoSITE, World Wide Web (URL: http://www.brc.riken.jp/lab/gsc/mouse/)
Title: A Large Scale Mutagenesis Program in RIKEN GSC
Publication
First Author: Banks AS
Year: 2011
Journal: Cell Metab
Title: Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice.
Volume: 14
Issue: 5
Pages: 587-97
Publication
First Author: Kahraman S
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring.
Volume: 307
Issue: 10
Pages: E906-18
Publication
First Author: Duvillié B
Year: 2002
Journal: Endocrinology
Title: Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.
Volume: 143
Issue: 4
Pages: 1530-7
Publication  
First Author: Ferrón SR
Year: 2015
Journal: Nat Commun
Title: Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis.
Volume: 6
Pages: 8265
Publication
First Author: Lin JC
Year: 2013
Journal: Mol Cell Biol
Title: RBM4 promotes pancreas cell differentiation and insulin expression.
Volume: 33
Issue: 2
Pages: 319-27
Publication
First Author: Lee KM
Year: 2013
Journal: Diabetes
Title: Disruption of the cereblon gene enhances hepatic AMPK activity and prevents high-fat diet-induced obesity and insulin resistance in mice.
Volume: 62
Issue: 6
Pages: 1855-64
Publication  
First Author: Xiao Z
Year: 2022
Journal: Front Cell Dev Biol
Title: The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.
Volume: 10
Pages: 882994
Publication
First Author: Colombo MP
Year: 1992
Journal: Mamm Genome
Title: Localization of growth arrest-specific genes on mouse chromosomes 1, 7, 8, 11, 13, and 16.
Volume: 2
Issue: 2
Pages: 130-4
Publication
First Author: Murakami-Kawaguchi S
Year: 2014
Journal: Cell Tissue Res
Title: Expression of Ins1 and Ins2 genes in mouse fetal liver.
Volume: 355
Issue: 2
Pages: 303-14
Publication
First Author: Talchai C
Year: 2012
Journal: Cell
Title: Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure.
Volume: 150
Issue: 6
Pages: 1223-34
Publication
First Author: Pais RS
Year: 2013
Journal: PLoS One
Title: Transcriptome analysis in prenatal IGF1-deficient mice identifies molecular pathways and target genes involved in distal lung differentiation.
Volume: 8
Issue: 12
Pages: e83028
Publication
First Author: Günschmann C
Year: 2013
Journal: Dev Cell
Title: Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition.
Volume: 26
Issue: 2
Pages: 176-87
Publication  
First Author: Häfner R
Year: 2015
Journal: Mol Cell Endocrinol
Title: Fgfr2 is required for the expansion of the early adrenocortical primordium.
Volume: 413
Pages: 168-77
Publication
First Author: López IP
Year: 2016
Journal: PLoS One
Title: Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation.
Volume: 11
Issue: 11
Pages: e0166388
Publication
First Author: Verma-Kurvari S
Year: 2004
Journal: Dev Dyn
Title: Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.
Volume: 230
Issue: 4
Pages: 660-5
Publication
First Author: Martinez-Lopez N
Year: 2013
Journal: EMBO Rep
Title: Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development.
Volume: 14
Issue: 9
Pages: 795-803
Publication
First Author: Pitetti JL
Year: 2013
Journal: PLoS Genet
Title: Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice.
Volume: 9
Issue: 1
Pages: e1003160
Publication
First Author: Fletcher CF
Year: 1997
Journal: Genomics
Title: Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens.
Volume: 45
Issue: 2
Pages: 313-9
Publication  
First Author: Lopez-Tello J
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age.
Volume: 14
Pages: 1116770
Publication
First Author: Ghai R
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Volume: 110
Issue: 8
Pages: E643-52
Publication
First Author: Robinson DR
Year: 2000
Journal: Oncogene
Title: The protein tyrosine kinase family of the human genome.
Volume: 19
Issue: 49
Pages: 5548-57
Publication  
First Author: Ghnaimawi S
Year: 2022
Journal: Front Physiol
Title: The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring's Muscle Development and Energy Homeostasis.
Volume: 13
Pages: 881624
Publication
First Author: Prokopuk L
Year: 2022
Journal: Reproduction
Title: An essential role for Polycomb Repressive Complex 2 in the mouse ovary.
Volume: 163
Issue: 3
Pages: 167-182
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China