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Search results 401 to 500 out of 1492 for Lck

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Category: Publication
Type Details Score
Publication
First Author: Carow B
Year: 2013
Journal: PLoS Pathog
Title: Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis.
Volume: 9
Issue: 7
Pages: e1003442
Publication
First Author: Tucker SN
Year: 2002
Journal: Blood
Title: Enforced expression of the Ikaros isoform IK5 decreases the numbers of extrathymic intraepithelial lymphocytes and natural killer 1.1+ T cells.
Volume: 99
Issue: 2
Pages: 513-9
Publication
First Author: Harlin H
Year: 2002
Journal: Eur J Immunol
Title: CTLA-4 engagement regulates NF-kappaB activation in vivo.
Volume: 32
Issue: 8
Pages: 2095-104
Publication
First Author: Chaffin KE
Year: 1990
Journal: EMBO J
Title: Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.
Volume: 9
Issue: 12
Pages: 3821-9
Publication
First Author: Kükenshöner T
Year: 2017
Journal: J Mol Biol
Title: Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
Volume: 429
Issue: 9
Pages: 1364-1380
Publication
First Author: Schmedt C
Year: 2001
Journal: J Exp Med
Title: Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk).
Volume: 193
Issue: 7
Pages: 815-26
Publication  
First Author: Francis N
Year: 2017
Journal: Int J Biochem Cell Biol
Title: A T cell-specific knockout reveals an important role for protease-activated receptor 2 in lymphocyte development.
Volume: 92
Pages: 95-103
Publication
First Author: Rybakin V
Year: 2011
Journal: EMBO Rep
Title: CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I.
Volume: 12
Issue: 12
Pages: 1251-6
Publication
First Author: Kamal M
Year: 2010
Journal: FEBS Lett
Title: C-mip interacts with the p85 subunit of PI3 kinase and exerts a dual effect on ERK signaling via the recruitment of Dip1 and DAP kinase.
Volume: 584
Issue: 3
Pages: 500-6
Publication
First Author: Wayne J
Year: 1994
Journal: Immunity
Title: A regulatory role for recombinase activating genes, RAG-1 and RAG-2, in T cell development.
Volume: 1
Issue: 2
Pages: 95-107
Publication
First Author: Dougan SK
Year: 2007
Journal: J Exp Med
Title: MTP regulated by an alternate promoter is essential for NKT cell development.
Volume: 204
Issue: 3
Pages: 533-45
Publication
First Author: Allende ML
Year: 2004
Journal: J Biol Chem
Title: Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration.
Volume: 279
Issue: 15
Pages: 15396-401
Publication
First Author: Hammerman PS
Year: 2004
Journal: Cancer Res
Title: Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation.
Volume: 64
Issue: 22
Pages: 8341-8
Publication
First Author: Pajerowski AG
Year: 2009
Journal: Immunity
Title: NKAP is a transcriptional repressor of notch signaling and is required for T cell development.
Volume: 30
Issue: 5
Pages: 696-707
Publication
First Author: Hashimoto M
Year: 2011
Journal: Int Immunol
Title: SOCS1 regulates type I/type II NKT cell balance by regulating IFNgamma signaling.
Volume: 23
Issue: 3
Pages: 165-76
Publication
First Author: Izbicki G
Year: 2002
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Bleomycin-induced lung fibrosis in IL-4-overexpressing and knockout mice.
Volume: 283
Issue: 5
Pages: L1110-6
Publication
First Author: Talaber G
Year: 2015
Journal: FASEB J
Title: ACTH controls thymocyte homeostasis independent of glucocorticoids.
Volume: 29
Issue: 6
Pages: 2526-34
Publication
First Author: Gu JJ
Year: 2012
Journal: Sci Signal
Title: Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1.
Volume: 5
Issue: 233
Pages: ra51
Publication
First Author: Gu JJ
Year: 2007
Journal: J Immunol
Title: Defective T cell development and function in the absence of Abelson kinases.
Volume: 179
Issue: 11
Pages: 7334-43
Publication
First Author: Jeong JH
Year: 2015
Journal: Mol Cells
Title: Brca2 deficiency leads to T cell loss and immune dysfunction.
Volume: 38
Issue: 3
Pages: 251-8
Publication
First Author: Ventura A
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Cre-lox-regulated conditional RNA interference from transgenes.
Volume: 101
Issue: 28
Pages: 10380-5
Publication
First Author: Tang F
Year: 2015
Journal: Sci Signal
Title: The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility.
Volume: 8
Issue: 397
Pages: ra100
Publication
First Author: Nguyen TV
Year: 2006
Journal: J Immunol
Title: Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals.
Volume: 177
Issue: 9
Pages: 5990-6
Publication  
First Author: Malhotra D
Year: 2020
Journal: Front Immunol
Title: Antigen-Specific CD4+ T Cells Exhibit Distinct Kinetic and Phenotypic Patterns During Primary and Secondary Responses to Infection.
Volume: 11
Pages: 2125
Publication
First Author: Mondragón L
Year: 2019
Journal: Cancer Cell
Title: GAPDH Overexpression in the T Cell Lineage Promotes Angioimmunoblastic T Cell Lymphoma through an NF-κB-Dependent Mechanism.
Volume: 36
Issue: 3
Pages: 268-287.e10
Publication
First Author: Nelson RK
Year: 2016
Journal: Lupus
Title: An Lck-cre transgene accelerates autoantibody production and lupus development in (NZB × NZW)F1 mice.
Volume: 25
Issue: 2
Pages: 137-54
Publication
First Author: Valdor R
Year: 2014
Journal: Nat Immunol
Title: Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation.
Volume: 15
Issue: 11
Pages: 1046-54
Publication
First Author: Roy E
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire.
Volume: 107
Issue: 35
Pages: 15529-34
Publication  
First Author: McFarlane E
Year: 2019
Journal: Front Immunol
Title: IL-4 Mediated Resistance of BALB/c Mice to Visceral Leishmaniasis Is Independent of IL-4Rα Signaling via T Cells.
Volume: 10
Pages: 1957
Publication
First Author: Leeto M
Year: 2006
Journal: Am J Pathol
Title: TH1-dominant granulomatous pathology does not inhibit fibrosis or cause lethality during murine schistosomiasis.
Volume: 169
Issue: 5
Pages: 1701-12
Publication
First Author: Choi SH
Year: 2014
Journal: J Clin Invest
Title: Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.
Volume: 124
Issue: 6
Pages: 2472-82
Publication
First Author: Okada H
Year: 2004
Journal: J Exp Med
Title: Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death.
Volume: 199
Issue: 3
Pages: 399-410
Publication
First Author: Lu KH
Year: 2015
Journal: J Leukoc Biol
Title: Nck adaptor proteins modulate differentiation and effector function of T cells.
Volume: 98
Issue: 3
Pages: 301-11
Publication
First Author: Inoshita H
Year: 2013
Journal: PLoS One
Title: Disruption of Smad4 expression in T cells leads to IgA nephropathy-like manifestations.
Volume: 8
Issue: 11
Pages: e78736
Publication  
First Author: Manresa-Arraut A
Year: 2018
Journal: Front Immunol
Title: RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis.
Volume: 9
Pages: 1235
Publication
First Author: Liou LY
Year: 2010
Journal: PLoS One
Title: Functional glycosylation of dystroglycan is crucial for thymocyte development in the mouse.
Volume: 5
Issue: 3
Pages: e9915
Publication
First Author: Hua DR
Year: 2003
Journal: Eur J Immunol
Title: T cell-specific gene targeting reveals that alpha4 is required for early T cell development.
Volume: 33
Issue: 7
Pages: 1899-906
Publication
First Author: Abdullah CS
Year: 2018
Journal: FASEB J
Title: Targeted deletion of T-cell S1P receptor 1 ameliorates cardiac fibrosis in streptozotocin-induced diabetic mice.
Volume: 32
Issue: 10
Pages: 5426-5435
Publication
First Author: Dezfouli S
Year: 2006
Journal: Mol Cell Biol
Title: Inflammatory disease and lymphomagenesis caused by deletion of the Myc antagonist Mnt in T cells.
Volume: 26
Issue: 6
Pages: 2080-92
Publication
First Author: Plotkin J
Year: 2003
Journal: J Immunol
Title: Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus.
Volume: 171
Issue: 9
Pages: 4521-7
Publication
First Author: Bedi B
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH.
Volume: 109
Issue: 12
Pages: E725-33
Publication
First Author: Thiel M
Year: 2007
Journal: PLoS One
Title: Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival.
Volume: 2
Issue: 9
Pages: e853
Publication
First Author: Higashiyama M
Year: 2012
Journal: J Leukoc Biol
Title: HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitis.
Volume: 91
Issue: 6
Pages: 901-9
Publication
First Author: Murata K
Year: 2002
Journal: J Immunol
Title: Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases.
Volume: 169
Issue: 8
Pages: 4628-36
Publication
First Author: Ishii N
Year: 2003
Journal: Eur J Immunol
Title: OX40 (CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses.
Volume: 33
Issue: 9
Pages: 2372-81
Publication
First Author: Hähnel PS
Year: 2014
Journal: Blood
Title: Targeting components of the alternative NHEJ pathway sensitizes KRAS mutant leukemic cells to chemotherapy.
Volume: 123
Issue: 15
Pages: 2355-66
Publication
First Author: Chiang MY
Year: 2008
Journal: J Clin Invest
Title: Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.
Volume: 118
Issue: 9
Pages: 3181-94
Publication
First Author: Riera-Sans L
Year: 2007
Journal: J Immunol
Title: Regulation of alphabeta/gammadelta T cell development by the activator protein 1 transcription factor c-Jun.
Volume: 178
Issue: 9
Pages: 5690-700
Publication
First Author: Berg T
Year: 2014
Journal: Blood
Title: A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis.
Volume: 123
Issue: 25
Pages: 3914-24
Publication  
First Author: Dios-Esponera A
Year: 2019
Journal: Front Immunol
Title: Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and CCR7.
Volume: 10
Pages: 370
Publication
First Author: Fu G
Year: 2017
Journal: Eur J Immunol
Title: Phospholipase Cγ1 is required for pre-TCR signal transduction and pre-T cell development.
Volume: 47
Issue: 1
Pages: 74-83
Publication
First Author: Smits WK
Year: 2023
Journal: Cell Rep
Title: Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia.
Volume: 42
Issue: 4
Pages: 112373
Publication
First Author: Cobb BS
Year: 2005
Journal: J Exp Med
Title: T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer.
Volume: 201
Issue: 9
Pages: 1367-73
Publication
First Author: Inuzuka H
Year: 2011
Journal: Nature
Title: SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Volume: 471
Issue: 7336
Pages: 104-9
Publication
First Author: Kitagawa K
Year: 2014
Journal: Mol Cell Biol
Title: Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development.
Volume: 34
Issue: 14
Pages: 2732-44
Publication
First Author: Ogawa M
Year: 2013
Journal: PLoS One
Title: Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.
Volume: 8
Issue: 10
Pages: e76254
Publication
First Author: Shi J
Year: 2011
Journal: Blood
Title: Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis.
Volume: 118
Issue: 9
Pages: 2511-9
Publication
First Author: Oravecz-Wilson K
Year: 2021
Journal: Cancer Res
Title: ATG5-Dependent Autophagy Uncouples T-cell Proliferative and Effector Functions and Separates Graft-versus-Host Disease from Graft-versus-Leukemia.
Volume: 81
Issue: 4
Pages: 1063-1075
Publication
First Author: Lo JF
Year: 2005
Journal: J Immunol
Title: Tid1 is required for T cell transition from double-negative 3 to double-positive stages.
Volume: 174
Issue: 10
Pages: 6105-12
Publication
First Author: Fukushima H
Year: 2012
Journal: Cell Rep
Title: SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.
Volume: 1
Issue: 5
Pages: 434-43
Publication
First Author: Goswami R
Year: 2012
Journal: J Immunol
Title: Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells.
Volume: 189
Issue: 6
Pages: 3026-33
Publication
First Author: Geisberger S
Year: 2015
Journal: Blood
Title: New role for the (pro)renin receptor in T-cell development.
Volume: 126
Issue: 4
Pages: 504-7
Publication
First Author: Pan W
Year: 2022
Journal: J Immunol
Title: PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma.
Volume: 209
Issue: 3
Pages: 621-628
Publication  
First Author: Pan W
Year: 2020
Journal: JCI Insight
Title: PPP2R2D suppresses IL-2 production and Treg function.
Volume: 5
Issue: 19
Publication
First Author: Pan W
Year: 2021
Journal: J Immunol
Title: The Regulatory Subunit PPP2R2A of PP2A Enhances Th1 and Th17 Differentiation through Activation of the GEF-H1/RhoA/ROCK Signaling Pathway.
Volume: 206
Issue: 8
Pages: 1719-1728
Publication
First Author: Wang H
Year: 2019
Journal: Virulence
Title: T-cell-specific mTOR deletion in mice ameliorated CD4+ T-cell survival in lethal sepsis induced by severe invasive candidiasis.
Volume: 10
Issue: 1
Pages: 892-901
Publication
First Author: Guo R
Year: 2023
Journal: Int Immunopharmacol
Title: Depletion of mTOR ameliorates CD(4)(+) T cell pyroptosis by promoting autophagy activity in septic mice.
Volume: 124
Issue: Pt B
Pages: 110964
Publication
First Author: Kelly AP
Year: 2006
Journal: FEBS Lett
Title: Phosphoinositide-dependent kinase l (PDK1) haplo-insufficiency inhibits production of alpha/beta (alpha/beta) but not gamma delta (gamma/delta) T lymphocytes.
Volume: 580
Issue: 8
Pages: 2135-40
Publication
First Author: Yoshimi M
Year: 2012
Journal: Eur J Immunol
Title: Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation.
Volume: 42
Issue: 4
Pages: 1044-50
Publication
First Author: Lewis DB
Year: 1991
Journal: J Exp Med
Title: Interleukin 4 expressed in situ selectively alters thymocyte development.
Volume: 173
Issue: 1
Pages: 89-100
Publication
First Author: LaFace DM
Year: 1995
Journal: J Exp Med
Title: Human CD8 transgene regulation of HLA recognition by murine T cells.
Volume: 182
Issue: 5
Pages: 1315-25
Publication
First Author: Boothby MR
Year: 1997
Journal: J Exp Med
Title: Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.
Volume: 185
Issue: 11
Pages: 1897-907
Publication
First Author: Aune TM
Year: 1999
Journal: J Immunol
Title: Costimulation reverses the defect in IL-2 but not effector cytokine production by T cells with impaired IkappaBalpha degradation.
Volume: 162
Issue: 10
Pages: 5805-12
Publication
First Author: Draheim KM
Year: 2011
Journal: Oncogene
Title: A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.
Volume: 30
Issue: 10
Pages: 1252-60
Publication
First Author: Tamás P
Year: 2010
Journal: Eur J Immunol
Title: LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells.
Volume: 40
Issue: 1
Pages: 242-53
Publication
First Author: Arechiga AF
Year: 2007
Journal: J Immunol
Title: A Fas-associated death domain protein/caspase-8-signaling axis promotes S-phase entry and maintains S6 kinase activity in T cells responding to IL-2.
Volume: 179
Issue: 8
Pages: 5291-300
Publication      
First Author: Cyster JG
Year: 2007
Journal: MGI Direct Data Submission
Title: Generation of mice expressing a CXCR5 trasnsgene
Publication      
First Author: Cyster JG
Year: 2007
Journal: MGI Direct Data Submission
Title: Generation of secong line of CXCR5 transgenic mice
Publication
First Author: Rao S
Year: 2012
Journal: Blood
Title: Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.
Volume: 120
Issue: 18
Pages: 3764-73
Publication
First Author: Wang J
Year: 2001
Journal: J Clin Invest
Title: The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT.
Volume: 108
Issue: 12
Pages: 1771-80
Publication
First Author: Tan Y
Year: 2020
Journal: Sci Rep
Title: Wnt signaling mediates oncogenic synergy between Akt and Dlx5 in T-cell lymphomagenesis by enhancing cholesterol synthesis.
Volume: 10
Issue: 1
Pages: 15837
Publication
First Author: Tan Y
Year: 2008
Journal: Cancer Res
Title: A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice.
Volume: 68
Issue: 5
Pages: 1296-302
Publication
First Author: Sylvester PA
Year: 2022
Journal: mBio
Title: T Cell-Specific STAT1 Expression Promotes Lytic Replication and Supports the Establishment of Gammaherpesvirus Latent Reservoir in Splenic B Cells.
Volume: 13
Issue: 4
Pages: e0210722
Publication
First Author: Yamashita M
Year: 2000
Journal: J Exp Med
Title: T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex.
Volume: 191
Issue: 11
Pages: 1869-79
Publication
First Author: El Hajj H
Year: 2014
Journal: Blood
Title: Preclinical efficacy of the synthetic retinoid ST1926 for treating adult T-cell leukemia/lymphoma.
Volume: 124
Issue: 13
Pages: 2072-80
Publication
First Author: Swarthout JT
Year: 2005
Journal: J Biol Chem
Title: DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras.
Volume: 280
Issue: 35
Pages: 31141-8
Publication
First Author: Kelly AP
Year: 2007
Journal: EMBO J
Title: Notch-induced T cell development requires phosphoinositide-dependent kinase 1.
Volume: 26
Issue: 14
Pages: 3441-50
Publication
First Author: Peng S
Year: 2007
Journal: Eur J Immunol
Title: c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cells.
Volume: 37
Issue: 10
Pages: 2868-80
Publication
First Author: Brewer JA
Year: 2003
Journal: Nat Med
Title: T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation.
Volume: 9
Issue: 10
Pages: 1318-22
Publication
First Author: Ichii H
Year: 2002
Journal: Nat Immunol
Title: Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells.
Volume: 3
Issue: 6
Pages: 558-63
Publication
First Author: Rajpal A
Year: 2003
Journal: EMBO J
Title: Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor.
Volume: 22
Issue: 24
Pages: 6526-36
Publication
First Author: Heideman MR
Year: 2013
Journal: Blood
Title: Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function.
Volume: 121
Issue: 11
Pages: 2038-50
Publication  
First Author: Choi SH
Year: 2022
Journal: Front Immunol
Title: Smad4-deficient T cells promote colitis-associated colon cancer via an IFN-γ-dependent suppression of 15-hydroxyprostaglandin dehydrogenase.
Volume: 13
Pages: 932412
Publication  
First Author: Chinen T
Year: 2011
Journal: Nat Commun
Title: Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance.
Volume: 2
Pages: 190
Publication
First Author: Liu Y
Year: 2008
Journal: Nat Immunol
Title: A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells.
Volume: 9
Issue: 6
Pages: 632-40
Publication
First Author: Li H
Year: 2018
Journal: Pathol Res Pract
Title: TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis in mice.
Volume: 214
Issue: 2
Pages: 217-227
Publication
First Author: Carey KT
Year: 2013
Journal: Endocrinology
Title: Nfil3 is a glucocorticoid-regulated gene required for glucocorticoid-induced apoptosis in male murine T cells.
Volume: 154
Issue: 4
Pages: 1540-52
Publication
First Author: Perruche S
Year: 2009
Journal: J Immunol
Title: Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome.
Volume: 183
Issue: 2
Pages: 953-61
Publication
First Author: Barker EC
Year: 2018
Journal: Carcinogenesis
Title: Potent suppression of both spontaneous and carcinogen-induced colitis-associated colorectal cancer in mice by dietary celastrol supplementation.
Volume: 39
Issue: 1
Pages: 36-46
Publication
First Author: Choi SH
Year: 2020
Journal: Oncoimmunology
Title: Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4.
Volume: 9
Issue: 1
Pages: 1847832