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Search results 601 to 700 out of 916 for Reln

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Category: Publication
Type Details Score
Publication
First Author: Venkataramanappa S
Year: 2022
Journal: Cell Rep
Title: Cxcr4 and Ackr3 regulate allocation of caudal ganglionic eminence-derived interneurons to superficial cortical layers.
Volume: 40
Issue: 5
Pages: 111157
Publication
First Author: Wang Y
Year: 2011
Journal: Neuron
Title: CXCR4 and CXCR7 have distinct functions in regulating interneuron migration.
Volume: 69
Issue: 1
Pages: 61-76
Publication
First Author: Vogt D
Year: 2014
Journal: Neuron
Title: Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position.
Volume: 82
Issue: 2
Pages: 350-64
Publication
First Author: Lian G
Year: 2012
Journal: J Neurosci
Title: Filamin a regulates neural progenitor proliferation and cortical size through Wee1-dependent Cdk1 phosphorylation.
Volume: 32
Issue: 22
Pages: 7672-84
Publication
First Author: Shinozaki K
Year: 2002
Journal: Development
Title: Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential cell migration from ganglionic eminence in Emx1/2 double mutant cerebral cortex.
Volume: 129
Issue: 14
Pages: 3479-92
Publication
First Author: Goryunov D
Year: 2010
Journal: Mol Cell Neurosci
Title: Nervous-tissue-specific elimination of microtubule-actin crosslinking factor 1a results in multiple developmental defects in the mouse brain.
Volume: 44
Issue: 1
Pages: 1-14
Publication  
First Author: Zechel S
Year: 2018
Journal: Biol Open
Title: Cell-autonomous role of GFRα1 in the development of olfactory bulb GABAergic interneurons.
Volume: 7
Issue: 5
Publication
First Author: Shinohara R
Year: 2012
Journal: Nat Neurosci
Title: A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.
Volume: 15
Issue: 3
Pages: 373-80, S1-2
Publication
First Author: Miquelajáuregui A
Year: 2010
Journal: J Neurosci
Title: LIM-homeobox gene Lhx5 is required for normal development of Cajal-Retzius cells.
Volume: 30
Issue: 31
Pages: 10551-62
Publication
First Author: Simon R
Year: 2012
Journal: EMBO J
Title: A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis.
Volume: 31
Issue: 13
Pages: 2922-36
Publication
First Author: Szabo NE
Year: 2015
Journal: J Neurosci
Title: Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception.
Volume: 35
Issue: 13
Pages: 5233-46
Publication
First Author: McRae HM
Year: 2024
Journal: PLoS Genet
Title: Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles and altered transcription in the cortex of a mouse model of the Börjeson-Forssman-Lehmann intellectual disability syndrome.
Volume: 20
Issue: 10
Pages: e1011428
Publication
First Author: Ke Y
Year: 2007
Journal: Mol Cell Biol
Title: Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality.
Volume: 27
Issue: 19
Pages: 6706-17
Publication
First Author: Li Q
Year: 2011
Journal: PLoS One
Title: Timing specific requirement of microRNA function is essential for embryonic and postnatal hippocampal development.
Volume: 6
Issue: 10
Pages: e26000
Publication
First Author: McFarland KN
Year: 2006
Journal: J Neurosci
Title: Neural-specific inactivation of ShcA results in increased embryonic neural progenitor apoptosis and microencephaly.
Volume: 26
Issue: 30
Pages: 7885-97
Publication
First Author: Myshrall TD
Year: 2012
Journal: J Neuropathol Exp Neurol
Title: Dystroglycan on radial glia end feet is required for pial basement membrane integrity and columnar organization of the developing cerebral cortex.
Volume: 71
Issue: 12
Pages: 1047-63
Publication
First Author: Kahoud RJ
Year: 2014
Journal: Dev Dyn
Title: Conditional ablation of Tbr2 results in abnormal development of the olfactory bulbs and subventricular zone-rostral migratory stream.
Volume: 243
Issue: 3
Pages: 440-50
Publication
First Author: Zhao X
Year: 2014
Journal: PLoS One
Title: Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor.
Volume: 9
Issue: 10
Pages: e109171
Publication
First Author: Zhou J
Year: 2022
Journal: Cereb Cortex
Title: Comparison of the Spatiotemporal Expression Patterns of Three Cre Lines, Emx1IRES-Cre, D6-Cre and hGFAP-Cre, Commonly Used in Neocortical Development Research.
Volume: 32
Issue: 8
Pages: 1668-1681
Publication
First Author: Levi G
Year: 2003
Journal: Mol Cell Neurosci
Title: The Dlx5 homeodomain gene is essential for olfactory development and connectivity in the mouse.
Volume: 22
Issue: 4
Pages: 530-43
Publication
First Author: Vogt D
Year: 2015
Journal: Cell Rep
Title: The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles.
Volume: 11
Issue: 6
Pages: 944-956
Publication
First Author: Chang Y
Year: 2006
Journal: Genes Dev
Title: Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression.
Volume: 20
Issue: 7
Pages: 836-47
Publication  
First Author: Deryckere A
Year: 2020
Journal: Development
Title: Multifaceted actions of Zeb2 in postnatal neurogenesis from the ventricular-subventricular zone to the olfactory bulb.
Volume: 147
Issue: 10
Publication
First Author: Harrison SJ
Year: 2012
Journal: Dis Model Mech
Title: Sall1 regulates cortical neurogenesis and laminar fate specification in mice: implications for neural abnormalities in Townes-Brocks syndrome.
Volume: 5
Issue: 3
Pages: 351-65
Publication
First Author: Guénette S
Year: 2006
Journal: EMBO J
Title: Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.
Volume: 25
Issue: 2
Pages: 420-31
Publication
First Author: Chiara F
Year: 2012
Journal: Dev Biol
Title: Early B-cell factors 2 and 3 (EBF2/3) regulate early migration of Cajal-Retzius cells from the cortical hem.
Volume: 365
Issue: 1
Pages: 277-89
Publication    
First Author: Vaswani AR
Year: 2019
Journal: Elife
Title: Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons.
Volume: 8
Publication
First Author: Wei S
Year: 2019
Journal: J Comp Neurol
Title: Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons.
Volume: 527
Issue: 17
Pages: 2860-2874
Publication
First Author: Narboux-Nême N
Year: 2012
Journal: J Neurosci
Title: Integration of H-2Z1, a somatosensory cortex-expressed transgene, interferes with the expression of the Satb1 and Tbc1d5 flanking genes and affects the differentiation of a subset of cortical interneurons.
Volume: 32
Issue: 21
Pages: 7287-300
Publication
First Author: Tan XJ
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Liver X receptor beta and thyroid hormone receptor alpha in brain cortical layering.
Volume: 107
Issue: 27
Pages: 12305-10
Publication
First Author: Son AI
Year: 2020
Journal: Cereb Cortex
Title: Dual Role of Rbpj in the Maintenance of Neural Progenitor Cells and Neuronal Migration in Cortical Development.
Volume: 30
Issue: 12
Pages: 6444-6457
Publication
First Author: Armentano M
Year: 2006
Journal: Development
Title: COUP-TFI is required for the formation of commissural projections in the forebrain by regulating axonal growth.
Volume: 133
Issue: 21
Pages: 4151-62
Publication
First Author: Feng J
Year: 2016
Journal: Cereb Cortex
Title: Celsr3 and Fzd3 Organize a Pioneer Neuron Scaffold to Steer Growing Thalamocortical Axons.
Volume: 26
Issue: 7
Pages: 3323-34
Publication
First Author: Antypa M
Year: 2011
Journal: Eur J Neurosci
Title: Differential gene expression in migratory streams of cortical interneurons.
Volume: 34
Issue: 10
Pages: 1584-94
Publication
First Author: Denaxa M
Year: 2018
Journal: Cell Rep
Title: Modulation of Apoptosis Controls Inhibitory Interneuron Number in the Cortex.
Volume: 22
Issue: 7
Pages: 1710-1721
Publication
First Author: Coffinier C
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency.
Volume: 107
Issue: 11
Pages: 5076-81
Publication
First Author: Chai G
Year: 2021
Journal: N Engl J Med
Title: A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion.
Volume: 385
Issue: 14
Pages: 1292-1301
Publication
First Author: Andrews TD
Year: 2012
Journal: Open Biol
Title: Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.
Volume: 2
Issue: 5
Pages: 120061
Publication
First Author: Yu D
Year: 2022
Journal: Sci Adv
Title: Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits.
Volume: 8
Issue: 18
Pages: eabm2545
Publication  
First Author: Nakagawa N
Year: 2015
Journal: Sci Rep
Title: Ectopic clustering of Cajal-Retzius and subplate cells is an initial pathological feature in Pomgnt2-knockout mice, a model of dystroglycanopathy.
Volume: 5
Pages: 11163
Publication
First Author: Zhou J
Year: 2023
Journal: Hum Mol Genet
Title: Reticulons 1 and 3 are essential for axonal growth and synaptic maintenance associated with intellectual development.
Volume: 32
Issue: 16
Pages: 2587-2599
Publication
First Author: Shi X
Year: 2020
Journal: Ann Neurol
Title: PIK3R2/Pik3r2 Activating Mutations Result in Brain Overgrowth and EEG Changes.
Volume: 88
Issue: 6
Pages: 1077-1094
Publication
First Author: Lutter S
Year: 2012
Journal: J Cell Biol
Title: Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation.
Volume: 197
Issue: 6
Pages: 837-49
Publication
First Author: Alcántara S
Year: 1998
Journal: J Neurosci
Title: Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse.
Volume: 18
Issue: 19
Pages: 7779-99
Publication
First Author: Englund C
Year: 2005
Journal: J Neurosci
Title: Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex.
Volume: 25
Issue: 1
Pages: 247-51
Publication
First Author: Issa L
Year: 2013
Journal: Cereb Cortex
Title: CDK5RAP2 expression during murine and human brain development correlates with pathology in primary autosomal recessive microcephaly.
Volume: 23
Issue: 9
Pages: 2245-60
Publication
First Author: Hirota Y
Year: 2018
Journal: Cereb Cortex
Title: ApoER2 Controls Not Only Neuronal Migration in the Intermediate Zone But Also Termination of Migration in the Developing Cerebral Cortex.
Volume: 28
Issue: 1
Pages: 223-235
Publication
First Author: Kikkawa T
Year: 2020
Journal: Dev Dyn
Title: Dmrt genes participate in the development of Cajal-Retzius cells derived from the cortical hem in the telencephalon.
Volume: 249
Issue: 6
Pages: 698-710
Publication
First Author: Sharaf A
Year: 2015
Journal: Cell Tissue Res
Title: Localization of reelin signaling pathway components in murine midbrain and striatum.
Volume: 359
Issue: 2
Pages: 393-407
Publication
First Author: Bechelli L
Year: 2023
Journal: Sci Rep
Title: Selective dopamine D2 receptor deletion from Nkx6.2 expressing cells causes impaired cognitive, motivation and anxiety phenotypes in mice.
Volume: 13
Issue: 1
Pages: 19473
Publication
First Author: Shen L
Year: 2006
Journal: Hippocampus
Title: FoxG1 haploinsufficiency results in impaired neurogenesis in the postnatal hippocampus and contextual memory deficits.
Volume: 16
Issue: 10
Pages: 875-90
Publication
First Author: Barnes AP
Year: 2007
Journal: Cell
Title: LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.
Volume: 129
Issue: 3
Pages: 549-63
Publication
First Author: Cheng HJ
Year: 2001
Journal: Neuron
Title: Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.
Volume: 32
Issue: 2
Pages: 249-63
Publication
First Author: Hirschberg A
Year: 2010
Journal: Mol Cell Biol
Title: Gene deletion mutants reveal a role for semaphorin receptors of the plexin-B family in mechanisms underlying corticogenesis.
Volume: 30
Issue: 3
Pages: 764-80
Publication
First Author: McEvilly RJ
Year: 2002
Journal: Science
Title: Transcriptional regulation of cortical neuron migration by POU domain factors.
Volume: 295
Issue: 5559
Pages: 1528-32
Publication
First Author: Segklia A
Year: 2012
Journal: PLoS One
Title: Bmp7 regulates the survival, proliferation, and neurogenic properties of neural progenitor cells during corticogenesis in the mouse.
Volume: 7
Issue: 3
Pages: e34088
Publication
First Author: Matsugami TR
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: From the Cover: Indispensability of the glutamate transporters GLAST and GLT1 to brain development.
Volume: 103
Issue: 32
Pages: 12161-6
Publication
First Author: Hack I
Year: 2007
Journal: Development
Title: Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons.
Volume: 134
Issue: 21
Pages: 3883-91
Publication
First Author: Laub F
Year: 2005
Journal: Mol Cell Biol
Title: Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system.
Volume: 25
Issue: 13
Pages: 5699-711
Publication
First Author: Zhao T
Year: 2006
Journal: Eur J Neurosci
Title: Emx2 in the developing hippocampal fissure region.
Volume: 23
Issue: 11
Pages: 2895-907
Publication
First Author: Genethliou N
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord.
Volume: 382
Issue: 1
Pages: 69-73
Publication
First Author: Stoykova A
Year: 2000
Journal: J Neurosci
Title: Pax6 modulates the dorsoventral patterning of the mammalian telencephalon.
Volume: 20
Issue: 21
Pages: 8042-50
Publication
First Author: Cocas LA
Year: 2009
Journal: J Neurosci
Title: Emx1-lineage progenitors differentially contribute to neural diversity in the striatum and amygdala.
Volume: 29
Issue: 50
Pages: 15933-46
Publication
First Author: Fotaki V
Year: 2006
Journal: J Neurosci
Title: Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3.
Volume: 26
Issue: 36
Pages: 9282-92
Publication
First Author: Hanashima C
Year: 2007
Journal: J Neurosci
Title: The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes.
Volume: 27
Issue: 41
Pages: 11103-11
Publication
First Author: Rash BG
Year: 2011
Journal: Dev Biol
Title: Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain.
Volume: 359
Issue: 2
Pages: 242-50
Publication
First Author: Bodea GO
Year: 2014
Journal: Development
Title: Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system.
Volume: 141
Issue: 3
Pages: 661-73
Publication
First Author: Remedios R
Year: 2007
Journal: Nat Neurosci
Title: A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex.
Volume: 10
Issue: 9
Pages: 1141-50
Publication
First Author: Palmesino E
Year: 2010
Journal: PLoS Biol
Title: Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling.
Volume: 8
Issue: 8
Pages: e1000446
Publication
First Author: Sentürk A
Year: 2011
Journal: Nature
Title: Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration.
Volume: 472
Issue: 7343
Pages: 356-60
Publication
First Author: Jacquet BV
Year: 2011
Journal: J Neurosci
Title: Specification of a Foxj1-dependent lineage in the forebrain is required for embryonic-to-postnatal transition of neurogenesis in the olfactory bulb.
Volume: 31
Issue: 25
Pages: 9368-82
Publication
First Author: Chae TH
Year: 2004
Journal: Nat Genet
Title: The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate.
Volume: 36
Issue: 3
Pages: 264-70
Publication    
First Author: Choe Y
Year: 2015
Journal: Elife
Title: Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets.
Volume: 4
Publication
First Author: Glickstein SB
Year: 2009
Journal: J Neurosci
Title: Cyclin D2 is critical for intermediate progenitor cell proliferation in the embryonic cortex.
Volume: 29
Issue: 30
Pages: 9614-24
Publication
First Author: Long JE
Year: 2007
Journal: J Neurosci
Title: Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation.
Volume: 27
Issue: 12
Pages: 3230-43
Publication
First Author: Park IK
Year: 2003
Journal: Nature
Title: Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Volume: 423
Issue: 6937
Pages: 302-5
Publication
First Author: Lake BB
Year: 2009
Journal: J Cell Biol
Title: Strabismus regulates asymmetric cell divisions and cell fate determination in the mouse brain.
Volume: 185
Issue: 1
Pages: 59-66
Publication
First Author: Miyoshi G
Year: 2012
Journal: Neuron
Title: Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate.
Volume: 74
Issue: 6
Pages: 1045-58
Publication  
First Author: Paštar V
Year: 2021
Journal: Int J Mol Sci
Title: Connexin Expression Is Altered in Liver Development of Yotari (dab1 -/-) Mice.
Volume: 22
Issue: 19
Publication
First Author: Long JE
Year: 2003
Journal: J Neurosci
Title: DLX5 regulates development of peripheral and central components of the olfactory system.
Volume: 23
Issue: 2
Pages: 568-78
Publication
First Author: Cobos I
Year: 2005
Journal: Nat Neurosci
Title: Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy.
Volume: 8
Issue: 8
Pages: 1059-68
Publication
First Author: Huilgol D
Year: 2013
Journal: Nat Neurosci
Title: Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream.
Volume: 16
Issue: 2
Pages: 157-65
Publication
First Author: Pascual M
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression.
Volume: 104
Issue: 12
Pages: 5193-8
Publication
First Author: Falk S
Year: 2014
Journal: Cereb Cortex
Title: Smad4 and Trim33/Tif1γ redundantly regulate neural stem cells in the developing cortex.
Volume: 24
Issue: 11
Pages: 2951-63
Publication  
First Author: Müller Smith K
Year: 2012
Journal: Brain Res
Title: Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice.
Volume: 1460
Pages: 12-24
Publication
First Author: Gan Q
Year: 2014
Journal: Stem Cells
Title: Pax6 mediates ß-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells.
Volume: 32
Issue: 1
Pages: 45-58
Publication
First Author: Coffinier C
Year: 2011
Journal: Mol Biol Cell
Title: Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons.
Volume: 22
Issue: 23
Pages: 4683-93
Publication
First Author: Lakhina V
Year: 2007
Journal: Dev Biol
Title: Early thalamocortical tract guidance and topographic sorting of thalamic projections requires LIM-homeodomain gene Lhx2.
Volume: 306
Issue: 2
Pages: 703-13
Publication
First Author: Marks C
Year: 2012
Journal: J Neurosci
Title: Critical role of GFRα1 in the development and function of the main olfactory system.
Volume: 32
Issue: 48
Pages: 17306-20
Publication
First Author: Hurtado-Chong A
Year: 2009
Journal: Eur J Neurosci
Title: IGF-I promotes neuronal migration and positioning in the olfactory bulb and the exit of neuroblasts from the subventricular zone.
Volume: 30
Issue: 5
Pages: 742-55
Publication
First Author: Shim S
Year: 2012
Journal: Nature
Title: Cis-regulatory control of corticospinal system development and evolution.
Volume: 486
Issue: 7401
Pages: 74-9
Publication
First Author: Zhou CJ
Year: 2006
Journal: Neuroscience
Title: Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway.
Volume: 142
Issue: 4
Pages: 1119-31
Publication
First Author: Barber M
Year: 2018
Journal: Cereb Cortex
Title: Vascular-Derived Vegfa Promotes Cortical Interneuron Migration and Proximity to the Vasculature in the Developing Forebrain.
Volume: 28
Issue: 7
Pages: 2577-2593
Publication  
First Author: Jaafar C
Year: 2016
Journal: Front Mol Neurosci
Title: Role of Rb during Neurogenesis and Axonal Guidance in the Developing Olfactory System.
Volume: 9
Pages: 81
Publication
First Author: Sessa A
Year: 2010
Journal: Genes Dev
Title: Tbr2-positive intermediate (basal) neuronal progenitors safeguard cerebral cortex expansion by controlling amplification of pallial glutamatergic neurons and attraction of subpallial GABAergic interneurons.
Volume: 24
Issue: 16
Pages: 1816-26
Publication
First Author: Siegenthaler JA
Year: 2008
Journal: Dev Biol
Title: Generation of Cajal-Retzius neurons in mouse forebrain is regulated by transforming growth factor beta-Fox signaling pathways.
Volume: 313
Issue: 1
Pages: 35-46
Publication
First Author: Li HS
Year: 2003
Journal: Neuron
Title: Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis.
Volume: 40
Issue: 6
Pages: 1105-18
Publication
First Author: Komada M
Year: 2008
Journal: Development
Title: Hedgehog signaling is involved in development of the neocortex.
Volume: 135
Issue: 16
Pages: 2717-27
Publication
First Author: Latremoliere A
Year: 2018
Journal: Cell Rep
Title: Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration.
Volume: 24
Issue: 7
Pages: 1865-1879.e9
Publication
First Author: Konno D
Year: 2012
Journal: PLoS One
Title: The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex.
Volume: 7
Issue: 10
Pages: e46577