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Search results 801 to 900 out of 2663 for Psen1

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Type Details Score
Publication
21103384 | J:166981
First Author: Bittner T
Year: 2010
Journal: PLoS One
Title: Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.
Volume: 5
Issue: 11
Pages: e15477
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Publication
25339759 | J:217151
First Author: Shibuya Y
Year: 2014
Journal: J Neurosci
Title: Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance.
Volume: 34
Issue: 43
Pages: 14484-501
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Publication
31004063 | J:274643
First Author: Xiang J
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies.
Volume: 116
Issue: 18
Pages: 9094-9102
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Publication
38906984 | J:350176
First Author: Jong Huat T
Year: 2024
Journal: Sci Rep
Title: The impact of astrocytic NF-κB on healthy and Alzheimer's disease brains.
Volume: 14
Issue: 1
Pages: 14305
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Publication
30850634 | J:275633
First Author: Caberlotto L
Year: 2019
Journal: Sci Rep
Title: Cross-disease analysis of Alzheimer's disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases.
Volume: 9
Issue: 1
Pages: 3965
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Publication
38555992 | J:351247
 
First Author: Wang J
Year: 2024
Journal: Brain Behav Immun
Title: A TrkB cleavage fragment in hippocampus promotes Depressive-Like behavior in mice.
Volume: 119
Pages: 56-83
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Publication
24698269 | J:213159
First Author: Sun S
Year: 2014
Journal: Neuron
Title: Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice.
Volume: 82
Issue: 1
Pages: 79-93
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Publication
34522902 | J:359101
First Author: Hegedüs P
Year: 2021
Journal: STAR Protoc
Title: Training protocol for probabilistic Pavlovian conditioning in mice using an open-source head-fixed setup.
Volume: 2
Issue: 3
Pages: 100795
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Publication
38131009 | J:343622
 
First Author: Wang Y
Year: 2023
Journal: Front Aging Neurosci
Title: A tau fragment links depressive-like behaviors and cognitive declines in Alzheimer's disease mouse models through attenuating mitochondrial function.
Volume: 15
Pages: 1293164
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Publication
33859747 | J:348495
First Author: Wang W
Year: 2021
Journal: Theranostics
Title: A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models.
Volume: 11
Issue: 11
Pages: 5279-5295
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Publication
30120733 | J:285073
First Author: Comerota MM
Year: 2019
Journal: Mol Neurobiol
Title: Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies.
Volume: 56
Issue: 5
Pages: 3341-3355
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Publication
33287900 | J:313473
First Author: Bevan RJ
Year: 2020
Journal: Acta Neuropathol Commun
Title: Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer's disease.
Volume: 8
Issue: 1
Pages: 216
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Publication
20305648 | J:159680
First Author: Fuhrmann M
Year: 2010
Journal: Nat Neurosci
Title: Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease.
Volume: 13
Issue: 4
Pages: 411-3
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Publication
38288580 | J:361050
First Author: Tapella L
Year: 2024
Journal: Glia
Title: Genetic deletion of astrocytic calcineurin B1 prevents cognitive impairment and neuropathology development in acute and chronic mouse models of Alzheimer's disease.
Volume: 72
Issue: 5
Pages: 899-915
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Publication
31467276 | J:279320
First Author: Jadiya P
Year: 2019
Journal: Nat Commun
Title: Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.
Volume: 10
Issue: 1
Pages: 3885
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Publication
29113959 | J:260831
 
First Author: Lardenoije R
Year: 2018
Journal: Mol Cell Neurosci
Title: Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease.
Volume: 86
Pages: 1-15
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Publication
27752775 | J:311368
First Author: Jan A
Year: 2017
Journal: Acta Neuropathol
Title: eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response.
Volume: 133
Issue: 1
Pages: 101-119
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Publication
28694463 | J:249724
First Author: Dudeffant C
Year: 2017
Journal: Sci Rep
Title: Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer's disease brains.
Volume: 7
Issue: 1
Pages: 4955
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Publication
23924630 | J:204466
First Author: Tadeu AM
Year: 2013
Journal: Development
Title: Notch signaling represses p63 expression in the developing surface ectoderm.
Volume: 140
Issue: 18
Pages: 3777-86
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Publication
22870188 | J:189666
First Author: Castello NA
Year: 2012
Journal: PLoS One
Title: Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology.
Volume: 7
Issue: 8
Pages: e39566
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Publication
15617678 | J:95889
First Author: Wines-Samuelson M
Year: 2005
Journal: Dev Biol
Title: Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons.
Volume: 277
Issue: 2
Pages: 332-46
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Publication
33155636 | J:300029
First Author: Kam MK
Year: 2020
Journal: Biochem J
Title: Amyloid-beta oligomers induce Parkin-mediated mitophagy by reducing Miro1.
Volume: 477
Issue: 23
Pages: 4581-4597
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Publication
25864429 | J:239283
First Author: Posada-Duque RA
Year: 2015
Journal: J Neurochem
Title: p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing.
Volume: 134
Issue: 2
Pages: 354-70
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Publication
23150673 | J:316096
First Author: Benoit ME
Year: 2013
Journal: J Biol Chem
Title: C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity.
Volume: 288
Issue: 1
Pages: 654-65
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Publication
28779511 | J:248482
First Author: Branca C
Year: 2017
Journal: Aging Cell
Title: Dyrk1 inhibition improves Alzheimer's disease-like pathology.
Volume: 16
Issue: 5
Pages: 1146-1154
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Publication
21835156 | J:176301
First Author: Montgomery SL
Year: 2011
Journal: Am J Pathol
Title: Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain.
Volume: 179
Issue: 4
Pages: 2053-70
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Publication
24012003 | J:201741
First Author: Um JW
Year: 2013
Journal: Neuron
Title: Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein.
Volume: 79
Issue: 5
Pages: 887-902
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Publication
20133765 | J:157545
First Author: Bryleva EY
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.
Volume: 107
Issue: 7
Pages: 3081-6
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Publication
27196744 | J:234011
   
First Author: Deyts C
Year: 2016
Journal: Elife
Title: Loss of presenilin function is associated with a selective gain of APP function.
Volume: 5
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Publication
29018038 | J:248850
First Author: Pera M
Year: 2017
Journal: EMBO J
Title: Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.
Volume: 36
Issue: 22
Pages: 3356-3371
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Publication
29501742 | J:273677
First Author: Li H
Year: 2018
Journal: Biochem Biophys Res Commun
Title: FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling.
Volume: 498
Issue: 1
Pages: 234-239
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Publication
20693289 | J:166379
First Author: Li H
Year: 2010
Journal: J Biol Chem
Title: Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.
Volume: 285
Issue: 40
Pages: 30598-605
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Publication
33893290 | J:304519
First Author: Baglietto-Vargas D
Year: 2021
Journal: Nat Commun
Title: Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.
Volume: 12
Issue: 1
Pages: 2421
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Publication
37071198 | J:351756
First Author: Chen J
Year: 2023
Journal: Cell Mol Life Sci
Title: APP mediates tau uptake and its overexpression leads to the exacerbated tau pathology.
Volume: 80
Issue: 5
Pages: 123
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Publication
29024660 | J:253213
First Author: Zhao Y
Year: 2017
Journal: Neuron
Title: Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels.
Volume: 96
Issue: 2
Pages: 355-372.e6
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18486110 | J:138344
 
First Author: Hirata-Fukae C
Year: 2008
Journal: Brain Res
Title: Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.
Volume: 1216
Pages: 92-103
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19625522 | J:151795
First Author: Peng S
Year: 2009
Journal: J Neurosci
Title: Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease.
Volume: 29
Issue: 29
Pages: 9321-9
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Publication
29211722 | J:274288
First Author: Sorrentino V
Year: 2017
Journal: Nature
Title: Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.
Volume: 552
Issue: 7684
Pages: 187-193
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29298895 | J:262527
First Author: Hashimoto S
Year: 2018
Journal: J Biol Chem
Title: Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: Overexpression paradigm versus knockin paradigm.
Volume: 293
Issue: 9
Pages: 3118-3125
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Publication
22912745 | J:189978
First Author: Kamphuis W
Year: 2012
Journal: PLoS One
Title: GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease.
Volume: 7
Issue: 8
Pages: e42823
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Publication
35339896 | J:322782
 
First Author: Zhou Q
Year: 2022
Journal: EBioMedicine
Title: Human tau accumulation promotes glycogen synthase kinase-3β acetylation and thus upregulates the kinase: A vicious cycle in Alzheimer neurodegeneration.
Volume: 78
Pages: 103970
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26280122 | J:228804
First Author: Ceglia I
Year: 2015
Journal: Nat Med
Title: APP intracellular domain-WAVE1 pathway reduces amyloid-β production.
Volume: 21
Issue: 9
Pages: 1054-9
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Publication
32727580 | J:311717
First Author: Kumar S
Year: 2020
Journal: Acta Neuropathol Commun
Title: Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer's-like mouse models.
Volume: 8
Issue: 1
Pages: 118
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Publication
28137967 | J:239593
First Author: Zhang ZH
Year: 2017
Journal: J Neurosci
Title: Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model.
Volume: 37
Issue: 9
Pages: 2449-2462
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Publication
27834631 | J:239104
   
First Author: Kam TI
Year: 2016
Journal: Elife
Title: FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model.
Volume: 5
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Publication
31793911 | J:355611
First Author: Kang SS
Year: 2020
Journal: J Clin Invest
Title: Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus.
Volume: 130
Issue: 1
Pages: 422-437
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35236988 | J:338102
First Author: Xiong J
Year: 2022
Journal: Nature
Title: FSH blockade improves cognition in mice with Alzheimer's disease.
Volume: 603
Issue: 7901
Pages: 470-476
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Publication
37083538 | J:337545
First Author: Zhou LT
Year: 2023
Journal: Sci Adv
Title: Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer's disease.
Volume: 9
Issue: 16
Pages: eabq7105
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32098978 | J:293886
First Author: Jiang H
Year: 2020
Journal: Sci Rep
Title: Live Neuron High-Content Screening Reveals Synaptotoxic Activity in Alzheimer Mouse Model Homogenates.
Volume: 10
Issue: 1
Pages: 3412
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Publication
33863723 | J:358337
 
First Author: Chen G
Year: 2021
Journal: Sci Adv
Title: Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies.
Volume: 7
Issue: 16
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Publication
27022623 | J:240236
 
First Author: Shen X
Year: 2016
Journal: eNeuro
Title: Neurons in Vulnerable Regions of the Alzheimer's Disease Brain Display Reduced ATM Signaling.
Volume: 3
Issue: 1
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26365177 | J:228348
First Author: Ishii M
Year: 2015
Journal: Cell Metab
Title: Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology.
Volume: 22
Issue: 5
Pages: 761-76
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19723505 | J:155627
First Author: Genethliou N
Year: 2009
Journal: Biochem Biophys Res Commun
Title: SOX1 links the function of neural patterning and Notch signalling in the ventral spinal cord during the neuron-glial fate switch.
Volume: 390
Issue: 4
Pages: 1114-20
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Publication
15081359 | J:90392
First Author: Yang X
Year: 2004
Journal: Dev Biol
Title: Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway.
Volume: 269
Issue: 1
Pages: 81-94
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35815610 | J:327338
 
First Author: Sartoretti MM
Year: 2022
Journal: Development
Title: Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling.
Volume: 149
Issue: 15
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Publication
36260685 | J:330576
First Author: Lacomme M
Year: 2022
Journal: Sci Adv
Title: Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models.
Volume: 8
Issue: 42
Pages: eabm4295
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Publication
24353058 | J:206586
First Author: Boyle SC
Year: 2014
Journal: Development
Title: Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development.
Volume: 141
Issue: 2
Pages: 346-54
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Publication
25331900 | J:216662
First Author: Chow HM
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: CDK5 activator protein p25 preferentially binds and activates GSK3β.
Volume: 111
Issue: 45
Pages: E4887-95
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Publication
38343132 | J:347607
First Author: Benzow K
Year: 2024
Journal: Alzheimers Dement
Title: Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice.
Volume: 20
Issue: 4
Pages: 3080-3087
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25654552 | J:219892
First Author: Frake RA
Year: 2015
Journal: J Clin Invest
Title: Autophagy and neurodegeneration.
Volume: 125
Issue: 1
Pages: 65-74
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7596406 | J:37100
First Author: Sherrington R
Year: 1995
Journal: Nature
Title: Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.
Volume: 375
Issue: 6534
Pages: 754-60
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9295283 | J:43028
First Author: Mitsuda N
Year: 1997
Journal: J Biol Chem
Title: Transcriptional regulation of the mouse presenilin-1 gene.
Volume: 272
Issue: 38
Pages: 23489-97
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11517342 | J:71473
First Author: Xia X
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis.
Volume: 98
Issue: 19
Pages: 10863-8
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Publication
9539133 | J:77306
First Author: Qian S
Year: 1998
Journal: Neuron
Title: Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.
Volume: 20
Issue: 3
Pages: 611-7
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Publication
11814648 | J:107974
First Author: Morton RA
Year: 2002
Journal: Neurosci Lett
Title: Impairment in hippocampal long-term potentiation in mice under-expressing the Alzheimer's disease related gene presenilin-1.
Volume: 319
Issue: 1
Pages: 37-40
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Publication
15123735 | J:90565
First Author: Wilson CA
Year: 2004
Journal: J Cell Biol
Title: Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons.
Volume: 165
Issue: 3
Pages: 335-46
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Publication
9539132 | J:182724
First Author: Davis JA
Year: 1998
Journal: Neuron
Title: An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.
Volume: 20
Issue: 3
Pages: 603-9
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Publication
15972961 | J:99508
First Author: Chevallier NL
Year: 2005
Journal: Am J Pathol
Title: Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation.
Volume: 167
Issue: 1
Pages: 151-9
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Publication
15703408 | J:98238
First Author: Parent AT
Year: 2005
Journal: J Neurosci
Title: Presenilin attenuates receptor-mediated signaling and synaptic function.
Volume: 25
Issue: 6
Pages: 1540-9
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9856475 | J:111807
First Author: Naruse S
Year: 1998
Journal: Neuron
Title: Effects of PS1 deficiency on membrane protein trafficking in neurons.
Volume: 21
Issue: 5
Pages: 1213-21
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9843412 | J:114204
First Author: Xia W
Year: 1998
Journal: Biochemistry
Title: Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Volume: 37
Issue: 47
Pages: 16465-71
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Publication
15548218 | J:101284
First Author: Kilb W
Year: 2004
Journal: Eur J Neurosci
Title: Altered morphological and electrophysiological properties of Cajal-Retzius cells in cerebral cortex of embryonic Presenilin-1 knockout mice.
Volume: 20
Issue: 10
Pages: 2749-56
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Publication
15486475 | J:103695
First Author: Cui JG
Year: 2004
Journal: Neuroreport
Title: Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expression.
Volume: 15
Issue: 13
Pages: 2025-8
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Publication
11738035 | J:73252
First Author: Feng R
Year: 2001
Journal: Neuron
Title: Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces.
Volume: 32
Issue: 5
Pages: 911-26
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Publication
10383647 | J:56247
First Author: Nakano Y
Year: 1999
Journal: Eur J Neurosci
Title: Accumulation of murine amyloidbeta42 in a gene-dosage-dependent manner in PS1 'knock-in' mice.
Volume: 11
Issue: 7
Pages: 2577-81
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Publication
35027883 | J:317694
 
First Author: Takasu K
Year: 2021
Journal: Front Mol Neurosci
Title: Histone Deacetylase Inhibitor Improves the Dysfunction of Hippocampal Gamma Oscillations and Fast Spiking Interneurons in Alzheimer's Disease Model Mice.
Volume: 14
Pages: 782206
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11978814 | J:123338
First Author: Savage MJ
Year: 2002
Journal: J Neurosci
Title: Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.
Volume: 22
Issue: 9
Pages: 3376-85
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Publication
16597739 | J:107251
First Author: Deng Y
Year: 2006
Journal: J Neurosci
Title: Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology.
Volume: 26
Issue: 14
Pages: 3845-54
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Publication
25172571 | J:215372
 
First Author: Chen CJ
Year: 2014
Journal: Neurosci Lett
Title: Biological evaluation of the radioiodinated imidazo[1,2-a]pyridine derivative DRK092 for amyloid-β imaging in mouse model of Alzheimer's disease.
Volume: 581
Pages: 103-8
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Publication
16713590 | J:110440
First Author: Samura E
Year: 2006
Journal: Brain Res
Title: Enhanced accumulation of tau in doubly transgenic mice expressing mutant betaAPP and presenilin-1.
Volume: 1094
Issue: 1
Pages: 192-9
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Publication
11804702 | J:80624
First Author: Rozmahel R
Year: 2002
Journal: Neurobiol Aging
Title: Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.
Volume: 23
Issue: 2
Pages: 187-94
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Publication
8938131 | J:80882
First Author: Borchelt DR
Year: 1996
Journal: Neuron
Title: Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.
Volume: 17
Issue: 5
Pages: 1005-13
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Publication
22459153 | J:187475
First Author: Vidal R
Year: 2012
Journal: FASEB J
Title: The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice.
Volume: 26
Issue: 7
Pages: 2899-910
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Publication
22874668 | J:197584
First Author: Vidal R
Year: 2012
Journal: Prion
Title: Generation of a novel murine model of Aβ deposition based on the expression of human wild-type amyloid precursor protein gene.
Volume: 6
Issue: 4
Pages: 346-9
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Publication
10078973 | J:57519
First Author: Parent A
Year: 1999
Journal: Neurobiol Dis
Title: Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1.
Volume: 6
Issue: 1
Pages: 56-62
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Publication
10660668 | J:60306
First Author: Yu H
Year: 2000
Journal: Genesis
Title: Heterogeneous populations of ES cells in the generation of a floxed Presenilin-1 allele.
Volume: 26
Issue: 1
Pages: 5-8
•
•
•
•
•
Publication
24344333 | J:211486
First Author: Balmaceda V
Year: 2014
Journal: FASEB J
Title: ApoER2 processing by presenilin-1 modulates reelin expression.
Volume: 28
Issue: 4
Pages: 1543-54
•
•
•
•
•
Publication
20419112 | J:160144
First Author: Wines-Samuelson M
Year: 2010
Journal: PLoS One
Title: Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice.
Volume: 5
Issue: 4
Pages: e10195
•
•
•
•
•
Publication
11978821 | J:87229
First Author: Dewachter I
Year: 2002
Journal: J Neurosci
Title: Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.
Volume: 22
Issue: 9
Pages: 3445-53
•
•
•
•
•
Publication
12902342 | J:86553
First Author: Ris L
Year: 2003
Journal: J Biol Chem
Title: Capacitative calcium entry induces hippocampal long term potentiation in the absence of presenilin-1.
Volume: 278
Issue: 45
Pages: 44393-9
•
•
•
•
•
Publication
15466394 | J:93770
First Author: Casas C
Year: 2004
Journal: Am J Pathol
Title: Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model.
Volume: 165
Issue: 4
Pages: 1289-300
•
•
•
•
•
Publication
16581193 | J:108941
First Author: Page G
Year: 2006
Journal: Neuroscience
Title: Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease.
Volume: 139
Issue: 4
Pages: 1343-54
•
•
•
•
•
Publication
17215062 | J:140923
First Author: Wirths O
Year: 2008
Journal: Neurobiol Aging
Title: Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease.
Volume: 29
Issue: 6
Pages: 891-901
•
•
•
•
•
Publication
18657882 | J:159590
First Author: Wirths O
Year: 2010
Journal: Neurobiol Aging
Title: Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease.
Volume: 31
Issue: 5
Pages: 747-57
•
•
•
•
•
Publication
25018730 | J:288957
 
First Author: Christensen DZ
Year: 2014
Journal: Front Aging Neurosci
Title: Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation.
Volume: 6
Pages: 139
•
•
•
•
•
Publication
16963164 | J:128106
First Author: Wirths O
Year: 2007
Journal: Neurobiol Aging
Title: Age-dependent axonal degeneration in an Alzheimer mouse model.
Volume: 28
Issue: 11
Pages: 1689-99
•
•
•
•
•
Publication
18771817 | J:161989
First Author: Christensen DZ
Year: 2010
Journal: Neurobiol Aging
Title: Intracellular Aß triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease.
Volume: 31
Issue: 7
Pages: 1153-63
•
•
•
•
•
Publication
22306812 | J:185010
First Author: Mouton-Liger F
Year: 2012
Journal: Biochim Biophys Acta
Title: Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway.
Volume: 1822
Issue: 6
Pages: 885-96
•
•
•
•
•
Publication
18585693 | J:139736
 
First Author: Cotel MC
Year: 2008
Journal: Brain Res
Title: Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice.
Volume: 1222
Pages: 207-13
•
•
•
•
•
Publication
19398247 | J:173740
First Author: Faure A
Year: 2011
Journal: Neurobiol Aging
Title: Impaired neurogenesis, neuronal loss, and brain functional deficits in the APPxPS1-Ki mouse model of Alzheimer's disease.
Volume: 32
Issue: 3
Pages: 407-18
•
•
•
•
•




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