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Search results 801 to 900 out of 4876 for Tcra

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Category: Publication
Type Details Score
Publication
First Author: Livák F
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Alternative splicing of rearranged T cell receptor delta sequences to the constant region of the alpha locus.
Volume: 95
Issue: 10
Pages: 5694-9
Publication
First Author: Senoo M
Year: 1998
Journal: Int Immunol
Title: Regulation of Vbeta germline transcription in RAG-deficient mice by the CD3epsilon-mediated signals: implication of Vbeta transcriptional regulation in TCR beta allelic exclusion.
Volume: 10
Issue: 5
Pages: 553-60
Publication
First Author: Zhao ML
Year: 1998
Journal: J Neuroimmunol
Title: Acute and relapsing experimental autoimmune encephalomyelitis in IL-4- and alpha/beta T cell-deficient C57BL/6 mice.
Volume: 87
Issue: 1-2
Pages: 171-8
Publication
First Author: Junta CM
Year: 1998
Journal: Mol Cell Biochem
Title: Emergence of TCR alpha/beta V(D)J recombination and transcription during ontogeny of inbred mouse strains.
Volume: 187
Issue: 1-2
Pages: 67-72
Publication
First Author: Azzam HS
Year: 1998
Journal: J Exp Med
Title: CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity.
Volume: 188
Issue: 12
Pages: 2301-11
Publication
First Author: Girgis L
Year: 1999
Journal: J Exp Med
Title: The avidity spectrum of T cell receptor interactions accounts for T cell anergy in a double transgenic model.
Volume: 189
Issue: 2
Pages: 265-78
Publication
First Author: Bercovici N
Year: 1999
Journal: Eur J Immunol
Title: Chronic intravenous injections of antigen induce and maintain tolerance in T cell receptor-transgenic mice.
Volume: 29
Issue: 1
Pages: 345-54
Publication  
First Author: Bhan AK
Year: 1999
Journal: Immunol Rev
Title: Colitis in transgenic and knockout animals as models of human inflammatory bowel disease.
Volume: 169
Pages: 195-207
Publication
First Author: Jones TB
Year: 2002
Journal: J Neurosci
Title: Pathological CNS autoimmune disease triggered by traumatic spinal cord injury: implications for autoimmune vaccine therapy.
Volume: 22
Issue: 7
Pages: 2690-700
Publication
First Author: Wang XM
Year: 2002
Journal: Clin Immunol
Title: T-cell antigen receptor peptides inhibit signal transduction within the membrane bilayer.
Volume: 105
Issue: 2
Pages: 199-207
Publication
First Author: Guo J
Year: 2002
Journal: Nat Immunol
Title: Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes.
Volume: 3
Issue: 5
Pages: 469-76
Publication
First Author: Girardi M
Year: 2003
Journal: J Exp Med
Title: The distinct contributions of murine T cell receptor (TCR)gammadelta+ and TCRalphabeta+ T cells to different stages of chemically induced skin cancer.
Volume: 198
Issue: 5
Pages: 747-55
Publication
First Author: Yamasaki S
Year: 2006
Journal: Nat Immunol
Title: Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development.
Volume: 7
Issue: 1
Pages: 67-75
Publication
First Author: Sommermeyer D
Year: 2006
Journal: Eur J Immunol
Title: Designer T cells by T cell receptor replacement.
Volume: 36
Issue: 11
Pages: 3052-9
Publication
First Author: Gui M
Year: 2001
Journal: J Immunol
Title: TCR beta chain influences but does not solely control autoreactivity of V alpha 14J281T cells.
Volume: 167
Issue: 11
Pages: 6239-46
Publication
First Author: Niederberger N
Year: 2003
Journal: J Immunol
Title: Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl.
Volume: 170
Issue: 9
Pages: 4557-63
Publication
First Author: Colombetti S
Year: 2006
Journal: J Immunol
Title: Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin.
Volume: 176
Issue: 5
Pages: 2730-8
Publication
First Author: Gomos-Klein J
Year: 2007
Journal: J Immunol
Title: CTCF-independent, but not CTCF-dependent, elements significantly contribute to TCR-alpha locus control region activity.
Volume: 179
Issue: 2
Pages: 1088-95
Publication
First Author: Fujita H
Year: 2009
Journal: J Immunol
Title: Production of both IL-27 and IFN-gamma after the treatment with a ligand for invariant NK T cells is responsible for the suppression of Th2 response and allergic inflammation in a mouse experimental asthma model.
Volume: 183
Issue: 1
Pages: 254-60
Publication
First Author: Li D
Year: 2009
Journal: J Biol Chem
Title: LFA-1 regulates CD8+ T cell activation via T cell receptor-mediated and LFA-1-mediated Erk1/2 signal pathways.
Volume: 284
Issue: 31
Pages: 21001-10
Publication
First Author: Huang J
Year: 2010
Journal: Nature
Title: The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.
Volume: 464
Issue: 7290
Pages: 932-6
Publication
First Author: Montaudouin C
Year: 2010
Journal: PLoS One
Title: Endogenous TCR recombination in TCR Tg single RAG-deficient mice uncovered by robust in vivo T cell activation and selection.
Volume: 5
Issue: 4
Pages: e10238
Publication
First Author: Zajonc DM
Year: 2008
Journal: J Mol Biol
Title: Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids.
Volume: 377
Issue: 4
Pages: 1104-16
Publication
First Author: Pape KA
Year: 2011
Journal: Science
Title: Different B cell populations mediate early and late memory during an endogenous immune response.
Volume: 331
Issue: 6021
Pages: 1203-7
Publication
First Author: Genolet R
Year: 2012
Journal: EMBO J
Title: Highly diverse TCRα chain repertoire of pre-immune CD8⁺ T cells reveals new insights in gene recombination.
Volume: 31
Issue: 7
Pages: 1666-78
Publication
First Author: Yin Y
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4.
Volume: 109
Issue: 14
Pages: 5405-10
Publication
First Author: Lynch JN
Year: 2013
Journal: Mol Immunol
Title: Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells.
Volume: 53
Issue: 3
Pages: 283-94
Publication
First Author: Kearse KP
Year: 1995
Journal: Immunity
Title: TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes.
Volume: 2
Issue: 4
Pages: 391-9
Publication
First Author: Collins B
Year: 2013
Journal: Eur J Immunol
Title: Ikaros promotes rearrangement of TCR α genes in an Ikaros null thymoma cell line.
Volume: 43
Issue: 2
Pages: 521-32
Publication  
First Author: Khairnar V
Year: 2015
Journal: Nat Commun
Title: CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.
Volume: 6
Pages: 6217
Publication  
First Author: Reynolds C
Year: 2014
Journal: BMC Biol
Title: Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.
Volume: 12
Pages: 32
Publication
First Author: Chen L
Year: 2015
Journal: Nat Immunol
Title: A discrete chromatin loop in the mouse Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires.
Volume: 16
Issue: 10
Pages: 1085-93
Publication    
First Author: Marrack P
Year: 2017
Journal: Elife
Title: The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor.
Volume: 6
Publication  
First Author: Immisch L
Year: 2023
Journal: Front Immunol
Title: Targeting the recurrent Rac1P29S neoepitope in melanoma with heterologous high-affinity T cell receptors.
Volume: 14
Pages: 1119498
Publication  
First Author: Su X
Year: 2023
Journal: Front Immunol
Title: γδ T cells recruitment and local proliferation in brain parenchyma benefit anti-neuroinflammation after cerebral microbleeds.
Volume: 14
Pages: 1139601
Publication
First Author: Giachino C
Year: 1992
Journal: J Immunol Res
Title: The J family of the human T-cell receptor alpha chain. A call for a unifying nomenclature.
Volume: 4
Issue: 3
Pages: 99-105
Publication
First Author: Matei IR
Year: 2007
Journal: Blood
Title: ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes.
Volume: 109
Issue: 5
Pages: 1887-96
Publication
First Author: Mancini SJ
Year: 2001
Journal: J Immunol
Title: TCRA gene rearrangement in immature thymocytes in absence of CD3, pre-TCR, and TCR signaling.
Volume: 167
Issue: 8
Pages: 4485-93
Publication
First Author: Mancini S
Year: 1999
Journal: J Immunol
Title: TCR alpha-chain repertoire in pTalpha-deficient mice is diverse and developmentally regulated: implications for pre-TCR functions and TCRA gene rearrangement.
Volume: 163
Issue: 11
Pages: 6053-9
Publication
First Author: Rubin B
Year: 1993
Journal: Scand J Immunol
Title: The IE allogeneic response of T cells from C57Bl/6 mice is associated with genes in the TCRa locus.
Volume: 37
Issue: 4
Pages: 479-86
Publication
First Author: D'Cruz LM
Year: 2010
Journal: Nat Immunol
Title: An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells.
Volume: 11
Issue: 3
Pages: 240-9
Publication
First Author: Feng D
Year: 2022
Journal: Nat Commun
Title: Chromatin organizer SATB1 controls the cell identity of CD4(+) CD8(+) double-positive thymocytes by regulating the activity of super-enhancers.
Volume: 13
Issue: 1
Pages: 5554
Publication
First Author: Lee SW
Year: 2018
Journal: Sci Rep
Title: Graphene oxide polarizes iNKT cells for production of TGFβ and attenuates inflammation in an iNKT cell-mediated sepsis model.
Volume: 8
Issue: 1
Pages: 10081
Publication
First Author: Mauvieux L
Year: 2001
Journal: Eur J Immunol
Title: T early alpha (TEA) regulates initial TCRVAJA rearrangements and leads to TCRJA coincidence.
Volume: 31
Issue: 7
Pages: 2080-6
Publication
First Author: Yang JQ
Year: 2011
Journal: J Immunol
Title: Invariant NKT cells inhibit autoreactive B cells in a contact- and CD1d-dependent manner.
Volume: 186
Issue: 3
Pages: 1512-20
Publication
First Author: Mars LT
Year: 2014
Journal: PLoS One
Title: Invariant NKT cells regulate the CD8 T cell response during Theiler's virus infection.
Volume: 9
Issue: 1
Pages: e87717
Publication
First Author: Callen E
Year: 2012
Journal: Immunity
Title: The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.
Volume: 37
Issue: 6
Pages: 971-85
Publication
First Author: Ranson T
Year: 2005
Journal: J Immunol
Title: Invariant V alpha 14+ NKT cells participate in the early response to enteric Listeria monocytogenes infection.
Volume: 175
Issue: 2
Pages: 1137-44
Publication
First Author: Barral P
Year: 2010
Journal: Nat Immunol
Title: CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes.
Volume: 11
Issue: 4
Pages: 303-12
Publication
First Author: Joseph C
Year: 2019
Journal: Eur J Immunol
Title: TCR density in early iNKT cell precursors regulates agonist selection and subset differentiation in mice.
Volume: 49
Issue: 6
Pages: 894-910
Publication
First Author: Wiethe C
Year: 2007
Journal: J Immunol
Title: Interdependency of MHC class II/self-peptide and CD1d/self-glycolipid presentation by TNF-matured dendritic cells for protection from autoimmunity.
Volume: 178
Issue: 8
Pages: 4908-16
Publication
First Author: Cui J
Year: 1997
Journal: Science
Title: Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors.
Volume: 278
Issue: 5343
Pages: 1623-6
Publication
First Author: Kawano T
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha14 NKT cells.
Volume: 95
Issue: 10
Pages: 5690-3
Publication
First Author: Brigl M
Year: 2011
Journal: J Exp Med
Title: Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection.
Volume: 208
Issue: 6
Pages: 1163-77
Publication
First Author: Thomas SY
Year: 2011
Journal: J Exp Med
Title: PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions.
Volume: 208
Issue: 6
Pages: 1179-88
Publication
First Author: Darmoise A
Year: 2010
Journal: Immunity
Title: Lysosomal alpha-galactosidase controls the generation of self lipid antigens for natural killer T cells.
Volume: 33
Issue: 2
Pages: 216-28
Publication
First Author: Seino KI
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Requirement for natural killer T (NKT) cells in the induction of allograft tolerance.
Volume: 98
Issue: 5
Pages: 2577-81
Publication
First Author: Diana J
Year: 2009
Journal: Immunity
Title: NKT cell-plasmacytoid dendritic cell cooperation via OX40 controls viral infection in a tissue-specific manner.
Volume: 30
Issue: 2
Pages: 289-99
Publication
First Author: Mars LT
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Invariant NKT cells inhibit development of the Th17 lineage.
Volume: 106
Issue: 15
Pages: 6238-43
Publication
First Author: Brandl C
Year: 2010
Journal: PLoS One
Title: B7-H1-deficiency enhances the potential of tolerogenic dendritic cells by activating CD1d-restricted type II NKT cells.
Volume: 5
Issue: 5
Pages: e10800
Publication
First Author: Paget C
Year: 2011
Journal: J Immunol
Title: Potential role of invariant NKT cells in the control of pulmonary inflammation and CD8+ T cell response during acute influenza A virus H3N2 pneumonia.
Volume: 186
Issue: 10
Pages: 5590-602
Publication
First Author: Michel ML
Year: 2016
Journal: Eur J Immunol
Title: SLAM-associated protein favors the development of iNKT2 over iNKT17 cells.
Volume: 46
Issue: 9
Pages: 2162-74
Publication
First Author: Chung Y
Year: 2006
Journal: Cancer Res
Title: CD1d-restricted T cells license B cells to generate long-lasting cytotoxic antitumor immunity in vivo.
Volume: 66
Issue: 13
Pages: 6843-50
Publication
First Author: Hong C
Year: 2009
Journal: Cancer Res
Title: Regulation of secondary antigen-specific CD8(+) T-cell responses by natural killer T cells.
Volume: 69
Issue: 10
Pages: 4301-8
Publication
First Author: Mattarollo SR
Year: 2011
Journal: Cancer Res
Title: Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumors.
Volume: 71
Issue: 14
Pages: 4809-20
Publication
First Author: Leadbetter EA
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: NK T cells provide lipid antigen-specific cognate help for B cells.
Volume: 105
Issue: 24
Pages: 8339-44
Publication
First Author: Fujii S
Year: 2009
Journal: Blood
Title: Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT-cell ligand confer antitumor immunity.
Volume: 113
Issue: 18
Pages: 4262-72
Publication
First Author: Bezbradica JS
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny.
Volume: 102
Issue: 14
Pages: 5114-9
Publication  
First Author: Hongo D
Year: 2021
Journal: Front Immunol
Title: Identification of Two Subsets of Murine DC1 Dendritic Cells That Differ by Surface Phenotype, Gene Expression, and Function.
Volume: 12
Pages: 746469
Publication
First Author: Hu T
Year: 2010
Journal: Nat Immunol
Title: The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage.
Volume: 11
Issue: 5
Pages: 435-41
Publication
First Author: Wuest TY
Year: 2008
Journal: J Leukoc Biol
Title: The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells.
Volume: 84
Issue: 4
Pages: 973-80
Publication
First Author: De Santo C
Year: 2008
Journal: J Clin Invest
Title: Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.
Volume: 118
Issue: 12
Pages: 4036-48
Publication
First Author: Shimizu K
Year: 2013
Journal: J Immunol
Title: Invariant NKT cells induce plasmacytoid dendritic cell (DC) cross-talk with conventional DCs for efficient memory CD8+ T cell induction.
Volume: 190
Issue: 11
Pages: 5609-19
Publication
First Author: De Santo C
Year: 2010
Journal: Nat Immunol
Title: Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A.
Volume: 11
Issue: 11
Pages: 1039-46
Publication  
First Author: Kuo P
Year: 2018
Journal: Front Immunol
Title: Recruitment of Antigen Presenting Cells to Skin Draining Lymph Node From HPV16E7-Expressing Skin Requires E7-Rb Interaction.
Volume: 9
Pages: 2896
Publication
First Author: Sosinowski T
Year: 2013
Journal: J Immunol
Title: CD8α+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function.
Volume: 190
Issue: 5
Pages: 1936-47
Publication
First Author: Nakagawa Y
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Thymic nurse cells provide microenvironment for secondary T cell receptor α rearrangement in cortical thymocytes.
Volume: 109
Issue: 50
Pages: 20572-7
Publication
First Author: Garbi N
Year: 2004
Journal: J Immunol
Title: CpG motifs as proinflammatory factors render autochthonous tumors permissive for infiltration and destruction.
Volume: 172
Issue: 10
Pages: 5861-9
Publication
First Author: Griessinger CM
Year: 2019
Journal: Carcinogenesis
Title: The administration route of tumor-antigen-specific T-helper cells differentially modulates the tumor microenvironment and senescence.
Volume: 40
Issue: 2
Pages: 289-302
Publication
First Author: Iwamura C
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo.
Volume: 109
Issue: 42
Pages: 16992-7
Publication
First Author: Chou HS
Year: 1986
Journal: EMBO J
Title: T cell receptor genes in an alloreactive CTL clone: implications for rearrangement and germline diversity of variable gene segments.
Volume: 5
Issue: 9
Pages: 2149-55
Publication
First Author: Fink PJ
Year: 1986
Journal: Nature
Title: Correlations between T-cell specificity and the structure of the antigen receptor.
Volume: 321
Issue: 6067
Pages: 219-26
Publication
First Author: Arden B
Year: 1985
Journal: Nature
Title: Diversity and structure of genes of the alpha family of mouse T-cell antigen receptor.
Volume: 316
Issue: 6031
Pages: 783-7
Publication
First Author: Hayday AC
Year: 1985
Journal: Nature
Title: Unusual organization and diversity of T-cell receptor alpha-chain genes.
Volume: 316
Issue: 6031
Pages: 828-32
Publication
First Author: Becker DM
Year: 1985
Journal: Nature
Title: Variability and repertoire size of T-cell receptor V alpha gene segments.
Volume: 317
Issue: 6036
Pages: 430-4
Publication
First Author: Winoto A
Year: 1986
Journal: Nature
Title: Predominant use of a V alpha gene segment in mouse T-cell receptors for cytochrome c.
Volume: 324
Issue: 6098
Pages: 679-82
Publication
First Author: Winoto A
Year: 1985
Journal: Nature
Title: Genomic organization of the genes encoding mouse T-cell receptor alpha-chain.
Volume: 316
Issue: 6031
Pages: 832-6
Publication
First Author: Huh JY
Year: 2013
Journal: Mol Cell Biol
Title: A novel function of adipocytes in lipid antigen presentation to iNKT cells.
Volume: 33
Issue: 2
Pages: 328-39
Publication
First Author: Wu L
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice.
Volume: 109
Issue: 19
Pages: E1143-52
Publication
First Author: Elewaut D
Year: 2003
Journal: J Exp Med
Title: The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells.
Volume: 198
Issue: 8
Pages: 1133-46
Publication
First Author: Neill DR
Year: 2010
Journal: Nature
Title: Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.
Volume: 464
Issue: 7293
Pages: 1367-70
Publication
First Author: Nishikawa H
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Accelerated chemically induced tumor development mediated by CD4+CD25+ regulatory T cells in wild-type hosts.
Volume: 102
Issue: 26
Pages: 9253-7
Publication
First Author: Tessmer MS
Year: 2011
Journal: PLoS Pathog
Title: Salivary gland NK cells are phenotypically and functionally unique.
Volume: 7
Issue: 1
Pages: e1001254
Publication
First Author: Yamamoto N
Year: 2016
Journal: Immunology
Title: Expression of activation-induced cytidine deaminase enhances the clearance of pneumococcal pneumonia: evidence of a subpopulation of protective anti-pneumococcal B1a cells.
Volume: 147
Issue: 1
Pages: 97-113
Publication
First Author: Kim EY
Year: 2008
Journal: Nat Med
Title: Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease.
Volume: 14
Issue: 6
Pages: 633-40
Publication
First Author: Wingender G
Year: 2010
Journal: J Immunol
Title: Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency.
Volume: 185
Issue: 5
Pages: 2721-9
Publication
First Author: Nowak M
Year: 2006
Journal: J Immunol
Title: Oral nickel tolerance: Fas ligand-expressing invariant NK T cells promote tolerance induction by eliciting apoptotic death of antigen-carrying, effete B cells.
Volume: 176
Issue: 8
Pages: 4581-9
Publication
First Author: Ishikawa T
Year: 2009
Journal: J Virol
Title: Protective role of Fas-FasL signaling in lethal infection with herpes simplex virus type 2 in mice.
Volume: 83
Issue: 22
Pages: 11777-83
Publication
First Author: Ogawa A
Year: 2006
Journal: Gut
Title: Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice.
Volume: 55
Issue: 1
Pages: 105-13
Publication
First Author: Hägglöf T
Year: 2016
Journal: Nat Immunol
Title: Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses.
Volume: 17
Issue: 12
Pages: 1407-1414