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Search results 901 to 1000 out of 2663 for Psen1

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Category: Publication
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Type Details Score
Publication
20359774 | J:188248
First Author: Cotel MC
Year: 2012
Journal: Neurobiol Aging
Title: Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice.
Volume: 33
Issue: 1
Pages: 96-107
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Publication
19547991 | J:278773
First Author: Wirths O
Year: 2009
Journal: Acta Neuropathol
Title: Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model.
Volume: 118
Issue: 4
Pages: 487-96
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Publication
30718666 | J:275902
First Author: Androuin A
Year: 2019
Journal: Sci Rep
Title: Activity-induced MEMRI cannot detect functional brain anomalies in the APPxPS1-Ki mouse model of Alzheimer's disease.
Volume: 9
Issue: 1
Pages: 1140
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Publication
19036474 | J:165243
First Author: Barrier L
Year: 2010
Journal: Neurobiol Aging
Title: Gender-dependent accumulation of ceramides in the cerebral cortex of the APP(SL)/PS1Ki mouse model of Alzheimer's disease.
Volume: 31
Issue: 11
Pages: 1843-53
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Publication
18974993 | J:146342
First Author: Christensen DZ
Year: 2008
Journal: Acta Neuropathol
Title: Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice.
Volume: 116
Issue: 6
Pages: 647-55
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Publication
20497909 | J:165464
First Author: Kågedal K
Year: 2010
Journal: Biochim Biophys Acta
Title: Increased expression of the lysosomal cholesterol transporter NPC1 in Alzheimer's disease.
Volume: 1801
Issue: 8
Pages: 831-8
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Publication
28974740 | J:255452
First Author: Kaneko J
Year: 2017
Journal: Sci Rep
Title: Anserine (beta-alanyl-3-methyl-L-histidine) improves neurovascular-unit dysfunction and spatial memory in aged AβPPswe/PSEN1dE9 Alzheimer's-model mice.
Volume: 7
Issue: 1
Pages: 12571
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Publication
31922229 | J:296741
First Author: Zhu Q
Year: 2020
Journal: Mol Med Rep
Title: Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer's disease.
Volume: 21
Issue: 3
Pages: 1172-1180
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Publication
15908021 | J:99353
First Author: Lalonde R
Year: 2005
Journal: Behav Brain Res
Title: PS1 knockin mice with the Japanese I213T mutation: effects on exploratory activity, motor coordination, and spatial learning.
Volume: 162
Issue: 2
Pages: 182-90
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Publication
28978478 | J:254278
First Author: Tagami S
Year: 2017
Journal: Cell Rep
Title: Semagacestat Is a Pseudo-Inhibitor of γ-Secretase.
Volume: 21
Issue: 1
Pages: 259-273
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Publication
11574534 | J:72951
First Author: Siman R
Year: 2001
Journal: J Biol Chem
Title: Endoplasmic reticulum stress-induced cysteine protease activation in cortical neurons: effect of an Alzheimer's disease-linked presenilin-1 knock-in mutation.
Volume: 276
Issue: 48
Pages: 44736-43
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Publication
27100200 | J:239477
First Author: Xia D
Year: 2016
Journal: Neuron
Title: Loss of Aβ43 Production Caused by Presenilin-1 Mutations in the Knockin Mouse Brain.
Volume: 90
Issue: 2
Pages: 417-22
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Publication
32822378 | J:293899
First Author: Ledo JH
Year: 2020
Journal: PLoS One
Title: Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development.
Volume: 15
Issue: 8
Pages: e0237773
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Publication
17431506 | J:122034
First Author: Nelson O
Year: 2007
Journal: J Clin Invest
Title: Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1.
Volume: 117
Issue: 5
Pages: 1230-9
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Publication
26094765 | J:248987
First Author: Teranishi Y
Year: 2015
Journal: FEBS J
Title: Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage.
Volume: 282
Issue: 17
Pages: 3438-51
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Publication
21325529 | J:281182
First Author: Gadadhar A
Year: 2011
Journal: J Neurosci
Title: Presenilin-1 regulates neural progenitor cell differentiation in the adult brain.
Volume: 31
Issue: 7
Pages: 2615-23
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Publication
11432968 | J:70268
First Author: Grünblatt E
Year: 2001
Journal: J Neurochem
Title: Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray: effect of R-apomorphine.
Volume: 78
Issue: 1
Pages: 1-12
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Publication
8925899 | J:32242
First Author: Moussaoui S
Year: 1996
Journal: FEBS Lett
Title: Immunohistochemical analysis of presenilin-1 expression in the mouse brain.
Volume: 383
Issue: 3
Pages: 219-22
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Publication
8669467 | J:33438
First Author: Cribbs DH
Year: 1996
Journal: Am J Pathol
Title: Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain.
Volume: 148
Issue: 6
Pages: 1797-806
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Publication
8710164 | J:36122
First Author: Takahashi H
Year: 1996
Journal: Neurosci Lett
Title: Molecular cloning and expression of the rat homologue of presenilin-1.
Volume: 206
Issue: 2-3
Pages: 113-6
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Publication
8905662 | J:40558
First Author: Cribbs DH
Year: 1996
Journal: Neuroreport
Title: Injury induces presenilin-1 gene expression in mouse brain.
Volume: 7
Issue: 11
Pages: 1773-6
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Publication
8920931 | J:37280
First Author: Calenda A
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Molecular cloning, sequencing, and brain expression of the presenilin 1 gene in Microcebus murinus.
Volume: 228
Issue: 2
Pages: 430-9
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Publication
8981396 | J:38074
First Author: Huynh DP
Year: 1996
Journal: Neuroreport
Title: Characterization and expression of presenilin 1 in mouse brain.
Volume: 7
Issue: 15-17
Pages: 2423-8
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Publication
9200512 | J:40753
First Author: Kim KS
Year: 1997
Journal: Brain Res
Title: Immunoreactivity of presenilin-1 in human, rat and mouse brain.
Volume: 757
Issue: 1
Pages: 159-63
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9404712 | J:44310
First Author: Mattson MP
Year: 1997
Journal: J Neurosci Res
Title: Cell and molecular neurobiology of presenilins: a role for the endoplasmic reticulum in the pathogenesis of Alzheimer's disease?
Volume: 50
Issue: 4
Pages: 505-13
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Publication
10361981 | J:54558
First Author: Nishimura M
Year: 1999
Journal: Clin Genet
Title: Biology of presenilins as causative molecules for Alzheimer disease.
Volume: 55
Issue: 4
Pages: 219-25
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Publication
12061869 | J:77235
First Author: Vaucher E
Year: 2002
Journal: Exp Neurol
Title: Object recognition memory and cholinergic parameters in mice expressing human presenilin 1 transgenes.
Volume: 175
Issue: 2
Pages: 398-406
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Publication
12545208 | J:81956
First Author: Al-Khedhairy AA
Year: 2002
Journal: Acta Biochim Pol
Title: Molecular cloning and sequencing of rabbit presenilin-1 cDNA fragment.
Volume: 49
Issue: 4
Pages: 1013-7
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Publication
15541883 | J:94666
First Author: Siman R
Year: 2004
Journal: Neuroscience
Title: Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain.
Volume: 129
Issue: 3
Pages: 615-28
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Publication
15044533 | J:96896
First Author: Yan XX
Year: 2004
Journal: J Neurosci
Title: Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation.
Volume: 24
Issue: 12
Pages: 2942-52
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Publication
10998555 | J:101789
First Author: Leutner S
Year: 2000
Journal: Neurosci Lett
Title: Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations.
Volume: 292
Issue: 2
Pages: 87-90
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Publication
16520237 | J:106757
First Author: Schuessel K
Year: 2006
Journal: Free Radic Biol Med
Title: Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice.
Volume: 40
Issue: 5
Pages: 850-62
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Publication
16520226 | J:106785
First Author: Zhu X
Year: 2006
Journal: Free Radic Biol Med
Title: Presenilin mutation: a deadly first hit in Alzheimer disease. A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice".
Volume: 40
Issue: 5
Pages: 737-9
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Publication
9221907 | J:109179
First Author: Czech C
Year: 1997
Journal: Brain Res Mol Brain Res
Title: Proteolytical processing of mutated human amyloid precursor protein in transgenic mice.
Volume: 47
Issue: 1-2
Pages: 108-16
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11303783 | J:121327
First Author: Martys-Zage JL
Year: 2000
Journal: J Mol Neurosci
Title: Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.
Volume: 15
Issue: 3
Pages: 189-204
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Publication
17577576 | J:123037
First Author: Kasuga K
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Generation of intracellular domain of insulin receptor tyrosine kinase by gamma-secretase.
Volume: 360
Issue: 1
Pages: 90-6
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18032377 | J:131340
First Author: Zhao B
Year: 2008
Journal: J Biol Chem
Title: Identification of gamma-secretase inhibitor potency determinants on presenilin.
Volume: 283
Issue: 5
Pages: 2927-38
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19176482 | J:149070
First Author: Waschbüsch D
Year: 2009
Journal: J Biol Chem
Title: Presenilin 1 affects focal adhesion site formation and cell force generation via c-Src transcriptional and posttranslational regulation.
Volume: 284
Issue: 15
Pages: 10138-49
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21929538 | J:184347
First Author: Wang Y
Year: 2012
Journal: J Neurochem
Title: Val97Leu mutant presenilin-1 induces tau hyperphosphorylation and spatial memory deficit in mice and the underlying mechanisms.
Volume: 121
Issue: 1
Pages: 135-45
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Publication
26098332 | J:237894
First Author: Bonds JA
Year: 2015
Journal: PLoS One
Title: Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory.
Volume: 10
Issue: 6
Pages: e0131266
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18710920 | J:138978
First Author: Song S
Year: 2008
Journal: J Cell Biol
Title: E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity.
Volume: 182
Issue: 4
Pages: 675-84
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10962005 | J:66016
First Author: Chen F
Year: 2000
Journal: J Biol Chem
Title: Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
Volume: 275
Issue: 47
Pages: 36794-802
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24612677 | J:213809
First Author: García-Ayllón MS
Year: 2014
Journal: Neurobiol Aging
Title: Presenilin-1 influences processing of the acetylcholinesterase membrane anchor PRiMA.
Volume: 35
Issue: 7
Pages: 1526-36
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Publication
16033885 | J:99847
First Author: Saura CA
Year: 2005
Journal: J Neurosci
Title: Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.
Volume: 25
Issue: 29
Pages: 6755-64
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Publication
28869466 | J:351695
First Author: Willén K
Year: 2017
Journal: J Alzheimers Dis
Title: Heterogeneous Association of Alzheimer's Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses.
Volume: 60
Issue: 2
Pages: 511-524
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28533411 | J:244817
First Author: Bustos V
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Bidirectional regulation of Aβ levels by Presenilin 1.
Volume: 114
Issue: 27
Pages: 7142-7147
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28533369 | J:244669
First Author: Bustos V
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome-lysosome fusion.
Volume: 114
Issue: 27
Pages: 7148-7153
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32803224 | J:348429
First Author: Griciuc A
Year: 2020
Journal: Hum Mol Genet
Title: Gene therapy for Alzheimer's disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation.
Volume: 29
Issue: 17
Pages: 2920-2935
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15035625 | J:89109
First Author: Crystal AS
Year: 2004
Journal: Biochemistry
Title: Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.
Volume: 43
Issue: 12
Pages: 3555-63
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22771797 | J:201292
First Author: Teranishi Y
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production.
Volume: 424
Issue: 3
Pages: 476-81
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12522139 | J:297314
First Author: Luo WJ
Year: 2003
Journal: J Biol Chem
Title: PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.
Volume: 278
Issue: 10
Pages: 7850-4
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8940094 | J:37098
First Author: Vito P
Year: 1996
Journal: J Biol Chem
Title: Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3.
Volume: 271
Issue: 49
Pages: 31025-8
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9450754 | J:71037
First Author: De Strooper B
Year: 1998
Journal: Nature
Title: Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
Volume: 391
Issue: 6665
Pages: 387-90
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11102478 | J:66147
First Author: Siman R
Year: 2000
Journal: J Neurosci
Title: Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.
Volume: 20
Issue: 23
Pages: 8717-26
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15128703 | J:91235
First Author: Tournoy J
Year: 2004
Journal: Hum Mol Genet
Title: Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.
Volume: 13
Issue: 13
Pages: 1321-31
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19641596 | J:150936
First Author: Zhang C
Year: 2009
Journal: Nature
Title: Presenilins are essential for regulating neurotransmitter release.
Volume: 460
Issue: 7255
Pages: 632-6
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21262207 | J:170860
 
First Author: Nakajima M
Year: 2011
Journal: Brain Res
Title: Hydrocephalus and abnormal subcommissural organ in mice lacking presenilin-1 in Wnt1 cell lineages.
Volume: 1382
Pages: 275-81
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18971484 | J:143253
First Author: Kallhoff-Munoz V
Year: 2008
Journal: J Neurosci
Title: Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death.
Volume: 28
Issue: 44
Pages: 11421-31
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17913918 | J:125592
First Author: Li T
Year: 2007
Journal: J Neurosci
Title: Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities.
Volume: 27
Issue: 40
Pages: 10849-59
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22048125 | J:188183
First Author: Son SM
Year: 2012
Journal: Neurobiol Aging
Title: Aβ-induced formation of autophagosomes is mediated by RAGE-CaMKKβ-AMPK signaling.
Volume: 33
Issue: 5
Pages: 1006.e11-23
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18539391 | J:138403
First Author: Gu F
Year: 2008
Journal: Neurosci Lett
Title: Enhanced oxidative stress is an early event during development of Alzheimer-like pathologies in presenilin conditional knock-out mice.
Volume: 440
Issue: 1
Pages: 44-8
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23563578 | J:197603
First Author: Dolev I
Year: 2013
Journal: Nat Neurosci
Title: Spike bursts increase amyloid-β 40/42 ratio by inducing a presenilin-1 conformational change.
Volume: 16
Issue: 5
Pages: 587-95
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12684521 | J:84109
First Author: Lai MT
Year: 2003
Journal: J Biol Chem
Title: Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.
Volume: 278
Issue: 25
Pages: 22475-81
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18822370 | J:143331
First Author: Zhu M
Year: 2008
Journal: Free Radic Biol Med
Title: Increased oxidative stress and astrogliosis responses in conditional double-knockout mice of Alzheimer-like presenilin-1 and presenilin-2.
Volume: 45
Issue: 10
Pages: 1493-9
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16103124 | J:128865
First Author: Hass MR
Year: 2005
Journal: J Biol Chem
Title: A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.
Volume: 280
Issue: 44
Pages: 36895-904
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17499883 | J:140910
First Author: Wu P
Year: 2008
Journal: Neurobiol Aging
Title: Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice.
Volume: 29
Issue: 10
Pages: 1502-11
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36370840 | J:332034
 
First Author: Lv J
Year: 2023
Journal: Exp Neurol
Title: Alpha7 nicotinic acetylcholine receptor agonist PHA-543613 improves memory deficits in presenilin 1 and presenilin 2 conditional double knockout mice.
Volume: 359
Pages: 114271
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17614943 | J:125930
First Author: Dong S
Year: 2007
Journal: Eur J Neurosci
Title: Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice.
Volume: 26
Issue: 1
Pages: 101-12
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29867447 | J:275237
 
First Author: Cao T
Year: 2018
Journal: Front Aging Neurosci
Title: Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice.
Volume: 10
Pages: 137
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30316051 | J:271567
 
First Author: Zhang L
Year: 2019
Journal: Neurobiol Aging
Title: miR-125b promotes tau phosphorylation by targeting the neural cell adhesion molecule in neuropathological progression.
Volume: 73
Pages: 41-49
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18297084 | J:133658
First Author: Engin F
Year: 2008
Journal: Nat Med
Title: Dimorphic effects of Notch signaling in bone homeostasis.
Volume: 14
Issue: 3
Pages: 299-305
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36805914 | J:339556
 
First Author: Si Y
Year: 2023
Journal: Sleep Med
Title: Circadian rhythm sleep disorders and time-of-day-dependent memory deficiency in Presenilin1/2 conditional knockout mice with long noncoding RNA expression profiling changes.
Volume: 103
Pages: 146-158
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20926667 | J:165096
First Author: Peethumnongsin E
Year: 2010
Journal: J Neurosci
Title: Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function.
Volume: 30
Issue: 40
Pages: 13409-18
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15148382 | J:90685
First Author: Feng R
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2.
Volume: 101
Issue: 21
Pages: 8162-7
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17980611 | J:141456
First Author: Chen Q
Year: 2008
Journal: Neurobiol Dis
Title: Adult neurogenesis is functionally associated with AD-like neurodegeneration.
Volume: 29
Issue: 2
Pages: 316-26
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Publication
23792007 | J:205538
 
First Author: Yan L
Year: 2013
Journal: Brain Res Bull
Title: Age-related neuropsychiatric symptoms in presenilins conditional double knockout mice.
Volume: 97
Pages: 104-11
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19584449 | J:274528
First Author: Jiang X
Year: 2009
Journal: J Alzheimers Dis
Title: Increased inflammatory response both in brain and in periphery in presenilin 1 and presenilin 2 conditional double knock-out mice.
Volume: 18
Issue: 3
Pages: 515-23
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11715026 | J:92211
First Author: Armogida M
Year: 2001
Journal: Nat Cell Biol
Title: Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts.
Volume: 3
Issue: 11
Pages: 1030-3
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Publication
23365231 | J:193889
First Author: Kaufmann MR
Year: 2013
Journal: J Neurosci
Title: Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations.
Volume: 33
Issue: 5
Pages: 1915-26
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10518543 | J:58118
First Author: Herreman A
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.
Volume: 96
Issue: 21
Pages: 11872-7
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17097608 | J:116653
First Author: Kim JS
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover.
Volume: 351
Issue: 4
Pages: 903-8
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Publication
34662541 | J:321406
 
First Author: Sánchez-Hidalgo AC
Year: 2022
Journal: Exp Neurol
Title: Selective expression of the neurexin substrate for presenilin in the adult forebrain causes deficits in associative memory and presynaptic plasticity.
Volume: 347
Pages: 113896
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17988898 | J:129118
First Author: Frye CA
Year: 2008
Journal: Neurobiol Learn Mem
Title: Effects of progesterone administration and APPswe+PSEN1Deltae9 mutation for cognitive performance of mid-aged mice.
Volume: 89
Issue: 1
Pages: 17-26
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19135431 | J:148219
 
First Author: Catlow BJ
Year: 2009
Journal: Brain Res
Title: Effects of environmental enrichment and physical activity on neurogenesis in transgenic PS1/APP mice.
Volume: 1256
Pages: 173-9
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