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Search results 1 to 100 out of 448 for Cnp

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Category: Publication
Type Details Score
Publication
First Author: Snaidero N
Year: 2017
Journal: Cell Rep
Title: Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin.
Volume: 18
Issue: 2
Pages: 314-323
Publication
First Author: Rasband MN
Year: 2005
Journal: Glia
Title: CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS.
Volume: 50
Issue: 1
Pages: 86-90
Publication
First Author: Tognatta R
Year: 2017
Journal: Glia
Title: Transient Cnp expression by early progenitors causes Cre-Lox-based reporter lines to map profoundly different fates.
Volume: 65
Issue: 2
Pages: 342-359
Publication  
First Author: Jeffries MA
Year: 2020
Journal: ASN Neuro
Title: Cnp Promoter-Driven Sustained ERK1/2 Activation Increases B-Cell Activation and Suppresses Experimental Autoimmune Encephalomyelitis.
Volume: 12
Pages: 1759091420971916
Publication
First Author: Unlu I
Year: 2018
Journal: J Biol Chem
Title: The cyclic phosphodiesterase CNP and RNA cyclase RtcA fine-tune noncanonical XBP1 splicing during ER stress.
Volume: 293
Issue: 50
Pages: 19365-19376
Publication
First Author: Ogawa Y
Year: 1994
Journal: Genomics
Title: Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC).
Volume: 24
Issue: 2
Pages: 383-7
Publication
First Author: Peyron F
Year: 1997
Journal: J Neurosci Res
Title: In situ expression of PLP/DM-20, MBP, and CNP during embryonic and postnatal development of the jimpy mutant and of transgenic mice overexpressing PLP.
Volume: 50
Issue: 2
Pages: 190-201
Publication
First Author: Garcia-Agudo LF
Year: 2019
Journal: FASEB J
Title: Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion.
Volume: 33
Issue: 7
Pages: 8634-8647
Publication
First Author: Hagemeyer N
Year: 2012
Journal: EMBO Mol Med
Title: A myelin gene causative of a catatonia-depression syndrome upon aging.
Volume: 4
Issue: 6
Pages: 528-39
Publication
First Author: Jo YR
Year: 2021
Journal: FASEB J
Title: Potential neuron-autonomous Purkinje cell degeneration by 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter/Cre-mediated autophagy impairments.
Volume: 35
Issue: 1
Pages: e21225
Publication
First Author: Bernier L
Year: 1987
Journal: J Neurosci
Title: Molecular cloning of a 2',3'-cyclic nucleotide 3'-phosphodiesterase: mRNAs with different 5' ends encode the same set of proteins in nervous and lymphoid tissues.
Volume: 7
Issue: 9
Pages: 2703-10
Publication
First Author: O'Neill RC
Year: 1997
Journal: J Neurosci Res
Title: CNP2 mRNA directs synthesis of both CNP1 and CNP2 polypeptides.
Volume: 50
Issue: 2
Pages: 248-57
Publication
First Author: Lee J
Year: 2005
Journal: J Cell Biol
Title: Process outgrowth in oligodendrocytes is mediated by CNP, a novel microtubule assembly myelin protein.
Volume: 170
Issue: 4
Pages: 661-73
Publication
First Author: Bernier L
Year: 1988
Journal: J Neurosci Res
Title: Chromosomal locations of genes encoding 2',3' cyclic nucleotide 3'-phosphodiesterase and glial fibrillary acidic protein in the mouse.
Volume: 20
Issue: 4
Pages: 497-504
Publication
First Author: Baxi EG
Year: 2014
Journal: Glia
Title: A selective thyroid hormone β receptor agonist enhances human and rodent oligodendrocyte differentiation.
Volume: 62
Issue: 9
Pages: 1513-29
Publication  
First Author: Luo F
Year: 2018
Journal: Exp Neurol
Title: Oligodendrocyte-specific loss of Cdk5 disrupts the architecture of nodes of Ranvier as well as learning and memory.
Volume: 306
Pages: 92-104
Publication
First Author: Wahl SE
Year: 2014
Journal: J Neurosci
Title: Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination.
Volume: 34
Issue: 13
Pages: 4453-65
Publication
First Author: Edgar JM
Year: 2009
Journal: Glia
Title: Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression of Cnp1.
Volume: 57
Issue: 16
Pages: 1815-24
Publication
First Author: Azer J
Year: 2014
Journal: J Physiol
Title: Effects of natriuretic peptides on electrical conduction in the sinoatrial node and atrial myocardium of the heart.
Volume: 592
Issue: 5
Pages: 1025-45
Publication
First Author: Pernet V
Year: 2008
Journal: J Neurosci
Title: Nogo-A and myelin-associated glycoprotein differently regulate oligodendrocyte maturation and myelin formation.
Volume: 28
Issue: 29
Pages: 7435-44
Publication
First Author: Janova H
Year: 2018
Journal: J Clin Invest
Title: Microglia ablation alleviates myelin-associated catatonic signs in mice.
Volume: 128
Issue: 2
Pages: 734-745
Publication
First Author: Monoh K
Year: 1989
Journal: Biochem Biophys Res Commun
Title: Structure of mouse 2',3'-cyclic-nucleotide 3'-phosphodiesterase gene.
Volume: 165
Issue: 3
Pages: 1213-20
Publication
First Author: Kurihara T
Year: 1990
Journal: Biochem Biophys Res Commun
Title: Alternative splicing of mouse brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase mRNA.
Volume: 170
Issue: 3
Pages: 1074-81
Publication
First Author: Brockschnieder D
Year: 2006
Journal: Genesis
Title: An improved mouse line for Cre-induced cell ablation due to diphtheria toxin A, expressed from the Rosa26 locus.
Volume: 44
Issue: 7
Pages: 322-7
Publication  
First Author: Harris MG
Year: 2014
Journal: Sci Rep
Title: Immune privilege of the CNS is not the consequence of limited antigen sampling.
Volume: 4
Pages: 4422
Publication
First Author: Ishii A
Year: 2016
Journal: J Neurosci
Title: Strength of ERK1/2 MAPK Activation Determines Its Effect on Myelin and Axonal Integrity in the Adult CNS.
Volume: 36
Issue: 24
Pages: 6471-87
Publication
First Author: Müller K
Year: 2018
Journal: Glia
Title: A predominantly glial origin of axonal ribosomes after nerve injury.
Volume: 66
Issue: 8
Pages: 1591-1610
Publication
First Author: Lappe-Siefke C
Year: 2003
Journal: Nat Genet
Title: Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination.
Volume: 33
Issue: 3
Pages: 366-74
Publication
First Author: Barron T
Year: 2019
Journal: Glia
Title: Neuronal input triggers Ca2+ influx through AMPA receptors and voltage-gated Ca2+ channels in oligodendrocytes.
Volume: 67
Issue: 10
Pages: 1922-1932
Publication
First Author: Wieser GL
Year: 2013
Journal: Glia
Title: Neuroinflammation in white matter tracts of Cnp1 mutant mice amplified by a minor brain injury.
Volume: 61
Issue: 6
Pages: 869-80
Publication  
First Author: Edgar NM
Year: 2011
Journal: Transl Psychiatry
Title: Resilient emotionality and molecular compensation in mice lacking the oligodendrocyte-specific gene Cnp1.
Volume: 1
Pages: e42
Publication
First Author: Iyer M
Year: 2024
Journal: Nat Commun
Title: Oligodendrocyte calcium signaling promotes actin-dependent myelin sheath extension.
Volume: 15
Issue: 1
Pages: 265
Publication
First Author: Jackson EK
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Role of 2',3'-cyclic nucleotide 3'-phosphodiesterase in the renal 2',3'-cAMP-adenosine pathway.
Volume: 307
Issue: 1
Pages: F14-24
Publication
First Author: Verrier JD
Year: 2012
Journal: J Neurochem
Title: The brain in vivo expresses the 2',3'-cAMP-adenosine pathway.
Volume: 122
Issue: 1
Pages: 115-25
Publication
First Author: Jackson EK
Year: 2016
Journal: J Am Soc Nephrol
Title: Renal 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase Is an Important Determinant of AKI Severity after Ischemia-Reperfusion.
Volume: 27
Issue: 7
Pages: 2069-81
Publication
First Author: Lee J
Year: 2001
Journal: J Biol Chem
Title: Identification of essential residues in 2',3'-cyclic nucleotide 3'-phosphodiesterase. Chemical modification and site-directed mutagenesis to investigate the role of cysteine and histidine residues in enzymatic activity.
Volume: 276
Issue: 18
Pages: 14804-13
Publication  
First Author: Kurihara T
Year: 1992
Journal: Adv Second Messenger Phosphoprotein Res
Title: 2',3'-Cyclic-nucleotide 3'-phosphodiesterase. Complementary DNA and gene cloning for mouse enzyme and in situ hybridization of the messenger RNA in mouse brain.
Volume: 25
Pages: 101-10
Publication
First Author: Verrier JD
Year: 2013
Journal: Glia
Title: Role of CNPase in the oligodendrocytic extracellular 2',3'-cAMP-adenosine pathway.
Volume: 61
Issue: 10
Pages: 1595-606
Publication  
First Author: Radtke C
Year: 2011
Journal: J Biomed Biotechnol
Title: CNPase expression in olfactory ensheathing cells.
Volume: 2011
Pages: 608496
Publication
First Author: Tuteja N
Year: 1988
Journal: FEBS Lett
Title: Gamma-subunit of mouse retinal cyclic-GMP phosphodiesterase: cDNA and corresponding amino acid sequence.
Volume: 232
Issue: 1
Pages: 182-6
Publication
First Author: Wu LM
Year: 2012
Journal: Curr Biol
Title: Increasing internodal distance in myelinated nerves accelerates nerve conduction to a flat maximum.
Volume: 22
Issue: 20
Pages: 1957-61
Publication
First Author: Howng SY
Year: 2010
Journal: Genes Dev
Title: ZFP191 is required by oligodendrocytes for CNS myelination.
Volume: 24
Issue: 3
Pages: 301-11
Publication
First Author: Poggi G
Year: 2016
Journal: Glia
Title: Cortical network dysfunction caused by a subtle defect of myelination.
Volume: 64
Issue: 11
Pages: 2025-40
Publication
First Author: Kurihara T
Year: 1989
Journal: Brain Res Mol Brain Res
Title: Developmental expression of 2',3'-cyclic-nucleotide 3'-phosphodiesterase mRNA in brains of normal and quaking mice.
Volume: 5
Issue: 3
Pages: 247-50
Publication
First Author: Frühbeis C
Year: 2020
Journal: PLoS Biol
Title: Oligodendrocytes support axonal transport and maintenance via exosome secretion.
Volume: 18
Issue: 12
Pages: e3000621
Publication    
First Author: Buscham TJ
Year: 2022
Journal: Elife
Title: Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5.
Volume: 11
Publication
First Author: Viader A
Year: 2011
Journal: PLoS One
Title: Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction.
Volume: 6
Issue: 11
Pages: e27727
Publication
First Author: van de Beek MC
Year: 2016
Journal: PLoS One
Title: C26:0-Carnitine Is a New Biomarker for X-Linked Adrenoleukodystrophy in Mice and Man.
Volume: 11
Issue: 4
Pages: e0154597
Publication
First Author: Schmucker J
Year: 2003
Journal: Glia
Title: erbB3 is dispensable for oligodendrocyte development in vitro and in vivo.
Volume: 44
Issue: 1
Pages: 67-75
Publication  
First Author: Verheijden S
Year: 2013
Journal: Neurobiol Dis
Title: Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation.
Volume: 58
Pages: 258-69
Publication
First Author: Hsu M
Year: 2019
Journal: Nat Commun
Title: Neuroinflammation-induced lymphangiogenesis near the cribriform plate contributes to drainage of CNS-derived antigens and immune cells.
Volume: 10
Issue: 1
Pages: 229
Publication
First Author: Rayasam A
Year: 2018
Journal: J Neurosci
Title: Regional Distribution of CNS Antigens Differentially Determines T-Cell Mediated Neuroinflammation in a CX3CR1-Dependent Manner.
Volume: 38
Issue: 32
Pages: 7058-7071
Publication
First Author: Potter KA
Year: 2011
Journal: Glia
Title: Central nervous system dysfunction in a mouse model of FA2H deficiency.
Volume: 59
Issue: 7
Pages: 1009-21
Publication
First Author: Cai J
Year: 2007
Journal: Development
Title: A crucial role for Olig2 in white matter astrocyte development.
Volume: 134
Issue: 10
Pages: 1887-99
Publication
First Author: Ben Haim L
Year: 2021
Journal: Glia
Title: Evidence for glutamine synthetase function in mouse spinal cord oligodendrocytes.
Volume: 69
Issue: 12
Pages: 2812-2827
Publication
First Author: Della-Flora Nunes G
Year: 2017
Journal: Glia
Title: Acetyl-CoA production from pyruvate is not necessary for preservation of myelin.
Volume: 65
Issue: 10
Pages: 1626-1639
Publication
First Author: Saher G
Year: 2012
Journal: Nat Med
Title: Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet.
Volume: 18
Issue: 7
Pages: 1130-5
Publication    
First Author: Erwig MS
Year: 2019
Journal: Elife
Title: Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin.
Volume: 8
Publication    
First Author: Gerber D
Year: 2019
Journal: Elife
Title: Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function.
Volume: 8
Publication
First Author: Chew LJ
Year: 2019
Journal: Cell Rep
Title: Sox17 Regulates a Program of Oligodendrocyte Progenitor Cell Expansion and Differentiation during Development and Repair.
Volume: 29
Issue: 10
Pages: 3173-3186.e7
Publication
First Author: Mei F
Year: 2013
Journal: J Neurosci
Title: Stage-specific deletion of Olig2 conveys opposing functions on differentiation and maturation of oligodendrocytes.
Volume: 33
Issue: 19
Pages: 8454-62
Publication
First Author: Pillai AM
Year: 2009
Journal: J Neurosci Res
Title: Spatiotemporal ablation of myelinating glia-specific neurofascin (Nfasc NF155) in mice reveals gradual loss of paranodal axoglial junctions and concomitant disorganization of axonal domains.
Volume: 87
Issue: 8
Pages: 1773-93
Publication
First Author: Park HJ
Year: 2022
Journal: iScience
Title: ACTL6a coordinates axonal caliber recognition and myelination in the peripheral nerve.
Volume: 25
Issue: 4
Pages: 104132
Publication
First Author: Fünfschilling U
Year: 2012
Journal: Nature
Title: Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity.
Volume: 485
Issue: 7399
Pages: 517-21
Publication
First Author: Joseph S
Year: 2019
Journal: J Neurosci
Title: Myelinating Glia-Specific Deletion of Fbxo7 in Mice Triggers Axonal Degeneration in the Central Nervous System Together with Peripheral Neuropathy.
Volume: 39
Issue: 28
Pages: 5606-5626
Publication
First Author: Vajda F
Year: 2015
Journal: Cell Death Differ
Title: Cell type-specific Nogo-A gene ablation promotes axonal regeneration in the injured adult optic nerve.
Volume: 22
Issue: 2
Pages: 323-35
Publication
First Author: Zemmar A
Year: 2018
Journal: Cereb Cortex
Title: Oligodendrocyte- and Neuron-Specific Nogo-A Restrict Dendritic Branching and Spine Density in the Adult Mouse Motor Cortex.
Volume: 28
Issue: 6
Pages: 2109-2117
Publication
First Author: Saher G
Year: 2005
Journal: Nat Neurosci
Title: High cholesterol level is essential for myelin membrane growth.
Volume: 8
Issue: 4
Pages: 468-75
Publication
First Author: Katanov C
Year: 2020
Journal: J Neurosci
Title: N-Wasp Regulates Oligodendrocyte Myelination.
Volume: 40
Issue: 32
Pages: 6103-6111
Publication
First Author: Luo F
Year: 2014
Journal: J Neurosci
Title: Cyclin-dependent kinase 5 mediates adult OPC maturation and myelin repair through modulation of Akt and GsK-3β signaling.
Volume: 34
Issue: 31
Pages: 10415-29
Publication
First Author: Budde H
Year: 2010
Journal: Development
Title: Control of oligodendroglial cell number by the miR-17-92 cluster.
Volume: 137
Issue: 13
Pages: 2127-32
Publication
First Author: Avey D
Year: 2018
Journal: Cell Rep
Title: Single-Cell RNA-Seq Uncovers a Robust Transcriptional Response to Morphine by Glia.
Volume: 24
Issue: 13
Pages: 3619-3629.e4
Publication
First Author: Fyffe-Maricich SL
Year: 2013
Journal: J Neurosci
Title: Signaling through ERK1/2 controls myelin thickness during myelin repair in the adult central nervous system.
Volume: 33
Issue: 47
Pages: 18402-8
Publication
First Author: Guzman KM
Year: 2020
Journal: Glia
Title: Conditional depletion of Fus in oligodendrocytes leads to motor hyperactivity and increased myelin deposition associated with Akt and cholesterol activation.
Volume: 68
Issue: 10
Pages: 2040-2056
Publication
First Author: Swire M
Year: 2021
Journal: J Neurosci
Title: Oligodendrocyte HCN2 Channels Regulate Myelin Sheath Length.
Volume: 41
Issue: 38
Pages: 7954-7964
Publication  
First Author: Chen X
Year: 2015
Journal: Front Cell Neurosci
Title: Impairment of Oligodendroglia Maturation Leads to Aberrantly Increased Cortical Glutamate and Anxiety-Like Behaviors in Juvenile Mice.
Volume: 9
Pages: 467
Publication
First Author: Rebbe NF
Year: 1991
Journal: Proc Natl Acad Sci U S A
Title: Identification of nucleotide pyrophosphatase/alkaline phosphodiesterase I activity associated with the mouse plasma cell differentiation antigen PC-1.
Volume: 88
Issue: 12
Pages: 5192-6
Publication    
First Author: Jang M
Year: 2019
Journal: Elife
Title: Oligodendrocytes regulate presynaptic properties and neurotransmission through BDNF signaling in the mouse brainstem.
Volume: 8
Publication
First Author: Feigenson K
Year: 2009
Journal: Mol Cell Neurosci
Title: Wnt signaling is sufficient to perturb oligodendrocyte maturation.
Volume: 42
Issue: 3
Pages: 255-65
Publication
First Author: Benninger Y
Year: 2006
Journal: J Neurosci
Title: Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination.
Volume: 26
Issue: 29
Pages: 7665-73
Publication
First Author: Saab AS
Year: 2016
Journal: Neuron
Title: Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism.
Volume: 91
Issue: 1
Pages: 119-32
Publication  
First Author: Luo F
Year: 2021
Journal: Int J Mol Sci
Title: Differential Role of p53 in Oligodendrocyte Survival in Response to Various Stresses: Experimental Autoimmune Encephalomyelitis, Cuprizone Intoxication or White Matter Stroke.
Volume: 22
Issue: 23
Publication
First Author: Brockschnieder D
Year: 2004
Journal: Mol Cell Biol
Title: Cell depletion due to diphtheria toxin fragment A after Cre-mediated recombination.
Volume: 24
Issue: 17
Pages: 7636-42
Publication
First Author: Goebbels S
Year: 2010
Journal: J Neurosci
Title: Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination.
Volume: 30
Issue: 26
Pages: 8953-64
Publication
First Author: Almeida RG
Year: 2018
Journal: Curr Biol
Title: Myelination of Neuronal Cell Bodies when Myelin Supply Exceeds Axonal Demand.
Volume: 28
Issue: 8
Pages: 1296-1305.e5
Publication
First Author: McClenahan FK
Year: 2016
Journal: Dev Cell
Title: Dystroglycan Suppresses Notch to Regulate Stem Cell Niche Structure and Function in the Developing Postnatal Subventricular Zone.
Volume: 38
Issue: 5
Pages: 548-66
Publication
First Author: Thaxton C
Year: 2010
Journal: J Neurosci
Title: In vivo deletion of immunoglobulin domains 5 and 6 in neurofascin (Nfasc) reveals domain-specific requirements in myelinated axons.
Volume: 30
Issue: 14
Pages: 4868-76
Publication
First Author: Kang Z
Year: 2013
Journal: Nat Neurosci
Title: Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells.
Volume: 16
Issue: 10
Pages: 1401-8
Publication
First Author: Pruvost M
Year: 2023
Journal: Cell Rep
Title: The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina.
Volume: 42
Issue: 8
Pages: 112848
Publication
First Author: Saadat L
Year: 2010
Journal: Glia
Title: Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT-deficient mice.
Volume: 58
Issue: 4
Pages: 391-8
Publication
First Author: Kassmann CM
Year: 2007
Journal: Nat Genet
Title: Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes.
Volume: 39
Issue: 8
Pages: 969-76
Publication
First Author: Kassmann CM
Year: 2011
Journal: FEBS Lett
Title: A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity.
Volume: 585
Issue: 14
Pages: 2205-11
Publication  
First Author: Pooya S
Year: 2014
Journal: Nat Commun
Title: The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism.
Volume: 5
Pages: 4993
Publication
First Author: Sherman DL
Year: 2012
Journal: J Neurosci
Title: Arrest of myelination and reduced axon growth when Schwann cells lack mTOR.
Volume: 32
Issue: 5
Pages: 1817-25
Publication      
First Author: Martens AK
Year: 2022
Journal: Cytoskeleton (Hoboken)
Title: Targeted inactivation of the Septin2 and Septin9 genes in myelinating Schwann cells of mice.
Publication  
First Author: Zhang X
Year: 2020
Journal: Sci Adv
Title: Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Volume: 6
Issue: 49
Publication
First Author: Zhang S
Year: 2018
Journal: J Neurosci
Title: Sox2 Is Essential for Oligodendroglial Proliferation and Differentiation during Postnatal Brain Myelination and CNS Remyelination.
Volume: 38
Issue: 7
Pages: 1802-1820
Publication
First Author: Baudouin L
Year: 2024
Journal: Glia
Title: Antagonistic actions of PAK1 and NF2/Merlin drive myelin membrane expansion in oligodendrocytes.
Volume: 72
Issue: 8
Pages: 1518-1540
Publication
First Author: Hussien Y
Year: 2015
Journal: J Neurosci
Title: ER Chaperone BiP/GRP78 Is Required for Myelinating Cell Survival and Provides Protection during Experimental Autoimmune Encephalomyelitis.
Volume: 35
Issue: 48
Pages: 15921-33
Publication
First Author: Musah AS
Year: 2020
Journal: J Neurosci
Title: Mechanistic Target of Rapamycin Regulates the Oligodendrocyte Cytoskeleton during Myelination.
Volume: 40
Issue: 15
Pages: 2993-3007