|  Help  |  About  |  Contact Us

Search our database by keyword

- or -

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 337 for Cryaa

Category restricted to Publication (x)

<< First    < Previous  |  Next >    Last >>
0.048s

Categories

Category: Publication
Type Details Score
Publication  
First Author: Wolf L
Year: 2008
Journal: BMC Dev Biol
Title: Transcriptional regulation of mouse alpha A-crystallin gene in a 148kb Cryaa BAC and its derivates.
Volume: 8
Pages: 88
Publication
First Author: Graw J
Year: 2001
Journal: Invest Ophthalmol Vis Sci
Title: Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene.
Volume: 42
Issue: 12
Pages: 2909-15
Publication  
First Author: Andley UP
Year: 2009
Journal: BMC Ophthalmol
Title: AlphaA-crystallin R49Cneo mutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice.
Volume: 9
Pages: 4
Publication
First Author: Xu Q
Year: 2015
Journal: Invest Ophthalmol Vis Sci
Title: Knockout of αA-crystallin inhibits ocular neovascularization.
Volume: 56
Issue: 2
Pages: 816-26
Publication
First Author: Frankfater C
Year: 2020
Journal: PLoS One
Title: Alpha-crystallin mutations alter lens metabolites in mouse models of human cataracts.
Volume: 15
Issue: 8
Pages: e0238081
Publication
First Author: Andley UP
Year: 2018
Journal: PLoS One
Title: Probing the changes in gene expression due to α-crystallin mutations in mouse models of hereditary human cataract.
Volume: 13
Issue: 1
Pages: e0190817
Publication
First Author: Xi JH
Year: 2008
Journal: J Biol Chem
Title: Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death.
Volume: 283
Issue: 9
Pages: 5801-14
Publication
First Author: Grimm C
Year: 1998
Journal: Dev Genet
Title: Aphakia (ak), a mouse mutation affecting early eye development: fine mapping, consideration of candidate genes and altered Pax6 and Six3 gene expression pattern.
Volume: 23
Issue: 4
Pages: 299-316
Publication
First Author: Xie Q
Year: 2016
Journal: J Biol Chem
Title: Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling.
Volume: 291
Issue: 8
Pages: 3947-58
Publication
First Author: Shaham O
Year: 2013
Journal: PLoS Genet
Title: Pax6 regulates gene expression in the vertebrate lens through miR-204.
Volume: 9
Issue: 3
Pages: e1003357
Publication
First Author: Wenzel PL
Year: 2011
Journal: Dev Biol
Title: Cell proliferation in the absence of E2F1-3.
Volume: 351
Issue: 1
Pages: 35-45
Publication
First Author: Cain S
Year: 2008
Journal: Dev Biol
Title: Differential requirement for beta-catenin in epithelial and fiber cells during lens development.
Volume: 321
Issue: 2
Pages: 420-33
Publication
First Author: Shaham O
Year: 2009
Journal: Development
Title: Pax6 is essential for lens fiber cell differentiation.
Volume: 136
Issue: 15
Pages: 2567-78
Publication
First Author: King CR
Year: 1983
Journal: Cell
Title: Alternative RNA splicing of the murine alpha A-crystallin gene: protein-coding information within an intron.
Volume: 32
Issue: 3
Pages: 707-12
Publication
First Author: King CR
Year: 1982
Journal: Science
Title: alpha A-crystallin messenger RNA of the mouse lens: more noncoding than coding sequences.
Volume: 215
Issue: 4535
Pages: 985-7
Publication
First Author: Barton KA
Year: 2009
Journal: Biochemistry
Title: Interactions between small heat shock protein alpha-crystallin and galectin-related interfiber protein (GRIFIN) in the ocular lens.
Volume: 48
Issue: 18
Pages: 3956-66
Publication  
First Author: Chang B
Year: 1999
Journal: Mol Vis
Title: Identification of a missense mutation in the alphaA-crystallin gene of the lop18 mouse.
Volume: 5
Pages: 21
Publication  
First Author: Ruebsam A
Year: 2018
Journal: JCI Insight
Title: A specific phosphorylation regulates the protective role of αA-crystallin in diabetes.
Volume: 3
Issue: 4
Publication  
First Author: Zhu W
Year: 2012
Journal: Exp Eye Res
Title: αA-crystallin in the pathogenesis and intervention of experimental murine corneal neovascularization.
Volume: 98
Pages: 44-51
Publication
First Author: Xi JH
Year: 2003
Journal: J Cell Sci
Title: Reduced survival of lens epithelial cells in the alphaA-crystallin-knockout mouse.
Volume: 116
Issue: Pt 6
Pages: 1073-85
Publication
First Author: Rao NA
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: Elevated retina-specific expression of the small heat shock protein, alphaA-crystallin, is associated with photoreceptor protection in experimental uveitis.
Volume: 49
Issue: 3
Pages: 1161-71
Publication
First Author: Zhou P
Year: 2012
Journal: PLoS One
Title: αA crystallin may protect against geographic atrophy-meta-analysis of cataract vs. cataract surgery for geographic atrophy and experimental studies.
Volume: 7
Issue: 8
Pages: e43173
Publication
First Author: Menko AS
Year: 2010
Journal: Exp Eye Res
Title: αA-Crystallin associates with α6 integrin receptor complexes and regulates cellular signaling.
Volume: 91
Issue: 5
Pages: 640-51
Publication
First Author: Xia CH
Year: 2006
Journal: Invest Ophthalmol Vis Sci
Title: Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency.
Volume: 47
Issue: 7
Pages: 3004-10
Publication
First Author: Andley UP
Year: 2010
Journal: Exp Eye Res
Title: In vivo lens deficiency of the R49C alphaA-crystallin mutant.
Volume: 90
Issue: 6
Pages: 699-702
Publication
First Author: Andley UP
Year: 2008
Journal: Biochemistry
Title: Mechanism of insolubilization by a single-point mutation in alphaA-crystallin linked with hereditary human cataracts.
Volume: 47
Issue: 36
Pages: 9697-706
Publication
First Author: Watson GW
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Activation of the unfolded protein response by a cataract-associated αA-crystallin mutation.
Volume: 401
Issue: 2
Pages: 192-6
Publication  
First Author: Reilly MA
Year: 2010
Journal: Mol Vis
Title: Quantitative biometric phenotype analysis in mouse lenses.
Volume: 16
Pages: 1041-6
Publication
First Author: van Dijk MA
Year: 2001
Journal: J Mol Evol
Title: The evolution of an alternatively spliced exon in the alphaA-crystallin gene.
Volume: 52
Issue: 6
Pages: 510-5
Publication
First Author: De Rijk EP
Year: 2000
Journal: Int J Exp Pathol
Title: Demyelination and axonal dystrophy in alpha A-crystallin transgenic mice.
Volume: 81
Issue: 4
Pages: 271-82
Publication
First Author: Chepelinsky AB
Year: 1985
Journal: Proc Natl Acad Sci U S A
Title: Lens-specific expression of the chloramphenicol acetyltransferase gene promoted by 5' flanking sequences of the murine alpha A-crystallin gene in explanted chicken lens epithelia.
Volume: 82
Issue: 8
Pages: 2334-8
Publication
First Author: Skow LC
Year: 1985
Journal: Immunogenetics
Title: Linkage of the locus encoding the A chain of alpha-crystallin (Acry-1) to the major histocompatibility complex in the rat.
Volume: 22
Issue: 3
Pages: 291-3
Publication
First Author: Kaye NW
Year: 1985
Journal: Curr Eye Res
Title: Assignment of the mouse alpha A-crystallin structural gene to chromosome 17.
Volume: 4
Issue: 12
Pages: 1263-8
Publication
First Author: Kaye NW
Year: 1990
Journal: Cytogenet Cell Genet
Title: Regional assignment of the mouse alpha A2-crystallin gene (Crya-1) to chromosome 17A3----B by in situ hybridization.
Volume: 53
Issue: 2-3
Pages: 95-6
Publication
First Author: Sax CM
Year: 1994
Journal: Gene
Title: Identification of negative-acting and protein-binding elements in the mouse alpha A-crystallin -1556/-1165 region.
Volume: 144
Issue: 2
Pages: 163-9
Publication
First Author: Jaworski CJ
Year: 1995
Journal: J Mol Evol
Title: A reassessment of mammalian alpha A-crystallin sequences using DNA sequencing: implications for anthropoid affinities of tarsier.
Volume: 41
Issue: 6
Pages: 901-8
Publication
First Author: Hsu CD
Year: 2006
Journal: Invest Ophthalmol Vis Sci
Title: A transgenic mouse model for human autosomal dominant cataract.
Volume: 47
Issue: 5
Pages: 2036-44
Publication
First Author: Huang Q
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Mechanism of cataract formation in alphaA-crystallin Y118D mutation.
Volume: 50
Issue: 6
Pages: 2919-26
Publication
First Author: Andley UP
Year: 2014
Journal: PLoS One
Title: In vivo substrates of the lens molecular chaperones αA-crystallin and αB-crystallin.
Volume: 9
Issue: 4
Pages: e95507
Publication
First Author: Kaur S
Year: 1989
Journal: Development
Title: Targeted ablation of alpha-crystallin-synthesizing cells produces lens-deficient eyes in transgenic mice.
Volume: 105
Issue: 3
Pages: 613-9
Publication  
First Author: Skow LC
Year: 1987
Journal: Mouse News Lett
Title: Alpha A crystallin RFLP's in t-haplotypes.
Volume: 77
Pages: 157
Publication  
First Author: Quax-Jeuken Y
Year: 1985
Journal: Cytogenet Cell Genet
Title: Assignment of the alphaA-crystallin gene (CRYA1) to chromosome 21.
Volume: 40
Pages: 727-728 (Abstr.)
Publication
First Author: Brennan LA
Year: 2009
Journal: Biochim Biophys Acta
Title: Methionine sulfoxide reductase A (MsrA) restores alpha-crystallin chaperone activity lost upon methionine oxidation.
Volume: 1790
Issue: 12
Pages: 1665-72
Publication
First Author: Oliveira AO
Year: 2016
Journal: Hum Mol Genet
Title: αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease.
Volume: 25
Issue: 9
Pages: 1677-89
Publication
First Author: Skow LC
Year: 1985
Journal: Genetics
Title: The locus encoding alpha A-crystallin is closely linked to H-2K on mouse chromosome 17.
Volume: 110
Issue: 4
Pages: 723-32
Publication
First Author: Park E
Year: 1988
Journal: Immunogenetics
Title: Ly-39: a new lymphocyte alloantigen defined with a monoclonal antibody.
Volume: 28
Issue: 1
Pages: 64-6
Publication
First Author: Vincek V
Year: 1990
Journal: Immunogenetics
Title: Mapping in the mouse of the region homologous to the rat growth and reproduction complex (grc).
Volume: 32
Issue: 4
Pages: 293-5
Publication
First Author: Jaworski CJ
Year: 1991
Journal: J Mol Evol
Title: The alpha A-crystallin gene: conserved features of the 5'-flanking regions in human, mouse, and chicken.
Volume: 33
Issue: 6
Pages: 495-505
Publication
First Author: Pilder SH
Year: 1993
Journal: Dev Biol
Title: Hybrid sterility-6: a mouse t complex locus controlling sperm flagellar assembly and movement.
Volume: 159
Issue: 2
Pages: 631-42
Publication
First Author: Nordsmark M
Year: 1997
Journal: Br J Cancer
Title: The effect of hypoxia and hyperoxia on nucleoside triphosphate/inorganic phosphate, pO2 and radiation response in an experimental tumour model.
Volume: 76
Issue: 11
Pages: 1432-9
Publication
First Author: Redkar AA
Year: 1998
Journal: Mamm Genome
Title: High-resolution mapping of sperm function defects in the t complex fourth inversion.
Volume: 9
Issue: 10
Pages: 825-30
Publication
First Author: Erhart MA
Year: 2002
Journal: Mamm Genome
Title: Pattern of segmental recombination in the distal inversion of mouse t haplotypes.
Volume: 13
Issue: 8
Pages: 438-44
Publication
First Author: Búcan M
Year: 1987
Journal: Genes Dev
Title: Deletion and duplication of DNA sequences is associated with the embryonic lethal phenotype of the t9 complementation group of the mouse t complex.
Volume: 1
Issue: 4
Pages: 376-85
Publication
First Author: Losiewicz MK
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Diabetes impairs the neuroprotective properties of retinal alpha-crystallins.
Volume: 52
Issue: 9
Pages: 5034-42
Publication
First Author: Chang B
Year: 1996
Journal: Genomics
Title: Chromosomal localization of a new mouse lens opacity gene (lop18)
Volume: 36
Issue: 1
Pages: 171-3
Publication
First Author: Brady JP
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin.
Volume: 94
Issue: 3
Pages: 884-9
Publication
First Author: Charukamnoetkanok P
Year: 2003
Journal: Immunol Lett
Title: Immunotolerance toward native alphaA-crystallin in knockout mice deficient in the functional protein.
Volume: 89
Issue: 2-3
Pages: 259-65
Publication
First Author: Andley UP
Year: 1998
Journal: J Biol Chem
Title: The molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stress.
Volume: 273
Issue: 47
Pages: 31252-61
Publication
First Author: Grisel JE
Year: 2002
Journal: Alcohol Clin Exp Res
Title: Mapping of quantitative trait loci underlying ethanol metabolism in BXD recombinant inbred mouse strains.
Volume: 26
Issue: 5
Pages: 610-6
Publication  
First Author: Wei Z
Year: 2023
Journal: Exp Eye Res
Title: A tamoxifen-inducible Cre knock-in mouse for lens-specific gene manipulation.
Volume: 226
Pages: 109306
Publication
First Author: Andley UP
Year: 2016
Journal: Biochim Biophys Acta
Title: Autophagy and UPR in alpha-crystallin mutant knock-in mouse models of hereditary cataracts.
Volume: 1860
Issue: 1 Pt B
Pages: 234-9
Publication
First Author: Andley UP
Year: 2020
Journal: BMC Res Notes
Title: Changes in relative histone abundance and heterochromatin in αA-crystallin and αB-crystallin knock-in mutant mouse lenses.
Volume: 13
Issue: 1
Pages: 315
Publication
First Author: Stubbs L
Year: 1990
Journal: Genomics
Title: The alpha-A-crystallin and cystathionine beta-synthase genes are physically very closely linked in proximal mouse chromosome 17.
Volume: 7
Issue: 2
Pages: 284-8
Publication
First Author: Wilson V
Year: 1993
Journal: Development
Title: Chimeric analysis of T (Brachyury) gene function.
Volume: 117
Issue: 4
Pages: 1321-31
Publication
First Author: Robinson ML
Year: 1996
Journal: Invest Ophthalmol Vis Sci
Title: Differential expression of alpha A- and alpha B-crystallin during murine ocular development.
Volume: 37
Issue: 11
Pages: 2276-84
Publication
First Author: Li W
Year: 1999
Journal: J Biol Chem
Title: Interferon consensus sequence-binding protein is constitutively expressed and differentially regulated in the ocular lens.
Volume: 274
Issue: 14
Pages: 9686-91
Publication
First Author: Haider NB
Year: 2002
Journal: Hum Mol Genet
Title: Genetic modifiers of vision and hearing.
Volume: 11
Issue: 10
Pages: 1195-206
Publication
First Author: Hamann S
Year: 2013
Journal: PLoS One
Title: Analysis of the cytoprotective role of α-crystallins in cell survival and implication of the αA-crystallin C-terminal extension domain in preventing Bax-induced apoptosis.
Volume: 8
Issue: 2
Pages: e55372
Publication
First Author: Fossella J
Year: 2000
Journal: Mamm Genome
Title: An axonemal dynein at the Hybrid Sterility 6 locus: implications for t haplotype-specific male sterility and the evolution of species barriers.
Volume: 11
Issue: 1
Pages: 8-15
Publication
First Author: Santhiya ST
Year: 1995
Journal: Graefes Arch Clin Exp Ophthalmol
Title: Reduced levels of gamma-crystallin transcripts during embryonic development of murine Cat2nop mutant lenses.
Volume: 233
Issue: 12
Pages: 795-800
Publication  
First Author: Yaung J
Year: 2007
Journal: Mol Vis
Title: alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress.
Volume: 13
Pages: 566-77
Publication
First Author: Sreekumar PG
Year: 2012
Journal: PLoS One
Title: Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux.
Volume: 7
Issue: 3
Pages: e33420
Publication  
First Author: Boyle DL
Year: 2003
Journal: BMC Ophthalmol
Title: Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens.
Volume: 3
Pages: 3
Publication
First Author: Xi JH
Year: 2006
Journal: FASEB J
Title: Alpha-crystallin expression affects microtubule assembly and prevents their aggregation.
Volume: 20
Issue: 7
Pages: 846-57
Publication
First Author: Yaung J
Year: 2008
Journal: Exp Eye Res
Title: Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia.
Volume: 86
Issue: 2
Pages: 355-65
Publication
First Author: Andley UP
Year: 2013
Journal: Biochemistry
Title: Comparative proteomic analysis identifies age-dependent increases in the abundance of specific proteins after deletion of the small heat shock proteins αA- and αB-crystallin.
Volume: 52
Issue: 17
Pages: 2933-48
Publication
First Author: Schmid PWN
Year: 2021
Journal: Nat Struct Mol Biol
Title: Imbalances in the eye lens proteome are linked to cataract formation.
Volume: 28
Issue: 2
Pages: 143-151
Publication
First Author: Kannan R
Year: 2001
Journal: Invest Ophthalmol Vis Sci
Title: Regulation of GSH in alphaA-expressing human lens epithelial cell lines and in alphaA knockout mouse lenses.
Volume: 42
Issue: 2
Pages: 409-16
Publication  
First Author: Nandi SK
Year: 2019
Journal: Exp Eye Res
Title: The absence of SIRT3 and SIRT5 promotes the acetylation of lens proteins and improves the chaperone activity of α-crystallin in mouse lenses.
Volume: 182
Pages: 1-9
Publication
First Author: Mann EA
Year: 1986
Journal: Genetics
Title: Genetic analysis of a mouse t complex locus that is homologous to a kidney cDNA clone.
Volume: 114
Issue: 3
Pages: 993-1006
Publication
First Author: Nadeau JH
Year: 1987
Journal: Genetics
Title: The putative oncogene Pim-1 in the mouse: its linkage and variation among t haplotypes.
Volume: 117
Issue: 3
Pages: 533-41
Publication
First Author: Lai F
Year: 1992
Journal: Mamm Genome
Title: Map positions of four dinucleotide repeats in the mouse t complex.
Volume: 3
Issue: 8
Pages: 476-7
Publication
First Author: Klemenz R
Year: 1993
Journal: J Cell Biol
Title: Expression of the murine small heat shock proteins hsp 25 and alpha B crystallin in the absence of stress.
Volume: 120
Issue: 3
Pages: 639-45
Publication
First Author: Stubbs L
Year: 1993
Journal: Mamm Genome
Title: The alpha 2(XI) collagen gene lies within 8 kb of Pb in the proximal portion of the murine major histocompatibility complex.
Volume: 4
Issue: 2
Pages: 95-103
Publication
First Author: Cvekl A
Year: 1995
Journal: Mol Cell Biol
Title: Transcriptional regulation of the mouse alpha A-crystallin gene: activation dependent on a cyclic AMP-responsive element (DE1/CRE) and a Pax-6-binding site.
Volume: 15
Issue: 2
Pages: 653-60
Publication
First Author: Samant SA
Year: 1999
Journal: Mamm Genome
Title: Mapping and cloning recombinant breakpoints demarcating the hybrid sterility 6-specific sperm tail assembly defect.
Volume: 10
Issue: 2
Pages: 88-94
Publication
First Author: Yang Y
Year: 2005
Journal: J Mol Biol
Title: Tissue-specific regulation of the mouse alphaA-crystallin gene in lens via recruitment of Pax6 and c-Maf to its promoter.
Volume: 351
Issue: 3
Pages: 453-69
Publication  
First Author: Ren S
Year: 2010
Journal: Mol Vis
Title: Physiological expression of lens α-, β-, and γ-crystallins in murine and human corneas.
Volume: 16
Pages: 2745-52
Publication  
First Author: Justice MJ
Year: 1988
Journal: Mouse News Lett
Title: New evidence supporting the allelism of T and tct.
Volume: 80
Pages: 168-9
Publication  
First Author: Bai F
Year: 2007
Journal: Mol Vis
Title: Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice.
Volume: 13
Pages: 1589-600
Publication
First Author: Morozov V
Year: 2006
Journal: Development
Title: Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice.
Volume: 133
Issue: 5
Pages: 813-21
Publication
First Author: Cheng C
Year: 2010
Journal: J Biol Chem
Title: Altered chaperone-like activity of alpha-crystallins promotes cataractogenesis.
Volume: 285
Issue: 52
Pages: 41187-93
Publication
First Author: Liu Y
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Inactivation of Smad4 leads to impaired ocular development and cataract formation.
Volume: 400
Issue: 4
Pages: 476-82
Publication
First Author: Barnum CE
Year: 2020
Journal: Hum Mol Genet
Title: The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology.
Volume: 29
Issue: 12
Pages: 2076-2097
Publication
First Author: Schöler HR
Year: 1990
Journal: EMBO J
Title: Oct-4: a germline-specific transcription factor mapping to the mouse t-complex.
Volume: 9
Issue: 7
Pages: 2185-95
Publication
First Author: Skow LC
Year: 1987
Journal: Genetics
Title: Polymorphism and linkage of the alpha A-crystallin gene in t-haplotypes of the mouse.
Volume: 116
Issue: 1
Pages: 107-11
Publication
First Author: Hammer MF
Year: 1989
Journal: Proc Natl Acad Sci U S A
Title: Evolution of mouse chromosome 17 and the origin of inversions associated with t haplotypes.
Volume: 86
Issue: 9
Pages: 3261-5
Publication
First Author: Hirano M
Year: 2003
Journal: Dev Dyn
Title: Generation of structures formed by lens and retinal cells differentiating from embryonic stem cells.
Volume: 228
Issue: 4
Pages: 664-71
Publication
First Author: Maerker D
Year: 2008
Journal: Histochem Cell Biol
Title: Expression of PTPIP51 during mouse eye development.
Volume: 129
Issue: 3
Pages: 345-56
Publication
First Author: Hu WF
Year: 2012
Journal: Curr Mol Med
Title: αA- and αB-crystallins interact with caspase-3 and Bax to guard mouse lens development.
Volume: 12
Issue: 2
Pages: 177-87