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Search results 1 to 100 out of 103 for Eif4ebp2

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Type Details Score
Publication
16237163 | J:102163
First Author: Banko JL
Year: 2005
Journal: J Neurosci
Title: The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus.
Volume: 25
Issue: 42
Pages: 9581-90
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Publication
17029989 | J:128841
First Author: Banko JL
Year: 2007
Journal: Neurobiol Learn Mem
Title: Behavioral alterations in mice lacking the translation repressor 4E-BP2.
Volume: 87
Issue: 2
Pages: 248-56
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Publication
7935836 | J:41738
First Author: Pause A
Year: 1994
Journal: Nature
Title: Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.
Volume: 371
Issue: 6500
Pages: 762-7
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Publication
33910008 | J:337368
First Author: Hooshmandi M
Year: 2021
Journal: Cell Rep
Title: 4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors.
Volume: 35
Issue: 4
Pages: 109036
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Publication
23365227 | J:193890
First Author: Ran I
Year: 2013
Journal: J Neurosci
Title: Selective regulation of GluA subunit synthesis and AMPA receptor-mediated synaptic function and plasticity by the translation repressor 4E-BP2 in hippocampal pyramidal cells.
Volume: 33
Issue: 5
Pages: 1872-86
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Publication
34326413 | J:359849
First Author: Roque PS
Year: 2021
Journal: Sci Rep
Title: Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1.
Volume: 11
Issue: 1
Pages: 15490
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Publication
26245973 | J:225875
First Author: Aguilar-Valles A
Year: 2015
Journal: J Neurosci
Title: Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2.
Volume: 35
Issue: 31
Pages: 11125-32
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Publication
31427534 | J:278826
First Author: Wiebe S
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2.
Volume: 116
Issue: 36
Pages: 18060-18067
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Publication
36170669 | J:332823
First Author: Miller WP
Year: 2022
Journal: Diabetes
Title: Activation of Disulfide Redox Switch in REDD1 Promotes Oxidative Stress Under Hyperglycemic Conditions.
Volume: 71
Issue: 12
Pages: 2764-2776
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Publication
17273556 | J:118038
First Author: Le Bacquer O
Year: 2007
Journal: J Clin Invest
Title: Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2.
Volume: 117
Issue: 2
Pages: 387-96
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Publication
19175792 | J:243830
First Author: Olson KE
Year: 2009
Journal: Immunology
Title: Impaired myelopoiesis in mice lacking the repressors of translation initiation, 4E-BP1 and 4E-BP2.
Volume: 128
Issue: 1 Suppl
Pages: e376-84
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Publication
26998719 | J:254615
First Author: Miller WP
Year: 2016
Journal: Invest Ophthalmol Vis Sci
Title: The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction.
Volume: 57
Issue: 3
Pages: 1327-37
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Publication
30894372 | J:274187
First Author: Wang Z
Year: 2019
Journal: Cancer Res
Title: 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer.
Volume: 79
Issue: 7
Pages: 1438-1450
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Publication
30927336 | J:295227
First Author: Le Bacquer O
Year: 2019
Journal: J Cachexia Sarcopenia Muscle
Title: 4E-BP1 and 4E-BP2 double knockout mice are protected from aging-associated sarcopenia.
Volume: 10
Issue: 3
Pages: 696-709
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Publication
19843855 | J:153953
First Author: Kim YY
Year: 2009
Journal: Cancer Res
Title: Eukaryotic initiation factor 4E binding protein family of proteins: sentinels at a translational control checkpoint in lung tumor defense.
Volume: 69
Issue: 21
Pages: 8455-62
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Publication
23434932 | J:208544
First Author: Dennis MD
Year: 2013
Journal: Diabetes
Title: Hyperglycemia mediates a shift from cap-dependent to cap-independent translation via a 4E-BP1-dependent mechanism.
Volume: 62
Issue: 7
Pages: 2204-14
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Publication
35675781 | J:326145
First Author: Saviuk N
Year: 2022
Journal: Cell Rep
Title: Loss of 4E-BP converts cerebellar long-term depression to long-term potentiation.
Volume: 39
Issue: 10
Pages: 110911
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Publication
27492367 | J:235616
First Author: Signer RA
Year: 2016
Journal: Genes Dev
Title: The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs.
Volume: 30
Issue: 15
Pages: 1698-703
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Publication
30733333 | J:280102
First Author: Dierschke SK
Year: 2019
Journal: J Biol Chem
Title: O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1-dependent mitochondrial dysfunction in the retina.
Volume: 294
Issue: 14
Pages: 5508-5520
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Publication
24945486 | J:216832
First Author: Steiner JL
Year: 2014
Journal: PLoS One
Title: Disruption of genes encoding eIF4E binding proteins-1 and -2 does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice.
Volume: 9
Issue: 6
Pages: e99582
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Publication
31825840 | J:296924
First Author: Kouloulia S
Year: 2019
Journal: Cell Rep
Title: Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity.
Volume: 29
Issue: 11
Pages: 3620-3635.e7
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Publication
20347422 | J:162956
First Author: Bidinosti M
Year: 2010
Journal: Mol Cell
Title: Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission.
Volume: 37
Issue: 6
Pages: 797-808
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9464245 | J:47955
First Author: Zhou J
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast.
Volume: 242
Issue: 3
Pages: 502-7
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20547975 | J:169349
First Author: Schrufer TL
Year: 2010
Journal: Diabetes
Title: Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture.
Volume: 59
Issue: 9
Pages: 2107-16
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29617653 | J:271198
First Author: Chong Y
Year: 2018
Journal: Cell Rep
Title: Removing 4E-BP Enables Synapses to Refine without Postsynaptic Activity.
Volume: 23
Issue: 1
Pages: 11-22
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33328636 | J:306868
First Author: Aguilar-Valles A
Year: 2021
Journal: Nature
Title: Antidepressant actions of ketamine engage cell-specific translation via eIF4E.
Volume: 590
Issue: 7845
Pages: 315-319
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31032899 | J:281990
First Author: William M
Year: 2019
Journal: Eur J Immunol
Title: Translational repression of Ccl5 and Cxcl10 by 4E-BP1 and 4E-BP2 restrains the ability of mouse macrophages to induce migration of activated T cells.
Volume: 49
Issue: 8
Pages: 1200-1212
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Publication
31747684 | J:283731
First Author: Starr CR
Year: 2019
Journal: Invest Ophthalmol Vis Sci
Title: Role of Translational Attenuation in Inherited Retinal Degeneration.
Volume: 60
Issue: 14
Pages: 4849-4857
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Publication
20493810 | J:160601
First Author: Carnevalli LS
Year: 2010
Journal: Dev Cell
Title: S6K1 plays a critical role in early adipocyte differentiation.
Volume: 18
Issue: 5
Pages: 763-74
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29712774 | J:263333
First Author: William M
Year: 2018
Journal: J Immunol
Title: eIF4E-Binding Proteins 1 and 2 Limit Macrophage Anti-Inflammatory Responses through Translational Repression of IL-10 and Cyclooxygenase-2.
Volume: 200
Issue: 12
Pages: 4102-4116
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32475820 | J:332824
First Author: Dierschke SK
Year: 2020
Journal: J Biol Chem
Title: Diabetes enhances translation of Cd40 mRNA in murine retinal Müller glia via a 4E-BP1/2-dependent mechanism.
Volume: 295
Issue: 31
Pages: 10831-10841
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28699639 | J:250382
 
First Author: Blandino-Rosano M
Year: 2017
Journal: Nat Commun
Title: Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.
Volume: 8
Pages: 16014
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18272964 | J:134222
First Author: Colina R
Year: 2008
Journal: Nature
Title: Translational control of the innate immune response through IRF-7.
Volume: 452
Issue: 7185
Pages: 323-8
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26678009 | J:228277
   
First Author: Khoutorsky A
Year: 2015
Journal: Elife
Title: Translational control of nociception via 4E-binding protein 1.
Volume: 4
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23658533 | J:197132
First Author: Bjur E
Year: 2013
Journal: PLoS Genet
Title: Distinct translational control in CD4+ T cell subsets.
Volume: 9
Issue: 5
Pages: e1003494
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23263185 | J:194400
First Author: Santini E
Year: 2013
Journal: Nature
Title: Exaggerated translation causes synaptic and behavioural aberrations associated with autism.
Volume: 493
Issue: 7432
Pages: 411-5
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8975712 | J:37710
First Author: Tsukiyama-Kohara K
Year: 1996
Journal: Genomics
Title: Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2.
Volume: 38
Issue: 3
Pages: 353-63
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Publication
19244480 | J:149769
First Author: Sukarieh R
Year: 2009
Journal: Am J Physiol Cell Physiol
Title: The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response.
Volume: 296
Issue: 5
Pages: C1207-17
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23172145 | J:194221
First Author: Gkogkas CG
Year: 2013
Journal: Nature
Title: Autism-related deficits via dysregulated eIF4E-dependent translational control.
Volume: 493
Issue: 7432
Pages: 371-7
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19878875 | J:153944
First Author: Petroulakis E
Year: 2009
Journal: Cancer Cell
Title: p53-dependent translational control of senescence and transformation via 4E-BPs.
Volume: 16
Issue: 5
Pages: 439-46
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24206664 | J:206172
First Author: Morita M
Year: 2013
Journal: Cell Metab
Title: mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.
Volume: 18
Issue: 5
Pages: 698-711
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27217487 | J:246863
First Author: Blandino-Rosano M
Year: 2016
Journal: Diabetes
Title: 4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass.
Volume: 65
Issue: 8
Pages: 2235-48
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Publication
33876772 | J:304843
 
First Author: Sharma V
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: 4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold.
Volume: 118
Issue: 15
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32213561 | J:288497
First Author: Pearl D
Year: 2020
Journal: J Immunol
Title: 4E-BP-Dependent Translational Control of Irf8 Mediates Adipose Tissue Macrophage Inflammatory Response.
Volume: 204
Issue: 9
Pages: 2392-2400
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29453322 | J:260731
First Author: Ding M
Year: 2018
Journal: Mol Cancer Res
Title: The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer.
Volume: 16
Issue: 4
Pages: 682-695
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21501832 | J:273483
First Author: Jaramillo M
Year: 2011
Journal: Cell Host Microbe
Title: Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection.
Volume: 9
Issue: 4
Pages: 331-41
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17635924 | J:124932
First Author: Gelinas JN
Year: 2007
Journal: J Biol Chem
Title: ERK and mTOR signaling couple beta-adrenergic receptors to translation initiation machinery to gate induction of protein synthesis-dependent long-term potentiation.
Volume: 282
Issue: 37
Pages: 27527-35
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23818585 | J:198805
First Author: Shen C
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: The mTOR pathway negatively controls ATM by up-regulating miRNAs.
Volume: 110
Issue: 29
Pages: 11869-74
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25872869 | J:260549
First Author: Chung J
Year: 2015
Journal: Sci Signal
Title: The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.
Volume: 8
Issue: 372
Pages: ra34
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8939971 | J:51748
First Author: Lin TA
Year: 1996
Journal: J Biol Chem
Title: Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes.
Volume: 271
Issue: 47
Pages: 30199-204
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23184952 | J:244821
First Author: Dennis MD
Year: 2013
Journal: J Biol Chem
Title: Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor.
Volume: 288
Issue: 1
Pages: 10-9
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26095252 | J:224214
First Author: Truitt ML
Year: 2015
Journal: Cell
Title: Differential Requirements for eIF4E Dose in Normal Development and Cancer.
Volume: 162
Issue: 1
Pages: 59-71
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27245614 | J:259056
First Author: So L
Year: 2016
Journal: Sci Signal
Title: The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes.
Volume: 9
Issue: 430
Pages: ra57
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24948799 | J:212082
First Author: Lebrun-Julien F
Year: 2014
Journal: J Neurosci
Title: Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination.
Volume: 34
Issue: 25
Pages: 8432-48
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23105104 | J:193766
First Author: Dennis MD
Year: 2012
Journal: J Biol Chem
Title: Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis.
Volume: 287
Issue: 51
Pages: 42890-9
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31968247 | J:288086
First Author: Muendlein HI
Year: 2020
Journal: Cell Rep
Title: Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation.
Volume: 30
Issue: 3
Pages: 699-713.e4
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28798047 | J:244375
First Author: Sinclair C
Year: 2017
Journal: Science
Title: mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation.
Volume: 357
Issue: 6355
Pages: 1014-1021
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11353388 | J:69574
First Author: Biggs WH 3rd
Year: 2001
Journal: Mamm Genome
Title: Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse.
Volume: 12
Issue: 6
Pages: 416-25
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34381067 | J:309451
First Author: Vinsland E
Year: 2021
Journal: Sci Rep
Title: The zinc finger/RING domain protein Unkempt regulates cognitive flexibility.
Volume: 11
Issue: 1
Pages: 16299
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27043414 | J:256715
First Author: Wang F
Year: 2016
Journal: Nat Immunol
Title: S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.
Volume: 17
Issue: 5
Pages: 514-522
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34242585 | J:308686
First Author: Tiu GC
Year: 2021
Journal: Dev Cell
Title: A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies.
Volume: 56
Issue: 14
Pages: 2089-2102.e11
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11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
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First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
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First Author: Carninci P
Year: 1999
Journal: Methods Enzymol
Title: High-efficiency full-length cDNA cloning.
Volume: 303
Pages: 19-44
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First Author: Shibata K
Year: 2000
Journal: Genome Res
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume: 10
Issue: 11
Pages: 1757-71
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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