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Search results 1 to 100 out of 102 for Hjv

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Type Details Score
Publication
20065295 | J:160796
First Author: Lee DH
Year: 2010
Journal: Blood
Title: Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis.
Volume: 115
Issue: 15
Pages: 3136-45
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Publication
25609138 | J:286322
First Author: Kent P
Year: 2015
Journal: J Mol Med (Berl)
Title: Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin.
Volume: 93
Issue: 5
Pages: 489-98
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Publication
18997172 | J:144043
First Author: Truksa J
Year: 2009
Journal: Blood
Title: Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness.
Volume: 113
Issue: 3
Pages: 688-95
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Publication
16075059 | J:100178
First Author: Huang FW
Year: 2005
Journal: J Clin Invest
Title: A mouse model of juvenile hemochromatosis.
Volume: 115
Issue: 8
Pages: 2187-91
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Publication
35194137 | J:321919
First Author: Allameh A
Year: 2022
Journal: Commun Biol
Title: Hemojuvelin deficiency promotes liver mitochondrial dysfunction and predisposes mice to hepatocellular carcinoma.
Volume: 5
Issue: 1
Pages: 153
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Publication
16075058 | J:100173
First Author: Niederkofler V
Year: 2005
Journal: J Clin Invest
Title: Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload.
Volume: 115
Issue: 8
Pages: 2180-6
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Publication
21748766 | J:231428
First Author: Gkouvatsos K
Year: 2011
Journal: Hepatology
Title: Conditional disruption of mouse HFE2 gene: maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin.
Volume: 54
Issue: 5
Pages: 1800-7
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Publication
24812553 | J:229834
First Author: Tawfik A
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: Deletion of hemojuvelin, an iron-regulatory protein, in mice results in abnormal angiogenesis and vasculogenesis in retina along with reactive gliosis.
Volume: 55
Issue: 6
Pages: 3616-25
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Publication
31307288 | J:328956
First Author: Young GH
Year: 2020
Journal: J Cereb Blood Flow Metab
Title: The functional role of hemojuvelin in acute ischemic stroke.
Volume: 40
Issue: 6
Pages: 1316-1327
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Publication
17395503 | J:141731
First Author: Krijt J
Year: 2007
Journal: Blood Cells Mol Dis
Title: Effect of phlebotomy on hepcidin expression in hemojuvelin-mutant mice.
Volume: 39
Issue: 1
Pages: 92-5
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Publication
25501544 | J:223851
First Author: Padda RS
Year: 2015
Journal: Am J Physiol Gastrointest Liver Physiol
Title: A high-fat diet modulates iron metabolism but does not promote liver fibrosis in hemochromatotic Hjv⁻/⁻ mice.
Volume: 308
Issue: 4
Pages: G251-61
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Publication
21943374 | J:179221
First Author: Gnana-Prakasam JP
Year: 2012
Journal: Biochem J
Title: Iron-mediated retinal degeneration in haemojuvelin-knockout mice.
Volume: 441
Issue: 2
Pages: 599-608
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Publication
27046124 | J:257134
First Author: Arjunan P
Year: 2016
Journal: Invest Ophthalmol Vis Sci
Title: Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis.
Volume: 57
Issue: 4
Pages: 1612-9
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Publication
22629388 | J:187222
First Author: Krijt J
Year: 2012
Journal: PLoS One
Title: Effect of iron overload and iron deficiency on liver hemojuvelin protein.
Volume: 7
Issue: 5
Pages: e37391
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Publication
16103117 | J:102461
First Author: Zhang AS
Year: 2005
Journal: J Biol Chem
Title: Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells.
Volume: 280
Issue: 40
Pages: 33885-94
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Publication
20837779 | J:167407
First Author: Schmidt PJ
Year: 2010
Journal: Blood
Title: Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin.
Volume: 116
Issue: 25
Pages: 5679-87
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Publication
30213871 | J:270056
First Author: Fillebeen C
Year: 2018
Journal: Blood
Title: Hepcidin-mediated hypoferremic response to acute inflammation requires a threshold of Bmp6/Hjv/Smad signaling.
Volume: 132
Issue: 17
Pages: 1829-1841
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Publication
20200349 | J:160248
First Author: Finberg KE
Year: 2010
Journal: Blood
Title: Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis.
Volume: 115
Issue: 18
Pages: 3817-26
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Publication
20363739 | J:163885
First Author: Zhang AS
Year: 2010
Journal: J Biol Chem
Title: The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo.
Volume: 285
Issue: 22
Pages: 16416-23
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Publication
28924039 | J:249190
First Author: Wahedi M
Year: 2017
Journal: J Biol Chem
Title: Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway.
Volume: 292
Issue: 44
Pages: 18354-18371
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Publication
29021231 | J:251922
First Author: Latour C
Year: 2017
Journal: Blood
Title: Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge.
Volume: 130
Issue: 21
Pages: 2339-2343
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Publication
24409331 | J:212210
First Author: Gkouvatsos K
Year: 2014
Journal: PLoS One
Title: Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels.
Volume: 9
Issue: 1
Pages: e85530
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Publication
27072365 | J:235031
First Author: Zhao N
Year: 2016
Journal: J Biol Chem
Title: Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver.
Volume: 291
Issue: 23
Pages: 12322-35
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Publication
33824974 | J:315672
First Author: Enns CA
Year: 2021
Journal: Blood
Title: Hepatocyte neogenin is required for hemojuvelin-mediated hepcidin expression and iron homeostasis in mice.
Volume: 138
Issue: 6
Pages: 486-499
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Publication
30884219 | J:294390
First Author: Zhang P
Year: 2019
Journal: J Cachexia Sarcopenia Muscle
Title: Hemojuvelin is a novel suppressor for Duchenne muscular dystrophy and age-related muscle wasting.
Volume: 10
Issue: 3
Pages: 557-573
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Publication
25860887 | J:222266
First Author: Rausa M
Year: 2015
Journal: PLoS One
Title: Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?
Volume: 10
Issue: 4
Pages: e0122696
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Publication
21493799 | J:174702
First Author: Chen W
Year: 2011
Journal: Blood
Title: Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis.
Volume: 117
Issue: 23
Pages: 6319-25
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Publication
21966437 | J:177657
First Author: Sebastiani G
Year: 2011
Journal: PLoS One
Title: Accelerated CCl4-induced liver fibrosis in Hjv-/- mice, associated with an oxidative burst and precocious profibrogenic gene expression.
Volume: 6
Issue: 9
Pages: e25138
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Publication
25220979 | J:230191
First Author: Brewer CJ
Year: 2014
Journal: Exp Hematol
Title: mRNA regulation of cardiac iron transporters and ferritin subunits in a mouse model of iron overload.
Volume: 42
Issue: 12
Pages: 1059-67
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Publication
16868025 | J:111710
First Author: Kuninger D
Year: 2006
Journal: J Cell Sci
Title: Complex biosynthesis of the muscle-enriched iron regulator RGMc.
Volume: 119
Issue: Pt 16
Pages: 3273-83
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31442254 | J:278735
First Author: Wagner J
Year: 2019
Journal: PLoS One
Title: Mouse models of hereditary hemochromatosis do not develop early liver fibrosis in response to a high fat diet.
Volume: 14
Issue: 8
Pages: e0221455
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Publication
23169885 | J:214358
First Author: Gnana-Prakasam JP
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells.
Volume: 54
Issue: 1
Pages: 63-71
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Publication
38310100 | J:349512
First Author: Wang XF
Year: 2024
Journal: Nat Commun
Title: The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity.
Volume: 15
Issue: 1
Pages: 1037
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36675185 | J:344535
 
First Author: Charlebois E
Year: 2023
Journal: Int J Mol Sci
Title: Genetic Iron Overload Hampers Development of Cutaneous Leishmaniasis in Mice.
Volume: 24
Issue: 2
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26124138 | J:223802
First Author: Singh SK
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Role of RAG1 autoubiquitination in V(D)J recombination.
Volume: 112
Issue: 28
Pages: 8579-83
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Publication
33800732 | J:315003
 
First Author: Krijt J
Year: 2021
Journal: Int J Mol Sci
Title: Matriptase-2 and Hemojuvelin in Hepcidin Regulation: In Vivo Immunoblot Studies in Mask Mice.
Volume: 22
Issue: 5
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23590607 | J:318979
First Author: Frýdlová J
Year: 2013
Journal: Physiol Res
Title: Decreased hemojuvelin protein levels in mask mice lacking matriptase-2-dependent proteolytic activity.
Volume: 62
Issue: 4
Pages: 405-11
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15053976 | J:89169
First Author: Oldekamp J
Year: 2004
Journal: Gene Expr Patterns
Title: Expression pattern of the repulsive guidance molecules RGM A, B and C during mouse development.
Volume: 4
Issue: 3
Pages: 283-8
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21993681 | J:219070
First Author: Bartnikas TB
Year: 2012
Journal: Haematologica
Title: Hemojuvelin is essential for transferrin-dependent and transferrin-independent hepcidin expression in mice.
Volume: 97
Issue: 2
Pages: 189-92
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Publication
26845567 | J:253523
First Author: Frýdlová J
Year: 2016
Journal: PLoS One
Title: Effect of Erythropoietin, Iron Deficiency and Iron Overload on Liver Matriptase-2 (TMPRSS6) Protein Content in Mice and Rats.
Volume: 11
Issue: 2
Pages: e0148540
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19751239 | J:182123
First Author: Truksa J
Year: 2009
Journal: Br J Haematol
Title: Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6.
Volume: 147
Issue: 4
Pages: 571-81
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8010975 | J:18891
 
First Author: Ramamoorthy S
Year: 1994
Journal: Biochem J
Title: Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta.
Volume: 300 ( Pt 3)
Pages: 893-900
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14985445 | J:90082
First Author: Samad TA
Year: 2004
Journal: J Neurosci
Title: DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties.
Volume: 24
Issue: 8
Pages: 2027-36
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14678836 | J:87381
First Author: Schmidtmer J
Year: 2004
Journal: Gene Expr Patterns
Title: Isolation and expression pattern of three mouse homologues of chick Rgm.
Volume: 4
Issue: 1
Pages: 105-10
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24880340 | J:211331
First Author: Kautz L
Year: 2014
Journal: Nat Genet
Title: Identification of erythroferrone as an erythroid regulator of iron metabolism.
Volume: 46
Issue: 7
Pages: 678-84
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27864295 | J:238919
First Author: Canali S
Year: 2017
Journal: Blood
Title: Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice.
Volume: 129
Issue: 4
Pages: 405-414
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Publication
29073189 | J:246669
First Author: Frýdlová J
Year: 2017
Journal: PLoS One
Title: Effect of erythropoietin administration on proteins participating in iron homeostasis in Tmprss6-mutated mask mice.
Volume: 12
Issue: 10
Pages: e0186844
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17942375 | J:127109
First Author: Schnichels S
Year: 2007
Journal: Gene Expr Patterns
Title: Gene expression of the repulsive guidance molecules/neogenin in the developing and mature mouse visual system: C57BL/6J vs. the glaucoma model DBA/2J.
Volume: 8
Issue: 1
Pages: 1-11
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16604073 | J:109016
First Author: Babitt JL
Year: 2006
Journal: Nat Genet
Title: Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.
Volume: 38
Issue: 5
Pages: 531-9
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14749425 | J:87768
First Author: Niederkofler V
Year: 2004
Journal: J Neurosci
Title: Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system.
Volume: 24
Issue: 4
Pages: 808-18
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Publication
22058337 | J:191392
First Author: Gnana-Prakasam JP
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis.
Volume: 52
Issue: 12
Pages: 9279-86
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Publication
17255318 | J:117889
First Author: Constante M
Year: 2007
Journal: Am J Pathol
Title: Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha.
Volume: 170
Issue: 2
Pages: 497-504
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26735394 | J:233837
First Author: Canali S
Year: 2016
Journal: Endocrinology
Title: Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
Volume: 157
Issue: 3
Pages: 1146-62
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22960056 | J:193218
First Author: Vujić Spasić M
Year: 2013
Journal: Biochim Biophys Acta
Title: Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload.
Volume: 1832
Issue: 1
Pages: 76-84
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Publication
24904115 | J:214455
First Author: Willemetz A
Year: 2014
Journal: Blood
Title: Matriptase-2 is essential for hepcidin repression during fetal life and postnatal development in mice to maintain iron homeostasis.
Volume: 124
Issue: 3
Pages: 441-4
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16032658 | J:127437
First Author: Metzger M
Year: 2005
Journal: Dev Dyn
Title: Gene expression of the repulsive guidance molecules during development of the mouse intestine.
Volume: 234
Issue: 1
Pages: 169-75
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- | J:344138
     
First Author: The Centre for Phenogenomics
Year: 2024
Journal: MGI Direct Data Submission
Title: Strains and alleles submitted by The Centre for Phenogenomics
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21907140 | J:176655
First Author: Moroishi T
Year: 2011
Journal: Cell Metab
Title: The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.
Volume: 14
Issue: 3
Pages: 339-51
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16787915 | J:116886
First Author: Yoon D
Year: 2006
Journal: J Biol Chem
Title: Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development.
Volume: 281
Issue: 35
Pages: 25703-11
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21187450 | J:168909
First Author: Xia Y
Year: 2011
Journal: J Immunol
Title: Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages.
Volume: 186
Issue: 3
Pages: 1369-76
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38226173 | J:344312
First Author: Liu H
Year: 2024
Journal: iScience
Title: Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development.
Volume: 27
Issue: 1
Pages: 108722
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15475267 | J:93913
First Author: Kuninger D
Year: 2004
Journal: Genomics
Title: Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiation.
Volume: 84
Issue: 5
Pages: 876-89
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28700664 | J:246066
First Author: Sundberg JP
Year: 2017
Journal: PLoS One
Title: Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Volume: 12
Issue: 7
Pages: e0180682
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
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First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
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First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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First Author: D'Alessio F
Year: 2012
Journal: J Hepatol
Title: The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation.
Volume: 57
Issue: 5
Pages: 1052-60
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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