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Search results 1 to 100 out of 776 for Lef1

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Category: Publication
Type Details Score
Publication
First Author: Nawshad A
Year: 2003
Journal: J Cell Biol
Title: TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development.
Volume: 163
Issue: 6
Pages: 1291-301
Publication
First Author: Boras-Granic K
Year: 2006
Journal: Dev Biol
Title: Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland.
Volume: 295
Issue: 1
Pages: 219-31
Publication
First Author: Reya T
Year: 2000
Journal: Immunity
Title: Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism.
Volume: 13
Issue: 1
Pages: 15-24
Publication
First Author: Yun K
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Lef1 regulates COX-2 transcription in chondrocytes.
Volume: 364
Issue: 2
Pages: 270-5
Publication
First Author: Eastman Q
Year: 1999
Journal: Curr Opin Cell Biol
Title: Regulation of LEF-1/TCF transcription factors by Wnt and other signals.
Volume: 11
Issue: 2
Pages: 233-40
Publication
First Author: Hovanes K
Year: 2000
Journal: Nucleic Acids Res
Title: The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing.
Volume: 28
Issue: 9
Pages: 1994-2003
Publication
First Author: Ross DA
Year: 2001
Journal: Mol Cell Biol
Title: The notch intracellular domain can function as a coactivator for LEF-1.
Volume: 21
Issue: 22
Pages: 7537-44
Publication  
First Author: Oulès B
Year: 2019
Journal: EMBO J
Title: Mutant Lef1 controls Gata6 in sebaceous gland development and cancer.
Volume: 38
Issue: 9
Publication
First Author: Shelton DN
Year: 2012
Journal: PLoS One
Title: The role of LEF1 in endometrial gland formation and carcinogenesis.
Volume: 7
Issue: 7
Pages: e40312
Publication
First Author: Sasaki T
Year: 2005
Journal: Dev Biol
Title: LEF1 is a critical epithelial survival factor during tooth morphogenesis.
Volume: 278
Issue: 1
Pages: 130-43
Publication
First Author: Elayyan J
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Lef1 ablation alleviates cartilage mineralization following posttraumatic osteoarthritis induction.
Volume: 119
Issue: 21
Pages: e2116855119
Publication
First Author: Merrill BJ
Year: 2001
Journal: Genes Dev
Title: Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin.
Volume: 15
Issue: 13
Pages: 1688-705
Publication    
First Author: Phan QM
Year: 2020
Journal: Elife
Title: Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds.
Volume: 9
Publication
First Author: Berga-Bolaños R
Year: 2015
Journal: Mol Immunol
Title: Cell-autonomous requirement for TCF1 and LEF1 in the development of Natural Killer T cells.
Volume: 68
Issue: 2 Pt B
Pages: 484-9
Publication
First Author: Sachdev S
Year: 2001
Journal: Genes Dev
Title: PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies.
Volume: 15
Issue: 23
Pages: 3088-103
Publication
First Author: Xing S
Year: 2016
Journal: Nat Immunol
Title: Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity.
Volume: 17
Issue: 6
Pages: 695-703
Publication
First Author: Yang BH
Year: 2019
Journal: Cell Rep
Title: TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases.
Volume: 27
Issue: 12
Pages: 3629-3645.e6
Publication
First Author: Kratochwil K
Year: 1996
Journal: Genes Dev
Title: Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development.
Volume: 10
Issue: 11
Pages: 1382-94
Publication
First Author: Ievlev V
Year: 2022
Journal: Stem Cells
Title: Sox9 and Lef1 Regulate the Fate and Behavior of Airway Glandular Progenitors in Response to Injury.
Volume: 40
Issue: 8
Pages: 778-790
Publication
First Author: Yu S
Year: 2016
Journal: J Biol Chem
Title: Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors.
Volume: 291
Issue: 21
Pages: 11148-60
Publication
First Author: Steinke FC
Year: 2014
Journal: Immunol Res
Title: From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells.
Volume: 59
Issue: 1-3
Pages: 45-55
Publication
First Author: Boras-Granic K
Year: 2006
Journal: Int J Dev Biol
Title: Genetic interaction between Lef1 and Alx4 is required for early embryonic development.
Volume: 50
Issue: 7
Pages: 601-10
Publication
First Author: Xing S
Year: 2019
Journal: J Exp Med
Title: Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells.
Volume: 216
Issue: 4
Pages: 847-866
Publication
First Author: Cui Q
Year: 2005
Journal: Oncogene
Title: Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP.
Volume: 24
Issue: 24
Pages: 3864-74
Publication
First Author: Noh T
Year: 2009
Journal: PLoS One
Title: Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner.
Volume: 4
Issue: 5
Pages: e5438
Publication
First Author: Lieven O
Year: 2014
Journal: PLoS One
Title: Differential binding of Lef1 and Msx1/2 transcription factors to Dkk1 CNEs correlates with reporter gene expression in vivo.
Volume: 9
Issue: 12
Pages: e115442
Publication
First Author: Kratochwil K
Year: 2002
Journal: Genes Dev
Title: FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice.
Volume: 16
Issue: 24
Pages: 3173-85
Publication
First Author: Mohri Y
Year: 2011
Journal: Dev Dyn
Title: Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3.
Volume: 240
Issue: 6
Pages: 1626-34
Publication
First Author: Nagalski A
Year: 2013
Journal: Brain Struct Funct
Title: Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain.
Volume: 218
Issue: 6
Pages: 1531-49
Publication
First Author: Fehrenschild D
Year: 2012
Journal: J Invest Dermatol
Title: TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function.
Volume: 132
Issue: 2
Pages: 337-45
Publication
First Author: Zhou P
Year: 1995
Journal: Genes Dev
Title: Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate.
Volume: 9
Issue: 6
Pages: 700-13
Publication
First Author: Niemann C
Year: 2002
Journal: Development
Title: Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours.
Volume: 129
Issue: 1
Pages: 95-109
Publication
First Author: Niemann C
Year: 2007
Journal: Cancer Res
Title: Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type.
Volume: 67
Issue: 7
Pages: 2916-21
Publication
First Author: Jamora C
Year: 2003
Journal: Nature
Title: Links between signal transduction, transcription and adhesion in epithelial bud development.
Volume: 422
Issue: 6929
Pages: 317-22
Publication
First Author: Carr T
Year: 2015
Journal: J Exp Med
Title: The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation.
Volume: 212
Issue: 5
Pages: 793-807
Publication  
First Author: Carr T
Year: 2022
Journal: Front Immunol
Title: Oncogenic and Tumor Suppressor Functions for Lymphoid Enhancer Factor 1 in E2a-/- T Acute Lymphoblastic Leukemia.
Volume: 13
Pages: 845488
Publication
First Author: Nguyen DX
Year: 2009
Journal: Cell
Title: WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.
Volume: 138
Issue: 1
Pages: 51-62
Publication
First Author: Okamura RM
Year: 1998
Journal: Immunity
Title: Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1.
Volume: 8
Issue: 1
Pages: 11-20
Publication
First Author: Spaulding C
Year: 2007
Journal: Blood
Title: Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas.
Volume: 110
Issue: 7
Pages: 2650-8
Publication
First Author: Kahler RA
Year: 2008
Journal: Matrix Biol
Title: Collagen 11a1 is indirectly activated by lymphocyte enhancer-binding factor 1 (Lef1) and negatively regulates osteoblast maturation.
Volume: 27
Issue: 4
Pages: 330-8
Publication
First Author: Duan D
Year: 1999
Journal: Development
Title: Submucosal gland development in the airway is controlled by lymphoid enhancer binding factor 1 (LEF1).
Volume: 126
Issue: 20
Pages: 4441-53
Publication
First Author: Choi YS
Year: 2015
Journal: Nat Immunol
Title: LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.
Volume: 16
Issue: 9
Pages: 980-90
Publication
First Author: Sasaki H
Year: 2010
Journal: J Dent Res
Title: Down-regulated genes in mouse dental papillae and pulp.
Volume: 89
Issue: 7
Pages: 679-83
Publication
First Author: Hoeppner LH
Year: 2011
Journal: J Biol Chem
Title: Lef1DeltaN binds beta-catenin and increases osteoblast activity and trabecular bone mass.
Volume: 286
Issue: 13
Pages: 10950-9
Publication
First Author: Ji Q
Year: 2019
Journal: Nat Commun
Title: Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis.
Volume: 10
Issue: 1
Pages: 313
Publication
First Author: Bélanger S
Year: 2023
Journal: J Immunol
Title: The Chromatin Regulator Mll1 Supports T Follicular Helper Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1.
Volume: 210
Issue: 11
Pages: 1752-1760
Publication
First Author: Yu S
Year: 2012
Journal: Immunity
Title: The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy.
Volume: 37
Issue: 5
Pages: 813-26
Publication
First Author: Tian H
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Beta-catenin/LEF1 activated enamelin expression in ameloblast-like cells.
Volume: 398
Issue: 3
Pages: 519-24
Publication
First Author: Chen X
Year: 2006
Journal: Mol Cell Biol
Title: The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy.
Volume: 26
Issue: 12
Pages: 4462-73
Publication
First Author: Malhotra N
Year: 2013
Journal: Immunity
Title: A network of high-mobility group box transcription factors programs innate interleukin-17 production.
Volume: 38
Issue: 4
Pages: 681-93
Publication  
First Author: Le PT
Year: 2021
Journal: Front Immunol
Title: Targeting Cbx3/HP1γ Induces LEF-1 and IL-21R to Promote Tumor-Infiltrating CD8 T-Cell Persistence.
Volume: 12
Pages: 738958
Publication
First Author: Adam RC
Year: 2018
Journal: Cell Stem Cell
Title: Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression.
Volume: 22
Issue: 3
Pages: 398-413.e7
Publication
First Author: Li F
Year: 2017
Journal: Cell Stem Cell
Title: Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1.
Volume: 21
Issue: 3
Pages: 359-373.e5
Publication
First Author: Xie Y
Year: 2017
Journal: PLoS Biol
Title: Lef1-dependent hypothalamic neurogenesis inhibits anxiety.
Volume: 15
Issue: 8
Pages: e2002257
Publication
First Author: Luderer HF
Year: 2011
Journal: J Biol Chem
Title: Lymphoid enhancer-binding factor-1 (LEF1) interacts with the DNA-binding domain of the vitamin D receptor.
Volume: 286
Issue: 21
Pages: 18444-51
Publication
First Author: Lisse TS
Year: 2014
Journal: Mol Endocrinol
Title: The vitamin D receptor is required for activation of cWnt and hedgehog signaling in keratinocytes.
Volume: 28
Issue: 10
Pages: 1698-706
Publication
First Author: Chan SC
Year: 2020
Journal: J Biol Chem
Title: Hepatocyte nuclear factor 1β suppresses canonical Wnt signaling through transcriptional repression of lymphoid enhancer-binding factor 1.
Volume: 295
Issue: 51
Pages: 17560-17572
Publication
First Author: Milatovich A
Year: 1991
Journal: Genomics
Title: Gene for lymphoid enhancer-binding factor 1 (LEF1) mapped to human chromosome 4 (q23-q25) and mouse chromosome 3 near Egf.
Volume: 11
Issue: 4
Pages: 1040-8
Publication
First Author: Fakhouri WD
Year: 2014
Journal: Hum Mol Genet
Title: An etiologic regulatory mutation in IRF6 with loss- and gain-of-function effects.
Volume: 23
Issue: 10
Pages: 2711-20
Publication
First Author: Mailleux AA
Year: 2002
Journal: Development
Title: Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo.
Volume: 129
Issue: 1
Pages: 53-60
Publication
First Author: Zhou CJ
Year: 2004
Journal: J Neurosci
Title: Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities.
Volume: 24
Issue: 1
Pages: 121-6
Publication
First Author: Kobielak K
Year: 2003
Journal: J Cell Biol
Title: Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA.
Volume: 163
Issue: 3
Pages: 609-23
Publication  
First Author: Ke H
Year: 2016
Journal: Sci Rep
Title: Nemo-like kinase regulates the expression of vascular endothelial growth factor (VEGF) in alveolar epithelial cells.
Volume: 6
Pages: 23987
Publication
First Author: Elayyan J
Year: 2017
Journal: FASEB J
Title: LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes.
Volume: 31
Issue: 7
Pages: 3116-3125
Publication  
First Author: Li F
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: TFH cells depend on Tcf1-intrinsic HDAC activity to suppress CTLA4 and guard B-cell help function.
Volume: 118
Issue: 2
Publication
First Author: Thapa P
Year: 2017
Journal: Sci Rep
Title: The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1.
Volume: 7
Issue: 1
Pages: 7018
Publication
First Author: Galceran J
Year: 1999
Journal: Genes Dev
Title: Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice.
Volume: 13
Issue: 6
Pages: 709-17
Publication
First Author: Galceran J
Year: 2000
Journal: Development
Title: Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1.
Volume: 127
Issue: 3
Pages: 469-82
Publication
First Author: Galceran J
Year: 2004
Journal: Genes Dev
Title: LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis.
Volume: 18
Issue: 22
Pages: 2718-23
Publication
First Author: DasGupta R
Year: 1999
Journal: Development
Title: Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation.
Volume: 126
Issue: 20
Pages: 4557-68
Publication
First Author: Osorio KM
Year: 2011
Journal: J Cell Biol
Title: Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments.
Volume: 193
Issue: 1
Pages: 235-50
Publication
First Author: Balasubramanian R
Year: 2021
Journal: Sci Adv
Title: Phase transition specified by a binary code patterns the vertebrate eye cup.
Volume: 7
Issue: 46
Pages: eabj9846
Publication
First Author: Christova T
Year: 2010
Journal: Int J Biochem Cell Biol
Title: Lymphoid enhancer factor-1 mediates loading of Pax3 to a promoter harbouring lymphoid enhancer factor-1 binding sites resulting in enhancement of transcription.
Volume: 42
Issue: 5
Pages: 630-40
Publication
First Author: Petersson M
Year: 2011
Journal: EMBO J
Title: TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis.
Volume: 30
Issue: 15
Pages: 3004-18
Publication  
First Author: Jia S
Year: 2020
Journal: Front Physiol
Title: Pax9's Interaction With the Ectodysplasin Signaling Pathway During the Patterning of Dentition.
Volume: 11
Pages: 581843
Publication
First Author: Pilon N
Year: 2006
Journal: Dev Biol
Title: Cdx4 is a direct target of the canonical Wnt pathway.
Volume: 289
Issue: 1
Pages: 55-63
Publication
First Author: Galceran J
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression.
Volume: 98
Issue: 15
Pages: 8668-73
Publication
First Author: Iwatsuki K
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Wnt signaling interacts with Shh to regulate taste papilla development.
Volume: 104
Issue: 7
Pages: 2253-8
Publication
First Author: Cho KW
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development.
Volume: 103
Issue: 45
Pages: 16788-93
Publication
First Author: Kahler RA
Year: 2003
Journal: J Biol Chem
Title: Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter.
Volume: 278
Issue: 14
Pages: 11937-44
Publication
First Author: Feng XY
Year: 2018
Journal: Eur J Oral Sci
Title: Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/β-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage.
Volume: 126
Issue: 1
Pages: 1-12
Publication
First Author: Wisniewska MB
Year: 2010
Journal: J Neurosci
Title: LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain.
Volume: 30
Issue: 14
Pages: 4957-69
Publication
First Author: Nawshad A
Year: 2007
Journal: J Cell Sci
Title: TGFbeta3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex.
Volume: 120
Issue: Pt 9
Pages: 1646-53
Publication
First Author: Zhao M
Year: 2013
Journal: Mol Cell Biol
Title: A network of transcription factors operates during early tooth morphogenesis.
Volume: 33
Issue: 16
Pages: 3099-112
Publication
First Author: Infarinato NR
Year: 2020
Journal: Genes Dev
Title: BMP signaling: at the gate between activated melanocyte stem cells and differentiation.
Volume: 34
Issue: 23-24
Pages: 1713-1734
Publication
First Author: Howard B
Year: 2005
Journal: Genes Dev
Title: Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification.
Volume: 19
Issue: 17
Pages: 2078-90
Publication
First Author: Brugmann SA
Year: 2007
Journal: Development
Title: Wnt signaling mediates regional specification in the vertebrate face.
Volume: 134
Issue: 18
Pages: 3283-95
Publication
First Author: Song H
Year: 2023
Journal: Dev Dyn
Title: Expression dynamics of lymphoid enhancer-binding factor 1 in terminal Schwann cells, dermal papilla, and interfollicular epidermis.
Volume: 252
Issue: 4
Pages: 527-535
Publication
First Author: Gao Y
Year: 2014
Journal: Development
Title: WT1 regulates the development of the posterior taste field.
Volume: 141
Issue: 11
Pages: 2271-8
Publication
First Author: Dassule HR
Year: 1998
Journal: Dev Biol
Title: Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth.
Volume: 202
Issue: 2
Pages: 215-27
Publication
First Author: Vendrell V
Year: 2009
Journal: Gene Expr Patterns
Title: Gene expression analysis of canonical Wnt pathway transcriptional regulators during early morphogenesis of the facial region in the mouse embryo.
Volume: 9
Issue: 5
Pages: 296-305
Publication
First Author: Lee JM
Year: 2011
Journal: Histochem Cell Biol
Title: Shh signaling is essential for rugae morphogenesis in mice.
Volume: 136
Issue: 6
Pages: 663-75
Publication
First Author: Deacon E
Year: 2023
Journal: Dev Dyn
Title: β-Catenin in the kidney stroma modulates pathways and genes to regulate kidney development.
Volume: 252
Issue: 9
Pages: 1224-1239
Publication
First Author: Foley J
Year: 2001
Journal: Development
Title: Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development.
Volume: 128
Issue: 4
Pages: 513-25
Publication  
First Author: Wang Y
Year: 2024
Journal: Int J Mol Sci
Title: Ectopic Activation of Fgf8 in Dental Mesenchyme Causes Incisor Agenesis and Molar Microdontia.
Volume: 25
Issue: 13
Publication  
First Author: Nouri P
Year: 2020
Journal: Front Cell Dev Biol
Title: Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling.
Volume: 8
Pages: 587778
Publication
First Author: Tsuji M
Year: 2017
Journal: Dev Growth Differ
Title: Foxc2 influences alveolar epithelial cell differentiation during lung development.
Volume: 59
Issue: 6
Pages: 501-514
Publication
First Author: Choe Y
Year: 2013
Journal: J Neurosci
Title: Bone morphogenic protein signaling is a major determinant of dentate development.
Volume: 33
Issue: 16
Pages: 6766-75
Publication
First Author: Chen J
Year: 2009
Journal: Dev Biol
Title: Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development.
Volume: 334
Issue: 1
Pages: 174-85
Publication
First Author: Laurikkala J
Year: 2001
Journal: Dev Biol
Title: TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis.
Volume: 229
Issue: 2
Pages: 443-55