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Search results 1 to 100 out of 137 for Pcsk1

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Category: Publication
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Type Details Score
Publication
31852976 | J:283160
First Author: Khaled ML
Year: 2019
Journal: Sci Rep
Title: PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus.
Volume: 9
Issue: 1
Pages: 19406
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Publication
31974728 | J:285767
First Author: Muhsin NIA
Year: 2020
Journal: Mamm Genome
Title: A novel mutation in the mouse Pcsk1 gene showing obesity and diabetes.
Volume: 31
Issue: 1-2
Pages: 17-29
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Publication
35245347 | J:324309
     
First Author: Shakya M
Year: 2022
Journal: Endocrinology
Title: The G209R mutant mouse as a model for human PCSK1 polyendocrinopathy.
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Publication
31504391 | J:281760
First Author: Jarvela TS
Year: 2019
Journal: Endocrinology
Title: Reduced Stability and pH-Dependent Activity of a Common Obesity-Linked PCSK1 Polymorphism, N221D.
Volume: 160
Issue: 11
Pages: 2630-2645
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Publication
17490633 | J:122555
First Author: Mbikay M
Year: 2007
Journal: Dev Biol
Title: A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat.
Volume: 306
Issue: 2
Pages: 584-98
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Publication
24828610 | J:214324
First Author: Prabhu Y
Year: 2014
Journal: Endocrinology
Title: Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function.
Volume: 155
Issue: 7
Pages: 2391-401
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Publication
27941249 | J:239842
First Author: Burnett LC
Year: 2017
Journal: J Clin Invest
Title: Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome.
Volume: 127
Issue: 1
Pages: 293-305
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Publication
33693631 | J:309179
     
First Author: Shakya M
Year: 2021
Journal: Endocrinology
Title: Mice lacking PC1/3 expression in POMC-expressing cells do not develop obesity.
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Publication
19156209 | J:161350
First Author: Nath AK
Year: 2009
Journal: PLoS One
Title: Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects.
Volume: 4
Issue: 1
Pages: e4221
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Publication
1862107 | J:33624
First Author: Korner J
Year: 1991
Journal: Proc Natl Acad Sci U S A
Title: Isolation and functional expression of a mammalian prohormone processing enzyme, murine prohormone convertase 1.
Volume: 88
Issue: 15
Pages: 6834-8
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Publication
1657897 | J:33115
First Author: Nakayama K
Year: 1991
Journal: J Biochem
Title: Cloning and functional expression of a novel endoprotease involved in prohormone processing at dibasic sites.
Volume: 109
Issue: 6
Pages: 803-6
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Publication
19376969 | J:248247
First Author: Dikeakos JD
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease.
Volume: 106
Issue: 18
Pages: 7408-13
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Publication
12136131 | J:78368
First Author: Zhu X
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.
Volume: 99
Issue: 16
Pages: 10299-304
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Publication
15056274 | J:108016
First Author: Cain BM
Year: 2004
Journal: J Neurochem
Title: Genetic inactivation of prohormone convertase (PC1) causes a reduction in cholecystokinin (CCK) levels in the hippocampus, amygdala, pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these structures in rat brain.
Volume: 89
Issue: 2
Pages: 307-13
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Publication
26778167 | J:269185
 
First Author: Duhamel M
Year: 2016
Journal: Sci Rep
Title: The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways.
Volume: 6
Pages: 19360
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Publication
14630721 | J:105584
First Author: Ugleholdt R
Year: 2004
Journal: Endocrinology
Title: Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1.
Volume: 145
Issue: 3
Pages: 1349-55
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Publication
28355570 | J:251808
First Author: Traub S
Year: 2017
Journal: Cell Rep
Title: Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis.
Volume: 18
Issue: 13
Pages: 3192-3203
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Publication
16644867 | J:109531
First Author: Lloyd DJ
Year: 2006
Journal: Hum Mol Genet
Title: Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice.
Volume: 15
Issue: 11
Pages: 1884-93
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Publication
10945231 | J:63889
First Author: Hwang SR
Year: 2000
Journal: DNA Cell Biol
Title: Molecular cloning demonstrates structural features of homologous bovine prohormone convertases 1 and 2.
Volume: 19
Issue: 7
Pages: 409-19
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8011166 | J:18170
First Author: Ftouhi N
Year: 1994
Journal: DNA Cell Biol
Title: Gene organization of the mouse pro-hormone and pro-protein convertase PC1.
Volume: 13
Issue: 4
Pages: 395-407
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Publication
7805868 | J:22022
First Author: Hanabusa T
Year: 1994
Journal: FEBS Lett
Title: Nucleotide sequence and analysis of the mouse SPC3 promoter region.
Volume: 356
Issue: 2-3
Pages: 339-41
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Publication
16407210 | J:110551
First Author: Rabah N
Year: 2006
Journal: J Biol Chem
Title: Single amino acid substitution in the PC1/3 propeptide can induce significant modifications of its inhibitory profile toward its cognate enzyme.
Volume: 281
Issue: 11
Pages: 7556-67
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Publication
21935423 | J:177685
First Author: Icimoto MY
Year: 2011
Journal: PLoS One
Title: Hysteretic behavior of proprotein convertase 1/3 (PC1/3).
Volume: 6
Issue: 9
Pages: e24545
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Publication
2017186 | J:11129
First Author: Seidah NG
Year: 1991
Journal: Mol Endocrinol
Title: Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.
Volume: 5
Issue: 1
Pages: 111-22
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2169760 | J:10744
First Author: Seidah NG
Year: 1990
Journal: DNA Cell Biol
Title: cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
Volume: 9
Issue: 6
Pages: 415-24
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15956344 | J:112500
First Author: Hardiman A
Year: 2005
Journal: J Mol Endocrinol
Title: Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry.
Volume: 34
Issue: 3
Pages: 739-51
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Publication
12145326 | J:78369
First Author: Zhu X
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects.
Volume: 99
Issue: 16
Pages: 10293-8
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Publication
20412386 | J:161820
First Author: Wardman JH
Year: 2010
Journal: J Neurochem
Title: Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics.
Volume: 114
Issue: 1
Pages: 215-25
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Publication
8262946 | J:131459
First Author: Breslin MB
Year: 1993
Journal: J Biol Chem
Title: Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin.
Volume: 268
Issue: 36
Pages: 27084-93
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Publication
8397508 | J:135486
 
First Author: Benjannet S
Year: 1993
Journal: Biochem J
Title: Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2.
Volume: 294 ( Pt 3)
Pages: 735-43
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Publication
1988934 | J:33623
First Author: Smeekens SP
Year: 1991
Journal: Proc Natl Acad Sci U S A
Title: Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.
Volume: 88
Issue: 2
Pages: 340-4
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Publication
8003017 | J:18659
First Author: Goodman LJ
Year: 1994
Journal: Biochem Biophys Res Commun
Title: Autoproteolytic activation of the mouse prohormone convertase mPC1.
Volume: 201
Issue: 2
Pages: 795-804
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Publication
7925129 | J:20976
First Author: Marcinkiewicz M
Year: 1994
Journal: Endocrinology
Title: Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets.
Volume: 135
Issue: 4
Pages: 1651-60
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8891276 | J:35361
First Author: Meyer A
Year: 1996
Journal: Brain Res
Title: Kainic acid increases the expression of the prohormone convertases furin and PC1 in the mouse hippocampus.
Volume: 732
Issue: 1-2
Pages: 121-32
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Publication
25153248 | J:220410
 
First Author: Miyamoto A
Year: 2014
Journal: Matrix Biol
Title: Binding of MAGP2 to microfibrils is regulated by proprotein convertase cleavage.
Volume: 40
Pages: 27-33
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12358783 | J:78623
First Author: Villeneuve P
Year: 2002
Journal: J Neurochem
Title: Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study.
Volume: 82
Issue: 4
Pages: 783-93
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Publication
22396549 | J:184882
First Author: Refaie S
Year: 2012
Journal: J Biol Chem
Title: Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.
Volume: 287
Issue: 18
Pages: 14703-17
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Publication
21888904 | J:176425
First Author: Tamura Y
Year: 2011
Journal: FEBS Lett
Title: NO donor induces Nec-1-inhibitable, but RIP1-independent, necrotic cell death in pancreatic β-cells.
Volume: 585
Issue: 19
Pages: 3058-64
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Publication
22579794 | J:192432
 
First Author: Chavez-Valdez R
Year: 2012
Journal: Neuroscience
Title: Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia-ischemia.
Volume: 219
Pages: 192-203
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7730317 | J:34511
First Author: Rothenberg ME
Year: 1995
Journal: J Biol Chem
Title: Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro.
Volume: 270
Issue: 17
Pages: 10136-46
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15018810 | J:75717
First Author: Feng Y
Year: 2002
Journal: Brain Res Gene Expr Patterns
Title: ProSAAS and prohormone convertase 1 are broadly expressed during mouse development.
Volume: 1
Issue: 2
Pages: 135-40
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Publication
16476726 | J:112681
First Author: Ugleholdt R
Year: 2006
Journal: J Biol Chem
Title: Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor.
Volume: 281
Issue: 16
Pages: 11050-7
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Publication
39435302 | J:360142
First Author: Moeller J
Year: 2024
Journal: J Endocr Soc
Title: Ablation of PC1/3 in POMC-Expressing Tissues but Not in Immune Cells Induces Sepsis Hypersensitivity.
Volume: 8
Issue: 11
Pages: bvae171
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Publication
18554181 | J:140372
First Author: Rehfeld JF
Year: 2008
Journal: Biochem J
Title: Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17.
Volume: 415
Issue: 1
Pages: 35-43
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Publication
9242664 | J:139345
First Author: Schaner P
Year: 1997
Journal: J Biol Chem
Title: Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.
Volume: 272
Issue: 32
Pages: 19958-68
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Publication
8940009 | J:137491
First Author: Decroly E
Year: 1996
Journal: J Biol Chem
Title: Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines.
Volume: 271
Issue: 48
Pages: 30442-50
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1765368 | J:419
First Author: Seidah NG
Year: 1991
Journal: Genomics
Title: Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region).
Volume: 11
Issue: 1
Pages: 103-7
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Publication
14693708 | J:87252
First Author: Marzban L
Year: 2004
Journal: Diabetes
Title: Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.
Volume: 53
Issue: 1
Pages: 141-8
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Publication
14684599 | J:88698
First Author: Dey A
Year: 2004
Journal: Endocrinology
Title: Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone.
Volume: 145
Issue: 4
Pages: 1961-71
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Publication
18356286 | J:136071
First Author: Fox DL
Year: 2008
Journal: Mol Endocrinol
Title: Nescient helix-loop-helix 2 interacts with signal transducer and activator of transcription 3 to regulate transcription of prohormone convertase 1/3.
Volume: 22
Issue: 6
Pages: 1438-48
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Publication
10701998 | J:59052
First Author: Seidah NG
Year: 1999
Journal: Brain Res
Title: Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides.
Volume: 848
Issue: 1-2
Pages: 45-62
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Publication
17050541 | J:117652
First Author: Zhu X
Year: 2006
Journal: J Biol Chem
Title: On the processing of proghrelin to ghrelin.
Volume: 281
Issue: 50
Pages: 38867-70
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Publication
19837164 | J:158324
First Author: Minokadeh A
Year: 2010
Journal: Mol Cell Neurosci
Title: Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression.
Volume: 43
Issue: 1
Pages: 98-107
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18410501 | J:137265
First Author: Funkelstein L
Year: 2008
Journal: J Neurochem
Title: Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression.
Volume: 106
Issue: 1
Pages: 384-91
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Publication
35963866 | J:328782
First Author: Meier DT
Year: 2022
Journal: Nat Commun
Title: Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing.
Volume: 13
Issue: 1
Pages: 4761
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Publication
24101515 | J:201970
First Author: Wetsel WC
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.
Volume: 110
Issue: 43
Pages: 17362-7
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Publication
23056534 | J:192100
First Author: Liu T
Year: 2012
Journal: PLoS One
Title: Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing.
Volume: 7
Issue: 10
Pages: e46934
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8198617 | J:23179
First Author: Behan DP
Year: 1993
Journal: Genomics
Title: Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)
Volume: 16
Issue: 1
Pages: 63-8
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1429684 | J:52522
First Author: Steiner DF
Year: 1992
Journal: J Biol Chem
Title: The new enzymology of precursor processing endoproteases.
Volume: 267
Issue: 33
Pages: 23435-8
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8389457 | J:35634
First Author: Marcinkiewicz M
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin.
Volume: 90
Issue: 11
Pages: 4922-6
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Publication
9291583 | J:42730
First Author: Rancourt SL
Year: 1997
Journal: Dev Genet
Title: Murine subtilisin-like proteinase SPC6 is expressed during embryonic implantation, somitogenesis, and skeletal formation.
Volume: 21
Issue: 1
Pages: 75-81
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Publication
23027401 | J:191140
First Author: Grigoryan M
Year: 2012
Journal: Dev Dyn
Title: Phenotype of entero-endocrine L cells becomes restricted during development.
Volume: 241
Issue: 12
Pages: 1986-92
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Publication
10894496 | J:62933
First Author: Kayo T
Year: 2000
Journal: Comp Med
Title: Identification of two chromosomal loci determining glucose intolerance in a C57BL/6 mouse strain.
Volume: 50
Issue: 3
Pages: 296-302
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7819324 | J:23191
First Author: Seidah NG
Year: 1994
Journal: Biochimie
Title: The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.
Volume: 76
Issue: 3-4
Pages: 197-209
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9885250 | J:52417
First Author: Constam DB
Year: 1999
Journal: J Cell Biol
Title: Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.
Volume: 144
Issue: 1
Pages: 139-49
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8698813 | J:34068
First Author: Constam DB
Year: 1996
Journal: J Cell Biol
Title: SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.
Volume: 134
Issue: 1
Pages: 181-91
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16627579 | J:129652
First Author: Vuguin PM
Year: 2006
Journal: Endocrinology
Title: Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation.
Volume: 147
Issue: 9
Pages: 3995-4006
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Publication
24855103 | J:213203
First Author: Chen Y
Year: 2014
Journal: Biol Reprod
Title: Preimplantation mouse embryo is a target for opioid ligand-receptor signaling.
Volume: 91
Issue: 1
Pages: 4
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12049785 | J:77320
First Author: Wilson ME
Year: 2002
Journal: Mech Dev
Title: Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas.
Volume: 115
Issue: 1-2
Pages: 171-6
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16163737 | J:104961
First Author: St Germain C
Year: 2005
Journal: Mol Reprod Dev
Title: Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.
Volume: 72
Issue: 4
Pages: 483-93
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8223273 | J:12612
First Author: Tessarollo L
Year: 1993
Journal: Development
Title: trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues.
Volume: 118
Issue: 2
Pages: 463-75
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12933680 | J:85590
First Author: Vincent M
Year: 2003
Journal: Endocrinology
Title: Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis.
Volume: 144
Issue: 9
Pages: 4061-9
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17938243 | J:125691
First Author: Masui T
Year: 2007
Journal: Genes Dev
Title: Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.
Volume: 21
Issue: 20
Pages: 2629-43
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15587270 | J:94589
First Author: Lamotte L
Year: 2004
Journal: Transgenic Res
Title: Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain.
Volume: 13
Issue: 5
Pages: 463-73
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20138042 | J:236958
First Author: Lu J
Year: 2010
Journal: Gastroenterology
Title: Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.
Volume: 138
Issue: 5
Pages: 1954-65
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1354647 | J:1676
First Author: Copeland NG
Year: 1992
Journal: Genomics
Title: Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes.
Volume: 13
Issue: 4
Pages: 1356-8
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8824815 | J:31188
First Author: Pathak BG
Year: 1996
Journal: Genomics
Title: Mouse chromosomal location of four Na/H exchanger isoform genes.
Volume: 31
Issue: 2
Pages: 261-3
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8114702 | J:16903
First Author: Martin JF
Year: 1994
Journal: Mol Cell Biol
Title: A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.
Volume: 14
Issue: 3
Pages: 1647-56
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11076772 | J:65594
First Author: Sander M
Year: 2000
Journal: Development
Title: Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.
Volume: 127
Issue: 24
Pages: 5533-40
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Publication
20876279 | J:165252
First Author: Mesnard D
Year: 2010
Journal: J Cell Biol
Title: Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.
Volume: 191
Issue: 1
Pages: 129-39
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Publication
9584121 | J:48576
First Author: Sussel L
Year: 1998
Journal: Development
Title: Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
Volume: 125
Issue: 12
Pages: 2213-21
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Publication
21880149 | J:176201
 
First Author: Kordowich S
Year: 2011
Journal: BMC Dev Biol
Title: Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage.
Volume: 11
Pages: 52
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