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Search results 1 to 100 out of 210 for Pkm

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Category: Publication
Type Details Score
Publication  
First Author: Seki SM
Year: 2020
Journal: Sci Signal
Title: Modulation of PKM activity affects the differentiation of T(H)17 cells.
Volume: 13
Issue: 655
Publication
First Author: de Luis O
Year: 1998
Journal: Biochim Biophys Acta
Title: Gene expression of mouse M1 and M2 pyruvate kinase isoenzymes correlates with differential poly[A] tract extension of their mRNAs during the development of spermatogenesis.
Volume: 1396
Issue: 3
Pages: 294-305
Publication
First Author: Izumi S
Year: 1995
Journal: Biochim Biophys Acta
Title: Molecular cloning of the complementary DNA for the mouse pyruvate kinase M-2 gene whose expression is dependent upon cell differentiation.
Volume: 1267
Issue: 2-3
Pages: 135-8
Publication
First Author: Lee J
Year: 2008
Journal: Int J Biochem Cell Biol
Title: Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription.
Volume: 40
Issue: 5
Pages: 1043-54
Publication
First Author: Simsek D
Year: 2017
Journal: Cell
Title: The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity.
Volume: 169
Issue: 6
Pages: 1051-1065.e18
Publication
First Author: Deng W
Year: 2018
Journal: Cell Rep
Title: The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis.
Volume: 24
Issue: 2
Pages: 366-378
Publication
First Author: Qian GQ
Year: 2024
Journal: Asian J Androl
Title: Pyruvate kinase M in germ cells is essential for sperm motility and male fertility but not spermatogenesis.
Volume: 26
Issue: 2
Pages: 212-219
Publication
First Author: Tech K
Year: 2017
Journal: Cancer Res
Title: Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation.
Volume: 77
Issue: 12
Pages: 3217-3230
Publication
First Author: Morita M
Year: 2018
Journal: Cancer Cell
Title: PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.
Volume: 33
Issue: 3
Pages: 355-367.e7
Publication
First Author: Gao Z
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Reexpression of pyruvate kinase M2 in type 1 myofibers correlates with altered glucose metabolism in myotonic dystrophy.
Volume: 110
Issue: 33
Pages: 13570-5
Publication  
First Author: Lin JC
Year: 2016
Journal: Sci Rep
Title: RBM4a-regulated splicing cascade modulates the differentiation and metabolic activities of brown adipocytes.
Volume: 6
Pages: 20665
Publication  
First Author: Su CH
Year: 2017
Journal: Mol Cell Biol
Title: RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M.
Volume: 37
Issue: 3
Publication
First Author: Dayton TL
Year: 2016
Journal: Genes Dev
Title: Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.
Volume: 30
Issue: 9
Pages: 1020-33
Publication
First Author: Ni L
Year: 2022
Journal: J Am Heart Assoc
Title: Pyruvate Kinase M2 Protects Heart from Pressure Overload-Induced Heart Failure by Phosphorylating RAC1.
Volume: 11
Issue: 11
Pages: e024854
Publication
First Author: Manuel AM
Year: 2021
Journal: Am J Respir Cell Mol Biol
Title: Dysregulation of Pyruvate Kinase M2 Promotes Inflammation in a Mouse Model of Obese Allergic Asthma.
Volume: 64
Issue: 6
Pages: 709-721
Publication
First Author: Xia Y
Year: 2022
Journal: Cancer Res
Title: PKM2 Is Essential for Bladder Cancer Growth and Maintenance.
Volume: 82
Issue: 4
Pages: 571-585
Publication
First Author: Rajala A
Year: 2018
Journal: Cell Death Dis
Title: Pyruvate kinase M2 isoform deletion in cone photoreceptors results in age-related cone degeneration.
Volume: 9
Issue: 7
Pages: 737
Publication
First Author: Ye Y
Year: 2021
Journal: FASEB J
Title: Pyruvate kinase M2 mediates fibroblast proliferation to promote tubular epithelial cell survival in acute kidney injury.
Volume: 35
Issue: 7
Pages: e21706
Publication
First Author: Wubben TJ
Year: 2017
Journal: Sci Rep
Title: Photoreceptor metabolic reprogramming provides survival advantage in acute stress while causing chronic degeneration.
Volume: 7
Issue: 1
Pages: 17863
Publication
First Author: Nayak MK
Year: 2021
Journal: Blood
Title: The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis.
Volume: 137
Issue: 12
Pages: 1658-1668
Publication
First Author: Stone OA
Year: 2018
Journal: Nat Commun
Title: Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells.
Volume: 9
Issue: 1
Pages: 4077
Publication
First Author: Jain M
Year: 2021
Journal: Arterioscler Thromb Vasc Biol
Title: Smooth Muscle Cell-Specific PKM2 (Pyruvate Kinase Muscle 2) Promotes Smooth Muscle Cell Phenotypic Switching and Neointimal Hyperplasia.
Volume: 41
Issue: 5
Pages: 1724-1737
Publication
First Author: Kim B
Year: 2018
Journal: J Clin Invest
Title: Endothelial pyruvate kinase M2 maintains vascular integrity.
Volume: 128
Issue: 10
Pages: 4543-4556
Publication  
First Author: Nash HR
Year: 1978
Journal: Mouse News Lett
Title: Strain distribution pattern of Pk-2, now Pk-3
Volume: 59
Pages: 31
Publication
First Author: Sun X
Year: 2019
Journal: Mucosal Immunol
Title: Intestinal epithelial PKM2 serves as a safeguard against experimental colitis via activating β-catenin signaling.
Volume: 12
Issue: 6
Pages: 1280-1290
Publication
First Author: Li Q
Year: 2021
Journal: Circulation
Title: PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart.
Volume: 144
Issue: 9
Pages: 712-727
Publication
First Author: Palsson-McDermott EM
Year: 2015
Journal: Cell Metab
Title: Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
Volume: 21
Issue: 1
Pages: 65-80
Publication
First Author: McKnight SL
Year: 2014
Journal: Mol Cell
Title: Please keep me 2uned to PKM2.
Volume: 53
Issue: 5
Pages: 683-4
Publication  
First Author: Liu Z
Year: 2022
Journal: JCI Insight
Title: Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathy.
Volume: 7
Issue: 23
Publication
First Author: Méndez-Lucas A
Year: 2017
Journal: Cancer Res
Title: Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities.
Volume: 77
Issue: 16
Pages: 4355-4364
Publication
First Author: Casson RJ
Year: 2016
Journal: Invest Ophthalmol Vis Sci
Title: M-Type Pyruvate Kinase Isoforms and Lactate Dehydrogenase A in the Mammalian Retina: Metabolic Implications.
Volume: 57
Issue: 1
Pages: 66-80
Publication
First Author: Wu X
Year: 2008
Journal: FEBS Lett
Title: Isoform-specific interaction of pyruvate kinase with hepatitis C virus NS5B.
Volume: 582
Issue: 15
Pages: 2155-60
Publication
First Author: Zafar S
Year: 2014
Journal: Mol Neurobiol
Title: Anchorless 23-230 PrPC interactomics for elucidation of PrPC protective role.
Volume: 49
Issue: 3
Pages: 1385-99
Publication
First Author: Christofk HR
Year: 2008
Journal: Nature
Title: Pyruvate kinase M2 is a phosphotyrosine-binding protein.
Volume: 452
Issue: 7184
Pages: 181-6
Publication
First Author: Hamabe A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.
Volume: 111
Issue: 43
Pages: 15526-31
Publication
First Author: Lunt SY
Year: 2015
Journal: Mol Cell
Title: Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.
Volume: 57
Issue: 1
Pages: 95-107
Publication
First Author: Hosios AM
Year: 2015
Journal: Mol Cell
Title: Lack of Evidence for PKM2 Protein Kinase Activity.
Volume: 59
Issue: 5
Pages: 850-7
Publication
First Author: Bravo-Adame ME
Year: 2017
Journal: Immunology
Title: An alternative mode of CD43 signal transduction activates pro-survival pathways of T lymphocytes.
Volume: 150
Issue: 1
Pages: 87-99
Publication  
First Author: Cai SZ
Year: 2019
Journal: Biosci Rep
Title: Allicin alleviates lead-induced hematopoietic stem cell aging by up-regulating PKM2.
Volume: 39
Issue: 7
Publication
First Author: Kodani A
Year: 2019
Journal: J Neurotrauma
Title: Acteoside Improves Muscle Atrophy and Motor Function by Inducing New Myokine Secretion in Chronic Spinal Cord Injury.
Volume: 36
Issue: 12
Pages: 1935-1948
Publication
First Author: Gómez-Escudero J
Year: 2019
Journal: Sci Rep
Title: PKM2 regulates endothelial cell junction dynamics and angiogenesis via ATP production.
Volume: 9
Issue: 1
Pages: 15022
Publication
First Author: Zheng D
Year: 2020
Journal: Am J Pathol
Title: Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis.
Volume: 190
Issue: 11
Pages: 2267-2281
Publication
First Author: Yuan Q
Year: 2020
Journal: Cell Death Dis
Title: Role of pyruvate kinase M2-mediated metabolic reprogramming during podocyte differentiation.
Volume: 11
Issue: 5
Pages: 355
Publication  
First Author: Dang G
Year: 2022
Journal: Redox Biol
Title: T lymphocyte-derived extracellular vesicles aggravate abdominal aortic aneurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2.
Volume: 50
Pages: 102257
Publication  
First Author: Fu J
Year: 2022
Journal: JCI Insight
Title: Regeneration of glomerular metabolism and function by podocyte pyruvate kinase M2 in diabetic nephropathy.
Volume: 7
Issue: 5
Publication
First Author: López-Alañón DM
Year: 1995
Journal: J Reprod Fertil
Title: Cloning and characterization of genes expressed during gametogenesis of female and male mice.
Volume: 103
Issue: 2
Pages: 323-9
Publication
First Author: Boeckel JN
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells.
Volume: 36
Issue: 7
Pages: 1425-33
Publication
First Author: Toller-Kawahisa JE
Year: 2023
Journal: Nat Commun
Title: The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils.
Volume: 14
Issue: 1
Pages: 4280
Publication
First Author: Wang YH
Year: 2014
Journal: Cell
Title: Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis.
Volume: 158
Issue: 6
Pages: 1309-1323
Publication  
First Author: Liu Y
Year: 2024
Journal: J Neurosci
Title: Imbalance in Glucose Metabolism Regulates the Transition of Microglia from Homeostasis to Disease-Associated Microglia Stage 1.
Volume: 44
Issue: 20
Publication
First Author: Lindsay KJ
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina.
Volume: 111
Issue: 43
Pages: 15579-84
Publication
First Author: Pan RY
Year: 2022
Journal: Cell Metab
Title: Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease.
Volume: 34
Issue: 4
Pages: 634-648.e6
Publication
First Author: Liu F
Year: 2021
Journal: EMBO J
Title: PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability.
Volume: 40
Issue: 22
Pages: e108065
Publication
First Author: Magadum A
Year: 2020
Journal: Circulation
Title: Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration.
Volume: 141
Issue: 15
Pages: 1249-1265
Publication    
First Author: Chinchore Y
Year: 2017
Journal: Elife
Title: Glycolytic reliance promotes anabolism in photoreceptors.
Volume: 6
Publication
First Author: Kim Y
Year: 2019
Journal: Sci Rep
Title: Loss of PKM2 in Lgr5+ intestinal stem cells promotes colitis-associated colorectal cancer.
Volume: 9
Issue: 1
Pages: 6212
Publication
First Author: Hao L
Year: 2021
Journal: J Invest Dermatol
Title: Inhibiting Protein Kinase Activity of Pyruvate Kinase M2 by SIRT2 Deacetylase Attenuates Psoriasis.
Volume: 141
Issue: 2
Pages: 355-363.e6
Publication    
First Author: Walls JF
Year: 2020
Journal: Elife
Title: Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses.
Volume: 9
Publication
First Author: Kong Q
Year: 2019
Journal: Diabetes
Title: HSPA12A Is a Novel Player in Nonalcoholic Steatohepatitis via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization.
Volume: 68
Issue: 2
Pages: 361-376
Publication  
First Author: Sinha T
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Absence of retbindin blocks glycolytic flux, disrupts metabolic homeostasis, and leads to photoreceptor degeneration.
Volume: 118
Issue: 6
Publication
First Author: Zhao J
Year: 2022
Journal: Cell Death Dis
Title: Mitochondrial PKM2 deacetylation by procyanidin B2-induced SIRT3 upregulation alleviates lung ischemia/reperfusion injury.
Volume: 13
Issue: 7
Pages: 594
Publication
First Author: Roche E
Year: 1997
Journal: J Biol Chem
Title: Induction by glucose of genes coding for glycolytic enzymes in a pancreatic beta-cell line (INS-1).
Volume: 272
Issue: 5
Pages: 3091-8
Publication
First Author: Vander Heiden MG
Year: 2010
Journal: Science
Title: Evidence for an alternative glycolytic pathway in rapidly proliferating cells.
Volume: 329
Issue: 5998
Pages: 1492-9
Publication
First Author: Lv L
Year: 2013
Journal: Mol Cell
Title: Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization.
Volume: 52
Issue: 3
Pages: 340-52
Publication
First Author: Hu X
Year: 2023
Journal: Int Immunopharmacol
Title: Fibrinogen-like protein 2 regulates macrophage glycolytic reprogramming by directly targeting PKM2 and exacerbates alcoholic liver injury.
Volume: 124
Issue: Pt B
Pages: 110957
Publication  
First Author: Weh E
Year: 2023
Journal: Cells
Title: Metabolic Alterations Caused by Simultaneous Loss of HK2 and PKM2 Leads to Photoreceptor Dysfunction and Degeneration.
Volume: 12
Issue: 16
Publication
First Author: Guo J
Year: 2024
Journal: J Transl Med
Title: The role of NAD-dependent deacetylase sirtuin-2 in liver metabolic stress through regulating pyruvate kinase M2 ubiquitination.
Volume: 22
Issue: 1
Pages: 656
Publication
First Author: Rajala A
Year: 2020
Journal: Sci Rep
Title: Metabolic and Non-metabolic Roles of Pyruvate Kinase M2 Isoform in Diabetic Retinopathy.
Volume: 10
Issue: 1
Pages: 7456
Publication
First Author: Qi W
Year: 2017
Journal: Nat Med
Title: Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.
Volume: 23
Issue: 6
Pages: 753-762
Publication
First Author: Das Gupta K
Year: 2020
Journal: Cell Rep
Title: Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2.
Volume: 30
Issue: 8
Pages: 2712-2728.e8
Publication
First Author: Yang J
Year: 2019
Journal: FASEB J
Title: T-cell-derived extracellular vesicles regulate B-cell IgG production via pyruvate kinase muscle isozyme 2.
Volume: 33
Issue: 11
Pages: 12780-12799
Publication
First Author: Lü S
Year: 2018
Journal: J Mol Med (Berl)
Title: PKM2-dependent metabolic reprogramming in CD4(+) T cells is crucial for hyperhomocysteinemia-accelerated atherosclerosis.
Volume: 96
Issue: 6
Pages: 585-600
Publication  
First Author: Xie C
Year: 2019
Journal: Cells
Title: Off-Target Deletion of Conditional Dbc1 Allele in the Foxp3YFP-Cre Mouse Line under Specific Setting.
Volume: 8
Issue: 11
Publication
First Author: Aguiar CF
Year: 2023
Journal: Cell Rep
Title: Tissue-specific metabolic profile drives iNKT cell function during obesity and liver injury.
Volume: 42
Issue: 1
Pages: 112035
Publication    
First Author: Foster HR
Year: 2022
Journal: Elife
Title: β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the KATP channel.
Volume: 11
Publication
First Author: Rajala A
Year: 2018
Journal: Cell Death Dis
Title: Pyruvate kinase M2 regulates photoreceptor structure, function, and viability.
Volume: 9
Issue: 2
Pages: 240
Publication  
First Author: Liu YZ
Year: 2021
Journal: Front Pharmacol
Title: Pyruvate Kinase M2 Mediates Glycolysis Contributes to Psoriasis by Promoting Keratinocyte Proliferation.
Volume: 12
Pages: 765790
Publication
First Author: Lalley PA
Year: 1978
Journal: Cytogenet Cell Genet
Title: The genes coding for pyruvate kinase (M2) and mannosephosphate isomerase are linked in man and mouse.
Volume: 22
Issue: 1-6
Pages: 581-4
Publication
First Author: Sun Q
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.
Volume: 108
Issue: 10
Pages: 4129-34
Publication
First Author: Abeywardana T
Year: 2018
Journal: J Biol Chem
Title: CARM1 suppresses de novo serine synthesis by promoting PKM2 activity.
Volume: 293
Issue: 39
Pages: 15290-15303
Publication
First Author: Siragusa M
Year: 2019
Journal: EMBO J
Title: Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition.
Volume: 38
Issue: 17
Pages: e100938
Publication
First Author: Wan L
Year: 2019
Journal: FASEB J
Title: Exosomes from activated hepatic stellate cells contain GLUT1 and PKM2: a role for exosomes in metabolic switch of liver nonparenchymal cells.
Volume: 33
Issue: 7
Pages: 8530-8542
Publication  
First Author: Chasalow F
Year: 1980
Journal: Mouse News Lett
Title: [Pk-3].
Volume: 62
Pages: 73
Publication  
First Author: Zhou J
Year: 2023
Journal: ASN Neuro
Title: Pyruvate Kinase 2, an Energy Metabolism Related Enzyme, May Have a Neuroprotective Function in Retinal Degeneration.
Volume: 15
Pages: 17590914231151534
Publication
First Author: Zhou HL
Year: 2019
Journal: Nature
Title: Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.
Volume: 565
Issue: 7737
Pages: 96-100
Publication
First Author: Fu J
Year: 2019
Journal: J Biol Chem
Title: Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus.
Volume: 294
Issue: 1
Pages: 327-340
Publication
First Author: Han J
Year: 2021
Journal: Cell Rep
Title: Aberrant role of pyruvate kinase M2 in the regulation of gamma-secretase and memory deficits in Alzheimer's disease.
Volume: 37
Issue: 10
Pages: 110102
Publication
First Author: Veras FP
Year: 2022
Journal: Cell Rep
Title: Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation.
Volume: 41
Issue: 13
Pages: 111897
Publication
First Author: Zhang E
Year: 2020
Journal: Mamm Genome
Title: PKM2 ablation enhanced retinal function and survival in a preclinical model of retinitis pigmentosa.
Volume: 31
Issue: 3-4
Pages: 77-85
Publication
First Author: Davidson SM
Year: 2022
Journal: Cancer Res
Title: Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma.
Volume: 82
Issue: 13
Pages: 2403-2416
Publication
First Author: Taylor SR
Year: 2021
Journal: Nature
Title: Dietary fructose improves intestinal cell survival and nutrient absorption.
Volume: 597
Issue: 7875
Pages: 263-267
Publication
First Author: Alquraishi M
Year: 2022
Journal: Cell Commun Signal
Title: Podocyte specific deletion of PKM2 ameliorates LPS-induced podocyte injury through beta-catenin.
Volume: 20
Issue: 1
Pages: 76
Publication
First Author: Johnson FM
Year: 1981
Journal: Genet Res
Title: A variation in mouse kidney pyruvate kinase activity determined by a mutant gene on chromosome 9.
Volume: 37
Issue: 2
Pages: 123-31
Publication      
First Author: Lewis SE
Year: 1983
Title: Dominant and recessive effects of electrophoretically detected specific locus mutations
Pages: 267-78
Publication
First Author: Faria TN
Year: 1998
Journal: Mol Cell Endocrinol
Title: Characterization of genes which exhibit reduced expression during the retinoic acid-induced differentiation of F9 teratocarcinoma cells: involvement of cyclin D3 in RA-mediated growth arrest.
Volume: 143
Issue: 1-2
Pages: 155-66
Publication  
First Author: Damasceno LEA
Year: 2020
Journal: J Exp Med
Title: PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation.
Volume: 217
Issue: 10
Publication
First Author: Israelsen WJ
Year: 2013
Journal: Cell
Title: PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.
Volume: 155
Issue: 2
Pages: 397-409
Publication
First Author: Zhang Y
Year: 2024
Journal: Cell Metab
Title: Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer.
Volume: 36
Issue: 1
Pages: 193-208.e8
Publication  
First Author: Xie M
Year: 2016
Journal: Nat Commun
Title: PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation.
Volume: 7
Pages: 13280
Publication
First Author: Wei Y
Year: 2020
Journal: Nat Commun
Title: Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection.
Volume: 11
Issue: 1
Pages: 941