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Search results 1 to 100 out of 112 for Por

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Category: Publication
Type Details Score
Publication
First Author: Por ED
Year: 2012
Journal: J Biol Chem
Title: β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel.
Volume: 287
Issue: 44
Pages: 37552-63
Publication
First Author: Uehara S
Year: 2022
Journal: Sci Rep
Title: Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism.
Volume: 12
Issue: 1
Pages: 14907
Publication
First Author: Finn RD
Year: 2009
Journal: Biochem J
Title: Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway.
Volume: 417
Issue: 1
Pages: 43-54
Publication
First Author: Lee C
Year: 2013
Journal: Drug Metab Dispos
Title: The role of cytochrome P450-dependent metabolism in the regulation of mouse hepatic growth hormone signaling components and target genes by 3-methylcholanthrene.
Volume: 41
Issue: 2
Pages: 457-65
Publication
First Author: Levová K
Year: 2011
Journal: Toxicol Sci
Title: Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.
Volume: 121
Issue: 1
Pages: 43-56
Publication
First Author: Barzi M
Year: 2017
Journal: Nat Commun
Title: A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism.
Volume: 8
Issue: 1
Pages: 39
Publication
First Author: Finn RD
Year: 2007
Journal: J Pharmacol Exp Ther
Title: Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system.
Volume: 322
Issue: 1
Pages: 40-7
Publication  
First Author: Malacarne PF
Year: 2022
Journal: Int J Mol Sci
Title: Epoxyeicosatrienoic Acid and Prostanoid Crosstalk at the Receptor and Intracellular Signaling Levels to Maintain Vascular Tone.
Volume: 23
Issue: 11
Publication  
First Author: Reed L
Year: 2019
Journal: Toxicol Appl Pharmacol
Title: Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine.
Volume: 366
Pages: 64-74
Publication  
First Author: Lopez M
Year: 2022
Journal: Front Physiol
Title: Endothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling.
Volume: 13
Pages: 1056369
Publication
First Author: Henderson CJ
Year: 2015
Journal: Biochem J
Title: Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.
Volume: 465
Issue: 3
Pages: 479-88
Publication  
First Author: Wang H
Year: 2016
Journal: Sci Rep
Title: Oscillating primary transcripts harbor miRNAs with circadian functions.
Volume: 6
Pages: 21598
Publication
First Author: D'Agostino J
Year: 2012
Journal: J Biol Chem
Title: Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.
Volume: 287
Issue: 21
Pages: 17777-88
Publication
First Author: Panda SP
Year: 2013
Journal: PLoS One
Title: Conditional deletion of cytochrome p450 reductase in osteoprogenitor cells affects long bone and skull development in mice recapitulating antley-bixler syndrome: role of a redox enzyme in development.
Volume: 8
Issue: 9
Pages: e75638
Publication
First Author: Schmidt K
Year: 2009
Journal: Mol Cell Biol
Title: Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb.
Volume: 29
Issue: 10
Pages: 2716-29
Publication
First Author: Ribes V
Year: 2007
Journal: Dev Biol
Title: Rescue of cytochrome P450 oxidoreductase (Por) mouse mutants reveals functions in vasculogenesis, brain and limb patterning linked to retinoic acid homeostasis.
Volume: 303
Issue: 1
Pages: 66-81
Publication
First Author: Ohgiya S
Year: 1994
Journal: Biochim Biophys Acta
Title: Mouse NADPH-cytochrome P-450 oxidoreductase: molecular cloning and functional expression in yeast.
Volume: 1186
Issue: 1-2
Pages: 137-41
Publication
First Author: Henderson CJ
Year: 2003
Journal: J Biol Chem
Title: Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.
Volume: 278
Issue: 15
Pages: 13480-6
Publication
First Author: Weng Y
Year: 2007
Journal: Cancer Res
Title: Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.
Volume: 67
Issue: 16
Pages: 7825-32
Publication
First Author: Wang XJ
Year: 2005
Journal: Biochem J
Title: Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice.
Volume: 388
Issue: Pt 3
Pages: 857-67
Publication
First Author: Gu J
Year: 2003
Journal: J Biol Chem
Title: Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase.
Volume: 278
Issue: 28
Pages: 25895-901
Publication
First Author: Weng Y
Year: 2005
Journal: J Biol Chem
Title: Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype.
Volume: 280
Issue: 36
Pages: 31686-98
Publication
First Author: Kunne C
Year: 2014
Journal: Biochim Biophys Acta
Title: FXR-dependent reduction of hepatic steatosis in a bile salt deficient mouse model.
Volume: 1842
Issue: 5
Pages: 739-46
Publication
First Author: Wei Y
Year: 2010
Journal: J Pharmacol Exp Ther
Title: Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues.
Volume: 334
Issue: 1
Pages: 69-77
Publication
First Author: Wu L
Year: 2003
Journal: Genesis
Title: Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene.
Volume: 36
Issue: 4
Pages: 177-81
Publication
First Author: Pass GJ
Year: 2005
Journal: Cancer Res
Title: Role of hepatic cytochrome p450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome p450 reductase null mouse.
Volume: 65
Issue: 10
Pages: 4211-7
Publication
First Author: Shen AL
Year: 2002
Journal: J Biol Chem
Title: Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase.
Volume: 277
Issue: 8
Pages: 6536-41
Publication  
First Author: Fang C
Year: 2012
Journal: Neuroscience
Title: Neurobehavioral abnormalities in a brain-specific NADPH-cytochrome P450 reductase knockout mouse model.
Volume: 218
Pages: 170-80
Publication
First Author: Conroy JL
Year: 2010
Journal: Nat Neurosci
Title: Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling.
Volume: 13
Issue: 3
Pages: 284-6
Publication
First Author: Wu L
Year: 2005
Journal: J Pharmacol Exp Ther
Title: Transgenic mice with a hypomorphic NADPH-cytochrome P450 reductase gene: effects on development, reproduction, and microsomal cytochrome P450.
Volume: 312
Issue: 1
Pages: 35-43
Publication
First Author: Zhang QY
Year: 2009
Journal: Drug Metab Dispos
Title: An intestinal epithelium-specific cytochrome P450 (P450) reductase-knockout mouse model: direct evidence for a role of intestinal p450s in first-pass clearance of oral nifedipine.
Volume: 37
Issue: 3
Pages: 651-7
Publication  
First Author: Ahlawat S
Year: 2014
Journal: Sci Rep
Title: Mice deficient in intestinal epithelium cytochrome P450 reductase are prone to acute toxin-induced mucosal damage.
Volume: 4
Pages: 5551
Publication
First Author: Arlt VM
Year: 2005
Journal: Cancer Res
Title: Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols.
Volume: 65
Issue: 7
Pages: 2644-52
Publication
First Author: Mutch DM
Year: 2006
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.
Volume: 291
Issue: 1
Pages: G63-72
Publication
First Author: Liu S
Year: 2013
Journal: Toxicol Appl Pharmacol
Title: The role of renal proximal tubule P450 enzymes in chloroform-induced nephrotoxicity: utility of renal specific P450 reductase knockout mouse models.
Volume: 272
Issue: 1
Pages: 230-7
Publication
First Author: Li Z
Year: 2012
Journal: Toxicol Sci
Title: PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene.
Volume: 125
Issue: 1
Pages: 233-47
Publication  
First Author: Yao Y
Year: 2013
Journal: Neurosci Lett
Title: Suppression of cytochrome P450 reductase expression promotes astrocytosis in subventricular zone of adult mice.
Volume: 548
Pages: 84-9
Publication
First Author: Chipinda I
Year: 2011
Journal: Toxicol Appl Pharmacol
Title: Discrimination of haptens from prohaptens using the metabolically deficient Cpr(low/low) mouse.
Volume: 252
Issue: 3
Pages: 268-72
Publication
First Author: Zhang Y
Year: 2013
Journal: PLoS One
Title: Suppression of cytochrome p450 reductase enhances long-term hematopoietic stem cell repopulation efficiency in mice.
Volume: 8
Issue: 7
Pages: e69913
Publication
First Author: Shephard EA
Year: 1989
Journal: Ann Hum Genet
Title: Isolation of a human cytochrome P-450 reductase cDNA clone and localization of the corresponding gene to chromosome 7q11.2.
Volume: 53
Issue: Pt 4
Pages: 291-301
Publication
First Author: Xie F
Year: 2010
Journal: Toxicol Appl Pharmacol
Title: Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.
Volume: 249
Issue: 1
Pages: 101-6
Publication
First Author: Bardowell SA
Year: 2012
Journal: J Lipid Res
Title: Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.
Volume: 53
Issue: 12
Pages: 2667-76
Publication
First Author: Lee C
Year: 2013
Journal: Drug Metab Dispos
Title: Downregulation of mouse hepatic CYP3A protein by 3-methylcholanthrene does not require cytochrome P450-dependent metabolism.
Volume: 41
Issue: 10
Pages: 1782-6
Publication
First Author: Li L
Year: 2007
Journal: Arch Biochem Biophys
Title: Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase.
Volume: 461
Issue: 1
Pages: 76-84
Publication
First Author: Shen AL
Year: 2010
Journal: PLoS One
Title: The PPCD1 mouse: characterization of a mouse model for posterior polymorphous corneal dystrophy and identification of a candidate gene.
Volume: 5
Issue: 8
Pages: e12213
Publication
First Author: Ismail HM
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions.
Volume: 110
Issue: 49
Pages: 19766-71
Publication
First Author: Gonzalez FJ
Year: 1982
Journal: J Biol Chem
Title: Cloning of DNA complementary to rat liver NADPH-cytochrome c (P-450) oxidoreductase and cytochrome P-450b mRNAs. Evidence that phenobarbital augments transcription of specific genes.
Volume: 257
Issue: 10
Pages: 5962-8
Publication
First Author: Ohgiya S
Year: 1992
Journal: Biochim Biophys Acta
Title: Molecular cloning and sequence analysis of guinea-pig NADPH-cytochrome P-450 oxidoreductase [corrected].
Volume: 1171
Issue: 1
Pages: 103-5
Publication
First Author: Lengler J
Year: 2006
Journal: Biochem Pharmacol
Title: Cytochrome P450 reductase dependent inhibition of cytochrome P450 2B1 activity: Implications for gene directed enzyme prodrug therapy.
Volume: 72
Issue: 7
Pages: 893-901
Publication
First Author: Kunne C
Year: 2014
Journal: Lab Invest
Title: Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis.
Volume: 94
Issue: 10
Pages: 1103-13
Publication
First Author: Spearow JL
Year: 1995
Journal: Mamm Genome
Title: P450 (cytochrome) oxidoreductase (Por) maps to mouse chromosome 5, not chromosome 6.
Volume: 6
Issue: 8
Pages: 558-9
Publication
First Author: Notarnicola C
Year: 2006
Journal: Gene Expr Patterns
Title: Transient expression of SOX9 protein during follicular development in the adult mouse ovary.
Volume: 6
Issue: 7
Pages: 695-702
Publication
First Author: Büdefeld T
Year: 2009
Journal: Anat Histol Embryol
Title: Initiation of steroidogenesis precedes expression of cholesterologenic enzymes in the fetal mouse testes.
Volume: 38
Issue: 6
Pages: 461-6
Publication
First Author: Keeney DS
Year: 1999
Journal: Dev Dyn
Title: Two novel sites of expression of NADPH cytochrome P450 reductase during murine embryogenesis: limb mesenchyme and developing olfactory neuroepithelia.
Volume: 216
Issue: 4-5
Pages: 511-7
Publication
First Author: Lorbek G
Year: 2012
Journal: FEBS J
Title: Cytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.
Volume: 279
Issue: 9
Pages: 1516-33
Publication
First Author: Keeney DS
Year: 1995
Journal: Endocrinology
Title: Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryo.
Volume: 136
Issue: 11
Pages: 4872-9
Publication
First Author: Simmons DL
Year: 1985
Journal: J Biol Chem
Title: Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes.
Volume: 260
Issue: 1
Pages: 515-21
Publication
First Author: Strömstedt M
Year: 1996
Journal: Mol Reprod Dev
Title: Preimplantation mouse blastocysts fail to express CYP genes required for estrogen biosynthesis.
Volume: 43
Issue: 4
Pages: 428-36
Publication
First Author: Keeney DS
Year: 1995
Journal: Mol Endocrinol
Title: Cholesterol side-chain cleavage cytochrome P450 gene expression in the primitive gut of the mouse embryo does not require steroidogenic factor 1.
Volume: 9
Issue: 8
Pages: 1091-8
Publication
First Author: Suto J
Year: 2004
Journal: J Vet Med Sci
Title: Further mapping and characterization of Naq1, a quantitative trait locus responsible for maternal inferior nurturing ability in RR mice.
Volume: 66
Issue: 9
Pages: 1033-8
Publication
First Author: Song C
Year: 2024
Journal: Sci China Life Sci
Title: Deleterious variants in RNF111 impair female fertility and induce premature ovarian insufficiency in humans and mice.
Volume: 67
Issue: 7
Pages: 1325-1337
Publication
First Author: Otto DM
Year: 2003
Journal: Mol Cell Biol
Title: Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasis.
Volume: 23
Issue: 17
Pages: 6103-16
Publication
First Author: DeSilva U
Year: 2002
Journal: Genome Res
Title: Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.
Volume: 12
Issue: 1
Pages: 3-15
Publication
First Author: Valero MC
Year: 2000
Journal: Genomics
Title: Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s).
Volume: 69
Issue: 1
Pages: 1-13
Publication
First Author: Lahbib-Mansais Y
Year: 2000
Journal: Mamm Genome
Title: Comparative mapping between humans and pigs: localization of 58 anchorage markers (TOASTs) by use of porcine somatic cell and radiation hybrid panels.
Volume: 11
Issue: 12
Pages: 1098-106
Publication        
First Author: UniProt curators
Year: 2014
Title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication        
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
Publication        
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database