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Search results 1 to 100 out of 404 for Rara

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Category: Publication
Type Details Score
Publication
First Author: Welch JS
Year: 2011
Journal: Blood
Title: Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.
Volume: 117
Issue: 8
Pages: 2460-8
Publication
First Author: Chung SS
Year: 2005
Journal: Differentiation
Title: Male sterility in mice lacking retinoic acid receptor alpha involves specific abnormalities in spermiogenesis.
Volume: 73
Issue: 4
Pages: 188-98
Publication
First Author: Chung SSW
Year: 2020
Journal: Biol Reprod
Title: Filamentous actin disorganization and absence of apical ectoplasmic specialization disassembly during spermiation upon interference with retinoid signaling†.
Volume: 103
Issue: 2
Pages: 378-389
Publication
First Author: Chung SS
Year: 2004
Journal: Dev Dyn
Title: Retinoic acid receptor alpha is required for synchronization of spermatogenic cycles and its absence results in progressive breakdown of the spermatogenic process.
Volume: 230
Issue: 4
Pages: 754-66
Publication
First Author: Massaro GD
Year: 2003
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Retinoic acid receptor-alpha regulates pulmonary alveolus formation in mice after, but not during, perinatal period.
Volume: 284
Issue: 2
Pages: L431-3
Publication
First Author: Zhu J
Year: 2007
Journal: Cancer Cell
Title: RXR is an essential component of the oncogenic PML/RARA complex in vivo.
Volume: 12
Issue: 1
Pages: 23-35
Publication
First Author: Brun PJ
Year: 2015
Journal: FASEB J
Title: Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass.
Volume: 29
Issue: 2
Pages: 671-83
Publication
First Author: Batourina E
Year: 2001
Journal: Nat Genet
Title: Vitamin A controls epithelial/mesenchymal interactions through Ret expression.
Volume: 27
Issue: 1
Pages: 74-8
Publication
First Author: Bouillet P
Year: 1997
Journal: Mech Dev
Title: Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein.
Volume: 63
Issue: 2
Pages: 173-86
Publication
First Author: Squire JA
Year: 1996
Journal: Cytogenet Cell Genet
Title: Allelic fusion of DNA topoisomerase II alpha and retinoic acid receptor alpha genes in adriamycin-resistant p388 murine leukemia revealed by fluorescence in situ hybridization.
Volume: 75
Issue: 2-3
Pages: 164-6
Publication
First Author: Brown CC
Year: 2015
Journal: Immunity
Title: Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program.
Volume: 42
Issue: 3
Pages: 499-511
Publication
First Author: Chung SS
Year: 2009
Journal: Development
Title: Expression of retinoic acid receptor alpha in the germline is essential for proper cellular association and spermiogenesis during spermatogenesis.
Volume: 136
Issue: 12
Pages: 2091-100
Publication
First Author: Sternsdorf T
Year: 2006
Journal: Cancer Cell
Title: Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia.
Volume: 9
Issue: 2
Pages: 81-94
Publication
First Author: Ratnam KK
Year: 2011
Journal: Kidney Int
Title: Role of the retinoic acid receptor-α in HIV-associated nephropathy.
Volume: 79
Issue: 6
Pages: 624-34
Publication
First Author: Tisserand J
Year: 2011
Journal: J Biol Chem
Title: Tripartite motif 24 (Trim24/Tif1α) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor α (Rarα) inhibition.
Volume: 286
Issue: 38
Pages: 33369-79
Publication  
First Author: Doyle TJ
Year: 2007
Journal: Ann N Y Acad Sci
Title: Potential functions of retinoic acid receptor A in Sertoli cells and germ cells during spermatogenesis.
Volume: 1120
Pages: 114-30
Publication
First Author: Manenti G
Year: 1996
Journal: Nat Genet
Title: Genetic mapping of a pulmonary adenoma resistance (Par1) in mouse.
Volume: 12
Issue: 4
Pages: 455-7
Publication
First Author: Peer NR
Year: 2018
Journal: Endocrinology
Title: Germ Cell-Specific Retinoic Acid Receptor α Functions in Germ Cell Organization, Meiotic Integrity, and Spermatogonia.
Volume: 159
Issue: 9
Pages: 3403-3420
Publication
First Author: He LZ
Year: 1998
Journal: Nat Genet
Title: Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.
Volume: 18
Issue: 2
Pages: 126-35
Publication
First Author: Li Z
Year: 2017
Journal: Cancer Cell
Title: FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase.
Volume: 31
Issue: 1
Pages: 127-141
Publication
First Author: Lufkin T
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice.
Volume: 90
Issue: 15
Pages: 7225-9
Publication  
First Author: Zhou G
Year: 2001
Journal: Mol Vis
Title: Modulation of retinal cell populations and eye size in retinoic acid receptor knockout mice.
Volume: 7
Pages: 253-60
Publication
First Author: Purton LE
Year: 2006
Journal: J Exp Med
Title: RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation.
Volume: 203
Issue: 5
Pages: 1283-93
Publication
First Author: Lee SA
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Adipocyte-specific expression of a retinoic acid receptor α dominant negative form causes glucose intolerance and hepatic steatosis in mice.
Volume: 514
Issue: 4
Pages: 1231-1237
Publication
First Author: Khetchoumian K
Year: 2007
Journal: Nat Genet
Title: Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha.
Volume: 39
Issue: 12
Pages: 1500-6
Publication
First Author: He Y
Year: 2014
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Biological functional annotation of retinoic acid alpha and beta in mouse liver based on genome-wide binding.
Volume: 307
Issue: 2
Pages: G205-18
Publication
First Author: Yang J
Year: 2015
Journal: Stem Cells
Title: Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells.
Volume: 33
Issue: 5
Pages: 1390-404
Publication
First Author: Houle M
Year: 2000
Journal: Mol Cell Biol
Title: Retinoic acid regulation of Cdx1: an indirect mechanism for retinoids and vertebral specification.
Volume: 20
Issue: 17
Pages: 6579-86
Publication
First Author: Kastner P
Year: 2001
Journal: Blood
Title: Positive and negative regulation of granulopoiesis by endogenous RARalpha.
Volume: 97
Issue: 5
Pages: 1314-20
Publication
First Author: Taketo M
Year: 1993
Journal: Jpn J Genet
Title: Mapping of the mouse Rar loci encoding retinoic acid receptors RAR alpha, RAR beta and RAR gamma.
Volume: 68
Issue: 3
Pages: 175-84
Publication
First Author: Wendland K
Year: 2018
Journal: J Immunol
Title: Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis.
Volume: 201
Issue: 2
Pages: 524-532
Publication
First Author: Cook M
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain.
Volume: 92
Issue: 6
Pages: 2249-53
Publication  
First Author: Jauregui EJ
Year: 2018
Journal: Development
Title: Retinoic acid receptor signaling is necessary in steroidogenic cells for normal spermatogenesis and epididymal function.
Volume: 145
Issue: 13
Publication  
First Author: Yin Y
Year: 2021
Journal: JCI Insight
Title: Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization.
Volume: 6
Issue: 17
Publication
First Author: Runkel F
Year: 2006
Journal: J Mol Histol
Title: Specific expression of annexin A8 in adult murine stratified epithelia.
Volume: 37
Issue: 8-9
Pages: 353-9
Publication
First Author: Kastner P
Year: 1997
Journal: Development
Title: Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes.
Volume: 124
Issue: 23
Pages: 4749-58
Publication
First Author: Chen CF
Year: 2005
Journal: J Biol Chem
Title: Dominant-negative retinoic acid receptors elicit epidermal defects through a non-canonical pathway.
Volume: 280
Issue: 4
Pages: 3012-21
Publication
First Author: Dupé V
Year: 1999
Journal: Development
Title: Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse.
Volume: 126
Issue: 22
Pages: 5051-9
Publication
First Author: Mendelsohn C
Year: 1999
Journal: Development
Title: Stromal cells mediate retinoid-dependent functions essential for renal development.
Volume: 126
Issue: 6
Pages: 1139-48
Publication
First Author: Blanchet S
Year: 1998
Journal: J Invest Dermatol
Title: Both retinoic acid receptors alpha (RARalpha) and gamma (RARgamma) are able to initiate mouse upper-lip skin glandular metaplasia.
Volume: 111
Issue: 2
Pages: 206-12
Publication
First Author: Dupé V
Year: 2009
Journal: Dev Dyn
Title: Retinoic acid receptors exhibit cell-autonomous functions in cranial neural crest cells.
Volume: 238
Issue: 10
Pages: 2701-11
Publication
First Author: Romand R
Year: 2002
Journal: Mech Dev
Title: The retinoic acid receptors RARalpha and RARgamma are required for inner ear development.
Volume: 119
Issue: 2
Pages: 213-23
Publication
First Author: Mendelsohn C
Year: 1994
Journal: Development
Title: Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants.
Volume: 120
Issue: 10
Pages: 2749-71
Publication
First Author: Lohnes D
Year: 1994
Journal: Development
Title: Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants.
Volume: 120
Issue: 10
Pages: 2723-48
Publication
First Author: Wendling O
Year: 2001
Journal: Development
Title: Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning.
Volume: 128
Issue: 11
Pages: 2031-8
Publication
First Author: Werner P
Year: 1997
Journal: Genomics
Title: Physical and linkage mapping of human chromosome 17 loci to dog chromosomes 9 and 5.
Volume: 42
Issue: 1
Pages: 74-82
Publication
First Author: Chapellier B
Year: 2002
Journal: EMBO J
Title: Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled.
Volume: 21
Issue: 13
Pages: 3402-13
Publication
First Author: Gattu S
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity.
Volume: 116
Issue: 22
Pages: 10911-10916
Publication
First Author: Ghyselinck NB
Year: 1997
Journal: Int J Dev Biol
Title: Role of the retinoic acid receptor beta (RARbeta) during mouse development.
Volume: 41
Issue: 3
Pages: 425-47
Publication  
First Author: Lorberbaum DS
Year: 2020
Journal: Development
Title: Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human β cell specification.
Volume: 147
Issue: 12
Publication
First Author: Batourina E
Year: 2002
Journal: Nat Genet
Title: Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret.
Volume: 32
Issue: 1
Pages: 109-15
Publication
First Author: Nolting J
Year: 2009
Journal: J Exp Med
Title: Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines.
Volume: 206
Issue: 10
Pages: 2131-9
Publication
First Author: Subbarayan V
Year: 1997
Journal: Mech Dev
Title: Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms.
Volume: 66
Issue: 1-2
Pages: 131-42
Publication
First Author: Larange A
Year: 2023
Journal: Immunity
Title: A regulatory circuit controlled by extranuclear and nuclear retinoic acid receptor α determines T cell activation and function.
Volume: 56
Issue: 9
Pages: 2054-2069.e10
Publication
First Author: Kastner P
Year: 1997
Journal: Development
Title: Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development.
Volume: 124
Issue: 2
Pages: 313-26
Publication
First Author: Minkina A
Year: 2017
Journal: Dev Biol
Title: Retinoic acid signaling is dispensable for somatic development and function in the mammalian ovary.
Volume: 424
Issue: 2
Pages: 208-220
Publication
First Author: Bonney S
Year: 2016
Journal: J Neurosci
Title: Diverse Functions of Retinoic Acid in Brain Vascular Development.
Volume: 36
Issue: 29
Pages: 7786-801
Publication
First Author: Matt N
Year: 2008
Journal: Dev Biol
Title: Impairing retinoic acid signalling in the neural crest cells is sufficient to alter entire eye morphogenesis.
Volume: 320
Issue: 1
Pages: 140-8
Publication
First Author: Mascrez B
Year: 2001
Journal: Development
Title: Differential contributions of AF-1 and AF-2 activities to the developmental functions of RXR alpha.
Volume: 128
Issue: 11
Pages: 2049-62
Publication
First Author: Mascrez B
Year: 1998
Journal: Development
Title: The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development.
Volume: 125
Issue: 23
Pages: 4691-707
Publication
First Author: Li P
Year: 2012
Journal: Dev Biol
Title: Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesis.
Volume: 361
Issue: 1
Pages: 116-24
Publication
First Author: van Loenhout RB
Year: 2009
Journal: Neonatology
Title: Congenital diaphragmatic hernia: comparison of animal models and relevance to the human situation.
Volume: 96
Issue: 3
Pages: 137-49
Publication
First Author: Leroy P
Year: 1991
Journal: EMBO J
Title: Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid.
Volume: 10
Issue: 1
Pages: 59-69
Publication
First Author: Kruyt FA
Year: 1992
Journal: Differentiation
Title: Retinoic acid resistance of the variant embryonal carcinoma cell line RAC65 is caused by expression of a truncated RAR alpha.
Volume: 49
Issue: 1
Pages: 27-37
Publication
First Author: Braun KW
Year: 2002
Journal: Biol Reprod
Title: Positive regulation of retinoic acid receptor alpha by protein kinase C and mitogen-activated protein kinase in sertoli cells.
Volume: 67
Issue: 1
Pages: 29-37
Publication
First Author: Li E
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene.
Volume: 90
Issue: 4
Pages: 1590-4
Publication
First Author: Chapellier B
Year: 2002
Journal: Genesis
Title: A conditional floxed (loxP-flanked) allele for the retinoic acid receptor alpha (RARalpha) gene.
Volume: 32
Issue: 2
Pages: 87-90
Publication
First Author: Park E
Year: 2018
Journal: J Neurosci
Title: Postnatal Ablation of Synaptic Retinoic Acid Signaling Impairs Cortical Information Processing and Sensory Discrimination in Mice.
Volume: 38
Issue: 23
Pages: 5277-5288
Publication
First Author: Arendt KL
Year: 2015
Journal: Neuron
Title: Retinoic Acid and LTP Recruit Postsynaptic AMPA Receptors Using Distinct SNARE-Dependent Mechanisms.
Volume: 86
Issue: 2
Pages: 442-56
Publication
First Author: Hsu YT
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Synaptic retinoic acid receptor signaling mediates mTOR-dependent metaplasticity that controls hippocampal learning.
Volume: 116
Issue: 14
Pages: 7113-7122
Publication  
First Author: Sarti F
Year: 2012
Journal: Front Mol Neurosci
Title: Conditional RARα knockout mice reveal acute requirement for retinoic acid and RARα in homeostatic plasticity.
Volume: 5
Pages: 16
Publication
First Author: Hall JA
Year: 2011
Journal: Immunity
Title: Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha.
Volume: 34
Issue: 3
Pages: 435-47
Publication
First Author: Grisolano JL
Year: 1997
Journal: Blood
Title: Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences.
Volume: 89
Issue: 2
Pages: 376-87
Publication
First Author: Zhong Y
Year: 2011
Journal: PLoS One
Title: Novel retinoic acid receptor alpha agonists for treatment of kidney disease.
Volume: 6
Issue: 11
Pages: e27945
Publication
First Author: Rego EM
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins.
Volume: 97
Issue: 18
Pages: 10173-8
Publication
First Author: Kastner P
Year: 2001
Journal: Oncogene
Title: Function of RARalpha during the maturation of neutrophils.
Volume: 20
Issue: 49
Pages: 7178-85
Publication
First Author: Piazza F
Year: 2001
Journal: Oncogene
Title: The theory of APL.
Volume: 20
Issue: 49
Pages: 7216-22
Publication
First Author: Haidar MA
Year: 2000
Journal: Int J Oncol
Title: Downregulation of the p53 tumor suppressor gene and upregulation of the bcl-2 gene in retinoic acid receptor alpha-deficient transgenic mice.
Volume: 16
Issue: 3
Pages: 561-5
Publication
First Author: Pratt MA
Year: 1993
Journal: Differentiation
Title: Retinoic acid fails to induce expression of Hox genes in differentiation-defective murine embryonal carcinoma cells carrying a mutant gene for alpha retinoic acid receptor.
Volume: 53
Issue: 2
Pages: 105-13
Publication
First Author: Chytil F
Year: 1996
Journal: FASEB J
Title: Retinoids in lung development.
Volume: 10
Issue: 9
Pages: 986-92
Publication
First Author: Attar PS
Year: 1997
Journal: Mol Endocrinol
Title: Inhibition of retinoid signaling in transgenic mice alters lipid processing and disrupts epidermal barrier function.
Volume: 11
Issue: 6
Pages: 792-800
Publication
First Author: He LZ
Year: 1999
Journal: Oncogene
Title: In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications.
Volume: 18
Issue: 38
Pages: 5278-92
Publication
First Author: Weston AD
Year: 2002
Journal: J Cell Biol
Title: Requirement for RAR-mediated gene repression in skeletal progenitor differentiation.
Volume: 158
Issue: 1
Pages: 39-51
Publication
First Author: Yang L
Year: 2003
Journal: Endocrinology
Title: Overexpression of dominant negative retinoic acid receptor alpha causes alveolar abnormality in transgenic neonatal lungs.
Volume: 144
Issue: 7
Pages: 3004-11
Publication
First Author: Walkley CR
Year: 2004
Journal: Blood
Title: Identification of the molecular requirements for an RAR alpha-mediated cell cycle arrest during granulocytic differentiation.
Volume: 103
Issue: 4
Pages: 1286-95
Publication
First Author: Gaub MP
Year: 1992
Journal: Exp Cell Res
Title: Immunodetection of multiple species of retinoic acid receptor alpha: evidence for phosphorylation.
Volume: 201
Issue: 2
Pages: 335-46
Publication
First Author: Wang YA
Year: 2005
Journal: Dev Dyn
Title: Retinoic acid signaling is required for proper morphogenesis of mammary gland.
Volume: 234
Issue: 4
Pages: 892-9
Publication  
First Author: Kupumbati TS
Year: 2006
Journal: Mol Cancer
Title: Dominant negative retinoic acid receptor initiates tumor formation in mice.
Volume: 5
Pages: 12
Publication
First Author: Matsushita H
Year: 2006
Journal: J Exp Med
Title: In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia.
Volume: 203
Issue: 4
Pages: 821-8
Publication
First Author: Epping MT
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors.
Volume: 104
Issue: 45
Pages: 17777-82
Publication
First Author: Lu Y
Year: 2010
Journal: Oncogene
Title: Mechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARalpha agonist AM580.
Volume: 29
Issue: 25
Pages: 3665-76
Publication  
First Author: Zhu S
Year: 2016
Journal: J Mol Cell Cardiol
Title: Loss of myocardial retinoic acid receptor α induces diastolic dysfunction by promoting intracellular oxidative stress and calcium mishandling in adult mice.
Volume: 99
Pages: 100-112
Publication  
First Author: Yuan X
Year: 2021
Journal: Front Immunol
Title: Short-Chain Fatty Acids Calibrate RARα Activity Regulating Food Sensitization.
Volume: 12
Pages: 737658
Publication
First Author: Suzuki K
Year: 2021
Journal: Cell Rep
Title: Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action.
Volume: 37
Issue: 5
Pages: 109918
Publication
First Author: Komori R
Year: 2013
Journal: PLoS One
Title: Csn3 gene is regulated by all-trans retinoic acid during neural differentiation in mouse P19 cells.
Volume: 8
Issue: 4
Pages: e61938
Publication
First Author: Marino D
Year: 2011
Journal: J Vasc Res
Title: A role for all-trans-retinoic acid in the early steps of lymphatic vasculature development.
Volume: 48
Issue: 3
Pages: 236-51
Publication
First Author: Hashimoto-Hill S
Year: 2018
Journal: Nat Commun
Title: RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells.
Volume: 9
Issue: 1
Pages: 3896
Publication
First Author: Bourguet W
Year: 2000
Journal: Mol Cell
Title: Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains.
Volume: 5
Issue: 2
Pages: 289-98
Publication
First Author: Taneja R
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types.
Volume: 92
Issue: 17
Pages: 7854-8
Publication
First Author: Galdones E
Year: 2006
Journal: Birth Defects Res A Clin Mol Teratol
Title: Role of retinoic acid receptors alpha1 and gamma in the response of murine limbs to retinol in vitro.
Volume: 76
Issue: 1
Pages: 39-45