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Search results 1 to 100 out of 211 for S100a4

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Category: Publication
Type Details Score
Publication
First Author: Li ZH
Year: 2010
Journal: Mol Biol Cell
Title: S100A4 regulates macrophage chemotaxis.
Volume: 21
Issue: 15
Pages: 2598-610
Publication
First Author: Zhang J
Year: 2018
Journal: Oncoimmunology
Title: S100A4 promotes colon inflammation and colitis-associated colon tumorigenesis.
Volume: 7
Issue: 8
Pages: e1461301
Publication
First Author: Barraclough R
Year: 1998
Journal: Biochim Biophys Acta
Title: Calcium-binding protein S100A4 in health and disease.
Volume: 1448
Issue: 2
Pages: 190-9
Publication    
First Author: Ackerman JE
Year: 2019
Journal: Elife
Title: Cell non-autonomous functions of S100a4 drive fibrotic tendon healing.
Volume: 8
Publication
First Author: Zhang J
Year: 2018
Journal: Oncoimmunology
Title: S100A4 blockage alleviates agonistic anti-CD137 antibody-induced liver pathology without disruption of antitumor immunity.
Volume: 7
Issue: 4
Pages: e1296996
Publication  
First Author: Doroudgar S
Year: 2016
Journal: J Mol Cell Cardiol
Title: S100A4 protects the myocardium against ischemic stress.
Volume: 100
Pages: 54-63
Publication
First Author: Wu Y
Year: 2018
Journal: Biol Reprod
Title: S100A4 promotes the development of lipopolysaccharide-induced mouse endometritis.
Volume: 99
Issue: 5
Pages: 960-967
Publication  
First Author: Dmytriyeva O
Year: 2012
Journal: Nat Commun
Title: The metastasis-promoting S100A4 protein confers neuroprotection in brain injury.
Volume: 3
Pages: 1197
Publication
First Author: Wu Y
Year: 2020
Journal: Biol Reprod
Title: S100A4 promotes the progression of lipopolysaccharide-induced acute epididymitis in mice†.
Volume: 102
Issue: 6
Pages: 1213-1224
Publication
First Author: Hou S
Year: 2018
Journal: Lab Invest
Title: S100A4 protects mice from high-fat diet-induced obesity and inflammation.
Volume: 98
Issue: 8
Pages: 1025-1038
Publication
First Author: Li Y
Year: 2020
Journal: Oncoimmunology
Title: S100A4 promotes hepatocellular carcinogenesis by intensifying fibrosis-associated cancer cell stemness.
Volume: 9
Issue: 1
Pages: 1725355
Publication
First Author: Chow KH
Year: 2017
Journal: Cancer Res
Title: S100A4 Is a Biomarker and Regulator of Glioma Stem Cells That Is Critical for Mesenchymal Transition in Glioblastoma.
Volume: 77
Issue: 19
Pages: 5360-5373
Publication  
First Author: Li Q
Year: 2018
Journal: Front Immunol
Title: S100A4 Protects Myeloid-Derived Suppressor Cells from Intrinsic Apoptosis via TLR4-ERK1/2 Signaling.
Volume: 9
Pages: 388
Publication  
First Author: Sun JB
Year: 2017
Journal: Front Immunol
Title: Deficiency in Calcium-Binding Protein S100A4 Impairs the Adjuvant Action of Cholera Toxin.
Volume: 8
Pages: 1119
Publication
First Author: Tarabykina S
Year: 2000
Journal: FEBS Lett
Title: Heterocomplex formation between metastasis-related protein S100A4 (Mts1) and S100A1 as revealed by the yeast two-hybrid system.
Volume: 475
Issue: 3
Pages: 187-91
Publication
First Author: Davies MP
Year: 1996
Journal: Oncogene
Title: Expression of the calcium-binding protein S100A4 (p9Ka) in MMTV-neu transgenic mice induces metastasis of mammary tumours.
Volume: 13
Issue: 8
Pages: 1631-7
Publication
First Author: Southern BD
Year: 2024
Journal: J Biol Chem
Title: A novel mechanoeffector role of fibroblast S100A4 in myofibroblast transdifferentiation and fibrosis.
Volume: 300
Issue: 1
Pages: 105530
Publication
First Author: Kunimura K
Year: 2019
Journal: Cell Rep
Title: S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer's Patches.
Volume: 29
Issue: 9
Pages: 2823-2834.e7
Publication
First Author: Grum-Schwensen B
Year: 2010
Journal: Cancer Res
Title: Lung metastasis fails in MMTV-PyMT oncomice lacking S100A4 due to a T-cell deficiency in primary tumors.
Volume: 70
Issue: 3
Pages: 936-47
Publication
First Author: Zhang J
Year: 2017
Journal: Sci Rep
Title: S100A4 contributes to colitis development by increasing the adherence of Citrobacter rodentium in intestinal epithelial cells.
Volume: 7
Issue: 1
Pages: 12099
Publication
First Author: Erlandsson MC
Year: 2013
Journal: Biochim Biophys Acta
Title: Expression of metastasin S100A4 is essential for bone resorption and regulates osteoclast function.
Volume: 1833
Issue: 12
Pages: 2653-2663
Publication
First Author: Bian L
Year: 2011
Journal: J Infect Dis
Title: S100A4 deficiency is associated with efficient bacterial clearance and protects against joint destruction during Staphylococcal infection.
Volume: 204
Issue: 5
Pages: 722-30
Publication
First Author: Erlandsson MC
Year: 2013
Journal: Mol Endocrinol
Title: Metastasin S100A4 is a mediator of sex hormone-dependent formation of the cortical bone.
Volume: 27
Issue: 8
Pages: 1311-21
Publication  
First Author: Tamaki Y
Year: 2013
Journal: J Mol Cell Cardiol
Title: Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts.
Volume: 57
Pages: 72-81
Publication
First Author: Bruhn S
Year: 2014
Journal: Sci Transl Med
Title: A generally applicable translational strategy identifies S100A4 as a candidate gene in allergy.
Volume: 6
Issue: 218
Pages: 218ra4
Publication
First Author: Brisslert M
Year: 2014
Journal: Biochim Biophys Acta
Title: S100A4 regulates the Src-tyrosine kinase dependent differentiation of Th17 cells in rheumatoid arthritis.
Volume: 1842
Issue: 11
Pages: 2049-59
Publication
First Author: Milani M
Year: 2021
Journal: J Neuroinflammation
Title: Targeting S100A4 with niclosamide attenuates inflammatory and profibrotic pathways in models of amyotrophic lateral sclerosis.
Volume: 18
Issue: 1
Pages: 132
Publication
First Author: Yuan Q
Year: 2019
Journal: J Mol Med (Berl)
Title: S100A4 promotes inflammation but suppresses lipid accumulation via the STAT3 pathway in chronic ethanol-induced fatty liver.
Volume: 97
Issue: 10
Pages: 1399-1412
Publication  
First Author: Atlasi Y
Year: 2016
Journal: Eur J Cancer
Title: The role of S100a4 (Mts1) in Apc- and Smad4-driven tumour onset and progression.
Volume: 68
Pages: 114-124
Publication  
First Author: Braumann S
Year: 2018
Journal: Front Physiol
Title: S100A4 as a Target of the E3-Ligase Asb2β and Its Effect on Engineered Heart Tissue.
Volume: 9
Pages: 1292
Publication
First Author: Siddique HR
Year: 2013
Journal: Genes Cancer
Title: The S100A4 Oncoprotein Promotes Prostate Tumorigenesis in a Transgenic Mouse Model: Regulating NFĪŗB through the RAGE Receptor.
Volume: 4
Issue: 5-6
Pages: 224-34
Publication
First Author: Maddala R
Year: 2021
Journal: Sci Rep
Title: Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract.
Volume: 11
Issue: 1
Pages: 2203
Publication
First Author: Takenaga K
Year: 1997
Journal: Oncogene
Title: Expression of antisense RNA to S100A4 gene encoding an S100-related calcium-binding protein suppresses metastatic potential of high-metastatic Lewis lung carcinoma cells.
Volume: 14
Issue: 3
Pages: 331-7
Publication
First Author: Rivard CJ
Year: 2007
Journal: J Biol Chem
Title: Expression of the calcium-binding protein S100A4 is markedly up-regulated by osmotic stress and is involved in the renal osmoadaptive response.
Volume: 282
Issue: 9
Pages: 6644-52
Publication
First Author: Zhang YH
Year: 2018
Journal: Yonsei Med J
Title: S100A4 Gene is Crucial for Methionine-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice.
Volume: 59
Issue: 9
Pages: 1064-1071
Publication
First Author: Zhang J
Year: 2013
Journal: Cancer Res
Title: Fibroblast-specific protein 1/S100A4-positive cells prevent carcinoma through collagen production and encapsulation of carcinogens.
Volume: 73
Issue: 9
Pages: 2770-81
Publication
First Author: Jiao J
Year: 2018
Journal: Exp Mol Med
Title: Depletion of S100A4+ stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors.
Volume: 50
Issue: 1
Pages: e422
Publication  
First Author: Sun L
Year: 2015
Journal: Sci Rep
Title: FSP1(+) fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells.
Volume: 5
Pages: 14871
Publication
First Author: O'Connell JT
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization.
Volume: 108
Issue: 38
Pages: 16002-7
Publication
First Author: Zhang H
Year: 2022
Journal: Eur J Immunol
Title: Dysfunction of S100A4+ effector memory CD8+ T cells aggravates asthma.
Volume: 52
Issue: 6
Pages: 978-993
Publication
First Author: Weatherly K
Year: 2015
Journal: Immun Inflamm Dis
Title: Functional profile of S100A4-deficient T cells.
Volume: 3
Issue: 4
Pages: 431-44
Publication
First Author: Grum-Schwensen B
Year: 2005
Journal: Cancer Res
Title: Suppression of tumor development and metastasis formation in mice lacking the S100A4(mts1) gene.
Volume: 65
Issue: 9
Pages: 3772-80
Publication
First Author: Ambartsumian NS
Year: 1996
Journal: Oncogene
Title: Metastasis of mammary carcinomas in GRS/A hybrid mice transgenic for the mts1 gene.
Volume: 13
Issue: 8
Pages: 1621-30
Publication
First Author: Vouyiouklis DA
Year: 2002
Journal: Genomics
Title: Mapping of the dysmyelinating murine Hindshaker mutation to a 1.2-cM interval on chromosome 3.
Volume: 80
Issue: 2
Pages: 126-8
Publication
First Author: Simpson PT
Year: 2003
Journal: Int J Exp Pathol
Title: Examination of tumour histopathology and gene expression in a neu/S100A4 transgenic model of metastatic breast cancer.
Volume: 84
Issue: 4
Pages: 173-84
Publication  
First Author: Li Y
Year: 2018
Journal: Front Immunol
Title: S100A4+ Macrophages Are Necessary for Pulmonary Fibrosis by Activating Lung Fibroblasts.
Volume: 9
Pages: 1776
Publication
First Author: EL Naaman C
Year: 2004
Journal: Oncogene
Title: Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene.
Volume: 23
Issue: 20
Pages: 3670-80
Publication
First Author: MĆøller HD
Year: 2011
Journal: Mol Cancer Res
Title: Role of fibulin-5 in metastatic organ colonization.
Volume: 9
Issue: 5
Pages: 553-63
Publication
First Author: Kim YM
Year: 2011
Journal: Am J Pathol
Title: Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions.
Volume: 179
Issue: 3
Pages: 1560-72
Publication  
First Author: Grum-Schwensen B
Year: 2015
Journal: BMC Cancer
Title: S100A4-neutralizing antibody suppresses spontaneous tumor progression, pre-metastatic niche formation and alters T-cell polarization balance.
Volume: 15
Pages: 44
Publication
First Author: Yang W
Year: 2020
Journal: PLoS Pathog
Title: S100A4+ macrophages facilitate zika virus invasion and persistence in the seminiferous tubules via interferon-gamma mediation.
Volume: 16
Issue: 12
Pages: e1009019
Publication
First Author: Li A
Year: 2023
Journal: Angiogenesis
Title: S100A4-dependent glycolysis promotes lymphatic vessel sprouting in tumor.
Volume: 26
Issue: 1
Pages: 19-36
Publication
First Author: Ito M
Year: 2001
Journal: J Invest Dermatol
Title: Expression of calcium-binding S100 proteins A4 and A6 in regions of the epithelial sac associated with the onset of hair follicle regeneration.
Volume: 116
Issue: 6
Pages: 956-63
Publication  
First Author: Studentsova V
Year: 2019
Journal: Bone Rep
Title: Insulin Receptor deletion in S100a4-lineage cells accelerates age-related bone loss.
Volume: 10
Pages: 100197
Publication
First Author: Daub B
Year: 2003
Journal: Cell Calcium
Title: Expression of members of the S100 Ca2+-binding protein family in guinea-pig smooth muscle.
Volume: 33
Issue: 1
Pages: 1-10
Publication
First Author: Ridinger K
Year: 1998
Journal: Biochim Biophys Acta
Title: Clustered organization of S100 genes in human and mouse.
Volume: 1448
Issue: 2
Pages: 254-63
Publication
First Author: Jackson-Grusby LL
Year: 1987
Journal: Nucleic Acids Res
Title: A growth-related mRNA in cultured mouse cells encodes a placental calcium binding protein.
Volume: 15
Issue: 16
Pages: 6677-90
Publication
First Author: Goto K
Year: 1988
Journal: J Biochem
Title: Cloning of the sequences expressed abundantly in established cell lines: identification of a cDNA clone highly homologous to S-100, a calcium binding protein.
Volume: 103
Issue: 1
Pages: 48-53
Publication
First Author: Ebralidze A
Year: 1989
Journal: Genes Dev
Title: Isolation and characterization of a gene specifically expressed in different metastatic cells and whose deduced gene product has a high degree of homology to a Ca2+-binding protein family.
Volume: 3
Issue: 7
Pages: 1086-93
Publication
First Author: Tulchinsky EM
Year: 1990
Journal: Gene
Title: Structure of gene mts1, transcribed in metastatic mouse tumor cells.
Volume: 87
Issue: 2
Pages: 219-23
Publication
First Author: Tulchinsky E
Year: 1993
Journal: Oncogene
Title: Characterization of a positive regulatory element in the mts1 gene.
Volume: 8
Issue: 1
Pages: 79-86
Publication
First Author: Kriajevska MV
Year: 1994
Journal: J Biol Chem
Title: Non-muscle myosin heavy chain as a possible target for protein encoded by metastasis-related mts-1 gene.
Volume: 269
Issue: 31
Pages: 19679-82
Publication
First Author: Sikandar SS
Year: 2017
Journal: Nat Commun
Title: Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis.
Volume: 8
Issue: 1
Pages: 1669
Publication
First Author: Ɩsterreicher CH
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver.
Volume: 108
Issue: 1
Pages: 308-13
Publication
First Author: Xue C
Year: 2003
Journal: Cancer Res
Title: The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis.
Volume: 63
Issue: 12
Pages: 3386-94
Publication  
First Author: Ambartsumian N
Journal: Invasion Metastasis
Title: Tissue-specific posttranscriptional downregulation of expression of the S100A4(mts1) gene in transgenic animals.
Volume: 18
Issue: 2
Pages: 96-104
Publication  
First Author: Dempsie Y
Year: 2011
Journal: Respir Res
Title: Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females.
Volume: 12
Pages: 159
Publication
First Author: Ambartsumian N
Year: 2001
Journal: Oncogene
Title: The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor.
Volume: 20
Issue: 34
Pages: 4685-95
Publication
First Author: Dutta K
Year: 2002
Journal: Biochemistry
Title: Calcium coordination studies of the metastatic Mts1 protein.
Volume: 41
Issue: 13
Pages: 4239-45
Publication
First Author: Tulchinsky E
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Transcriptional analysis of the mts1 gene with specific reference to 5' flanking sequences.
Volume: 89
Issue: 19
Pages: 9146-50
Publication
First Author: Grigorian MS
Year: 1993
Journal: Gene
Title: The mts1 gene and control of tumor metastasis.
Volume: 135
Issue: 1-2
Pages: 229-38
Publication
First Author: Herzog CR
Year: 1994
Journal: Cancer Res
Title: Deletion mapping of a putative tumor suppressor gene on chromosome 4 in mouse lung tumors.
Volume: 54
Issue: 15
Pages: 4007-10
Publication
First Author: Cajone F
Year: 1994
Journal: Melanoma Res
Title: Metastasis-associated mts1 gene expression is down-regulated by heat shock in variant cell lines of the B16 murine melanoma.
Volume: 4
Issue: 3
Pages: 143-50
Publication
First Author: Zimmer DB
Year: 1995
Journal: Brain Res Bull
Title: The S100 protein family: history, function, and expression.
Volume: 37
Issue: 4
Pages: 417-29
Publication
First Author: Davies M
Year: 1995
Journal: DNA Cell Biol
Title: Expression of the rat, S-100-related, calcium-binding protein gene, p9Ka, in transgenic mice demonstrates different patterns of expression between these two species.
Volume: 14
Issue: 10
Pages: 825-32
Publication
First Author: SchƤfer BW
Year: 1996
Journal: Trends Biochem Sci
Title: The S100 family of EF-hand calcium-binding proteins: functions and pathology.
Volume: 21
Issue: 4
Pages: 134-40
Publication
First Author: Grigorian M
Year: 1996
Journal: Int J Cancer
Title: Effect of mts1 (S100A4) expression on the progression of human breast cancer cells.
Volume: 67
Issue: 6
Pages: 831-41
Publication
First Author: Tulchinsky E
Year: 1997
Journal: J Biol Chem
Title: A kappaB-related binding site is an integral part of the mts1 gene composite enhancer element located in the first intron of the gene.
Volume: 272
Issue: 8
Pages: 4828-35
Publication
First Author: Klingelhƶfer J
Year: 1997
Journal: Dev Dyn
Title: Expression of the metastasis-associated mts1 gene during mouse development.
Volume: 210
Issue: 2
Pages: 87-95
Publication
First Author: Albertazzi E
Year: 1998
Journal: DNA Cell Biol
Title: Heat shock modulates the expression of the metastasis associated gene MTS1 and proliferation of murine and human cancer cells.
Volume: 17
Issue: 1
Pages: 1-7
Publication
First Author: Keirsebilck A
Year: 1998
Journal: Cancer Res
Title: E-cadherin and metastasin (mts-1/S100A4) expression levels are inversely regulated in two tumor cell families.
Volume: 58
Issue: 20
Pages: 4587-91
Publication
First Author: Jie Z
Year: 2017
Journal: J Immunol
Title: Retinoic Acid Regulates Immune Responses by Promoting IL-22 and Modulating S100 Proteins in Viral Hepatitis.
Volume: 198
Issue: 9
Pages: 3448-3460
Publication  
First Author: Chen X
Year: 2024
Journal: Redox Biol
Title: SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of FSP1.
Volume: 75
Pages: 103267
Publication
First Author: Strutz F
Year: 1995
Journal: J Cell Biol
Title: Identification and characterization of a fibroblast marker: FSP1.
Volume: 130
Issue: 2
Pages: 393-405
Publication
First Author: Hjelmsoe I
Year: 2000
Journal: J Biol Chem
Title: The kappaB and V(D)J recombination signal sequence binding protein KRC regulates transcription of the mouse metastasis-associated gene S100A4/mts1.
Volume: 275
Issue: 2
Pages: 913-20
Publication
First Author: Luo J
Year: 2015
Journal: Endocrinology
Title: FSP-1 Impairs the Function of Endothelium Leading to Failure of Arteriovenous Grafts in Diabetic Mice.
Volume: 156
Issue: 6
Pages: 2200-10
Publication  
First Author: Wu Y
Year: 2023
Journal: Cells
Title: Notch Blockade Specifically in Bone Marrow-Derived FSP-1-Positive Cells Ameliorates Renal Fibrosis.
Volume: 12
Issue: 2
Publication  
First Author: Chen J
Year: 2019
Journal: Int J Mol Sci
Title: The Potential of the FSP1cre-Pparb/d-/- Mouse Model for Studying Juvenile NAFLD.
Volume: 20
Issue: 20
Publication
First Author: Spiekerkoetter E
Year: 2008
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin.
Volume: 294
Issue: 2
Pages: L276-89
Publication
First Author: Dorin JR
Year: 1990
Journal: Genomics
Title: Related calcium-binding proteins map to the same subregion of chromosome 1q and to an extended region of synteny on mouse chromosome 3.
Volume: 8
Issue: 3
Pages: 420-6
Publication
First Author: Parker C
Year: 1994
Journal: DNA Cell Biol
Title: Metastasis-associated mts1 gene expression correlates with increased p53 detection in the B16 murine melanoma.
Volume: 13
Issue: 4
Pages: 343-51
Publication
First Author: Lakshmi MS
Year: 1997
Journal: Anticancer Res
Title: Expression of the transmembrane glycoprotein CD44 and metastasis associated 18A2/MTS1 gene in B16 murine melanoma cells.
Volume: 17
Issue: 5A
Pages: 3451-5
Publication
First Author: Sundberg JP
Year: 2020
Journal: PLoS One
Title: Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.
Volume: 15
Issue: 7
Pages: e0235295
Publication  
First Author: Philcox JC
Year: 1995
Journal: Biochem J
Title: Endotoxin-induced inflammation does not cause hepatic zinc accumulation in mice lacking metallothionein gene expression.
Volume: 308 ( Pt 2)
Pages: 543-6
Publication
First Author: Davis JL
Year: 2021
Journal: PLoS One
Title: Constitutive activation of NF-ĪŗB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma.
Volume: 16
Issue: 7
Pages: e0254426
Publication
First Author: Parker C
Year: 1992
Journal: Melanoma Res
Title: Modulators of intracellular Ca2+ and the calmodulin inhibitor W-7 alter the expression of metastasis-associated genes MTS1 and NM23 in metastatic variants of the B16 murine melanoma.
Volume: 2
Issue: 5-6
Pages: 337-43
Publication  
First Author: Raftery MJ
Year: 1996
Journal: Biochem J
Title: Isolation of the murine S100 protein MRP14 (14 kDa migration-inhibitory-factor-related protein) from activated spleen cells: characterization of post-translational modifications and zinc binding.
Volume: 316 ( Pt 1)
Pages: 285-93
Publication
First Author: Ueda S
Year: 1994
Journal: Brain Res
Title: Neuro-glial neurotrophic interaction in the S-100 beta retarded mutant mouse (Polydactyly Nagoya). I. Immunocytochemical and neurochemical studies.
Volume: 633
Issue: 1-2
Pages: 275-83
Publication
First Author: Zhang R
Year: 2018
Journal: PLoS Biol
Title: FSP1-positive fibroblasts are adipogenic niche and regulate adipose homeostasis.
Volume: 16
Issue: 8
Pages: e2001493
Publication
First Author: Liang M
Year: 2015
Journal: Kidney Int
Title: Migration of smooth muscle cells from the arterial anastomosis of arteriovenous fistulas requires Notch activation to form neointima.
Volume: 88
Issue: 3
Pages: 490-502