| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Acyl-coenzyme A thioesterases hydrolyse acyl-CoA to generate free fatty acid and coenzyme A. Acyl-coenzyme A thioesterase 13 (ACOT13) acts on medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Naturally, it exists as a homotetramer and adopts a hotdog fold []. Homologues are found in eukaryotes and bacteria. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
140
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
140
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cao J |
| Year: |
2009 |
| Journal: |
Biochemistry |
| Title: |
The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. |
| Volume: |
48 |
| Issue: |
6 |
| Pages: |
1293-304 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bekeova C |
| Year: |
2019 |
| Journal: |
J Biol Chem |
| Title: |
Multiple mitochondrial thioesterases have distinct tissue and substrate specificity and CoA regulation, suggesting unique functional roles. |
| Volume: |
294 |
| Issue: |
50 |
| Pages: |
19034-19047 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kang HW |
| Year: |
2012 |
| Journal: |
FASEB J |
| Title: |
Thioesterase superfamily member 2/acyl-CoA thioesterase 13 (Them2/Acot13) regulates hepatic lipid and glucose metabolism. |
| Volume: |
26 |
| Issue: |
5 |
| Pages: |
2209-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kang HW |
| Year: |
2013 |
| Journal: |
J Biol Chem |
| Title: |
Thioesterase superfamily member 2/Acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in mice. |
| Volume: |
288 |
| Issue: |
46 |
| Pages: |
33376-86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alves-Bezerra M |
| Year: |
2019 |
| Journal: |
Hepatology |
| Title: |
Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids Into Triglyceride Biosynthesis. |
| Volume: |
70 |
| Issue: |
2 |
| Pages: |
496-510 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1671523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_15 |
|
| Specimen Label: |
euxassay_001075_15 |
| Detected: |
true |
| Specimen Num: |
13 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1671523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_16 |
|
| Specimen Label: |
euxassay_001075_16 |
| Detected: |
true |
| Specimen Num: |
14 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1671523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_17 |
|
| Specimen Label: |
euxassay_001075_17 |
| Detected: |
true |
| Specimen Num: |
15 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1768123 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_03 |
|
| Specimen Label: |
euxassay_001075_03 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1768123 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_04 |
|
| Specimen Label: |
euxassay_001075_04 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1768123 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_05 |
|
| Specimen Label: |
euxassay_001075_05 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1768123 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_06 |
|
| Specimen Label: |
euxassay_001075_06 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1768123 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_07 |
|
| Specimen Label: |
euxassay_001075_07 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1768123 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_08 |
|
| Specimen Label: |
euxassay_001075_08 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1768123 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_09 |
|
| Specimen Label: |
euxassay_001075_09 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1768123 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_10 |
|
| Specimen Label: |
euxassay_001075_10 |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1625523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_07 |
|
| Specimen Label: |
euxassay_001075_07 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1625523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_08 |
|
| Specimen Label: |
euxassay_001075_08 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1625523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_09 |
|
| Specimen Label: |
euxassay_001075_09 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1625523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_10 |
|
| Specimen Label: |
euxassay_001075_10 |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1625523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_11 |
|
| Specimen Label: |
euxassay_001075_11 |
| Detected: |
true |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1625523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_12 |
|
| Specimen Label: |
euxassay_001075_12 |
| Detected: |
true |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1625523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_13 |
|
| Specimen Label: |
euxassay_001075_13 |
| Detected: |
true |
| Specimen Num: |
11 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1625523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_14 |
|
| Specimen Label: |
euxassay_001075_14 |
| Detected: |
true |
| Specimen Num: |
12 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1625523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_15 |
|
| Specimen Label: |
euxassay_001075_15 |
| Detected: |
true |
| Specimen Num: |
13 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1625523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_16 |
|
| Specimen Label: |
euxassay_001075_16 |
| Detected: |
true |
| Specimen Num: |
14 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1000099 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1625523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822925 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_001075_17 |
|
| Specimen Label: |
euxassay_001075_17 |
| Detected: |
true |
| Specimen Num: |
15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nicholls HT |
| Year: |
2017 |
| Journal: |
Am J Physiol Gastrointest Liver Physiol |
| Title: |
Phosphatidylcholine transfer protein/StarD2 promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis. |
| Volume: |
313 |
| Issue: |
1 |
| Pages: |
G50-G61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ersoy BA |
| Year: |
2013 |
| Journal: |
Sci Signal |
| Title: |
Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. |
| Volume: |
6 |
| Issue: |
286 |
| Pages: |
ra64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ersoy BA |
| Year: |
2018 |
| Journal: |
J Clin Invest |
| Title: |
Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress. |
| Volume: |
128 |
| Issue: |
1 |
| Pages: |
141-156 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawano Y |
| Year: |
2014 |
| Journal: |
Mol Cell Biol |
| Title: |
Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization. |
| Volume: |
34 |
| Issue: |
13 |
| Pages: |
2396-408 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tillander V |
| Year: |
2019 |
| Journal: |
J Biol Chem |
| Title: |
Thioesterase superfamily member 2 promotes hepatic insulin resistance in the setting of glycerol-3-phosphate acyltransferase 1-induced steatosis. |
| Volume: |
294 |
| Issue: |
6 |
| Pages: |
2009-2020 |
|
•
•
•
•
•
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