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Search results 1 to 100 out of 103 for Ascc3

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
10973 | ASCC3
Type: gene
Organism: human
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Gene
448036 | ascc3
Type: gene
Organism: frog, western clawed
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Gene
309887 | Ascc3
Type: gene
Organism: rat
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Gene
475008 | ASCC3
Type: gene
Organism: dog, domestic
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Gene
462898 | ASCC3
Type: gene
Organism: chimpanzee
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Gene
538416 | ASCC3
Type: gene
Organism: cattle
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Gene
421790 | ASCC3
Type: gene
Organism: chicken
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Gene
100332599 | ascc3
Type: gene
Organism: zebrafish
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Gene
695429 | ASCC3
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1925237 | Ascc3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0015302 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
ENSMUSG00200006613 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00195002726 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00220005602 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00180011366 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00175009874 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1925237 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00215001982 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSTCUG00005008410 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00210008192 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00185003200 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00205004598 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00230005221 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSUMUG00000016978 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00190005373 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00225022059 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSLUMG00010004547 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSIUOG00005014445 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030719 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
ENSMSPG00010012354 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:6115800
Assay Type: RT-PCR
Annotation Date: 2018-02-13
Strength: Present
Sex: Female
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:6115895
Age: embryonic day 10.5
Image: S6
Specimen Label: WT-F
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6115800
Assay Type: RT-PCR
Annotation Date: 2018-02-13
Strength: Present
Sex: Female
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:6115895
Age: embryonic day 10.5
Image: S6
Specimen Label: KO-F
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6115800
Assay Type: RT-PCR
Annotation Date: 2018-02-13
Strength: Present
Sex: Female
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:6115900
Age: embryonic day 18.5
Image: S6
Specimen Label: WT-F
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6115800
Assay Type: RT-PCR
Annotation Date: 2018-02-13
Strength: Present
Sex: Female
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:6115900
Age: embryonic day 18.5
Image: S6
Specimen Label: KO-F
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6115800
Assay Type: RT-PCR
Annotation Date: 2018-02-13
Strength: Present
Sex: Male
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:6115901
Age: embryonic day 18.5
Image: S6
Specimen Label: WT-M
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6115800
Assay Type: RT-PCR
Annotation Date: 2018-02-13
Strength: Present
Sex: Male
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:6115901
Age: embryonic day 18.5
Image: S6
Specimen Label: KO-M
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6115800
Assay Type: RT-PCR
Annotation Date: 2018-02-13
Strength: Present
Sex: Male
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:6115902
Age: embryonic day 10.5
Image: S6
Specimen Label: WT-M
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6115800
Assay Type: RT-PCR
Annotation Date: 2018-02-13
Strength: Present
Sex: Male
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:6115902
Age: embryonic day 10.5
Image: S6
Specimen Label: KO-M
Detected: true
Specimen Num: 2
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Publication
28609438 | J:246912
First Author: Ye A
Year: 2017
Journal: PLoS One
Title: PEG3 control on the mammalian MSL complex.
Volume: 12
Issue: 6
Pages: e0178363
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Publication
36551904 | J:342743
 
First Author: Meziane H
Year: 2022
Journal: Biomedicines
Title: Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.
Volume: 10
Issue: 12
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Publication
- | J:165965
     
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
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Publication
- | J:66660
       
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:384794
     
First Author: MGI and IMPC
Year: 2026
Journal: Database Release
Title: MGI Load of Molecular Notes for Endonuclease-Mediated (CRISPR) Alleles from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342609
       
First Author: UniProt
Year: 2021
Title: Electronic Gene Ontology annotations created by ARBA machine learning models
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:389486
     
First Author: Mouse Genome Informatics and Ensembl Genome Database Project
Year: 2026
Journal: Database Release
Title: MGI Strain Genome Feature and Gene Model Load from Ensembl.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Interaction Experiment
Geng J (2025)
Description: CRISPR activation of the ribosome-associated quality control factor ASCC3 ameliorates fragile X syndrome phenotypes in mice.
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Publication
22055184 | -
First Author: Dango S
Year: 2011
Journal: Mol Cell
Title: DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.
Volume: 44
Issue: 3
Pages: 373-84
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Publication
33139697 | -
First Author: Jia J
Year: 2020
Journal: Nat Commun
Title: The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations.
Volume: 11
Issue: 1
Pages: 5535
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Publication
41061044 | -
First Author: Geng J
Year: 2025
Journal: Sci Transl Med
Title: CRISPR activation of the ribosome-associated quality control factor ASCC3 ameliorates fragile X syndrome phenotypes in mice.
Volume: 17
Issue: 819
Pages: eadq3551
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Publication
35180429 | -
First Author: Stoneley M
Year: 2022
Journal: Mol Cell
Title: Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress.
Volume: 82
Issue: 8
Pages: 1557-1572.e7
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Publication
37092320 | -
First Author: Kito Y
Year: 2023
Journal: EMBO J
Title: The ASC-1 complex promotes translation initiation by scanning ribosomes.
Volume: 42
Issue: 12
Pages: e112869
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Publication
38366554 | -
First Author: Mi?cicka A
Year: 2024
Journal: Nucleic Acids Res
Title: Ribosomal collision is not a prerequisite for ZNF598-mediated ribosome ubiquitination and disassembly of ribosomal complexes by ASCC.
Volume: 52
Issue: 8
Pages: 4627-4643
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Protein Domain
IPR047538 | KH-I_ASCC1
Type: Domain
Description: This entry represents the type I KH RNA-binding domain of ASCC1 from animals.ASCC1, also called ASC-1 complex subunit p50, or Trip4 complex subunit p50, plays a role in DNA damage repair as component of the ASCC complex which consists of ASCC1, ASCC2 and ASCC3 subunits (p50, p100 and p200, respectively) [, ]. It is part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation []. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin []. ASCC1 may also play a role in the development of neuromuscular junction []. This protein has an RNA-binding KH domain fused to a 2H RNA-phosphoesterase [, ]and modulates the ASCC3 helicase recruitment to the ASCC complex during alkylation damage.
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Protein Domain
IPR009210 | ASCC1
Type: Family
Description: ASCC1, also called ASC-1 complex subunit p50, or Trip4 complex subunit p50, is essential for DNA damage repair as component of the ASCC complex which consists of ASCC1, ASCC2 and ASCC3 subunits (p50, p100 and p200, respectively) [, , ]. ASC-1 is also involved in ribosome assembly. The ASCC is required not only for dissociation of colliding 80S ribosomes but also for efficient translation initiation by scanning ribosomes at a subset of transcripts [, , ].In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin []. ASCC1 may also play a role in the development of neuromuscular junction [].This protein has an RNA-binding KH domain fused to a 2H RNA-phosphoesterase [, ]and modulates the ASCC3 helicase recruitment to the ASCC complex during alkylation damage.This entry also includes some uncharacterised proteins from fungi, such as the ASCC1 orthologue from S.pombe, C15D4.13c.
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Publication
19074642 | -
First Author: Almeida-Vega S
Year: 2009
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1.
Volume: 296
Issue: 2
Pages: G414-23
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Publication
12077347 | -
First Author: Jung DJ
Year: 2002
Journal: Mol Cell Biol
Title: Novel transcription coactivator complex containing activating signal cointegrator 1.
Volume: 22
Issue: 14
Pages: 5203-11
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Publication
29144457 | -
First Author: Brickner JR
Year: 2017
Journal: Nature
Title: A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.
Volume: 551
Issue: 7680
Pages: 389-393
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Publication
26924529 | J:231973
First Author: Knierim E
Year: 2016
Journal: Am J Hum Genet
Title: Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures.
Volume: 98
Issue: 3
Pages: 473-489
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Protein
Q9CVZ2
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: false
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Publication
29997253 | -
First Author: Soll JM
Year: 2018
Journal: J Biol Chem
Title: RNA ligase-like domain in activating signal cointegrator 1 complex subunit 1 (ASCC1) regulates ASCC complex function during alkylation damage.
Volume: 293
Issue: 35
Pages: 13524-13533
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Protein Domain
IPR052586 | ASCC2
Type: Family
Description: This family represents the activating signal cointegrator 1 complex subunit 2 (ASCC2), also known as ASC-1 complex subunit p100, and its yeast orthologue CUE3 (also known as RQT3). ASCC2 is a ubiquitin-binding protein involved in DNA repair and the rescue of stalled ribosomes [, , , ]. In mammals, it plays a role in DNA damage repair as a component of the ASCC complex, recruiting ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins []. It is also part of the ASC-1 complex that enhances NF-kappa-B, SRF, and AP1 transactivation []. Furthermore, ASCC2 and CUE3 are involved in the activation of the ribosome quality control (RQC) pathway, which degrades nascent peptide chains during problematic translation. They specifically recognise and bind ubiquitinated RPS20/uS10, promoting the recruitment of the RQT (ribosome quality control trigger) complex to stalled ribosomes, followed by their disassembly [, , ]. The interaction with ubiquitin is mediated by a CUE domain [].
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Protein
Q3UMX8
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: false
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Protein
Q9D8Z1
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
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Protein
Q91WR3
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: false
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Protein
Q3UG63
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Publication
32099016 | -
First Author: Hashimoto S
Year: 2020
Journal: Sci Rep
Title: Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells.
Volume: 10
Issue: 1
Pages: 3422
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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