| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
ATF4 belongs to the ATF/cAMP-response element-binding protein family. It is a transcriptional activator that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters [, ]. It plays a crucial role in the adaptation to stresses by regulating the transcription of many genes []. |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5000865 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2013-01-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3643723 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:5448215 |
| Age: |
embryonic day 15.5 |
| Image: |
4 Atf4 |
| Note: |
Expression was detected in cortical kidney mesenchyme. |
| Specimen Label: |
4 Atf4 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vallejo M |
| Year: |
1993 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. |
| Volume: |
90 |
| Issue: |
10 |
| Pages: |
4679-83 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5811605 |
| Assay Type: |
Western blot |
| Annotation Date: |
2016-12-09 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689420 |
|
| Stage: |
TS20 |
| Assay Id: |
MGI:5811619 |
| Age: |
embryonic day 12.0 |
| Image: |
S4 |
|
| Specimen Label: |
IP ATF4 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5811601 |
| Assay Type: |
Western blot |
| Annotation Date: |
2016-12-09 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689420 |
|
| Stage: |
TS20 |
| Assay Id: |
MGI:5811620 |
| Age: |
embryonic day 12.0 |
| Image: |
S4 |
|
| Specimen Label: |
IP ATF4 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
153
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
116
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
B'chir W |
| Year: |
2013 |
| Journal: |
Nucleic Acids Res |
| Title: |
The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression. |
| Volume: |
41 |
| Issue: |
16 |
| Pages: |
7683-99 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gachon F |
| Year: |
2002 |
| Journal: |
Virology |
| Title: |
Activation of HTLV-I transcription in the presence of Tax is independent of the acetylation of CREB-2 (ATF-4). |
| Volume: |
299 |
| Issue: |
2 |
| Pages: |
271-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang X |
| Year: |
2013 |
| Journal: |
Nat Med |
| Title: |
miR-214 targets ATF4 to inhibit bone formation. |
| Volume: |
19 |
| Issue: |
1 |
| Pages: |
93-100 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tanaka T |
| Year: |
1998 |
| Journal: |
Genes Cells |
| Title: |
Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres. |
| Volume: |
3 |
| Issue: |
12 |
| Pages: |
801-10 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
349
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
263
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
349
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
381
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
350
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li H |
| Year: |
2011 |
| Journal: |
Biochem J |
| Title: |
ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis. |
| Volume: |
438 |
| Issue: |
2 |
| Pages: |
283-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sobajima M |
| Year: |
2022 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion. |
| Volume: |
611 |
|
| Pages: |
165-171 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Seo J |
| Year: |
2009 |
| Journal: |
Diabetes |
| Title: |
Atf4 regulates obesity, glucose homeostasis, and energy expenditure. |
| Volume: |
58 |
| Issue: |
11 |
| Pages: |
2565-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang W |
| Year: |
2012 |
| Journal: |
Development |
| Title: |
Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh. |
| Volume: |
139 |
| Issue: |
3 |
| Pages: |
601-11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xiao G |
| Year: |
2013 |
| Journal: |
J Biol Chem |
| Title: |
ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice. |
| Volume: |
288 |
| Issue: |
35 |
| Pages: |
25350-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang Y |
| Year: |
2019 |
| Journal: |
J Bone Miner Res |
| Title: |
Hop2 Interacts with ATF4 to Promote Osteoblast Differentiation. |
| Volume: |
34 |
| Issue: |
12 |
| Pages: |
2287-2300 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ord D |
| Year: |
2003 |
| Journal: |
Exp Cell Res |
| Title: |
Mouse NIPK interacts with ATF4 and affects its transcriptional activity. |
| Volume: |
286 |
| Issue: |
2 |
| Pages: |
308-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang X |
| Year: |
2022 |
| Journal: |
Circ Res |
| Title: |
ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress. |
| Volume: |
131 |
| Issue: |
1 |
| Pages: |
91-105 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang X |
| Year: |
2018 |
| Journal: |
Cell Rep |
| Title: |
ATF4 Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming. |
| Volume: |
23 |
| Issue: |
6 |
| Pages: |
1754-1766 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Paulo E |
| Year: |
2021 |
| Journal: |
Cell Rep |
| Title: |
Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism. |
| Volume: |
36 |
| Issue: |
12 |
| Pages: |
109742 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yue Y |
| Year: |
2019 |
| Journal: |
J Neuroinflammation |
| Title: |
Oligodendrocyte-specific ATF4 inactivation does not influence the development of EAE. |
| Volume: |
16 |
| Issue: |
1 |
| Pages: |
23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xie MX |
| Year: |
2021 |
| Journal: |
Nat Commun |
| Title: |
ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
1401 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miller MJ |
| Year: |
2023 |
| Journal: |
Geroscience |
| Title: |
The transcription regulator ATF4 is a mediator of skeletal muscle aging. |
|
|
| Pages: |
1-19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tameire F |
| Year: |
2019 |
| Journal: |
Nat Cell Biol |
| Title: |
ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. |
| Volume: |
21 |
| Issue: |
7 |
| Pages: |
889-899 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pasini S |
| Year: |
2015 |
| Journal: |
Cell Rep |
| Title: |
Specific downregulation of hippocampal ATF4 reveals a necessary role in synaptic plasticity and memory. |
| Volume: |
11 |
| Issue: |
2 |
| Pages: |
183-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Suragani RN |
| Year: |
2012 |
| Journal: |
Blood |
| Title: |
Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis. |
| Volume: |
119 |
| Issue: |
22 |
| Pages: |
5276-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
He F |
| Year: |
2023 |
| Journal: |
J Hepatol |
| Title: |
ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis. |
| Volume: |
79 |
| Issue: |
2 |
| Pages: |
362-377 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Matus S |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis. |
| Volume: |
8 |
| Issue: |
7 |
| Pages: |
e66672 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Horiguchi M |
| Year: |
2012 |
| Journal: |
Cancer Res |
| Title: |
Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors. |
| Volume: |
72 |
| Issue: |
2 |
| Pages: |
395-401 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang W |
| Year: |
2009 |
| Journal: |
Development |
| Title: |
Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription. |
| Volume: |
136 |
| Issue: |
24 |
| Pages: |
4143-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kasetti RB |
| Year: |
2020 |
| Journal: |
Nat Commun |
| Title: |
ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
5594 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Trinh MA |
| Year: |
2012 |
| Journal: |
Cell Rep |
| Title: |
Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. |
| Volume: |
1 |
| Issue: |
6 |
| Pages: |
676-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen H |
| Year: |
2016 |
| Journal: |
Biochim Biophys Acta |
| Title: |
ATF4 regulates SREBP1c expression to control fatty acids synthesis in 3T3-L1 adipocytes differentiation. |
| Volume: |
1859 |
| Issue: |
11 |
| Pages: |
1459-1469 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6167890 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689419 |
| Pattern: |
Not Specified |
| Stage: |
TS19 |
| Assay Id: |
MGI:6189822 |
| Age: |
embryonic day 11.5 |
|
|
| Specimen Label: |
Table S2 - E11.5 - Atf4 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6167890 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689421 |
| Pattern: |
Not Specified |
| Stage: |
TS21 |
| Assay Id: |
MGI:6189822 |
| Age: |
embryonic day 13.5 |
|
|
| Specimen Label: |
Table S2 - E13.5 - Atf4 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6167890 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689424 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:6189822 |
| Age: |
embryonic day 15.5 |
|
|
| Specimen Label: |
Table S2 - E15.5 - Atf4 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6167890 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689426 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:6189822 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
Table S2 - E18.5 - Atf4 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6167890 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6189822 |
| Age: |
postnatal day 4 |
|
|
| Specimen Label: |
Table S2 - P4 - Atf4 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6167890 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6189822 |
| Age: |
postnatal day 14 |
|
|
| Specimen Label: |
Table S2 - P14 - Atf4 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6167890 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6189822 |
| Age: |
postnatal day 28 |
|
|
| Specimen Label: |
Table S2 - P28 - Atf4 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lange PS |
| Year: |
2008 |
| Journal: |
J Exp Med |
| Title: |
ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo. |
| Volume: |
205 |
| Issue: |
5 |
| Pages: |
1227-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Quirós PM |
| Year: |
2017 |
| Journal: |
J Cell Biol |
| Title: |
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals. |
| Volume: |
216 |
| Issue: |
7 |
| Pages: |
2027-2045 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang X |
| Year: |
2013 |
| Journal: |
Invest Ophthalmol Vis Sci |
| Title: |
Modulation of angiogenesis by genetic manipulation of ATF4 in mouse model of oxygen-induced retinopathy [corrected]. |
| Volume: |
54 |
| Issue: |
9 |
| Pages: |
5995-6002 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang C |
| Year: |
2013 |
| Journal: |
Metabolism |
| Title: |
Effects of ATF4 on PGC1α expression in brown adipose tissue and metabolic responses to cold stress. |
| Volume: |
62 |
| Issue: |
2 |
| Pages: |
282-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li K |
| Year: |
2016 |
| Journal: |
J Biol Chem |
| Title: |
Liver-specific Gene Inactivation of the Transcription Factor ATF4 Alleviates Alcoholic Liver Steatosis in Mice. |
| Volume: |
291 |
| Issue: |
35 |
| Pages: |
18536-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kode A |
| Year: |
2012 |
| Journal: |
J Biol Chem |
| Title: |
FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis. |
| Volume: |
287 |
| Issue: |
12 |
| Pages: |
8757-68 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoshizawa T |
| Year: |
2009 |
| Journal: |
J Clin Invest |
| Title: |
The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. |
| Volume: |
119 |
| Issue: |
9 |
| Pages: |
2807-17 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang C |
| Year: |
2014 |
| Journal: |
J Cell Mol Med |
| Title: |
ATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression. |
| Volume: |
18 |
| Issue: |
1 |
| Pages: |
80-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chérasse Y |
| Year: |
2007 |
| Journal: |
Nucleic Acids Res |
| Title: |
The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP. |
| Volume: |
35 |
| Issue: |
17 |
| Pages: |
5954-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Deng J |
| Year: |
2017 |
| Journal: |
Diabetes |
| Title: |
Deletion of ATF4 in AgRP Neurons Promotes Fat Loss Mainly via Increasing Energy Expenditure. |
| Volume: |
66 |
| Issue: |
3 |
| Pages: |
640-650 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bjorkman SH |
| Year: |
2024 |
| Journal: |
Sci Rep |
| Title: |
ATF4 expression in thermogenic adipocytes is required for cold-induced thermogenesis in mice via FGF21-independent mechanisms. |
| Volume: |
14 |
| Issue: |
1 |
| Pages: |
1563 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li W |
| Year: |
2015 |
| Journal: |
J Gerontol A Biol Sci Med Sci |
| Title: |
Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice. |
| Volume: |
70 |
| Issue: |
3 |
| Pages: |
263-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yu VW |
| Year: |
2009 |
| Journal: |
Gene Expr Patterns |
| Title: |
FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes. |
| Volume: |
9 |
| Issue: |
5 |
| Pages: |
335-40 |
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•
•
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| Publication |
| First Author: |
Byles V |
| Year: |
2021 |
| Journal: |
Mol Metab |
| Title: |
Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin. |
| Volume: |
53 |
|
| Pages: |
101309 |
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•
•
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| Publication |
| First Author: |
Fox DK |
| Year: |
2014 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization. |
| Volume: |
307 |
| Issue: |
3 |
| Pages: |
E245-61 |
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•
•
•
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| Publication |
| First Author: |
Elefteriou F |
| Year: |
2006 |
| Journal: |
Cell Metab |
| Title: |
ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. |
| Volume: |
4 |
| Issue: |
6 |
| Pages: |
441-51 |
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•
•
•
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| Publication |
| First Author: |
Chen A |
| Year: |
2003 |
| Journal: |
Neuron |
| Title: |
Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins. |
| Volume: |
39 |
| Issue: |
4 |
| Pages: |
655-69 |
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•
•
•
•
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| Publication |
| First Author: |
Ambivero CT |
| Year: |
2012 |
| Journal: |
Biochim Biophys Acta |
| Title: |
ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway. |
| Volume: |
1823 |
| Issue: |
12 |
| Pages: |
2149-56 |
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•
•
•
•
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| Publication |
| First Author: |
Horiguchi M |
| Year: |
2013 |
| Journal: |
Cancer Res |
| Title: |
Rhythmic control of the ARF-MDM2 pathway by ATF4 underlies circadian accumulation of p53 in malignant cells. |
| Volume: |
73 |
| Issue: |
8 |
| Pages: |
2639-49 |
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•
•
•
•
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| Publication |
| First Author: |
Yang X |
| Year: |
2004 |
| Journal: |
Cell |
| Title: |
ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. |
| Volume: |
117 |
| Issue: |
3 |
| Pages: |
387-98 |
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•
•
•
•
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| Publication |
| First Author: |
Zhu K |
| Year: |
2013 |
| Journal: |
J Bone Miner Res |
| Title: |
ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. |
| Volume: |
28 |
| Issue: |
9 |
| Pages: |
1870-1884 |
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•
•
•
•
|
| Publication |
| First Author: |
Xiang J |
| Year: |
2023 |
| Journal: |
Cells |
| Title: |
ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment. |
| Volume: |
12 |
| Issue: |
22 |
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•
•
•
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| Publication |
| First Author: |
Zhao Y |
| Year: |
2015 |
| Journal: |
Blood |
| Title: |
ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver. |
| Volume: |
126 |
| Issue: |
21 |
| Pages: |
2383-91 |
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•
•
•
•
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| Publication |
| First Author: |
Liew CW |
| Year: |
2010 |
| Journal: |
J Clin Invest |
| Title: |
The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. |
| Volume: |
120 |
| Issue: |
8 |
| Pages: |
2876-88 |
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•
•
•
•
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| Publication |
| First Author: |
Hu X |
| Year: |
2019 |
| Journal: |
Gastroenterology |
| Title: |
ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides. |
| Volume: |
156 |
| Issue: |
4 |
| Pages: |
1098-1111 |
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•
•
•
•
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| Publication |
| First Author: |
Gao Y |
| Year: |
2023 |
| Journal: |
Sci Rep |
| Title: |
Opposite modulation of functional recovery following contusive spinal cord injury in mice with oligodendrocyte-selective deletions of Atf4 and Chop/Ddit3. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
9193 |
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•
•
•
•
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| Publication |
| First Author: |
Fusakio ME |
| Year: |
2016 |
| Journal: |
Mol Biol Cell |
| Title: |
Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver. |
| Volume: |
27 |
| Issue: |
9 |
| Pages: |
1536-51 |
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•
•
•
•
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| Publication |
| First Author: |
Oyabu M |
| Year: |
2022 |
| Journal: |
FASEB J |
| Title: |
FOXO1 cooperates with C/EBPδ and ATF4 to regulate skeletal muscle atrophy transcriptional program during fasting. |
| Volume: |
36 |
| Issue: |
2 |
| Pages: |
e22152 |
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•
•
•
•
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| Publication |
| First Author: |
Ritter B |
| Year: |
2004 |
| Journal: |
Brain Res Dev Brain Res |
| Title: |
The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development. |
| Volume: |
149 |
| Issue: |
1 |
| Pages: |
73-7 |
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•
•
•
•
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| Publication |
| First Author: |
Bhootada Y |
| Year: |
2016 |
| Journal: |
PLoS One |
| Title: |
Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa. |
| Volume: |
11 |
| Issue: |
5 |
| Pages: |
e0154779 |
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•
•
•
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| Publication |
| First Author: |
Song H |
| Year: |
2008 |
| Journal: |
J Biol Chem |
| Title: |
Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway. |
| Volume: |
283 |
| Issue: |
52 |
| Pages: |
36687-97 |
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•
•
•
•
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| Publication |
| First Author: |
Luo S |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. |
| Volume: |
278 |
| Issue: |
39 |
| Pages: |
37375-85 |
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•
•
•
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| Publication |
| First Author: |
Masuoka HC |
| Year: |
2002 |
| Journal: |
Blood |
| Title: |
Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. |
| Volume: |
99 |
| Issue: |
3 |
| Pages: |
736-45 |
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•
•
•
•
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| Publication |
| First Author: |
Yu VW |
| Year: |
2005 |
| Journal: |
J Cell Biol |
| Title: |
FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice. |
| Volume: |
169 |
| Issue: |
4 |
| Pages: |
591-601 |
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•
•
•
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| Publication |
| First Author: |
MacArthur MR |
| Year: |
2022 |
| Journal: |
Cell Rep |
| Title: |
Multiomics assessment of dietary protein titration reveals altered hepatic glucose utilization. |
| Volume: |
40 |
| Issue: |
7 |
| Pages: |
111187 |
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•
•
•
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| Publication |
| First Author: |
Yu S |
| Year: |
2009 |
| Journal: |
PLoS One |
| Title: |
Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone. |
| Volume: |
4 |
| Issue: |
10 |
| Pages: |
e7583 |
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•
•
•
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| Publication |
| First Author: |
Fan Z |
| Year: |
2021 |
| Journal: |
Cell Metab |
| Title: |
Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells. |
| Volume: |
33 |
| Issue: |
9 |
| Pages: |
1793-1807.e9 |
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•
•
•
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| Publication |
| First Author: |
Jin HO |
| Year: |
2009 |
| Journal: |
FEBS Lett |
| Title: |
SP600125 negatively regulates the mammalian target of rapamycin via ATF4-induced Redd1 expression. |
| Volume: |
583 |
| Issue: |
1 |
| Pages: |
123-7 |
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•
•
•
•
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| Publication |
| First Author: |
Mendes A |
| Year: |
2021 |
| Journal: |
Life Sci Alliance |
| Title: |
Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4. |
| Volume: |
4 |
| Issue: |
2 |
|
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•
•
•
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| Publication |
| First Author: |
Kumar A |
| Year: |
2023 |
| Journal: |
Neuron |
| Title: |
2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience. |
| Volume: |
111 |
| Issue: |
18 |
| Pages: |
2831-2846.e10 |
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•
•
•
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| Publication |
| First Author: |
Stone S |
| Year: |
2019 |
| Journal: |
JCI Insight |
| Title: |
Neuron-specific PERK inactivation exacerbates neurodegeneration during experimental autoimmune encephalomyelitis. |
| Volume: |
4 |
| Issue: |
2 |
|
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•
•
•
•
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| Publication |
| First Author: |
D'Aniello C |
| Year: |
2015 |
| Journal: |
Cell Death Differ |
| Title: |
A novel autoregulatory loop between the Gcn2-Atf4 pathway and (L)-Proline [corrected] metabolism controls stem cell identity. |
| Volume: |
22 |
| Issue: |
7 |
| Pages: |
1094-105 |
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•
•
•
•
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| Publication |
| First Author: |
Han J |
| Year: |
2013 |
| Journal: |
Nat Cell Biol |
| Title: |
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. |
| Volume: |
15 |
| Issue: |
5 |
| Pages: |
481-90 |
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•
•
•
•
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| Publication |
| First Author: |
Masuda M |
| Year: |
2016 |
| Journal: |
JCI Insight |
| Title: |
Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells. |
| Volume: |
1 |
| Issue: |
18 |
| Pages: |
e88646 |
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•
•
•
•
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| Publication |
| First Author: |
Pereira RO |
| Year: |
2021 |
| Journal: |
Elife |
| Title: |
OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21. |
| Volume: |
10 |
|
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