| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
Not Specified |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Transcription factor ATOH1, previously known as Protein atonal homologue 1 (ATOH1/Math1), is a basic helix-loop-helix (bHLH) transcription factor that is essential for the differentiation of hair cells (HCs), mechanotransducers that convert sound into auditory signals in the mammalian organ of Corti (OC) []. It also controls cerebellar granule cells - the most abundant neurons in the mammalian brain - differentiation []. ATOH1 has been found to affect the differentiation of cancer cells [, ].The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators []. |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jahan I |
| Year: |
2015 |
| Journal: |
Development |
| Title: |
Neurog1 can partially substitute for Atoh1 function in hair cell differentiation and maintenance during organ of Corti development. |
| Volume: |
142 |
| Issue: |
16 |
| Pages: |
2810-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gazit R |
| Year: |
2004 |
| Journal: |
Development |
| Title: |
Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway. |
| Volume: |
131 |
| Issue: |
4 |
| Pages: |
903-13 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
351
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Han ME |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
ATOH1 Can Regulate the Tumorigenicity of Gastric Cancer Cells by Inducing the Differentiation of Cancer Stem Cells. |
| Volume: |
10 |
| Issue: |
5 |
| Pages: |
e0126085 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fukushima K |
| Year: |
2015 |
| Journal: |
Cancer Sci |
| Title: |
Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line. |
| Volume: |
106 |
| Issue: |
8 |
| Pages: |
1000-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vervoort M |
| Year: |
2001 |
| Journal: |
ScientificWorldJournal |
| Title: |
The evolution of the neural basic Helix-Loop-Helix proteins. |
| Volume: |
1 |
|
| Pages: |
396-426 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Luo Z |
| Year: |
2022 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Three distinct Atoh1 enhancers cooperate for sound receptor hair cell development. |
| Volume: |
119 |
| Issue: |
32 |
| Pages: |
e2119850119 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6402637 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2020-04-02 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1760026 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6402642 |
| Age: |
embryonic day 18.5 |
| Image: |
3B cochlea Atoh1 null |
|
| Specimen Label: |
3B cochlea Atoh1 null |
| Detected: |
false |
| Specimen Num: |
20 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6402637 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2020-04-02 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757226 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:6402642 |
| Age: |
embryonic day 18.5 |
| Image: |
3B cochlea Atoh1 null |
|
| Specimen Label: |
3B cochlea Atoh1 null |
| Detected: |
true |
| Specimen Num: |
20 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6402637 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2020-04-02 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1730126 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6402642 |
| Age: |
embryonic day 18.5 |
| Image: |
3B vestibule Atoh1 null |
|
| Specimen Label: |
3B vestibule Atoh1 null |
| Detected: |
false |
| Specimen Num: |
22 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6402637 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2020-04-02 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1782326 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6402642 |
| Age: |
embryonic day 18.5 |
| Image: |
3B vestibule Atoh1 null |
|
| Specimen Label: |
3B vestibule Atoh1 null |
| Detected: |
false |
| Specimen Num: |
22 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6402637 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2020-04-02 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1729526 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6402642 |
| Age: |
embryonic day 18.5 |
| Image: |
3B vestibule Atoh1 null |
|
| Specimen Label: |
3B vestibule Atoh1 null |
| Detected: |
false |
| Specimen Num: |
22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Akazawa C |
| Year: |
1995 |
| Journal: |
J Biol Chem |
| Title: |
A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. |
| Volume: |
270 |
| Issue: |
15 |
| Pages: |
8730-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Klisch TJ |
| Year: |
2017 |
| Journal: |
Elife |
| Title: |
Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth. |
| Volume: |
6 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Grausam KB |
| Year: |
2017 |
| Journal: |
Cancer Res |
| Title: |
ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas. |
| Volume: |
77 |
| Issue: |
14 |
| Pages: |
3766-3777 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tomic G |
| Year: |
2018 |
| Journal: |
Cell Stem Cell |
| Title: |
Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration. |
| Volume: |
23 |
| Issue: |
3 |
| Pages: |
436-443.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sayyid ZN |
| Year: |
2019 |
| Journal: |
Cell Rep |
| Title: |
Atoh1 Directs Regeneration and Functional Recovery of the Mature Mouse Vestibular System. |
| Volume: |
28 |
| Issue: |
2 |
| Pages: |
312-324.e4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chonko KT |
| Year: |
2013 |
| Journal: |
Dev Biol |
| Title: |
Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear. |
| Volume: |
381 |
| Issue: |
2 |
| Pages: |
401-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pan N |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
e30358 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu SR |
| Year: |
2023 |
| Journal: |
Sci Adv |
| Title: |
Atoh1 drives the heterogeneity of the pontine nuclei neurons and promotes their differentiation. |
| Volume: |
9 |
| Issue: |
26 |
| Pages: |
eadg1671 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ferreira CB |
| Year: |
2022 |
| Journal: |
Elife |
| Title: |
Phox2b mutation mediated by Atoh1 expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapnia. |
| Volume: |
11 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Owa T |
| Year: |
2018 |
| Journal: |
J Neurosci |
| Title: |
Meis1 Coordinates Cerebellar Granule Cell Development by Regulating Pax6 Transcription, BMP Signaling and Atoh1 Degradation. |
| Volume: |
38 |
| Issue: |
5 |
| Pages: |
1277-1294 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Scheffer D |
| Year: |
2007 |
| Journal: |
FEBS Lett |
| Title: |
Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells. |
| Volume: |
581 |
| Issue: |
24 |
| Pages: |
4651-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ruffault PL |
| Year: |
2015 |
| Journal: |
Elife |
| Title: |
The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO₂. |
| Volume: |
4 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jahan I |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
e30853 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lai HC |
| Year: |
2011 |
| Journal: |
J Neurosci |
| Title: |
In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord. |
| Volume: |
31 |
| Issue: |
30 |
| Pages: |
10859-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Green MJ |
| Year: |
2014 |
| Journal: |
Development |
| Title: |
Independently specified Atoh1 domains define novel developmental compartments in rhombomere 1. |
| Volume: |
141 |
| Issue: |
2 |
| Pages: |
389-98 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chang CH |
| Year: |
2019 |
| Journal: |
Dev Cell |
| Title: |
Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation. |
| Volume: |
48 |
| Issue: |
2 |
| Pages: |
184-199.e5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang T |
| Year: |
2024 |
| Journal: |
Nat Commun |
| Title: |
Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle. |
| Volume: |
15 |
| Issue: |
1 |
| Pages: |
9166 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Filova I |
| Year: |
2020 |
| Journal: |
Mol Neurobiol |
| Title: |
Combined Atoh1 and Neurod1 Deletion Reveals Autonomous Growth of Auditory Nerve Fibers. |
| Volume: |
57 |
| Issue: |
12 |
| Pages: |
5307-5323 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoon H |
| Year: |
2011 |
| Journal: |
Anat Cell Biol |
| Title: |
Identification of genes concordantly expressed with Atoh1 during inner ear development. |
| Volume: |
44 |
| Issue: |
1 |
| Pages: |
69-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Flora A |
| Year: |
2009 |
| Journal: |
Science |
| Title: |
Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma. |
| Volume: |
326 |
| Issue: |
5958 |
| Pages: |
1424-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Butts JC |
| Year: |
2024 |
| Journal: |
Dev Cell |
| Title: |
A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. |
| Volume: |
59 |
| Issue: |
16 |
| Pages: |
2171-2188.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huang WH |
| Year: |
2012 |
| Journal: |
Neuron |
| Title: |
Atoh1 governs the migration of postmitotic neurons that shape respiratory effectiveness at birth and chemoresponsiveness in adulthood. |
| Volume: |
75 |
| Issue: |
5 |
| Pages: |
799-809 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ostrowski SM |
| Year: |
2015 |
| Journal: |
Development |
| Title: |
Ectopic Atoh1 expression drives Merkel cell production in embryonic, postnatal and adult mouse epidermis. |
| Volume: |
142 |
| Issue: |
14 |
| Pages: |
2533-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin X |
| Year: |
2022 |
| Journal: |
Immunity |
| Title: |
IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment. |
| Volume: |
55 |
| Issue: |
2 |
| Pages: |
237-253.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee S |
| Year: |
2020 |
| Journal: |
Sci Rep |
| Title: |
Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
21397 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gao Y |
| Year: |
2020 |
| Journal: |
Gastroenterology |
| Title: |
LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate. |
| Volume: |
158 |
| Issue: |
5 |
| Pages: |
1389-1401.e10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li S |
| Year: |
2022 |
| Journal: |
Dev Dyn |
| Title: |
Fate-mapping analysis of cochlear cells expressing Atoh1 mRNA via a new Atoh13*HA-P2A-Cre knockin mouse strain. |
| Volume: |
251 |
| Issue: |
7 |
| Pages: |
1156-1174 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yu HV |
| Year: |
2021 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
POU4F3 pioneer activity enables ATOH1 to drive diverse mechanoreceptor differentiation through a feed-forward epigenetic mechanism. |
| Volume: |
118 |
| Issue: |
29 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Klisch TJ |
| Year: |
2011 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
In vivo Atoh1 targetome reveals how a proneural transcription factor regulates cerebellar development. |
| Volume: |
108 |
| Issue: |
8 |
| Pages: |
3288-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kirjavainen A |
| Year: |
2008 |
| Journal: |
Dev Biol |
| Title: |
Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia. |
| Volume: |
322 |
| Issue: |
1 |
| Pages: |
33-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kelly MC |
| Year: |
2012 |
| Journal: |
J Neurosci |
| Title: |
Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo. |
| Volume: |
32 |
| Issue: |
19 |
| Pages: |
6699-710 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cai T |
| Year: |
2015 |
| Journal: |
J Neurosci |
| Title: |
Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor. |
| Volume: |
35 |
| Issue: |
14 |
| Pages: |
5870-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miesegaes GR |
| Year: |
2009 |
| Journal: |
Dev Biol |
| Title: |
Identification and subclassification of new Atoh1 derived cell populations during mouse spinal cord development. |
| Volume: |
327 |
| Issue: |
2 |
| Pages: |
339-51 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6167927 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689419 |
| Pattern: |
Not Specified |
| Stage: |
TS19 |
| Assay Id: |
MGI:6189823 |
| Age: |
embryonic day 11.5 |
|
|
| Specimen Label: |
Table S2 - E11.5 - Atoh1 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6167927 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689426 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:6189823 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
Table S2 - E18.5 - Atoh1 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6167927 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:6189823 |
| Age: |
postnatal day 28 |
|
|
| Specimen Label: |
Table S2 - P28 - Atoh1 |
| Detected: |
false |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6167927 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689421 |
| Pattern: |
Not Specified |
| Stage: |
TS21 |
| Assay Id: |
MGI:6189823 |
| Age: |
embryonic day 13.5 |
|
|
| Specimen Label: |
Table S2 - E13.5 - Atoh1 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6167927 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689424 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:6189823 |
| Age: |
embryonic day 15.5 |
|
|
| Specimen Label: |
Table S2 - E15.5 - Atoh1 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6167927 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6189823 |
| Age: |
postnatal day 4 |
|
|
| Specimen Label: |
Table S2 - P4 - Atoh1 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6167927 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6189823 |
| Age: |
postnatal day 14 |
|
|
| Specimen Label: |
Table S2 - P14 - Atoh1 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yamada M |
| Year: |
2014 |
| Journal: |
J Neurosci |
| Title: |
Specification of spatial identities of cerebellar neuron progenitors by ptf1a and atoh1 for proper production of GABAergic and glutamatergic neurons. |
| Volume: |
34 |
| Issue: |
14 |
| Pages: |
4786-800 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Duval N |
| Year: |
2014 |
| Journal: |
Development |
| Title: |
Msx1 and Msx2 act as essential activators of Atoh1 expression in the murine spinal cord. |
| Volume: |
141 |
| Issue: |
8 |
| Pages: |
1726-36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen Y |
| Year: |
2021 |
| Journal: |
Cell Rep |
| Title: |
Generation of mature and functional hair cells by co-expression of Gfi1, Pou4f3, and Atoh1 in the postnatal mouse cochlea. |
| Volume: |
35 |
| Issue: |
3 |
| Pages: |
109016 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Machold R |
| Year: |
2011 |
| Journal: |
Gene Expr Patterns |
| Title: |
Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. |
| Volume: |
11 |
| Issue: |
5-6 |
| Pages: |
349-59 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Abdolazimi Y |
| Year: |
2016 |
| Journal: |
Development |
| Title: |
Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter. |
| Volume: |
143 |
| Issue: |
5 |
| Pages: |
841-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tateya T |
| Year: |
2019 |
| Journal: |
Development |
| Title: |
Three-dimensional live imaging of Atoh1 reveals the dynamics of hair cell induction and organization in the developing cochlea. |
| Volume: |
146 |
| Issue: |
21 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ahmed M |
| Year: |
2012 |
| Journal: |
Dev Cell |
| Title: |
Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2. |
| Volume: |
22 |
| Issue: |
2 |
| Pages: |
377-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li X |
| Year: |
2023 |
| Journal: |
Development |
| Title: |
In situ regeneration of inner hair cells in the damaged cochlea by temporally regulated co-expression of Atoh1 and Tbx2. |
| Volume: |
150 |
| Issue: |
24 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu Z |
| Year: |
2012 |
| Journal: |
J Neurosci |
| Title: |
Age-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expression. |
| Volume: |
32 |
| Issue: |
19 |
| Pages: |
6600-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cai T |
| Year: |
2013 |
| Journal: |
J Neurosci |
| Title: |
Conditional deletion of Atoh1 reveals distinct critical periods for survival and function of hair cells in the organ of Corti. |
| Volume: |
33 |
| Issue: |
24 |
| Pages: |
10110-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fritzsch B |
| Year: |
2005 |
| Journal: |
Dev Dyn |
| Title: |
Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retention. |
| Volume: |
233 |
| Issue: |
2 |
| Pages: |
570-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sheykholeslami K |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
A new mutation of the Atoh1 gene in mice with normal life span allows analysis of inner ear and cerebellar phenotype in aging. |
| Volume: |
8 |
| Issue: |
11 |
| Pages: |
e79791 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Farah MH |
| Year: |
2000 |
| Journal: |
Development |
| Title: |
Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. |
| Volume: |
127 |
| Issue: |
4 |
| Pages: |
693-702 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gerbe F |
| Year: |
2011 |
| Journal: |
J Cell Biol |
| Title: |
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. |
| Volume: |
192 |
| Issue: |
5 |
| Pages: |
767-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pan N |
| Year: |
2011 |
| Journal: |
Hear Res |
| Title: |
Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti. |
| Volume: |
275 |
| Issue: |
1-2 |
| Pages: |
66-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shu M |
| Year: |
2022 |
| Journal: |
Dev Cell |
| Title: |
Single-cell chromatin accessibility identifies enhancer networks driving gene expression during spinal cord development in mouse. |
| Volume: |
57 |
| Issue: |
24 |
| Pages: |
2761-2775.e6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mulvaney J |
| Year: |
2012 |
| Journal: |
J Assoc Res Otolaryngol |
| Title: |
Atoh1, an essential transcription factor in neurogenesis and intestinal and inner ear development: function, regulation, and context dependency. |
| Volume: |
13 |
| Issue: |
3 |
| Pages: |
281-93 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3056756 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2023-02-06 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3667221 |
| Pattern: |
Not Specified |
| Stage: |
TS21 |
| Assay Id: |
MGI:7431459 |
| Age: |
embryonic day 13.75 |
| Image: |
S5E |
| Note: |
Many more Lmx1a+ cells coexpress Atoh1 in dreher rhombic lip than in wild type. |
| Specimen Label: |
S5E |
| Detected: |
true |
| Specimen Num: |
12 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6502141 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2021-01-27 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1616619 |
| Pattern: |
Regionally restricted |
| Stage: |
TS19 |
| Assay Id: |
MGI:6502147 |
| Age: |
embryonic day 11.5 |
|
| Note: |
Expression domains of Atoh1 and Ascl1 were distinct with a clear space separating them. |
| Specimen Label: |
6G |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3056756 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2023-02-06 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3521627 |
| Pattern: |
Not Specified |
| Stage: |
TS27 |
| Assay Id: |
MGI:7431459 |
| Age: |
postnatal day 3 |
| Image: |
S4C |
| Note: |
In dreher mice, some beta-gal+ cells were detected co-expressing with Atoh1 in granule cells. |
| Specimen Label: |
S4C |
| Detected: |
true |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ogujiofor OW |
| Year: |
2021 |
| Journal: |
eNeuro |
| Title: |
An Atoh1 CRE Knock-In Mouse Labels Motor Neurons Involved in Fine Motor Control. |
| Volume: |
8 |
| Issue: |
1 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Helms AW |
| Year: |
2000 |
| Journal: |
Development |
| Title: |
Autoregulation and multiple enhancers control Math1 expression in the developing nervous system. |
| Volume: |
127 |
| Issue: |
6 |
| Pages: |
1185-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
van der Heijden ME |
| Year: |
2018 |
| Journal: |
Elife |
| Title: |
Loss of Atoh1 from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice. |
| Volume: |
7 |
|
|
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
1 |
| Description: |
Transcription factor Atoh1 |
| Type: |
chain |
| End: |
351 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE22111 |
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang H |
| Year: |
2010 |
| Journal: |
Genesis |
| Title: |
Generation and characterization of Atoh1-Cre knock-in mouse line. |
| Volume: |
48 |
| Issue: |
6 |
| Pages: |
407-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu H |
| Year: |
2016 |
| Journal: |
PLoS One |
| Title: |
Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival? |
| Volume: |
11 |
| Issue: |
12 |
| Pages: |
e0168953 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pan N |
| Year: |
2009 |
| Journal: |
Cell Tissue Res |
| Title: |
Defects in the cerebella of conditional Neurod1 null mice correlate with effective Tg(Atoh1-cre) recombination and granule cell requirements for Neurod1 for differentiation. |
| Volume: |
337 |
| Issue: |
3 |
| Pages: |
407-28 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tupal S |
| Year: |
2014 |
| Journal: |
Elife |
| Title: |
Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice. |
| Volume: |
3 |
|
| Pages: |
e02265 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tan X |
| Year: |
2018 |
| Journal: |
Sci Rep |
| Title: |
Auditory Neural Activity in Congenitally Deaf Mice Induced by Infrared Neural Stimulation. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
388 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Du H |
| Year: |
2021 |
| Journal: |
Front Cell Dev Biol |
| Title: |
The Rho GTPase Cell Division Cycle 42 Regulates Stereocilia Development in Cochlear Hair Cells. |
| Volume: |
9 |
|
| Pages: |
765559 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu Y |
| Year: |
2019 |
| Journal: |
Sci Adv |
| Title: |
Critical role of spectrin in hearing development and deafness. |
| Volume: |
5 |
| Issue: |
4 |
| Pages: |
eaav7803 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Specht CG |
| Year: |
2001 |
| Journal: |
BMC Neurosci |
| Title: |
Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice. |
| Volume: |
2 |
|
| Pages: |
11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang A |
| Year: |
2020 |
| Journal: |
G3 (Bethesda) |
| Title: |
Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans. |
| Volume: |
10 |
| Issue: |
9 |
| Pages: |
3271-3278 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu SR |
| Year: |
2023 |
| Journal: |
eNeuro |
| Title: |
The Atoh1-Cre Knock-In Allele Ectopically Labels a Subpopulation of Amacrine Cells and Bipolar Cells in Mouse Retina. |
| Volume: |
10 |
| Issue: |
11 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Matei V |
| Year: |
2005 |
| Journal: |
Dev Dyn |
| Title: |
Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit. |
| Volume: |
234 |
| Issue: |
3 |
| Pages: |
633-50 |
|
•
•
•
•
•
|