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Search results 1 to 100 out of 2452 for Brca1

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
Gene
672 | BRCA1
Type: gene
Organism: human
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Gene
403437 | BRCA1
Type: gene
Organism: dog, domestic
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Gene
449497 | BRCA1
Type: gene
Organism: chimpanzee
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Gene
353120 | BRCA1
Type: gene
Organism: cattle
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Gene
373983 | BRCA1
Type: gene
Organism: chicken
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Gene
712634 | BRCA1
Type: gene
Organism: macaque, rhesus
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Gene
733513 | brca1
Type: gene
Organism: frog, western clawed
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Protein
B0FT00
Organism: Mus musculus/domesticus
Length: 882  
Fragment?: true
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Gene
497672 | Brca1
Type: gene
Organism: rat
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Protein Domain
IPR011364 | BRCA1
Type: Family
Description: Breast cancer is a common malignancy, affecting 1 in 8 women. A major contributary factor in disease development lies in a positive family history, a correlation that is striking for early-onset breast cancer. Mutations in the DNA-damage repair protein BRCA1 [, ]are believed to be responsible for 45% of inherited breast cancer and more than 80% of inherited breast and ovarian cancer.The BRCA1 protein is a E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage [, ]. It contains an N-terminal zinc-finger domain. It also contains a BRCT C-terminal domain, an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain [].
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Protein Coding Gene
MGI:104537 | Brca1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
10198641 | J:54105
First Author: Xu X
Year: 1999
Journal: Mol Cell
Title: Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.
Volume: 3
Issue: 3
Pages: 389-95
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Protein
Q9Z1D2
Organism: Mus musculus/domesticus
Length: 1812  
Fragment?: false
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Protein
Q99LI1
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: true
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Publication
10500182 | J:64924
First Author: Lorick KL
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.
Volume: 96
Issue: 20
Pages: 11364-9
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Publication
8975707 | J:37713
First Author: Chambers JA
Year: 1996
Journal: Genomics
Title: Isolation of the murine Nbr1 gene adjacent to the murine Brca1 gene.
Volume: 38
Issue: 3
Pages: 305-13
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Gene
8315 | BRAP
Type: gene
Organism: human
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Gene
394269 | BRCA1P1
Type: gene
Organism: human
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Gene
111589215 | LOC111589215
Type: gene
Organism: human
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Protein
P48754
Organism: Mus musculus/domesticus
Length: 1812  
Fragment?: false
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Gene
8314 | BAP1
Type: gene
Organism: human
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Gene
110485084 | LOC110485084
Type: gene
Organism: human
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Publication
10724175 | -
First Author: Lee JS
Year: 2000
Journal: Nature
Title: hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response.
Volume: 404
Issue: 6774
Pages: 201-4
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Publication
30244837 | J:269011
First Author: Billing D
Year: 2018
Journal: Mol Cell
Title: The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection.
Volume: 72
Issue: 1
Pages: 127-139.e8
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Publication
12419249 | J:79872
First Author: Ganesan S
Year: 2002
Journal: Cell
Title: BRCA1 supports XIST RNA concentration on the inactive X chromosome.
Volume: 111
Issue: 3
Pages: 393-405
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Publication
34421362 | J:328516
First Author: Yang J
Year: 2021
Journal: Int J Biol Sci
Title: BRCA1 Antibodies Matter.
Volume: 17
Issue: 12
Pages: 3239-3254
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Publication
12832489 | J:84329
First Author: McCarthy EE
Year: 2003
Journal: Mol Cell Biol
Title: Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability.
Volume: 23
Issue: 14
Pages: 5056-63
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Publication
18443292 | J:134977
First Author: Shakya R
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.
Volume: 105
Issue: 19
Pages: 7040-5
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Publication
38554279 | J:348335
First Author: Georgieva D
Year: 2024
Journal: Cell Rep
Title: BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks.
Volume: 43
Issue: 4
Pages: 114006
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Publication
8698242 | J:34458
First Author: Liu CY
Year: 1996
Journal: Genes Dev
Title: Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.
Volume: 10
Issue: 14
Pages: 1835-43
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Publication
17420720 | J:125539
First Author: Jeng YM
Year: 2007
Journal: Oncogene
Title: Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.
Volume: 26
Issue: 42
Pages: 6160-6
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Publication
16807234 | J:116940
First Author: El-Tanani MK
Year: 2006
Journal: J Biol Chem
Title: BRCA1 suppresses osteopontin-mediated breast cancer.
Volume: 281
Issue: 36
Pages: 26587-601
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Publication
8673121 | J:33731
First Author: Koonin EV
Year: 1996
Journal: Nat Genet
Title: BRCA1 protein products ... Functional motifs...
Volume: 13
Issue: 3
Pages: 266-8
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Publication
27241552 | J:312831
First Author: Sigl V
Year: 2016
Journal: Cell Res
Title: RANKL/RANK control Brca1 mutation- .
Volume: 26
Issue: 7
Pages: 761-74
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Publication
31499338 | J:338644
 
First Author: Holmstrom SR
Year: 2019
Journal: iScience
Title: Functional Interaction of BRCA1 and CREBBP in Murine Hematopoiesis.
Volume: 19
Pages: 809-820
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Publication
12214252 | J:113943
First Author: Deng CX
Year: 2002
Journal: Oncogene
Title: Roles of BRCA1 in centrosome duplication.
Volume: 21
Issue: 40
Pages: 6222-7
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Publication
10918303 | J:114832
First Author: Deng CX
Year: 2000
Journal: Bioessays
Title: Roles of BRCA1 and its interacting proteins.
Volume: 22
Issue: 8
Pages: 728-37
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Publication
21901007 | J:356903
First Author: Zhu Q
Year: 2011
Journal: Nature
Title: BRCA1 tumour suppression occurs via heterochromatin-mediated silencing.
Volume: 477
Issue: 7363
Pages: 179-84
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Publication
32359443 | J:295420
First Author: Nacson J
Year: 2020
Journal: Mol Cell
Title: BRCA1 Mutational Complementation Induces Synthetic Viability.
Volume: 78
Issue: 5
Pages: 951-959.e6
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Publication
22369660 | J:320080
First Author: Wang B
Year: 2012
Journal: Cell Biosci
Title: BRCA1 tumor suppressor network: focusing on its tail.
Volume: 2
Issue: 1
Pages: 6
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Publication
11921186 | J:75759
First Author: Deng CX
Year: 2002
Journal: Environ Mol Mutagen
Title: Tumor formation in Brca1 conditional mutant mice.
Volume: 39
Issue: 2-3
Pages: 171-7
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Publication
15131084 | J:90512
First Author: McPherson JP
Year: 2004
Journal: Genes Dev
Title: Collaboration of Brca1 and Chk2 in tumorigenesis.
Volume: 18
Issue: 10
Pages: 1144-53
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Publication
28122244 | J:240315
First Author: Mgbemena VE
Year: 2017
Journal: Cell Rep
Title: Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function.
Volume: 18
Issue: 4
Pages: 947-960
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Publication
11156530 | J:67112
First Author: Zheng L
Year: 2000
Journal: Oncogene
Title: Lessons learned from BRCA1 and BRCA2.
Volume: 19
Issue: 53
Pages: 6159-75
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Publication
18230721 | J:131868
First Author: Liu S
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: BRCA1 regulates human mammary stem/progenitor cell fate.
Volume: 105
Issue: 5
Pages: 1680-5
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Publication
11832208 | J:76921
First Author: Venkitaraman AR
Year: 2002
Journal: Cell
Title: Cancer susceptibility and the functions of BRCA1 and BRCA2.
Volume: 108
Issue: 2
Pages: 171-82
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Publication
11358863 | J:69187
First Author: Ludwig T
Year: 2001
Journal: Genes Dev
Title: Tumorigenesis in mice carrying a truncating Brca1 mutation.
Volume: 15
Issue: 10
Pages: 1188-93
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Publication
26490168 | J:227337
First Author: Sun X
Year: 2016
Journal: Chromosoma
Title: FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.
Volume: 125
Issue: 2
Pages: 237-52
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Publication
24776801 | J:212935
First Author: Willis NA
Year: 2014
Journal: Nature
Title: BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks.
Volume: 510
Issue: 7506
Pages: 556-9
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Publication
11170347 | J:67880
First Author: Chandler J
Year: 2001
Journal: Genesis
Title: Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice.
Volume: 29
Issue: 2
Pages: 72-7
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Publication
16782705 | J:116898
First Author: Dizin E
Year: 2006
Journal: J Biol Chem
Title: BRCA1 interacts with poly(A)-binding protein: implication of BRCA1 in translation regulation.
Volume: 281
Issue: 34
Pages: 24236-46
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Publication
12242698 | J:115553
First Author: Daniel DC
Year: 2002
Journal: Microsc Res Tech
Title: Highlight: BRCA1 and BRCA2 proteins in breast cancer.
Volume: 59
Issue: 1
Pages: 68-83
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Publication
23712259 | J:197743
First Author: Reczek CR
Year: 2013
Journal: J Cell Biol
Title: The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.
Volume: 201
Issue: 5
Pages: 693-707
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Publication
8589722 | J:31760
First Author: Jensen RA
Year: 1996
Journal: Nat Genet
Title: BRCA1 is secreted and exhibits properties of a granin.
Volume: 12
Issue: 3
Pages: 303-8
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Publication
28869585 | J:349149
First Author: Sengodan SK
Year: 2017
Journal: Oncogenesis
Title: BRCA1 regulation on β-hCG: a mechanism for tumorigenicity in BRCA1 defective breast cancer.
Volume: 6
Issue: 9
Pages: e376
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Publication
24639535 | J:207293
First Author: Pao GM
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Role of BRCA1 in brain development.
Volume: 111
Issue: 13
Pages: E1240-8
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Publication
15187254 | J:90788
 
First Author: Deng CX
Year: 2004
Journal: Methods Mol Biol
Title: Generation and analysis of Brca1 conditional knockout mice.
Volume: 280
Pages: 185-200
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Publication
18343216 | J:134494
First Author: Wang Y
Year: 2008
Journal: Biochem Biophys Res Commun
Title: BRCA1 regulates caveolin-1 expression and inhibits cell invasiveness.
Volume: 370
Issue: 2
Pages: 201-6
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Publication
30704900 | J:274082
First Author: Zong D
Year: 2019
Journal: Mol Cell
Title: BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.
Volume: 73
Issue: 6
Pages: 1267-1281.e7
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Publication
22492723 | J:185042
First Author: Kawai S
Year: 2012
Journal: J Cell Biol
Title: BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex.
Volume: 197
Issue: 2
Pages: 201-8
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Publication
8872468 | J:35240
First Author: Szabo CI
Year: 1996
Journal: Hum Mol Genet
Title: Human, canine and murine BRCA1 genes: sequence comparison among species.
Volume: 5
Issue: 9
Pages: 1289-98
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Publication
30652068 | J:293750
 
First Author: Kim SE
Year: 2018
Journal: Anal Cell Pathol (Amst)
Title: Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland.
Volume: 2018
Pages: 8120579
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Publication
21507987 | J:175001
First Author: Kang HJ
Year: 2011
Journal: Toxicol Sci
Title: Detoxification: a novel function of BRCA1 in tumor suppression?
Volume: 122
Issue: 1
Pages: 26-37
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Publication
20820192 | J:173146
First Author: Shukla V
Year: 2010
Journal: Cell Res
Title: BRCA1 affects global DNA methylation through regulation of DNMT1.
Volume: 20
Issue: 11
Pages: 1201-15
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Publication
36731891 | J:354057
 
First Author: Wu B
Year: 2023
Journal: J Immunother Cancer
Title: BRCA1 deficiency in mature CD8(+) T lymphocytes impairs antitumor immunity.
Volume: 11
Issue: 2
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Publication
35459234 | J:336919
First Author: He Z
Year: 2022
Journal: Nat Commun
Title: Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation.
Volume: 13
Issue: 1
Pages: 2200
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Publication
19770520 | J:154631
First Author: Chang S
Year: 2009
Journal: J Clin Invest
Title: Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations.
Volume: 119
Issue: 10
Pages: 3160-71
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Publication
25582120 | J:219278
First Author: Badie S
Year: 2015
Journal: EMBO J
Title: BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.
Volume: 34
Issue: 3
Pages: 410-24
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Publication
36346676 | J:333109
 
First Author: Lopez-Perez G
Year: 2022
Journal: JCI Insight
Title: BRCA1 and TP53 codeficiency causes a PARP inhibitor-sensitive erythroproliferative neoplasm.
Volume: 7
Issue: 24
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Protein
A0A6M5UQ05
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UP38
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UM29
Organism: Mus musculus/domesticus
Length: 777  
Fragment?: true
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Protein
A0A6M5UQ19
Organism: Mus musculus/domesticus
Length: 777  
Fragment?: true
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Protein
A0A6M5UNK6
Organism: Mus musculus/domesticus
Length: 777  
Fragment?: true
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Protein
A0A6M5UKJ0
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UP58
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UNX3
Organism: Mus musculus/domesticus
Length: 777  
Fragment?: true
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Protein
A0A6M5ULZ1
Organism: Mus musculus/domesticus
Length: 777  
Fragment?: true
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Protein
A0A6M5UNI5
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UNJ4
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UP39
Organism: Mus musculus/domesticus
Length: 777  
Fragment?: true
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Protein
A0A6M5UNT0
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UNP5
Organism: Mus musculus/domesticus
Length: 777  
Fragment?: true
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Protein
A0A6M5UNJ9
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UK40
Organism: Mus musculus/domesticus
Length: 777  
Fragment?: true
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Protein
A0A6M5UP52
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UJY5
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UKN4
Organism: Mus musculus/domesticus
Length: 777  
Fragment?: true
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Protein
A0A6M5UNS0
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5ULC1
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UKK1
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5ULA1
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UNH3
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UK06
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UNL8
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UK21
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UP30
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UL81
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Protein
A0A6M5UNU9
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
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Publication
12531920 | J:81831
First Author: Fleming MA
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Understanding missense mutations in the BRCA1 gene: an evolutionary approach.
Volume: 100
Issue: 3
Pages: 1151-6
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom