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Search results 1 to 100 out of 481 for Cdk6

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
1021 | CDK6
Type: gene
Organism: human
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Gene
100489734 | cdk6
Type: gene
Organism: frog, western clawed
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Gene
114483 | Cdk6
Type: gene
Organism: rat
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Gene
609920 | CDK6
Type: gene
Organism: dog, domestic
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Gene
746968 | CDK6
Type: gene
Organism: chimpanzee
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Gene
511754 | CDK6
Type: gene
Organism: cattle
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Gene
420558 | CDK6
Type: gene
Organism: chicken
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Gene
100034507 | cdk6
Type: gene
Organism: zebrafish
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Gene
701822 | CDK6
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028788 | CDK6
Type: Family
Description: Cyclin-dependent kinase 6 (CDK6) is a D-Cyclin-activated kinase that is involved in driving the cell cycle through inactivation of pRB in G1 phase [, ]. It has been implicated in cell proliferation []and tumor angiogenesis []. It is also involved in cell differentiation through regulation of gene expression []. CDK6 interacts with the p65 subunit of NFkB in the nucleus, and is found at promoters of many transcriptionally active NFkB target genes [].
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Protein Coding Gene
MGI:1277162 | Cdk6
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23948297 | J:201595
First Author: Kollmann K
Year: 2013
Journal: Cancer Cell
Title: A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis.
Volume: 24
Issue: 2
Pages: 167-81
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GXD Expression
GXD Expression
Probe: MGI:5811347
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5823588
Age: embryonic day 11.5
Image: S1A - Cdk6 - E11.5
Note: This gene exhibits category 1 expression: staining is observed in the posterior/posterior-distal limb bud.
Specimen Label: S1A - Cdk6 - E11.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5811347
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5823588
Age: embryonic day 10.5
Image: S1A - Cdk6 - E10.5
Note: This gene exhibits category 1 expression: staining is observed in the posterior/posterior-distal limb bud.
Specimen Label: S1A - Cdk6 - E10.5
Detected: true
Specimen Num: 1
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Gene
101927497 | CDK6-AS1
Type: gene
Organism: human
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Publication
24196439 | -
First Author: Kohrt D
Year: 2014
Journal: Cell Cycle
Title: CDK6 binds and promotes the degradation of the EYA2 protein.
Volume: 13
Issue: 1
Pages: 62-71
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Publication
34145036 | J:339832
First Author: Dutta A
Year: 2021
Journal: Cancer Res
Title: CDK6 Is a Therapeutic Target in Myelofibrosis.
Volume: 81
Issue: 16
Pages: 4332-4345
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Publication
29899063 | J:263926
First Author: Bellutti F
Year: 2018
Journal: Cancer Discov
Title: CDK6 Antagonizes p53-Induced Responses during Tumorigenesis.
Volume: 8
Issue: 7
Pages: 884-897
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Publication
33179102 | J:305376
 
First Author: Li B
Year: 2021
Journal: Mol Med Rep
Title: miR‑449a‑5p suppresses CDK6 expression to inhibit cardiomyocyte proliferation.
Volume: 23
Issue: 1
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Publication
29523786 | J:259700
First Author: Hou X
Year: 2018
Journal: Nat Commun
Title: CDK6 inhibits white to beige fat transition by suppressing RUNX1.
Volume: 9
Issue: 1
Pages: 1023
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Publication
21508411 | J:174697
First Author: Hu MG
Year: 2011
Journal: Blood
Title: CDK6 kinase activity is required for thymocyte development.
Volume: 117
Issue: 23
Pages: 6120-31
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Publication
19501046 | J:150656
First Author: Yang Z
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Znhit1 causes cell cycle arrest and down-regulates CDK6 expression.
Volume: 386
Issue: 1
Pages: 146-52
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Publication
38684032 | J:357398
First Author: Mayer IM
Year: 2024
Journal: Blood
Title: Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells.
Volume: 144
Issue: 2
Pages: 156-170
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Publication
8114739 | -
First Author: Meyerson M
Year: 1994
Journal: Mol Cell Biol
Title: Identification of G1 kinase activity for cdk6, a novel cyclin D partner.
Volume: 14
Issue: 3
Pages: 2077-86
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Publication
14985467 | -
First Author: Lucas JJ
Year: 2004
Journal: Mol Cancer Res
Title: Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells.
Volume: 2
Issue: 2
Pages: 105-14
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Publication
15254224 | -
First Author: Ogasawara T
Year: 2004
Journal: Mol Cell Biol
Title: Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6.
Volume: 24
Issue: 15
Pages: 6560-8
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Publication
24389100 | -
First Author: Handschick K
Year: 2014
Journal: Mol Cell
Title: Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-κB-dependent gene expression.
Volume: 53
Issue: 2
Pages: 193-208
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Publication
30635286 | J:276224
First Author: Uras IZ
Year: 2019
Journal: Blood
Title: CDK6 coordinates JAK2 V617F mutant MPN via NF-κB and apoptotic networks.
Volume: 133
Issue: 15
Pages: 1677-1690
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Publication
34248938 | J:314470
 
First Author: Klein K
Year: 2021
Journal: Front Immunol
Title: T Cell-Intrinsic CDK6 Is Dispensable for Anti-Viral and Anti-Tumor Responses In Vivo.
Volume: 12
Pages: 650977
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Publication
25342715 | J:220783
First Author: Scheicher R
Year: 2015
Journal: Blood
Title: CDK6 as a key regulator of hematopoietic and leukemic stem cell activation.
Volume: 125
Issue: 1
Pages: 90-101
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Publication
27915416 | J:240638
First Author: Patel SP
Year: 2017
Journal: Cell Mol Life Sci
Title: Opposing effects on the cell cycle of T lymphocytes by Fbxo7 via Cdk6 and p27.
Volume: 74
Issue: 8
Pages: 1553-1566
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Publication
32855282 | J:314121
First Author: Maurer B
Year: 2021
Journal: Haematologica
Title: Inducible deletion of CDK4 and CDK6 - deciphering CDK4/6 inhibitor effects in the hematopoietic system.
Volume: 106
Issue: 10
Pages: 2624-2632
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Publication
34415667 | J:340039
First Author: Xu X
Year: 2021
Journal: Aging Cell
Title: YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling.
Volume: 20
Issue: 9
Pages: e13465
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Publication
14647273 | J:87867
First Author: Veiga-Fernandes H
Year: 2004
Journal: Nat Immunol
Title: High expression of active CDK6 in the cytoplasm of CD8 memory cells favors rapid division.
Volume: 5
Issue: 1
Pages: 31-7
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Publication
7739548 | J:24520
First Author: Chan FK
Year: 1995
Journal: Mol Cell Biol
Title: Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.
Volume: 15
Issue: 5
Pages: 2682-8
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Publication
25157181 | J:218704
First Author: Rodríguez-Díez E
Year: 2014
Journal: Blood
Title: Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis.
Volume: 124
Issue: 15
Pages: 2380-90
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Protein
Q64261
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Protein
Q3U4J9
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Protein
Q0VBK8
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Publication
23918663 | J:203127
First Author: Hussain MS
Year: 2013
Journal: Hum Mol Genet
Title: CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly.
Volume: 22
Issue: 25
Pages: 5199-214
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Publication
25483078 | J:317860
First Author: Pekkonen P
Year: 2014
Journal: Cell Cycle
Title: KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo.
Volume: 13
Issue: 23
Pages: 3670-84
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Publication
23622063 | J:197897
First Author: Mi D
Year: 2013
Journal: Neuron
Title: Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb.
Volume: 78
Issue: 2
Pages: 269-84
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Publication
29570951 | J:263497
First Author: Grison A
Year: 2018
Journal: Dev Neurobiol
Title: Ablation of cdk4 and cdk6 affects proliferation of basal progenitor cells in the developing dorsal and ventral forebrain.
Volume: 78
Issue: 7
Pages: 660-670
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Publication
23624920 | J:212365
First Author: Ito K
Year: 2014
Journal: Oncogene
Title: Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53-dependent apoptosis without enhancing proliferation.
Volume: 33
Issue: 14
Pages: 1862-71
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Publication
11804782 | J:74491
First Author: Tan J
Year: 2002
Journal: Mech Dev
Title: Evidence for coordinated interaction of cyclin D3 with p21 and cdk6 in directing the development of uterine stromal cell decidualization and polyploidy during implantation.
Volume: 111
Issue: 1-2
Pages: 99-113
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Publication
30093555 | J:266542
 
First Author: Hasenpusch-Theil K
Year: 2018
Journal: Development
Title: Gli3 controls the onset of cortical neurogenesis by regulating the radial glial cell cycle through Cdk6 expression.
Volume: 145
Issue: 17
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Publication
19155308 | J:144975
First Author: Hu MG
Year: 2009
Journal: Cancer Res
Title: A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis.
Volume: 69
Issue: 3
Pages: 810-8
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Publication
21224071 | J:168080
First Author: Wang X
Year: 2011
Journal: Am J Pathol
Title: Unexpected reduction of skin tumorigenesis on expression of cyclin-dependent kinase 6 in mouse epidermis.
Volume: 178
Issue: 1
Pages: 345-54
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Publication
37000627 | J:334729
First Author: Gao X
Year: 2023
Journal: Cell Rep
Title: Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance.
Volume: 42
Issue: 4
Pages: 112314
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Publication
15315761 | J:92529
First Author: Malumbres M
Year: 2004
Journal: Cell
Title: Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6.
Volume: 118
Issue: 4
Pages: 493-504
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Publication
20534551 | J:161377
First Author: Wiedemeyer WR
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM.
Volume: 107
Issue: 25
Pages: 11501-6
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Publication
16869759 | J:115184
 
First Author: Barbacid M
Year: 2005
Journal: Cold Spring Harb Symp Quant Biol
Title: Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases.
Volume: 70
Pages: 233-40
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Publication
18191580 | J:132685
First Author: Atanasoski S
Year: 2008
Journal: Mol Cell Neurosci
Title: Postnatal Schwann cell proliferation but not myelination is strictly and uniquely dependent on cyclin-dependent kinase 4 (cdk4).
Volume: 37
Issue: 3
Pages: 519-27
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Publication
27099147 | J:234793
First Author: Uras IZ
Year: 2016
Journal: Blood
Title: Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6.
Volume: 127
Issue: 23
Pages: 2890-902
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Publication
39487364 | J:359110
First Author: Dinakaran S
Year: 2024
Journal: Nat Cardiovasc Res
Title: CDK6-mediated endothelial cell cycle acceleration drives arteriovenous malformations in hereditary hemorrhagic telangiectasia.
Volume: 3
Issue: 11
Pages: 1301-1317
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Publication
22564414 | J:185130
First Author: Wei J
Year: 2012
Journal: J Cell Biol
Title: miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2.
Volume: 197
Issue: 4
Pages: 509-21
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Publication
7651726 | J:28319
First Author: Quelle DE
Year: 1995
Journal: Oncogene
Title: Cloning and characterization of murine p16INK4a and p15INK4b genes.
Volume: 11
Issue: 4
Pages: 635-45
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Publication
26707936 | J:231481
First Author: Jena N
Year: 2016
Journal: Leukemia
Title: CDK6-mediated repression of CD25 is required for induction and maintenance of Notch1-induced T-cell acute lymphoblastic leukemia.
Volume: 30
Issue: 5
Pages: 1033-43
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Publication
23839966 | J:199443
First Author: Nobs L
Year: 2013
Journal: Glia
Title: Cyclin D1 is required for proliferation of Olig2-expressing progenitor cells in the injured cerebral cortex.
Volume: 61
Issue: 9
Pages: 1443-55
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Publication
21652635 | J:183053
First Author: Meziane el K
Year: 2011
Journal: J Cell Sci
Title: Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells.
Volume: 124
Issue: Pt 13
Pages: 2175-86
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Publication
22465667 | J:184012
First Author: Lopez-Rios J
Year: 2012
Journal: Dev Cell
Title: GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.
Volume: 22
Issue: 4
Pages: 837-48
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Publication
21300982 | J:172844
First Author: Kollmann K
Year: 2011
Journal: Blood
Title: c-JUN promotes BCR-ABL-induced lymphoid leukemia by inhibiting methylation of the 5' region of Cdk6.
Volume: 117
Issue: 15
Pages: 4065-75
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Publication
37545879 | J:338956
 
First Author: de Campos VS
Year: 2023
Journal: Front Cell Neurosci
Title: Maternal Toxoplasma gondii infection affects proliferation, differentiation and cell cycle regulation of retinal neural progenitor cells in mouse embryo.
Volume: 17
Pages: 1211446
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Publication
9372237 | J:44526
First Author: Zindy F
Year: 1997
Journal: Cell Growth Differ
Title: Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development.
Volume: 8
Issue: 11
Pages: 1139-50
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Publication
36095192 | J:334078
First Author: Wang L
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia expansion and neocortical folding.
Volume: 119
Issue: 38
Pages: e2206147119
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Publication
25986147 | J:310132
 
First Author: Zhou L
Year: 2015
Journal: J Mol Cell Cardiol
Title: Tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation.
Volume: 85
Pages: 1-12
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Protein Coding Gene
MGP_CAROLIEiJ_G0026928 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0029255 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029220 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029168 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029236 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028957 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1277162 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0029686 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028369 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028919 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029068 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029031 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029158 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029058 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0029717 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028090 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0028449 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021700 | -
Type: protein_coding_gene
Organism: Mus pahari
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GXD Expression
GXD Expression
     
Probe: MGI:3514164
Assay Type: Western blot
Annotation Date: 2005-01-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:3514219
Age: embryonic day 13.5
Specimen Label: wt
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3514164
Assay Type: Western blot
Annotation Date: 2005-01-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:3514219
Age: embryonic day 13.5
Specimen Label: D1-/-, D2-/-, D3-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3800502
Assay Type: Western blot
Annotation Date: 2008-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3800514
Age: embryonic day 14.5
Specimen Label: E14.5 +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3800502
Assay Type: Western blot
Annotation Date: 2008-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3800514
Age: embryonic day 14.5
Specimen Label: E14.5 delta/delta
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3800502
Assay Type: Western blot
Annotation Date: 2008-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:3800514
Age: embryonic day 17.5
Specimen Label: E17.5 +/+
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3800502
Assay Type: Western blot
Annotation Date: 2008-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:3800514
Age: embryonic day 17.5
Specimen Label: E17.5 delta/delta
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3800502
Assay Type: Western blot
Annotation Date: 2008-08-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3800877
Age: embryonic day 14.5
Specimen Label: E14.5 +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3800502
Assay Type: Western blot
Annotation Date: 2008-08-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3800877
Age: embryonic day 14.5
Specimen Label: E14.5 delta/delta
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3800502
Assay Type: Western blot
Annotation Date: 2008-08-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716827
Stage: TS27
Assay Id: MGI:3800877
Age: postnatal day 1
Specimen Label: Retina +/+
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3800502
Assay Type: Western blot
Annotation Date: 2008-08-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716827
Stage: TS27
Assay Id: MGI:3800877
Age: postnatal day 1
Specimen Label: Retina delta/delta
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3803686
Assay Type: Western blot
Annotation Date: 2008-09-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:3803920
Age: embryonic day 13.5
Specimen Label: WT
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3803686
Assay Type: Western blot
Annotation Date: 2008-09-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:3803920
Age: embryonic day 13.5
Specimen Label: DKO
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3803686
Assay Type: Western blot
Annotation Date: 2008-09-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3803920
Age: embryonic day 14.5
Specimen Label: WT
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3803686
Assay Type: Western blot
Annotation Date: 2008-09-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3803920
Age: embryonic day 14.5
Specimen Label: DKO
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3803686
Assay Type: Western blot
Annotation Date: 2008-09-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:3803920
Age: embryonic day 16.5
Specimen Label: WT
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3803686
Assay Type: Western blot
Annotation Date: 2008-09-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:3803920
Age: embryonic day 16.5
Specimen Label: DKO
Detected: true
Specimen Num: 6
•
•
•
•
•




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