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Search results 1 to 100 out of 2892 for Cdkn1a

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
1026 | CDKN1A
Type: gene
Organism: human
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Gene
100038054 | cdkn1a
Type: gene
Organism: frog, western clawed
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Gene
104001067 | CDKN1A
Type: gene
Organism: chimpanzee
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Gene
key_80076 | CDKN1A
Type: gene
Organism: cat, domestic
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Gene
114851 | Cdkn1a
Type: gene
Organism: rat
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Gene
474890 | CDKN1A
Type: gene
Organism: dog, domestic
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Gene
513497 | CDKN1A
Type: gene
Organism: cattle
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Gene
378914 | CDKN1A
Type: gene
Organism: chicken
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Gene
100151416 | cdkn1a
Type: gene
Organism: zebrafish
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Gene
719199 | CDKN1A
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR029841 | CDKN1A
Type: Family
Description: This entry represents the cyclin-dependent kinase inhibitor 1 (CDKN1A, also known as p21) from animals. It is a direct transcriptional target of p53 and may repress apoptosis []. It mediates several important physiological effects of p53, including DNA-damage-induced cell cycle checkpoints [, ]. p21 plays a critical role in regulating cell growth and the cell response to DNA damage[].
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Protein Coding Gene
MGI:104556 | Cdkn1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q4FK34
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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Publication
25024194 | J:212249
First Author: Gupta R
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A.
Volume: 111
Issue: 30
Pages: E3062-71
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GXD Expression
GXD Expression
 
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7520017
Age: embryonic day 15.0
Image: S3 Cdkn1a E15
Specimen Label: S3 Cdkn1a E15
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7520017
Age: postnatal day 3
Image: S3 Cdkn1a P3
Specimen Label: S3 Cdkn1a P3
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7520017
Age: postnatal day 14
Image: S3 Cdkn1a P14
Specimen Label: S3 Cdkn1a P14
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7520017
Age: postnatal day 0
Image: S2I Cdkn1a P0
Specimen Label: S2I Cdkn1a P0
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7520017
Age: embryonic day 15.0
Image: 3M Cdkn1a E15
Note: Expression in transitional cells.
Specimen Label: 3M Cdkn1a E15
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7520017
Age: postnatal day 14
Image: 3K Cdkn1a P14
Specimen Label: 3K Cdkn1a P14
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7520017
Age: embryonic day 15.0
Image: 3K Cdkn1a E15
Specimen Label: 3K Cdkn1a E15
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7520017
Age: postnatal day 0
Image: 3K Cdkn1a P0
Specimen Label: 3K Cdkn1a P0
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286026
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7520017
Age: embryonic day 18.0
Image: S3 Cdkn1a E18
Specimen Label: S3 Cdkn1a E18
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7520017
Age: postnatal day 0
Image: S3 Cdkn1a P0
Specimen Label: S3 Cdkn1a P0
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7520017
Age: postnatal day 5
Image: S3 Cdkn1a P5
Specimen Label: S3 Cdkn1a P5
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7520017
Age: postnatal day 7
Image: S3 Cdkn1a P7
Specimen Label: S3 Cdkn1a P7
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7520017
Age: embryonic day 15.0
Image: S2I Cdkn1a E15
Specimen Label: S2I Cdkn1a E15
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286026
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7520017
Age: embryonic day 18.0
Image: S2I Cdkn1a E18
Specimen Label: S2I Cdkn1a E18
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7520017
Age: postnatal day 3
Image: S2I Cdkn1a P3
Specimen Label: S2I Cdkn1a P3
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
 
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7520017
Age: postnatal day 5
Image: S2I Cdkn1a P5
Specimen Label: S2I Cdkn1a P5
Detected: true
Specimen Num: 18
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GXD Expression
GXD Expression
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7520017
Age: postnatal day 0
Image: 3M Cdkn1a P0
Note: Expression in transitional cells.
Specimen Label: 3M Cdkn1a P0
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
Probe: MGI:7519204
Assay Type: RNA in situ
Annotation Date: 2023-08-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7520017
Age: postnatal day 5
Image: 3M Cdkn1a P5
Note: Expression in transitional cells.
Specimen Label: 3M Cdkn1a P5
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:3820892
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3565022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3826203
Age: embryonic day 14.5
Image: Additional file 4 Cdkn1a
Specimen Label: Additional file 4 Cdkn1a
Detected: true
Specimen Num: 1
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Gene
100861512 | CDKN1A-AS1
Type: gene
Organism: human
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Gene
56647 | BCCIP
Type: gene
Organism: human
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Protein
P39689
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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Protein
Q564P6
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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Publication
7585571 | -
First Author: Waldman T
Year: 1995
Journal: Cancer Res
Title: p21 is necessary for the p53-mediated G1 arrest in human cancer cells.
Volume: 55
Issue: 22
Pages: 5187-90
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Publication
10858953 | -
First Author: Boulaire J
Year: 2000
Journal: Pathol Biol (Paris)
Title: The functions of the cdk-cyclin kinase inhibitor p21WAF1.
Volume: 48
Issue: 3
Pages: 190-202
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Publication
22509363 | J:187095
First Author: Hönnemann J
Year: 2012
Journal: PLoS One
Title: Miz1 is a critical repressor of cdkn1a during skin tumorigenesis.
Volume: 7
Issue: 4
Pages: e34885
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Gene
25792 | CIZ1
Type: gene
Organism: human
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Gene
101154753 | PANDAR
Type: gene
Organism: human
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Publication
25609837 | J:221684
First Author: Lin H
Year: 2015
Journal: Biol Reprod
Title: Deficiency of CDKN1A or both CDKN1A and CDKN1B affects the pubertal development of mouse Leydig cells.
Volume: 92
Issue: 3
Pages: 77
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Publication
36765862 | J:333332
 
First Author: Khan MGM
Year: 2023
Journal: Cancers (Basel)
Title: SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation.
Volume: 15
Issue: 3
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Publication
26343536 | J:233646
First Author: Price JG
Year: 2015
Journal: Nat Immunol
Title: CDKN1A regulates Langerhans cell survival and promotes Treg cell generation upon exposure to ionizing irradiation.
Volume: 16
Issue: 10
Pages: 1060-8
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Publication
22956607 | J:214056
First Author: Matthaei M
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy.
Volume: 53
Issue: 10
Pages: 6718-27
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Publication
25329316 | J:217430
First Author: Esteve-Puig R
Year: 2014
Journal: PLoS Genet
Title: A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.
Volume: 10
Issue: 10
Pages: e1004721
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Publication
29026085 | J:254397
First Author: Béguelin W
Year: 2017
Journal: Nat Commun
Title: EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.
Volume: 8
Issue: 1
Pages: 877
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Publication
24497168 | J:310129
First Author: Koike H
Year: 2014
Journal: Hepatology
Title: Ring1B promotes hepatic stem/progenitor cell expansion through simultaneous suppression of Cdkn1a and Cdkn2a in mice.
Volume: 60
Issue: 1
Pages: 323-33
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Publication
22241836 | J:181189
First Author: Ishimura A
Year: 2012
Journal: Development
Title: Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression.
Volume: 139
Issue: 4
Pages: 749-59
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Publication
23341776 | J:195172
First Author: Lüdtke TH
Year: 2013
Journal: PLoS Genet
Title: Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b.
Volume: 9
Issue: 1
Pages: e1003189
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Publication
32253738 | J:316308
First Author: Ock SA
Year: 2020
Journal: Cell Stress Chaperones
Title: Involvement of CDKN1A (p21) in cellular senescence in response to heat and irradiation stress during preimplantation development.
Volume: 25
Issue: 3
Pages: 503-508
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Publication
29777010 | J:264117
 
First Author: Nayak G
Year: 2018
Journal: Development
Title: Developmental vascular regression is regulated by a Wnt/β-catenin, MYC and CDKN1A pathway that controls cell proliferation and cell death.
Volume: 145
Issue: 12
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Publication
17881769 | J:130792
First Author: Li F
Year: 2008
Journal: Biol Reprod
Title: Involvement of cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) in interleukin 11 stimulation of decidualization in mice.
Volume: 78
Issue: 1
Pages: 127-33
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Publication
15467370 | J:93129
First Author: Ashley T
Year: 2004
Journal: Cytogenet Genome Res
Title: The mammalian mid-pachytene checkpoint: meiotic arrest in spermatocytes with a mutation in Atm alone or in combination with a Trp53 (p53) or Cdkn1a (p21/cip1) mutation.
Volume: 107
Issue: 3-4
Pages: 256-62
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Publication
17143283 | J:117492
First Author: Choudhury AR
Year: 2007
Journal: Nat Genet
Title: Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation.
Volume: 39
Issue: 1
Pages: 99-105
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GXD Expression
GXD Expression
Probe: MGI:5704491
Assay Type: Immunohistochemistry
Annotation Date: 2024-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1627617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:7571559
Age: embryonic day 10.5
Image: 17A p21
Note: Authors report almost exclusive expression of either Cdkn1a or Mki67.
Specimen Label: 17A p21
Detected: true
Specimen Num: 2
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Publication
32201259 | J:297226
First Author: Lu H
Year: 2020
Journal: Am J Pathol
Title: Spontaneous Development of Hepatocellular Carcinoma and B-Cell Lymphoma in Mosaic and Heterozygous Brca2 and Cdkn1a Interacting Protein Knockout Mice.
Volume: 190
Issue: 6
Pages: 1175-1187
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Publication
17848507 | J:125208
First Author: Ohtani N
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Visualizing the dynamics of p21(Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals.
Volume: 104
Issue: 38
Pages: 15034-9
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Gene
361666 | Bccip
Type: gene
Organism: rat
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Gene
477864 | BCCIP
Type: gene
Organism: dog, domestic
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Gene
738638 | BCCIP
Type: gene
Organism: chimpanzee
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Gene
512466 | BCCIP
Type: gene
Organism: cattle
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Gene
426225 | BCCIP
Type: gene
Organism: chicken
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Gene
541348 | bccip
Type: gene
Organism: zebrafish
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Gene
699437 | BCCIP
Type: gene
Organism: macaque, rhesus
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Gene
448392 | bccip
Type: gene
Organism: frog, western clawed
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Publication
30355482 | J:266858
First Author: Torgovnick A
Year: 2018
Journal: Cell Rep
Title: The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression.
Volume: 25
Issue: 4
Pages: 1027-1039.e6
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Protein Coding Gene
MGI:1913415 | Bccip
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
8595876 | J:31291
First Author: Wu H
Year: 1996
Journal: Genes Dev
Title: Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration.
Volume: 10
Issue: 3
Pages: 245-60
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Publication
34808017 | J:345646
First Author: Furuhata R
Year: 2022
Journal: Genes Cells
Title: LincRNA-p21 exon 1 expression correlates with Cdkn1a expression in vivo.
Volume: 27
Issue: 1
Pages: 14-24
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Publication
37169880 | J:357734
First Author: Kawamoto S
Year: 2023
Journal: Nat Cell Biol
Title: Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota.
Volume: 25
Issue: 6
Pages: 865-876
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Publication
29234059 | J:257682
First Author: Okuma A
Year: 2017
Journal: Nat Commun
Title: p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis.
Volume: 8
Issue: 1
Pages: 2050
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Publication
34192538 | J:327994
First Author: Marney CB
Year: 2021
Journal: Cell Rep
Title: p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino.
Volume: 35
Issue: 13
Pages: 109329
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Publication
24777532 | J:259589
First Author: Obata Y
Year: 2014
Journal: Nat Immunol
Title: The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells.
Volume: 15
Issue: 6
Pages: 571-9
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Publication
29357734 | J:283579
First Author: Luyckx E
Year: 2018
Journal: Stem Cells Dev
Title: Loss of Neuroglobin Expression Alters Cdkn1a/Cdk6-Expression Resulting in Increased Proliferation of Neural Stem Cells.
Volume: 27
Issue: 6
Pages: 378-390
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Publication
35931081 | J:334650
First Author: Kanatsu-Shinohara M
Year: 2022
Journal: Stem Cell Reports
Title: Regulation of male germline transmission patterns by the Trp53-Cdkn1a pathway.
Volume: 17
Issue: 9
Pages: 1924-1941
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Publication
36689330 | J:352393
First Author: Müller L
Year: 2023
Journal: Cell Rep
Title: Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling.
Volume: 42
Issue: 1
Pages: 112031
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Publication
24616249 | J:213340
First Author: Huang T
Year: 2014
Journal: Genesis
Title: Senescence-associated β-galactosidase activity marks the visceral endoderm of mouse embryos but is not indicative of senescence.
Volume: 52
Issue: 4
Pages: 300-8
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Publication
20160708 | J:184124
 
First Author: Passos JF
Year: 2010
Journal: Mol Syst Biol
Title: Feedback between p21 and reactive oxygen production is necessary for cell senescence.
Volume: 6
Pages: 347
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Pathway
R-MMU-8941855 | RUNX3 regulates CDKN1A transcription
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Publication
30703085 | J:270809
First Author: Thwaites MJ
Year: 2019
Journal: PLoS One
Title: Context dependent roles for RB-E2F transcriptional regulation in tumor suppression.
Volume: 14
Issue: 1
Pages: e0203577
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Publication
28442710 | J:275323
First Author: Han Y
Year: 2017
Journal: Sci Rep
Title: Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells.
Volume: 7
Issue: 1
Pages: 1136
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Publication
21288574 | J:169375
First Author: Shansab M
Year: 2011
Journal: Mol Immunol
Title: p21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation.
Volume: 48
Issue: 6-7
Pages: 973-8
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Publication
26944543 | J:233010
First Author: Man N
Year: 2016
Journal: Blood
Title: Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin.
Volume: 127
Issue: 19
Pages: 2322-6
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Publication
26898952 | J:251648
 
First Author: Wang H
Year: 2016
Journal: Sci Rep
Title: Oscillating primary transcripts harbor miRNAs with circadian functions.
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