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Search results 1 to 100 out of 171 for Clpp

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Hits by Strain

Type Details Score
Gene
8192 | CLPP
Type: gene
Organism: human
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Gene
100135748 | clpp
Type: gene
Organism: frog, western clawed
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Gene
301117 | Clpp
Type: gene
Organism: rat
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Gene
611738 | CLPP
Type: gene
Organism: dog, domestic
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Gene
455637 | CLPP
Type: gene
Organism: chimpanzee
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Gene
535981 | CLPP
Type: gene
Organism: cattle
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Gene
553713 | clpp
Type: gene
Organism: zebrafish
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Gene
699593 | CLPP
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1858213 | Clpp
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR001907 | ClpP
Type: Family
Description: Clp is an ATP-dependent protease that cleaves a number of proteins, such as casein and albumin []and is a member of peptidase family S14. It exists as a heterodimer of ATP-binding regulatory A and catalytic P subunits, both of which are required for effective levels of protease activity in the presence of ATP [, ], although the P subunit alone does possess some catalytic activity []. This entry represents the P subunit.Proteases highly similar to ClpP have been found to be encoded in the genomeof bacteria, metazoa, some viruses and in the chloroplast of plants, but seems to be absent in archaea, mollicutes and some fungi []. Clp proteases are involved in a number of cellular processes such as degradation of misfolded proteins, regulation of short-lived proteins and housekeeping removal of dysfunctional proteins. They are also implicated in the control of cell growth, targeting DNA-binding protein from starved cells. ClpP has also been linked to the tight regulation of virulence genes in the pathogens Listeria monocytogenes and Salmonella typhimurium []. Active site consists of the triad Ser, His and Asp []; some members have lost all of these active site residues and are therefore inactive, while others may have one or two large insertions. ClpP seems to prefer hydrophobic or non-polar residues at P1 or P1' positions in its substrate. The protease exists as a tetradecamer made up of two heptameric rings stacked back-to-back such that the catalytic triad of each subunit is located at the interface between three monomers, thus making oligomerization essential for function [, ].
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Publication
29588285 | J:261711
 
First Author: Becker C
Year: 2018
Journal: EMBO Rep
Title: CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis.
Volume: 19
Issue: 5
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Publication
27797820 | J:238790
First Author: Szczepanowska K
Year: 2016
Journal: EMBO J
Title: CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels.
Volume: 35
Issue: 23
Pages: 2566-2583
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Publication
10754102 | J:61064
First Author: Andresen BS
Year: 2000
Journal: Mamm Genome
Title: Characterization of mouse Clpp protease cDNA, gene, and protein.
Volume: 11
Issue: 4
Pages: 275-80
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Publication
9390554 | -
First Author: Wang J
Year: 1997
Journal: Cell
Title: The structure of ClpP at 2.3 A resolution suggests a model for ATP-dependent proteolysis.
Volume: 91
Issue: 4
Pages: 447-56
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Publication
17302811 | -
First Author: Frees D
Year: 2007
Journal: Mol Microbiol
Title: Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram-positive bacteria.
Volume: 63
Issue: 5
Pages: 1285-95
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Publication
27154400 | J:234481
First Author: Seiferling D
Year: 2016
Journal: EMBO Rep
Title: Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt.
Volume: 17
Issue: 7
Pages: 953-64
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Publication
26058080 | J:222914
First Author: Cole A
Year: 2015
Journal: Cancer Cell
Title: Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.
Volume: 27
Issue: 6
Pages: 864-76
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Publication
29420235 | J:259198
 
First Author: Bhaskaran S
Year: 2018
Journal: EMBO Rep
Title: Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance.
Volume: 19
Issue: 3
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Publication
30877431 | J:308601
First Author: Hu D
Year: 2019
Journal: Acta Neuropathol
Title: Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.
Volume: 137
Issue: 6
Pages: 939-960
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Publication
33731338 | J:324737
First Author: Torres-Odio S
Year: 2021
Journal: J Immunol
Title: Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis.
Volume: 206
Issue: 8
Pages: 1890-1900
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Publication
19154341 | J:147890
First Author: Guillon B
Year: 2009
Journal: FEBS J
Title: Frataxin deficiency causes upregulation of mitochondrial Lon and ClpP proteases and severe loss of mitochondrial Fe-S proteins.
Volume: 276
Issue: 4
Pages: 1036-47
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Publication
36611846 | J:332598
 
First Author: Key J
Year: 2022
Journal: Cells
Title: CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2.
Volume: 12
Issue: 1
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Publication
23851121 | J:203140
First Author: Gispert S
Year: 2013
Journal: Hum Mol Genet
Title: Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.
Volume: 22
Issue: 24
Pages: 4871-87
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Publication
2197275 | -
First Author: Maurizi MR
Year: 1990
Journal: J Biol Chem
Title: Sequence and structure of Clp P, the proteolytic component of the ATP-dependent Clp protease of Escherichia coli.
Volume: 265
Issue: 21
Pages: 12536-45
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Publication
17499722 | -
First Author: Yu AY
Year: 2007
Journal: FEBS Lett
Title: ClpP: a distinctive family of cylindrical energy-dependent serine proteases.
Volume: 581
Issue: 19
Pages: 3749-57
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Publication
10320569 | -
First Author: Porankiewicz J
Year: 1999
Journal: Mol Microbiol
Title: New insights into the ATP-dependent Clp protease: Escherichia coli and beyond.
Volume: 32
Issue: 3
Pages: 449-58
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Publication
2103893 | -
First Author: Goldberg AL
Year: 1990
Journal: Semin Cell Biol
Title: ATP-dependent proteases in prokaryotic and eukaryotic cells.
Volume: 1
Issue: 6
Pages: 423-32
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Publication
19038348 | -
First Author: Bewley MC
Year: 2009
Journal: J Struct Biol
Title: Turned on for degradation: ATPase-independent degradation by ClpP.
Volume: 165
Issue: 2
Pages: 118-25
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Protein
O88696
Organism: Mus musculus/domesticus
Length: 272  
Fragment?: false
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Protein
Q8CF81
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
Q3UGW4
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: true
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Publication
33374937 | J:307532
 
First Author: Esencan E
Year: 2020
Journal: Antioxidants (Basel)
Title: Mitochondrial Stress Response Gene Clpp Is Not Required for Granulosa Cell Function.
Volume: 10
Issue: 1
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Publication
18824507 | -
First Author: Ekici OD
Year: 2008
Journal: Protein Sci
Title: Unconventional serine proteases: variations on the catalytic Ser/His/Asp triad configuration.
Volume: 17
Issue: 12
Pages: 2023-37
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Publication
38139332 | J:343763
 
First Author: Key J
Year: 2023
Journal: Int J Mol Sci
Title: Translation Fidelity and Respiration Deficits in CLPP-Deficient Tissues: Mechanistic Insights from Mitochondrial Complexome Profiling.
Volume: 24
Issue: 24
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Publication
37798322 | J:341934
First Author: Guo C
Year: 2023
Journal: Commun Biol
Title: ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis.
Volume: 6
Issue: 1
Pages: 1012
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Publication
10347188 | J:55436
First Author: Santagata S
Year: 1999
Journal: J Biol Chem
Title: Molecular cloning and characterization of a mouse homolog of bacterial ClpX, a novel mammalian class II member of the Hsp100/Clp chaperone family.
Volume: 274
Issue: 23
Pages: 16311-9
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Protein Coding Gene
MGP_CAROLIEiJ_G0021796 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0023945 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0023903 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0023872 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0023904 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0023668 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1858213 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024350 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023150 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0023644 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0023772 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0023738 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0023854 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0023766 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0024394 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0022896 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023216 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0020785 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0022707 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
32242014 | J:289135
First Author: Szczepanowska K
Year: 2020
Journal: Nat Commun
Title: A salvage pathway maintains highly functional respiratory complex I.
Volume: 11
Issue: 1
Pages: 1643
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GXD Expression
GXD Expression
     
Probe: MGI:1332177
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1332178
Age: embryonic day 7.5
Specimen Label: 1x
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:1332177
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1332178
Age: embryonic day 7.5
Specimen Label: 10x
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:1332177
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1332178
Age: embryonic day 7.5
Specimen Label: 100x
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:1332177
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1332178
Age: embryonic day 7.5
Specimen Label: 1x
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:1332177
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1332178
Age: embryonic day 7.5
Specimen Label: 10x
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:1332177
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1332178
Age: embryonic day 7.5
Specimen Label: 100x
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:1859246
Assay Type: Northern blot
Annotation Date: 2000-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1859327
Age: postnatal adult
Specimen Label: H
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:1859246
Assay Type: Northern blot
Annotation Date: 2000-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1859327
Age: postnatal adult
Specimen Label: B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:1859246
Assay Type: Northern blot
Annotation Date: 2000-06-20
Strength: Present
Sex: Female
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:1859327
Age: postnatal adult
Specimen Label: Pl
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:1859246
Assay Type: Northern blot
Annotation Date: 2000-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:1859327
Age: postnatal adult
Specimen Label: Lu
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:1859246
Assay Type: Northern blot
Annotation Date: 2000-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1859327
Age: postnatal adult
Specimen Label: Li
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:1859246
Assay Type: Northern blot
Annotation Date: 2000-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1859327
Age: postnatal adult
Specimen Label: SM
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:1859246
Assay Type: Northern blot
Annotation Date: 2000-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1859327
Age: postnatal adult
Specimen Label: K
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:1859246
Assay Type: Northern blot
Annotation Date: 2000-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:1859327
Age: postnatal adult
Specimen Label: Pa
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:7506670
Assay Type: RT-PCR
Annotation Date: 2023-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:7506787
Age: embryonic day 3.5
Image: 6
Specimen Label: In vivo
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7614417
Assay Type: Western blot
Annotation Date: 2024-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Stage: TS21
Assay Id: MGI:7616337
Age: embryonic day 13.5
Specimen Label: 13.5 dpc
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7614417
Assay Type: Western blot
Annotation Date: 2024-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Stage: TS21
Assay Id: MGI:7616337
Age: embryonic day 13.5
Specimen Label: 13.5 dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7614417
Assay Type: Western blot
Annotation Date: 2024-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Stage: TS21
Assay Id: MGI:7616337
Age: embryonic day 13.5
Specimen Label: 13.5 dpc
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:7614417
Assay Type: Western blot
Annotation Date: 2024-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610524
Stage: TS24
Assay Id: MGI:7616337
Age: embryonic day 16.5
Specimen Label: 16.5 dpc
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:7614417
Assay Type: Western blot
Annotation Date: 2024-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610524
Stage: TS24
Assay Id: MGI:7616337
Age: embryonic day 16.5
Specimen Label: 16.5 dpc
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:7614417
Assay Type: Western blot
Annotation Date: 2024-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610524
Stage: TS24
Assay Id: MGI:7616337
Age: embryonic day 16.5
Specimen Label: 16.5 dpc
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:7614417
Assay Type: Western blot
Annotation Date: 2024-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:7616337
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:7614417
Assay Type: Western blot
Annotation Date: 2024-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:7616337
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:7614417
Assay Type: Western blot
Annotation Date: 2024-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:7616337
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
     
Probe: MGI:7614417
Assay Type: Western blot
Annotation Date: 2024-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3679328
Stage: TS28
Assay Id: MGI:7616337
Age: postnatal week 8
Specimen Label: 8 weeks
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
     
Probe: MGI:7614417
Assay Type: Western blot
Annotation Date: 2024-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3679328
Stage: TS28
Assay Id: MGI:7616337
Age: postnatal week 8
Specimen Label: 8 weeks
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
     
Probe: MGI:7614417
Assay Type: Western blot
Annotation Date: 2024-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3679328
Stage: TS28
Assay Id: MGI:7616337
Age: postnatal week 8
Specimen Label: 8 weeks
Detected: true
Specimen Num: 12
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Publication
32342250 | J:308515
First Author: Key J
Year: 2020
Journal: Neurogenetics
Title: Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease.
Volume: 21
Issue: 3
Pages: 187-203
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Publication
35385313 | J:327265
First Author: Croon M
Year: 2022
Journal: Sci Adv
Title: FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction.
Volume: 8
Issue: 14
Pages: eabn7105
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Publication
34974310 | J:317438
 
First Author: Sheng X
Year: 2022
Journal: EBioMedicine
Title: The mitochondrial protease LONP1 maintains oocyte development and survival by suppressing nuclear translocation of AIFM1 in mammals.
Volume: 75
Pages: 103790
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Publication
36167966 | J:329326
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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