| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang XD |
| Year: |
2011 |
| Journal: |
Neurobiol Dis |
| Title: |
Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling. |
| Volume: |
42 |
| Issue: |
3 |
| Pages: |
300-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang XD |
| Year: |
2013 |
| Journal: |
Nat Neurosci |
| Title: |
Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss. |
| Volume: |
16 |
| Issue: |
6 |
| Pages: |
706-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Savarese A |
| Year: |
2018 |
| Journal: |
Psychoneuroendocrinology |
| Title: |
Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3. |
| Volume: |
92 |
|
| Pages: |
13-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Molander A |
| Year: |
2012 |
| Journal: |
Neuropsychopharmacology |
| Title: |
Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking. |
| Volume: |
37 |
| Issue: |
4 |
| Pages: |
1047-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Garcia I |
| Year: |
2016 |
| Journal: |
Brain Struct Funct |
| Title: |
Local corticotropin releasing hormone (CRH) signals to its receptor CRHR1 during postnatal development of the mouse olfactory bulb. |
| Volume: |
221 |
| Issue: |
1 |
| Pages: |
1-20 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6170338 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689419 |
| Pattern: |
Not Specified |
| Stage: |
TS19 |
| Assay Id: |
MGI:6190044 |
| Age: |
embryonic day 11.5 |
|
|
| Specimen Label: |
Table S2 - E11.5 - Crhr1 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6170338 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689421 |
| Pattern: |
Not Specified |
| Stage: |
TS21 |
| Assay Id: |
MGI:6190044 |
| Age: |
embryonic day 13.5 |
|
|
| Specimen Label: |
Table S2 - E13.5 - Crhr1 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6170338 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689424 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:6190044 |
| Age: |
embryonic day 15.5 |
|
|
| Specimen Label: |
Table S2 - E15.5 - Crhr1 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6170338 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689426 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:6190044 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
Table S2 - E18.5 - Crhr1 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6170338 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6190044 |
| Age: |
postnatal day 4 |
|
|
| Specimen Label: |
Table S2 - P4 - Crhr1 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6170338 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6190044 |
| Age: |
postnatal day 14 |
|
|
| Specimen Label: |
Table S2 - P14 - Crhr1 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6170338 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6190044 |
| Age: |
postnatal day 28 |
|
|
| Specimen Label: |
Table S2 - P28 - Crhr1 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| QTL |
| Type: |
QTL |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| QTL |
| Type: |
QTL |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| QTL |
| Type: |
QTL |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Garlow SJ |
| Year: |
2005 |
| Journal: |
Endocrinology |
| Title: |
Genetic analysis of the hypothalamic corticotropin-releasing factor system. |
| Volume: |
146 |
| Issue: |
5 |
| Pages: |
2362-8 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
210
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Müller MB |
| Year: |
2003 |
| Journal: |
Nat Neurosci |
| Title: |
Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. |
| Volume: |
6 |
| Issue: |
10 |
| Pages: |
1100-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Timpl P |
| Year: |
1998 |
| Journal: |
Nat Genet |
| Title: |
Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. |
| Volume: |
19 |
| Issue: |
2 |
| Pages: |
162-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Müller MB |
| Year: |
2000 |
| Journal: |
Neuroreport |
| Title: |
Disruption of feeding behavior in CRH receptor 1-deficient mice is dependent on glucocorticoids. |
| Volume: |
11 |
| Issue: |
9 |
| Pages: |
1963-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Raftogianni A |
| Year: |
2018 |
| Journal: |
Front Mol Neurosci |
| Title: |
Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis. |
| Volume: |
11 |
|
| Pages: |
305 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Refojo D |
| Year: |
2011 |
| Journal: |
Science |
| Title: |
Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. |
| Volume: |
333 |
| Issue: |
6051 |
| Pages: |
1903-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schierloh A |
| Year: |
2007 |
| Journal: |
Neurosci Lett |
| Title: |
Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity. |
| Volume: |
416 |
| Issue: |
1 |
| Pages: |
82-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schmidt MV |
| Year: |
2006 |
| Journal: |
Eur J Neurosci |
| Title: |
Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice. |
| Volume: |
24 |
| Issue: |
8 |
| Pages: |
2291-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang XD |
| Year: |
2012 |
| Journal: |
Eur J Neurosci |
| Title: |
Early-life stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1. |
| Volume: |
36 |
| Issue: |
3 |
| Pages: |
2360-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Deussing JM |
| Year: |
2007 |
| Journal: |
J Cereb Blood Flow Metab |
| Title: |
Expression profiling identifies the CRH/CRH-R1 system as a modulator of neurovascular gene activity. |
| Volume: |
27 |
| Issue: |
8 |
| Pages: |
1476-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schmidt MV |
| Year: |
2003 |
| Journal: |
Neuroscience |
| Title: |
Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice. |
| Volume: |
119 |
| Issue: |
2 |
| Pages: |
589-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu Y |
| Year: |
2014 |
| Journal: |
Endocr Relat Cancer |
| Title: |
The role of corticotropin-releasing hormone receptor 1 in the development of colitis-associated cancer in mouse model. |
| Volume: |
21 |
| Issue: |
4 |
| Pages: |
639-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoshida-Hiroi M |
| Year: |
2002 |
| Journal: |
Mol Psychiatry |
| Title: |
Chromaffin cell function and structure is impaired in corticotropin-releasing hormone receptor type 1-null mice. |
| Volume: |
7 |
| Issue: |
9 |
| Pages: |
967-74 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yamamoto M |
| Year: |
2018 |
| Journal: |
JCI Insight |
| Title: |
Somatostatin receptor subtype 5 modifies hypothalamic-pituitary-adrenal axis stress function. |
| Volume: |
3 |
| Issue: |
19 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sotnikov SV |
| Year: |
2014 |
| Journal: |
Transl Psychiatry |
| Title: |
Bidirectional rescue of extreme genetic predispositions to anxiety: impact of CRH receptor 1 as epigenetic plasticity gene in the amygdala. |
| Volume: |
4 |
| Issue: |
2 |
| Pages: |
e359 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kameda H |
| Year: |
2019 |
| Journal: |
Endocrinology |
| Title: |
Proton Sensitivity of Corticotropin-Releasing Hormone Receptor 1 Signaling to Proopiomelanocortin in Male Mice. |
| Volume: |
160 |
| Issue: |
2 |
| Pages: |
276-291 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bernardi RE |
| Year: |
2017 |
| Journal: |
Front Behav Neurosci |
| Title: |
Dissociable Role of Corticotropin Releasing Hormone Receptor Subtype 1 on Dopaminergic and D1 Dopaminoceptive Neurons in Cocaine Seeking Behavior. |
| Volume: |
11 |
|
| Pages: |
221 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sotnikov SV |
| Year: |
2014 |
| Journal: |
Eur J Neurosci |
| Title: |
Enriched environment impacts trimethylthiazoline-induced anxiety-related behavior and immediate early gene expression: critical role of Crhr1. |
| Volume: |
40 |
| Issue: |
4 |
| Pages: |
2691-700 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gray JM |
| Year: |
2015 |
| Journal: |
J Neurosci |
| Title: |
Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. |
| Volume: |
35 |
| Issue: |
9 |
| Pages: |
3879-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hu P |
| Year: |
2020 |
| Journal: |
J Neurosci |
| Title: |
Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria Terminalis. |
| Volume: |
40 |
| Issue: |
12 |
| Pages: |
2519-2537 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sanford CA |
| Year: |
2017 |
| Journal: |
Neuron |
| Title: |
A Central Amygdala CRF Circuit Facilitates Learning about Weak Threats. |
| Volume: |
93 |
| Issue: |
1 |
| Pages: |
164-178 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Thoeringer CK |
| Year: |
2012 |
| Journal: |
Neuropsychopharmacology |
| Title: |
Consolidation of remote fear memories involves Corticotropin-Releasing Hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in the dentate gyrus. |
| Volume: |
37 |
| Issue: |
3 |
| Pages: |
787-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Preil J |
| Year: |
2001 |
| Journal: |
Endocrinology |
| Title: |
Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2. |
| Volume: |
142 |
| Issue: |
11 |
| Pages: |
4946-55 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li Y |
| Year: |
2019 |
| Journal: |
Brain Res |
| Title: |
Sevoflurane-induced learning deficits and spine loss via nectin-1/corticotrophin-releasing hormone receptor type 1 signaling. |
| Volume: |
1710 |
|
| Pages: |
188-198 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kühne C |
| Year: |
2012 |
| Journal: |
J Comp Neurol |
| Title: |
Visualizing corticotropin-releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele. |
| Volume: |
520 |
| Issue: |
14 |
| Pages: |
3150-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Müller MB |
| Year: |
2000 |
| Journal: |
Endocrinology |
| Title: |
Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids. |
| Volume: |
141 |
| Issue: |
11 |
| Pages: |
4262-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
de León Reyes NS |
| Year: |
2023 |
| Journal: |
Cell |
| Title: |
Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum suppresses interaction with familiar mice. |
| Volume: |
186 |
| Issue: |
19 |
| Pages: |
4152-4171.e31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McClard CK |
| Year: |
2018 |
| Journal: |
J Neurosci |
| Title: |
POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult Brain. |
| Volume: |
38 |
| Issue: |
6 |
| Pages: |
1443-1461 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bender J |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif. |
| Volume: |
10 |
| Issue: |
9 |
| Pages: |
e0136768 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Heymann G |
| Year: |
2020 |
| Journal: |
Neuron |
| Title: |
Synergy of Distinct Dopamine Projection Populations in Behavioral Reinforcement. |
| Volume: |
105 |
| Issue: |
5 |
| Pages: |
909-920.e5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Simard M |
| Year: |
2010 |
| Journal: |
Reprod Biol Endocrinol |
| Title: |
Expression of genes related to the hypothalamic-pituitary-adrenal axis in murine fetal lungs in late gestation. |
| Volume: |
8 |
|
| Pages: |
134 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chang S |
| Year: |
2018 |
| Journal: |
Neuropsychopharmacology |
| Title: |
NPTX2 is a key component in the regulation of anxiety. |
| Volume: |
43 |
| Issue: |
9 |
| Pages: |
1943-1953 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vita N |
| Year: |
1993 |
| Journal: |
FEBS Lett |
| Title: |
Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. |
| Volume: |
335 |
| Issue: |
1 |
| Pages: |
1-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Smith GW |
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CRF type I receptor-deficient mice exhibit a pronounced pituitary-adrenal response to local inflammation. |
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Pharmacol Biochem Behav |
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Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout. |
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86 |
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4 |
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Proc Natl Acad Sci U S A |
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CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner. |
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107 |
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J Neurosci |
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50 |
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