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Search results 1 to 100 out of 183 for Ddb2

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
1643 | DDB2
Type: gene
Organism: human
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Gene
493565 | ddb2
Type: gene
Organism: frog, western clawed
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Gene
483626 | DDB2
Type: gene
Organism: dog, domestic
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Gene
451165 | DDB2
Type: gene
Organism: chimpanzee
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Gene
519357 | DDB2
Type: gene
Organism: cattle
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Gene
100362121 | Ddb2
Type: gene
Organism: rat
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Gene
423185 | DDB2
Type: gene
Organism: chicken
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Gene
100004133 | ddb2
Type: gene
Organism: zebrafish
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Gene
713813 | DDB2
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1355314 | Ddb2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR033312 | DDB2
Type: Family
Description: DNA damage-binding protein 2 (DDB2) is required for DNA repair. It binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair []. It is also involved in the initiation of nucleotide excision repair via an ubiquitin ligase complex together with DDB1 and CUL4A (cullin 4A) [].
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Protein
Q4FZK4
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: false
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Publication
19541625 | J:150832
First Author: Stoyanova T
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: DDB2 decides cell fate following DNA damage.
Volume: 106
Issue: 26
Pages: 10690-5
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Publication
22492724 | J:185041
First Author: Luijsterburg MS
Year: 2012
Journal: J Cell Biol
Title: DDB2 promotes chromatin decondensation at UV-induced DNA damage.
Volume: 197
Issue: 2
Pages: 267-81
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Publication
10713455 | J:61007
First Author: Zolezzi F
Year: 2000
Journal: Gene
Title: Studies of the murine DDB1 and DDB2 genes.
Volume: 245
Issue: 1
Pages: 151-9
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Publication
29021137 | J:271423
First Author: Huang S
Year: 2017
Journal: Cancer Res
Title: DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer.
Volume: 77
Issue: 23
Pages: 6562-6575
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Publication
16288018 | J:103406
First Author: Alekseev S
Year: 2005
Journal: Cancer Res
Title: Enhanced DDB2 expression protects mice from carcinogenic effects of chronic UV-B irradiation.
Volume: 65
Issue: 22
Pages: 10298-306
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Publication
14751237 | -
First Author: Inoki T
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Human DDB2 splicing variants are dominant negative inhibitors of UV-damaged DNA repair.
Volume: 314
Issue: 4
Pages: 1036-43
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Publication
26205499 | -
First Author: Qiao S
Year: 2015
Journal: Biochem J
Title: DDB2 is involved in ubiquitination and degradation of PAQR3 and regulates tumorigenesis of gastric cancer cells.
Volume: 469
Issue: 3
Pages: 469-80
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Publication
11971958 | J:76244
First Author: Tan T
Year: 2002
Journal: Mol Cell Biol
Title: p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice.
Volume: 22
Issue: 10
Pages: 3247-54
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Publication
17635991 | J:125000
First Author: Luijsterburg MS
Year: 2007
Journal: J Cell Sci
Title: Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC.
Volume: 120
Issue: Pt 15
Pages: 2706-16
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Publication
17468495 | J:125108
First Author: Itoh T
Year: 2007
Journal: Hum Mol Genet
Title: Ddb2 is a haploinsufficient tumor suppressor and controls spontaneous germ cell apoptosis.
Volume: 16
Issue: 13
Pages: 1578-86
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Publication
22167187 | J:181512
First Author: Stoyanova T
Year: 2012
Journal: J Biol Chem
Title: p21 cooperates with DDB2 protein in suppression of ultraviolet ray-induced skin malignancies.
Volume: 287
Issue: 5
Pages: 3019-28
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Publication
17967871 | J:128935
First Author: Stoyanova T
Year: 2008
Journal: Mol Cell Biol
Title: The xeroderma pigmentosum group E gene product DDB2 activates nucleotide excision repair by regulating the level of p21Waf1/Cip1.
Volume: 28
Issue: 1
Pages: 177-87
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Publication
14769931 | J:88125
First Author: Itoh T
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: DDB2 gene disruption leads to skin tumors and resistance to apoptosis after exposure to ultraviolet light but not a chemical carcinogen.
Volume: 101
Issue: 7
Pages: 2052-7
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Protein
Q99J79
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Protein
A2AGR6
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
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Publication
20351176 | J:162585
First Author: Roy N
Year: 2010
Journal: Mol Cell Biol
Title: DDB2, an essential mediator of premature senescence.
Volume: 30
Issue: 11
Pages: 2681-92
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Publication
15558025 | J:95633
First Author: Yoon T
Year: 2005
Journal: Oncogene
Title: Tumor-prone phenotype of the DDB2-deficient mice.
Volume: 24
Issue: 3
Pages: 469-78
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Publication
18996499 | J:145899
First Author: Pines A
Year: 2009
Journal: DNA Repair (Amst)
Title: Differential activity of UV-DDB in mouse keratinocytes and fibroblasts: impact on DNA repair and UV-induced skin cancer.
Volume: 8
Issue: 2
Pages: 153-61
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Publication
17127714 | J:120007
First Author: Nijhof JG
Year: 2007
Journal: Carcinogenesis
Title: Epidermal stem and progenitor cells in murine epidermis accumulate UV damage despite NER proficiency.
Volume: 28
Issue: 4
Pages: 792-800
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Publication
23319653 | J:193692
First Author: Robu M
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair.
Volume: 110
Issue: 5
Pages: 1658-63
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Publication
22118460 | J:320034
First Author: Fischer ES
Year: 2011
Journal: Cell
Title: The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.
Volume: 147
Issue: 5
Pages: 1024-39
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Publication
17173070 | J:122861
First Author: Prost S
Year: 2007
Journal: Oncogene
Title: E2F regulates DDB2: consequences for DNA repair in Rb-deficient cells.
Volume: 26
Issue: 24
Pages: 3572-81
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Protein Coding Gene
MGP_CAROLIEiJ_G0023957 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026146 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026107 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026088 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026116 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0025867 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1355314 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026567 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025332 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0025845 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0025981 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0025944 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026085 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0025970 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026621 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025067 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025399 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025394 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0024868 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
33937266 | J:314115
 
First Author: Zhang Y
Year: 2021
Journal: Front Cell Dev Biol
Title: USP44 Stabilizes DDB2 to Facilitate Nucleotide Excision Repair and Prevent Tumors.
Volume: 9
Pages: 663411
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Publication
18936169 | J:144549
First Author: Alekseev S
Year: 2008
Journal: Mol Cell Biol
Title: Cellular concentrations of DDB2 regulate dynamic binding of DDB1 at UV-induced DNA damage.
Volume: 28
Issue: 24
Pages: 7402-13
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Allele
Ddb2<em2Smoc> | MGI:7289291
Name: damage specific DNA binding protein 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
23159851 | -
First Author: Zhang L
Year: 2012
Journal: Cell Cycle
Title: The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability.
Volume: 11
Issue: 23
Pages: 4378-84
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Interaction Experiment
Stoyanova T (2008)
Description: The xeroderma pigmentosum group E gene product DDB2 activates nucleotide excision repair by regulating the level of p21Waf1/Cip1.
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Strain
MGI:6770689 | C57BL/6JSmoc-Ddb2<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Ddb2<tm1Linn> | MGI:3036308
Name: damage specific DNA binding protein 2; targeted mutation 1, Stuart Linn
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Ddb2<tm1Pra> | MGI:3511965
Name: damage specific DNA binding protein 2; targeted mutation 1, Pradip Raychaudhuri
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Ddb2<em1Smoc> | MGI:7289290
Name: damage specific DNA binding protein 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
12732143 | -
First Author: Groisman R
Year: 2003
Journal: Cell
Title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.
Volume: 113
Issue: 3
Pages: 357-67
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Genotype
Genotype
Symbol: Ddb2/Ddb2<+>
Background: involves: 129S/SvEv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ddb2/Ddb2
Background: involves: 129S/SvEv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ddb2/Ddb2
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ddb2/Ddb2<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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