| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
The founding member of this family, XendoU, is a uridylate-specific, divalent cation-dependent enzyme that produces molecules with 2',3'-cyclic phosphate ends [, ]. The human Endou, known as PP11, has endoribonuclease activity with placental tissue specificity [, ]. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Poe JC |
| Year: |
2014 |
| Journal: |
J Exp Med |
| Title: |
EndoU is a novel regulator of AICD during peripheral B cell selection. |
| Volume: |
211 |
| Issue: |
1 |
| Pages: |
57-69 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee HC |
| Year: |
2017 |
| Journal: |
Gene Expr Patterns |
| Title: |
Embryonic expression patterns of Eukaryotic EndoU ribonuclease family gene endouC in zebrafish. |
| Volume: |
25-26 |
|
| Pages: |
66-70 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
412
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Renzi F |
| Year: |
2006 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
The structure of the endoribonuclease XendoU: From small nucleolar RNA processing to severe acute respiratory syndrome coronavirus replication. |
| Volume: |
103 |
| Issue: |
33 |
| Pages: |
12365-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gioia U |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
Functional characterization of XendoU, the endoribonuclease involved in small nucleolar RNA biosynthesis. |
| Volume: |
280 |
| Issue: |
19 |
| Pages: |
18996-9002 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Laneve P |
| Year: |
2008 |
| Journal: |
J Biol Chem |
| Title: |
The tumor marker human placental protein 11 is an endoribonuclease. |
| Volume: |
283 |
| Issue: |
50 |
| Pages: |
34712-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Endou M |
| Year: |
1994 |
| Journal: |
J Pharmacol Exp Ther |
| Title: |
Histamine H3-receptor signaling in the heart: possible involvement of Gi/Go proteins and N-type Ca++ channels. |
| Volume: |
269 |
| Issue: |
1 |
| Pages: |
221-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mushegian A |
| Year: |
2020 |
| Journal: |
RNA |
| Title: |
An ancient evolutionary connection between Ribonuclease A and EndoU families. |
| Volume: |
26 |
| Issue: |
7 |
| Pages: |
803-813 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Baughman G |
| Year: |
1992 |
| Journal: |
J Immunol |
| Title: |
Tcl-30, a new T cell-specific gene expressed in immature glucocorticoid-sensitive thymocytes. |
| Volume: |
149 |
| Issue: |
5 |
| Pages: |
1488-96 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6434213 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2020-06-17 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3187817 |
|
| Stage: |
TS17 |
| Assay Id: |
MGI:6434496 |
| Age: |
embryonic day 10.5 |
| Image: |
S4 |
|
| Specimen Label: |
WT |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6434213 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2020-06-17 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3187817 |
|
| Stage: |
TS17 |
| Assay Id: |
MGI:6434496 |
| Age: |
embryonic day 10.5 |
| Image: |
S4 |
|
| Specimen Label: |
KO |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1737328 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693188 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1881302 |
| Note: |
kidney |
| Specimen Label: |
UC Davis_1881302 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1737328 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693188 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1881303 |
| Note: |
kidney |
| Specimen Label: |
UC Davis_1881303 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1737328 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693188 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1881304 |
| Note: |
kidney |
| Specimen Label: |
UC Davis_1881304 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1737328 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693188 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1881295 |
| Note: |
kidney |
| Specimen Label: |
UC Davis_1881295 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1737328 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693188 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1881296 |
| Note: |
kidney |
| Specimen Label: |
UC Davis_1881296 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1737328 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693188 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1881297 |
| Note: |
kidney |
| Specimen Label: |
UC Davis_1881297 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1868128 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693188 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1881300 |
| Note: |
vas deferens |
| Specimen Label: |
UC Davis_1881300 |
| Detected: |
true |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1797228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693188 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1881298 |
|
| Specimen Label: |
UC Davis_1881298 |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1929028 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693188 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1881299 |
|
| Specimen Label: |
UC Davis_1881299 |
| Detected: |
true |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:3276428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693188 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1881301 |
|
| Specimen Label: |
UC Davis_1881301 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jia F |
| Year: |
2020 |
| Journal: |
Cell Rep |
| Title: |
Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease. |
| Volume: |
30 |
| Issue: |
6 |
| Pages: |
1848-1861.e5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kingsmore SF |
| Year: |
1993 |
| Journal: |
Mamm Genome |
| Title: |
Genetic mapping of Pp11r, a thymocyte gene expressed during apoptosis, to mouse chromosome 15. |
| Volume: |
4 |
| Issue: |
8 |
| Pages: |
459-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Baughman G |
| Year: |
1991 |
| Journal: |
Mol Endocrinol |
| Title: |
Genes newly identified as regulated by glucocorticoids in murine thymocytes. |
| Volume: |
5 |
| Issue: |
5 |
| Pages: |
637-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Michalska K |
| Year: |
2018 |
| Journal: |
Mol Microbiol |
| Title: |
Functional plasticity of antibacterial EndoU toxins. |
| Volume: |
109 |
| Issue: |
4 |
| Pages: |
509-527 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Paikari A |
| Year: |
2017 |
| Journal: |
Development |
| Title: |
The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport. |
| Volume: |
144 |
| Issue: |
20 |
| Pages: |
3731-3743 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ingham NJ |
| Year: |
2019 |
| Journal: |
PLoS Biol |
| Title: |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. |
| Volume: |
17 |
| Issue: |
4 |
| Pages: |
e3000194 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2016 |
|
| Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Koscielny G |
| Year: |
2014 |
| Journal: |
Nucleic Acids Res |
| Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
| Volume: |
42 |
| Issue: |
Database issue |
| Pages: |
D802-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
International Knockout Mouse Consortium |
| Year: |
2014 |
| Journal: |
Database Download |
| Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Velocigene |
| Year: |
2008 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
International Mouse Strain Resource |
| Year: |
2014 |
| Journal: |
Database Download |
| Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
| Year: |
2014 |
| Journal: |
Database Release |
| Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
| Year: |
2001 |
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| Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
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•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
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| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
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•
•
•
•
•
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| First Author: |
MGD Nomenclature Committee |
| Year: |
1995 |
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| Title: |
Nomenclature Committee Use |
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•
•
•
•
•
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| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
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| Title: |
GemPharmatech Website. |
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•
•
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| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
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| Title: |
Cyagen Biosciences Website. |
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•
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•
•
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| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
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| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
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•
•
•
•
•
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| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
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| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
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•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
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|
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
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| Title: |
Annotation inferences using phylogenetic trees |
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| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
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| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
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| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
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| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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| Protein Domain |
| Type: |
Domain |
| Description: |
This EndoU nuclease domain is a bacterial version eukaryotic EndoU nuclease. It is found at the C-terminal region of polymorphic toxin proteins [, ]. Nucleases are widely used as toxins for defense, offense or addiction of selfish elements. |
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| Publication |
| First Author: |
Schwarz DS |
| Year: |
2014 |
| Journal: |
J Cell Biol |
| Title: |
The calcium-dependent ribonuclease XendoU promotes ER network formation through local RNA degradation. |
| Volume: |
207 |
| Issue: |
1 |
| Pages: |
41-57 |
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| Publication |
| First Author: |
Laneve P |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration. |
| Volume: |
7 |
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| Pages: |
41559 |
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| Publication |
| First Author: |
Ragno R |
| Year: |
2011 |
| Journal: |
ChemMedChem |
| Title: |
Identification of small-molecule inhibitors of the XendoU endoribonucleases family. |
| Volume: |
6 |
| Issue: |
10 |
| Pages: |
1797-805 |
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| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the EndoU domain found at the C-terminal of EndoU endoribonucleases, which carries out a conserved RNA processing function. The EndoU domain cleaves RNA at uridylates and release 2',3'-cyclic phosphodiester ends. The EndoU domain is an α/β domain, that contains nine α-helices and three antiparallel β-sheets; the latter are clustered on one side of the domain, whereas the α-helices are largely on the other side []. It contains a conserved trio of catalytic residues, two histidines and a lysine.EndoU is a family of metal-dependent endoribonucleases that is broadly conserved among eukaryotes [, ]. EndoU family members have RNA-binding and endoribonuclease activities and appear to be involved in many aspects ofbiology, including small nucleolar RNA biogenesis, endoplasmic reticulum (ER) network formation, immune response, and neurodegeneration:Xenopus laevis endoribonuclease XendoU is responsible for processing the intron encoded U16 and U86 small nucleolar RNAs (snoRNAs) [, , ].Human EndoU, also known as PP11 (placental protein 11), has an endoribonuclease activity with placental tissue specificity [, , ].Drosophila melanogaster CG2145 and DendoU endoribonucleases [].Caenorhabditis elegans endu-2 regulates nucleotide metabolism and germ cell proliferation in response to nucleotide imbalance and other genotoxic stress []. |
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| Author |
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| Author |
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| Publication |
| First Author: |
Utsunomiya-Tate N |
| Year: |
1996 |
| Journal: |
J Biol Chem |
| Title: |
Cloning and functional characterization of a system ASC-like Na+-dependent neutral amino acid transporter. |
| Volume: |
271 |
| Issue: |
25 |
| Pages: |
14883-90 |
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| Publication |
| First Author: |
Utsunomiya-Tate N |
| Year: |
1997 |
| Journal: |
FEBS Lett |
| Title: |
Tissue specific variants of glutamate transporter GLT-1. |
| Volume: |
416 |
| Issue: |
3 |
| Pages: |
312-6 |
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| Publication |
| First Author: |
Sekine T |
| Year: |
2006 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
Molecular physiology of renal organic anion transporters. |
| Volume: |
290 |
| Issue: |
2 |
| Pages: |
F251-61 |
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| Publication |
| First Author: |
Hosoyamada M |
| Year: |
2004 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Function and localization of urate transporter 1 in mouse kidney. |
| Volume: |
15 |
| Issue: |
2 |
| Pages: |
261-8 |
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| Publication |
| First Author: |
Yanai K |
| Year: |
1998 |
| Journal: |
Life Sci |
| Title: |
Targeting disruption of histamine H1 receptors in mice: behavioral and neurochemical characterization. |
| Volume: |
62 |
| Issue: |
17-18 |
| Pages: |
1607-10 |
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