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Search results 1 to 100 out of 103 for Fbxo8

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0.073s
Type Details Score
Gene
Type: gene
Organism: human
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Gene
Type: gene
Organism: frog, western clawed
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Gene
Type: gene
Organism: rat
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Gene
Type: gene
Organism: dog, domestic
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Gene
Type: gene
Organism: chimpanzee
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Gene
Type: gene
Organism: cattle
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Gene
Type: gene
Organism: chicken
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Gene
Type: gene
Organism: zebrafish
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Gene
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: 1D - Fbxo8
Note: This gene exhibits category 2 expression: staining is observed in the central limb bud.
Specimen Label: 1D - Fbxo8
Detected: true
Specimen Num: 1
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GXD Expression
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: S1A - Fbxo8 - E10.5
Note: This gene exhibits category 2 expression: staining is observed in the central limb bud.
Specimen Label: S1A - Fbxo8 - E10.5
Detected: true
Specimen Num: 2
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GXD Expression
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5823617
Age: embryonic day 11.5
Image: S1A - Fbxo8 - E11.5
Note: This gene exhibits category 2 expression: staining is observed in the central limb bud.
Specimen Label: S1A - Fbxo8 - E11.5
Detected: true
Specimen Num: 3
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Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression    
Probe: MGI:5810890
Assay Type: RT-PCR
Annotation Date: 2016-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Stage: TS17
Assay Id: MGI:5812456
Age: embryonic day 10.5
Image: 3
Specimen Label: Wild-type
Detected: true
Specimen Num: 1
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GXD Expression    
Probe: MGI:5810890
Assay Type: RT-PCR
Annotation Date: 2016-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Stage: TS17
Assay Id: MGI:5812456
Age: embryonic day 10.5
Image: 3
Specimen Label: Shh-/-;Gli3-/-
Detected: true
Specimen Num: 2
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GXD Expression  
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1619317
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5a_8NOV13
Specimen Label: Fbxo8_a43_E10.5a_8NOV13
Detected: true
Specimen Num: 11
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GXD Expression  
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1619317
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5a_JL
Specimen Label: Fbxo8_a43_E10.5a_JL
Detected: true
Specimen Num: 12
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GXD Expression  
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1619317
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5b_JL
Specimen Label: Fbxo8_a43_E10.5b_JL
Detected: true
Specimen Num: 13
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GXD Expression
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5a_RF_8NOV13
Note: Staining is observed in the central limb bud.
Specimen Label: Fbxo8_a43_E10.5a_RF_8NOV13
Detected: true
Specimen Num: 4
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GXD Expression
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5a_RF_JL
Note: Staining is observed in the central limb bud.
Specimen Label: Fbxo8_a43_E10.5a_RF_JL
Detected: true
Specimen Num: 5
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GXD Expression
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5b_RF_JL
Note: Staining is observed in the central limb bud.
Specimen Label: Fbxo8_a43_E10.5b_RF_JL
Detected: true
Specimen Num: 6
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GXD Expression
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5823617
Age: embryonic day 11.5
Image: Fbxo8_a43_E11.5a_RF_8NOV13
Note: Domains of staining are similar to those seen at E10.5.
Specimen Label: Fbxo8_a43_E11.5a_RF_8NOV13
Detected: true
Specimen Num: 7
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GXD Expression
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5823617
Age: embryonic day 11.5
Image: Fbxo8_a43_E11.5a_RF_JL
Note: Domains of staining are similar to those seen at E10.5.
Specimen Label: Fbxo8_a43_E11.5a_RF_JL
Detected: true
Specimen Num: 8
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GXD Expression
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5823617
Age: embryonic day 11.5
Image: Fbxo8_a43_E11.5b_RF_8NOV13
Note: Domains of staining are similar to those seen at E10.5.
Specimen Label: Fbxo8_a43_E11.5b_RF_8NOV13
Detected: true
Specimen Num: 9
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GXD Expression
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5823617
Age: embryonic day 11.5
Image: Fbxo8_a43_E11.5b_RF_JL
Note: Domains of staining are similar to those seen at E10.5.
Specimen Label: Fbxo8_a43_E11.5b_RF_JL
Detected: true
Specimen Num: 10
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GXD Expression  
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1610517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5a_8NOV13
Specimen Label: Fbxo8_a43_E10.5a_8NOV13
Detected: true
Specimen Num: 11
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GXD Expression  
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1610517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5a_JL
Specimen Label: Fbxo8_a43_E10.5a_JL
Detected: true
Specimen Num: 12
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GXD Expression  
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1610517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5b_JL
Specimen Label: Fbxo8_a43_E10.5b_JL
Detected: true
Specimen Num: 13
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GXD Expression
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5823617
Age: embryonic day 11.5
Image: Fbxo8_a43_E11.5a_8NOV13
Note: Staining is similar to that observed at E10.5. At that time it was seen in the ear, heart, somites, branchial arch and notochord.
Specimen Label: Fbxo8_a43_E11.5a_8NOV13
Detected: true
Specimen Num: 14
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GXD Expression
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5823617
Age: embryonic day 11.5
Image: Fbxo8_a43_E11.5a_JL
Note: Staining is similar to that observed at E10.5. At that time it was seen in the ear, heart, somites, branchial arch and notochord.
Specimen Label: Fbxo8_a43_E11.5a_JL
Detected: true
Specimen Num: 15
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GXD Expression
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5823617
Age: embryonic day 11.5
Image: Fbxo8_a43_E11.5b_8NOV13
Note: Staining is similar to that observed at E10.5. At that time it was seen in the ear, heart, somites, branchial arch and notochord.
Specimen Label: Fbxo8_a43_E11.5b_8NOV13
Detected: true
Specimen Num: 16
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GXD Expression
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5823617
Age: embryonic day 11.5
Image: Fbxo8_a43_E11.5b_JL
Note: Staining is similar to that observed at E10.5. At that time it was seen in the ear, heart, somites, branchial arch and notochord.
Specimen Label: Fbxo8_a43_E11.5b_JL
Detected: true
Specimen Num: 17
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GXD Expression  
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3116917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5a_8NOV13
Specimen Label: Fbxo8_a43_E10.5a_8NOV13
Detected: true
Specimen Num: 11
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GXD Expression  
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3116917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5a_JL
Specimen Label: Fbxo8_a43_E10.5a_JL
Detected: true
Specimen Num: 12
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GXD Expression  
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3116917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5b_JL
Specimen Label: Fbxo8_a43_E10.5b_JL
Detected: true
Specimen Num: 13
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GXD Expression  
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1611717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5a_8NOV13
Specimen Label: Fbxo8_a43_E10.5a_8NOV13
Detected: true
Specimen Num: 11
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GXD Expression  
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1611717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5a_JL
Specimen Label: Fbxo8_a43_E10.5a_JL
Detected: true
Specimen Num: 12
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GXD Expression  
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1611717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5b_JL
Specimen Label: Fbxo8_a43_E10.5b_JL
Detected: true
Specimen Num: 13
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GXD Expression  
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1619117
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5a_8NOV13
Specimen Label: Fbxo8_a43_E10.5a_8NOV13
Detected: true
Specimen Num: 11
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GXD Expression  
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1619117
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5a_JL
Specimen Label: Fbxo8_a43_E10.5a_JL
Detected: true
Specimen Num: 12
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GXD Expression  
Probe: MGI:5811391
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1619117
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823617
Age: embryonic day 10.5
Image: Fbxo8_a43_E10.5b_JL
Specimen Label: Fbxo8_a43_E10.5b_JL
Detected: true
Specimen Num: 13
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Publication
First Author: Winston JT
Year: 1999
Journal: Curr Biol
Title: A family of mammalian F-box proteins.
Volume: 9
Issue: 20
Pages: 1180-2
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Publication
First Author: Kenney-Hunt JP
Year: 2006
Journal: Mamm Genome
Title: Quantitative trait loci for body size components in mice.
Volume: 17
Issue: 6
Pages: 526-37
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Publication
First Author: Lewandowski JP
Year: 2015
Journal: Dev Biol
Title: Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Volume: 406
Issue: 1
Pages: 92-103
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Publication
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication        
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication  
First Author: Wang FF
Year: 2017
Journal: Cancer Lett
Title: FBX8 is a metastasis suppressor downstream of miR-223 and targeting mTOR for degradation in colorectal carcinoma.
Volume: 388
Pages: 85-95
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Publication
First Author: Wu P
Year: 2015
Journal: Exp Mol Pathol
Title: Significance of FBX8 in progression of gastric cancer.
Volume: 98
Issue: 3
Pages: 360-6
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Publication
First Author: Yu Y
Year: 2014
Journal: Int J Clin Exp Pathol
Title: Down-expression of F box only protein 8 correlates with tumor grade and poor prognosis in human glioma.
Volume: 7
Issue: 11
Pages: 8071-6
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Publication
First Author: Wang F
Year: 2013
Journal: PLoS One
Title: FBX8 Acts as an Invasion and Metastasis Suppressor and Correlates with Poor Survival in Hepatocellular Carcinoma.
Volume: 8
Issue: 6
Pages: e65495
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Publication
First Author: Cho HJ
Year: 2010
Journal: Mol Cells
Title: c-Myc stimulates cell invasion by inhibiting FBX8 function.
Volume: 30
Issue: 4
Pages: 355-62
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Publication
First Author: Yano H
Year: 2008
Journal: Mol Biol Cell
Title: Fbx8 makes Arf6 refractory to function via ubiquitination.
Volume: 19
Issue: 3
Pages: 822-32
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Protein Domain
Type: Domain
Description: This entry represents the F-box domain of F-box only protein 8 (FBXO8, also called FBX8, or F-box/SEC7 protein FBS). FBXO8 is a novel component of F-box proteins which contains an F-box domain and a Sec7 domain. This protein was originally identified as a Skp1-binding protein. It is involved in the ubiquitin-dependent proteolytic pathway. It acts as a metastasis suppressor that functions through mTOR signaling pathway [, , , , ]. FBXO8 may promote the activation of ADP-ribosylation factor (ARF) through replacement of GDP with GTP []. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.
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Protein
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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