| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
The folate receptors are involved in the transport and maintenance of intracellular levels of folate. Folate receptor alpha (FR-alpha, FOLR1) and beta (FR-beta, FOLR2) are glycosyl phosphatidylinositol (GPI)-anchored proteins that facilitate unidirectional transport of folates into cells via receptor-mediated endocytosis [, ].This entry represents folate receptor beta. FOLR2 is expressed on the proinflammatory subset of monocytes and can be targeted selectively with folate-linked drugs []. |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shen J |
| Year: |
2014 |
| Journal: |
J Leukoc Biol |
| Title: |
Folate receptor-β constitutes a marker for human proinflammatory monocytes. |
| Volume: |
96 |
| Issue: |
4 |
| Pages: |
563-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Verma RS |
| Year: |
1992 |
| Journal: |
J Biol Chem |
| Title: |
Evidence that the hydrophobicity of isolated, in situ, and de novo-synthesized native human placental folate receptors is a function of glycosyl-phosphatidylinositol anchoring to membranes. |
| Volume: |
267 |
| Issue: |
6 |
| Pages: |
4119-27 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Henderson GI |
| Year: |
1995 |
| Journal: |
J Lab Clin Med |
| Title: |
Maternal-to-fetal transfer of 5-methyltetrahydrofolate by the perfused human placental cotyledon: evidence for a concentrative role by placental folate receptors in fetal folate delivery. |
| Volume: |
126 |
| Issue: |
2 |
| Pages: |
184-203 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
251
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
87
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
177
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meredith M |
| Year: |
2016 |
| Journal: |
Biol Reprod |
| Title: |
Growing Mouse Oocytes Transiently Activate Folate Transport via Folate Receptors As They Approach Full Size. |
| Volume: |
94 |
| Issue: |
6 |
| Pages: |
125 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kooistra M |
| Year: |
2013 |
| Journal: |
Biol Reprod |
| Title: |
Folate transport in mouse cumulus-oocyte complexes and preimplantation embryos. |
| Volume: |
89 |
| Issue: |
3 |
| Pages: |
63 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brigle KE |
| Year: |
1994 |
| Journal: |
J Biol Chem |
| Title: |
Increased expression and genomic organization of a folate-binding protein homologous to the human placental isoform in L1210 murine leukemia cell lines with a defective reduced folate carrier. |
| Volume: |
269 |
| Issue: |
6 |
| Pages: |
4267-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Spiegelstein O |
| Year: |
2003 |
| Journal: |
Birth Defects Res A Clin Mol Teratol |
| Title: |
Valproate-induced neural tube defects in folate-binding protein-2 (Folbp2) knockout mice. |
| Volume: |
67 |
| Issue: |
12 |
| Pages: |
974-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kappen C |
| Year: |
2004 |
| Journal: |
Genesis |
| Title: |
Folate modulates Hox gene-controlled skeletal phenotypes. |
| Volume: |
39 |
| Issue: |
3 |
| Pages: |
155-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schniering J |
| Year: |
2019 |
| Journal: |
Front Immunol |
| Title: |
18F-AzaFol for Detection of Folate Receptor-β Positive Macrophages in Experimental Interstitial Lung Disease-A Proof-of-Concept Study. |
| Volume: |
10 |
|
| Pages: |
2724 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Han W |
| Year: |
2015 |
| Journal: |
Am J Respir Cell Mol Biol |
| Title: |
Molecular imaging of folate receptor β-positive macrophages during acute lung inflammation. |
| Volume: |
53 |
| Issue: |
1 |
| Pages: |
50-9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2652688 |
| Assay Type: |
RNase protection |
| Annotation Date: |
2003-03-28 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689424 |
|
| Stage: |
TS24 |
| Assay Id: |
MGI:2652708 |
| Age: |
embryonic day 16.0 |
|
|
| Specimen Label: |
GD 16 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2652688 |
| Assay Type: |
RNase protection |
| Annotation Date: |
2003-03-28 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689426 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:2652708 |
| Age: |
embryonic day 18.0 |
|
|
| Specimen Label: |
GD 18 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2652688 |
| Assay Type: |
RNase protection |
| Annotation Date: |
2003-03-28 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3568928 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:2652708 |
| Age: |
embryonic day 18.0 |
|
|
| Specimen Label: |
Placenta |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5556069 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2014-04-09 |
| Strength: |
Absent |
| Sex: |
Female |
| Emaps: |
EMAPS:3526728 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5556231 |
| Age: |
postnatal |
|
|
| Specimen Label: |
C |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5556069 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2014-04-09 |
| Strength: |
Absent |
| Sex: |
Female |
| Emaps: |
EMAPS:3102528 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5556231 |
| Age: |
postnatal |
|
|
| Specimen Label: |
C |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5556069 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2014-04-09 |
| Strength: |
Absent |
| Sex: |
Female |
| Emaps: |
EMAPS:3570528 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5556231 |
| Age: |
postnatal |
|
|
| Specimen Label: |
G |
| Detected: |
false |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5556069 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2014-04-09 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:360411 |
|
| Stage: |
TS01 |
| Assay Id: |
MGI:5556231 |
| Age: |
embryonic day 0.5 |
|
|
| Specimen Label: |
1 |
| Detected: |
false |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5556069 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2014-04-09 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:360422 |
|
| Stage: |
TS02 |
| Assay Id: |
MGI:5556231 |
| Age: |
embryonic day 1.0 |
|
|
| Specimen Label: |
2 |
| Detected: |
false |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5556069 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2014-04-09 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:360433 |
|
| Stage: |
TS03 |
| Assay Id: |
MGI:5556231 |
| Age: |
embryonic day 2.0 |
|
|
| Specimen Label: |
4 |
| Detected: |
false |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5556069 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2014-04-09 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:360443 |
|
| Stage: |
TS03 |
| Assay Id: |
MGI:5556231 |
| Age: |
embryonic day 2.5 |
|
|
| Specimen Label: |
8 |
| Detected: |
false |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5556069 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2014-04-09 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:360453 |
|
| Stage: |
TS03 |
| Assay Id: |
MGI:5556231 |
| Age: |
embryonic day 3.0 |
|
|
| Specimen Label: |
M |
| Detected: |
false |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5556069 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2014-04-09 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:360464 |
|
| Stage: |
TS04 |
| Assay Id: |
MGI:5556231 |
| Age: |
embryonic day 3.5 |
|
|
| Specimen Label: |
B |
| Detected: |
false |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5556069 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2014-04-09 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1737328 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5556231 |
| Age: |
postnatal |
|
|
| Specimen Label: |
+ |
| Detected: |
true |
| Specimen Num: |
11 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5556069 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2014-04-09 |
| Strength: |
Absent |
| Sex: |
Female |
| Emaps: |
EMAPS:3575528 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5556231 |
| Age: |
postnatal |
|
|
| Specimen Label: |
E |
| Detected: |
false |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2652688 |
| Assay Type: |
RNase protection |
| Annotation Date: |
2003-03-28 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3185812 |
|
| Stage: |
TS12 |
| Assay Id: |
MGI:2652708 |
| Age: |
embryonic day 8.0 |
|
|
| Specimen Label: |
GD 8 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2652688 |
| Assay Type: |
RNase protection |
| Annotation Date: |
2003-03-28 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3185814 |
|
| Stage: |
TS14 |
| Assay Id: |
MGI:2652708 |
| Age: |
embryonic day 9.0 |
|
|
| Specimen Label: |
GD 9 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2652688 |
| Assay Type: |
RNase protection |
| Annotation Date: |
2003-03-28 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3185816 |
|
| Stage: |
TS16 |
| Assay Id: |
MGI:2652708 |
| Age: |
embryonic day 10.0 |
|
|
| Specimen Label: |
GD 10 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2652688 |
| Assay Type: |
RNase protection |
| Annotation Date: |
2003-03-28 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3185820 |
|
| Stage: |
TS20 |
| Assay Id: |
MGI:2652708 |
| Age: |
embryonic day 12.0 |
|
|
| Specimen Label: |
GD 12 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2652688 |
| Assay Type: |
RNase protection |
| Annotation Date: |
2003-03-28 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1604226 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:2652713 |
| Age: |
embryonic day 18.0 |
|
|
| Specimen Label: |
Embryonic tissue 1 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2652688 |
| Assay Type: |
RNase protection |
| Annotation Date: |
2003-03-28 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1604226 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:2652713 |
| Age: |
embryonic day 18.0 |
|
|
| Specimen Label: |
Embryonic tissue 2 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2652688 |
| Assay Type: |
RNase protection |
| Annotation Date: |
2003-03-28 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:3568928 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:2652713 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Maternal tissue 1 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2652688 |
| Assay Type: |
RNase protection |
| Annotation Date: |
2003-03-28 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:3568928 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:2652713 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Maternal tissue 2 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rodriguez-Garcia A |
| Year: |
2021 |
| Journal: |
Nat Commun |
| Title: |
CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
877 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alfar R |
| Year: |
2023 |
| Journal: |
Front Immunol |
| Title: |
Selective reprogramming of regulatory T cells in solid tumors can strongly enhance or inhibit tumor growth. |
| Volume: |
14 |
|
| Pages: |
1274199 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brigle KE |
| Year: |
1991 |
| Journal: |
J Biol Chem |
| Title: |
Characterization of two cDNAs encoding folate-binding proteins from L1210 murine leukemia cells. Increased expression associated with a genomic rearrangement. |
| Volume: |
266 |
| Issue: |
26 |
| Pages: |
17243-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Piedrahita JA |
| Year: |
1999 |
| Journal: |
Nat Genet |
| Title: |
Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development. |
| Volume: |
23 |
| Issue: |
2 |
| Pages: |
228-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Birn H |
| Year: |
2005 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Renal tubular reabsorption of folate mediated by folate binding protein 1. |
| Volume: |
16 |
| Issue: |
3 |
| Pages: |
608-15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Spiegelstein O |
| Year: |
2005 |
| Journal: |
Toxicol Appl Pharmacol |
| Title: |
Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies. |
| Volume: |
203 |
| Issue: |
1 |
| Pages: |
18-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brigle KE |
| Year: |
1994 |
| Journal: |
Biochem Pharmacol |
| Title: |
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