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Search results 1 to 100 out of 948 for Gpx4

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
2879 | GPX4
Type: gene
Organism: human
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Gene
100496541 | gpx4
Type: gene
Organism: frog, western clawed
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Gene
286809 | GPX4
Type: gene
Organism: cattle
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Gene
119864793 | GPX4
Type: gene
Organism: dog, domestic
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Gene
key_75855 | GPX4
Type: gene
Organism: guinea pig
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Gene
29328 | Gpx4
Type: gene
Organism: rat
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Gene
741876 | GPX4
Type: gene
Organism: chimpanzee
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Gene
374056 | GPX4
Type: gene
Organism: chicken
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Gene
705333 | GPX4
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:104767 | Gpx4
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17395155 | J:121515
First Author: Liang H
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Gpx4 protects mitochondrial ATP generation against oxidative damage.
Volume: 356
Issue: 4
Pages: 893-8
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Protein
Q76LV0
Organism: Mus musculus/domesticus
Length: 253  
Fragment?: false
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Publication
32541831 | J:298910
First Author: Jia M
Year: 2020
Journal: Nat Immunol
Title: Redox homeostasis maintained by GPX4 facilitates STING activation.
Volume: 21
Issue: 7
Pages: 727-735
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Publication
29290465 | J:255340
First Author: Ingold I
Year: 2018
Journal: Cell
Title: Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.
Volume: 172
Issue: 3
Pages: 409-422.e21
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Publication
36585109 | J:357810
 
First Author: Tu LF
Year: 2023
Journal: J Adv Res
Title: GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS.
Volume: 43
Pages: 205-218
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Publication
19783653 | J:156326
First Author: Imai H
Year: 2009
Journal: J Biol Chem
Title: Depletion of selenoprotein GPx4 in spermatocytes causes male infertility in mice.
Volume: 284
Issue: 47
Pages: 32522-32
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Publication
34145375 | J:322021
First Author: Chen L
Year: 2021
Journal: Sci Rep
Title: Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice.
Volume: 11
Issue: 1
Pages: 12890
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Publication
16246897 | J:116838
First Author: Scimeca MS
Year: 2005
Journal: Exp Biol Med (Maywood)
Title: Effects of gpx4 haploid insufficiency on GPx4 activity, selenium concentration, and paraquat-induced protein oxidation in murine tissues.
Volume: 230
Issue: 10
Pages: 709-14
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Publication
38598341 | J:354857
First Author: Li H
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy.
Volume: 121
Issue: 16
Pages: e2315541121
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Publication
36565564 | J:332413
 
First Author: Li H
Year: 2023
Journal: Biochem Biophys Res Commun
Title: GPX4 aggravates experimental autoimmune encephalomyelitis by inhibiting the functions of CD4(+) T cells.
Volume: 642
Pages: 57-65
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Publication
18206984 | J:134214
First Author: Garry MR
Year: 2008
Journal: Free Radic Biol Med
Title: Sensitivity of mouse lung fibroblasts heterozygous for GPx4 to oxidative stress.
Volume: 44
Issue: 6
Pages: 1075-87
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Publication
21402720 | J:174328
First Author: Mannes AM
Year: 2011
Journal: FASEB J
Title: Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme.
Volume: 25
Issue: 7
Pages: 2135-44
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Publication
12566075 | J:82053
First Author: Yant LJ
Year: 2003
Journal: Free Radic Biol Med
Title: The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults.
Volume: 34
Issue: 4
Pages: 496-502
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Publication
22401858 | J:183246
First Author: Yoo SE
Year: 2012
Journal: Free Radic Biol Med
Title: Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain.
Volume: 52
Issue: 9
Pages: 1820-7
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Publication
39158281 | J:360898
First Author: Sok SPM
Year: 2024
Journal: J Immunol
Title: Gpx4 Regulates Invariant NKT Cell Homeostasis and Function by Preventing Lipid Peroxidation and Ferroptosis.
Volume: 213
Issue: 7
Pages: 941-951
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Publication
37910602 | J:343620
First Author: Li J
Year: 2023
Journal: Sci Transl Med
Title: Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer.
Volume: 15
Issue: 720
Pages: eadg3049
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Publication
35031697 | J:345066
First Author: Schwärzler J
Year: 2022
Journal: Int J Obes (Lond)
Title: Adipocyte GPX4 protects against inflammation, hepatic insulin resistance and metabolic dysregulation.
Volume: 46
Issue: 5
Pages: 951-959
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Publication
31775041 | J:314405
First Author: Muri J
Year: 2019
Journal: Cell Rep
Title: B1 and Marginal Zone B Cells but Not Follicular B2 Cells Require Gpx4 to Prevent Lipid Peroxidation and Ferroptosis.
Volume: 29
Issue: 9
Pages: 2731-2744.e4
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Publication
26042203 | J:297698
First Author: Katunga LA
Year: 2015
Journal: Mol Metab
Title: Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy.
Volume: 4
Issue: 6
Pages: 493-506
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Publication
34133924 | J:307114
First Author: Xu C
Year: 2021
Journal: Cell Rep
Title: The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity.
Volume: 35
Issue: 11
Pages: 109235
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Publication
25402683 | J:217747
First Author: Friedmann Angeli JP
Year: 2014
Journal: Nat Cell Biol
Title: Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.
Volume: 16
Issue: 12
Pages: 1180-91
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Publication
15496407 | J:94555
First Author: Ran Q
Year: 2004
Journal: J Biol Chem
Title: Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis.
Volume: 279
Issue: 53
Pages: 55137-46
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Publication
37279604 | J:337246
 
First Author: Czyżowska A
Year: 2023
Journal: Redox Biol
Title: Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness.
Volume: 64
Pages: 102761
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Publication
25922076 | J:225651
First Author: Ingold I
Year: 2015
Journal: J Biol Chem
Title: Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility.
Volume: 290
Issue: 23
Pages: 14668-78
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Publication
19447173 | J:150574
First Author: Liang H
Year: 2009
Journal: Free Radic Biol Med
Title: Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria.
Volume: 47
Issue: 3
Pages: 312-20
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Publication
31316058 | J:279412
First Author: Yoshida M
Year: 2019
Journal: Nat Commun
Title: Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis.
Volume: 10
Issue: 1
Pages: 3145
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Publication
23695217 | J:199260
First Author: Koulajian K
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Overexpression of glutathione peroxidase 4 prevents β-cell dysfunction induced by prolonged elevation of lipids in vivo.
Volume: 305
Issue: 2
Pages: E254-62
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Publication
22207760 | J:182776
First Author: Ueta T
Year: 2012
Journal: J Biol Chem
Title: Glutathione peroxidase 4 is required for maturation of photoreceptor cells.
Volume: 287
Issue: 10
Pages: 7675-82
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Publication
24897344 | J:218507
First Author: Roggia MF
Year: 2014
Journal: PLoS One
Title: Protective role of glutathione peroxidase 4 in laser-induced choroidal neovascularization in mice.
Volume: 9
Issue: 6
Pages: e98864
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Publication
31534007 | J:280860
First Author: Tsubouchi K
Year: 2019
Journal: J Immunol
Title: Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis.
Volume: 203
Issue: 8
Pages: 2076-2087
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Publication
32376803 | J:311500
 
First Author: Tadokoro T
Year: 2020
Journal: JCI Insight
Title: Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity.
Volume: 5
Issue: 9
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Publication
25313597 | J:264805
First Author: Brütsch SH
Year: 2015
Journal: Antioxid Redox Signal
Title: Expression of inactive glutathione peroxidase 4 leads to embryonic lethality, and inactivation of the Alox15 gene does not rescue such knock-in mice.
Volume: 22
Issue: 4
Pages: 281-93
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Publication
32286299 | J:289123
First Author: Mayr L
Year: 2020
Journal: Nat Commun
Title: Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Volume: 11
Issue: 1
Pages: 1775
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Publication
17895430 | J:129984
First Author: Ran Q
Year: 2007
Journal: J Gerontol A Biol Sci Med Sci
Title: Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis.
Volume: 62
Issue: 9
Pages: 932-42
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Publication
19417079 | J:186906
First Author: Schneider M
Year: 2009
Journal: FASEB J
Title: Mitochondrial glutathione peroxidase 4 disruption causes male infertility.
Volume: 23
Issue: 9
Pages: 3233-42
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Publication
31248967 | J:306950
First Author: Altamura S
Year: 2020
Journal: Haematologica
Title: Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis.
Volume: 105
Issue: 4
Pages: 937-950
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Publication
19744930 | J:156336
First Author: Liang H
Year: 2009
Journal: J Biol Chem
Title: Short form glutathione peroxidase 4 is the essential isoform required for survival and somatic mitochondrial functions.
Volume: 284
Issue: 45
Pages: 30836-44
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Publication
35288190 | J:337803
First Author: Azuma K
Year: 2022
Journal: J Biol Chem
Title: Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice.
Volume: 298
Issue: 4
Pages: 101824
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Publication
23770613 | J:213394
First Author: Wortmann M
Year: 2013
Journal: Circ Res
Title: Combined deficiency in glutathione peroxidase 4 and vitamin E causes multiorgan thrombus formation and early death in mice.
Volume: 113
Issue: 4
Pages: 408-17
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Publication
26400084 | J:276304
First Author: Chen L
Year: 2015
Journal: J Biol Chem
Title: Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis.
Volume: 290
Issue: 47
Pages: 28097-106
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Publication
28212525 | J:272186
 
First Author: Hambright WS
Year: 2017
Journal: Redox Biol
Title: Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration.
Volume: 12
Pages: 8-17
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Publication
16684775 | J:114857
First Author: Borchert A
Year: 2006
Journal: J Biol Chem
Title: The role of phospholipid hydroperoxide glutathione peroxidase isoforms in murine embryogenesis.
Volume: 281
Issue: 28
Pages: 19655-64
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Publication
26463424 | J:232369
First Author: Canli Ö
Year: 2016
Journal: Blood
Title: Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors.
Volume: 127
Issue: 1
Pages: 139-48
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Publication
38348353 | J:353413
 
First Author: Berdaweel IA
Year: 2023
Journal: Front Pharmacol
Title: Iron scavenging and suppression of collagen cross-linking underlie antifibrotic effects of carnosine in the heart with obesity.
Volume: 14
Pages: 1275388
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Publication
26083388 | J:237804
First Author: Sakai O
Year: 2015
Journal: PLoS One
Title: Role of Glutathione Peroxidase 4 in Glutamate-Induced Oxytosis in the Retina.
Volume: 10
Issue: 6
Pages: e0130467
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Publication
15901730 | J:100840
First Author: Su D
Year: 2005
Journal: J Biol Chem
Title: Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation.
Volume: 280
Issue: 28
Pages: 26491-8
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Publication
19890015 | J:158033
First Author: Wirth EK
Year: 2010
Journal: FASEB J
Title: Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration.
Volume: 24
Issue: 3
Pages: 844-52
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Publication
27634046 | J:237371
First Author: Brütsch SH
Year: 2016
Journal: J Biol Chem
Title: Male Subfertility Induced by Heterozygous Expression of Catalytically Inactive Glutathione Peroxidase 4 Is Rescued in Vivo by Systemic Inactivation of the Alox15 Gene.
Volume: 291
Issue: 45
Pages: 23578-23588
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Publication
36077303 | J:329311
 
First Author: Soria-Tiedemann M
Year: 2022
Journal: Int J Mol Sci
Title: Unbalanced Expression of Glutathione Peroxidase 4 and Arachidonate 15-Lipoxygenase Affects Acrosome Reaction and In Vitro Fertilization.
Volume: 23
Issue: 17
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Publication
34272880 | J:360402
First Author: Piattini F
Year: 2021
Journal: Eur J Immunol
Title: Differential sensitivity of inflammatory macrophages and alternatively activated macrophages to ferroptosis.
Volume: 51
Issue: 10
Pages: 2417-2429
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Publication
27262435 | J:302020
 
First Author: Carlson BA
Year: 2016
Journal: Redox Biol
Title: Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration.
Volume: 9
Pages: 22-31
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Publication
23364477 | J:198008
First Author: Sengupta A
Year: 2013
Journal: J Invest Dermatol
Title: Targeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2.
Volume: 133
Issue: 7
Pages: 1731-41
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Publication
34285231 | J:320588
First Author: Tonnus W
Year: 2021
Journal: Nat Commun
Title: Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.
Volume: 12
Issue: 1
Pages: 4402
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Publication
18593884 | J:137422
First Author: Ufer C
Year: 2008
Journal: Genes Dev
Title: Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development.
Volume: 22
Issue: 13
Pages: 1838-50
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Publication
39547222 | J:359335
First Author: Ito J
Year: 2024
Journal: Mol Cell
Title: PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization.
Volume: 84
Issue: 23
Pages: 4629-4644.e9
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Publication
34385713 | J:321322
First Author: Li P
Year: 2021
Journal: Nat Immunol
Title: Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity.
Volume: 22
Issue: 9
Pages: 1107-1117
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Publication
33311482 | J:300988
First Author: Dai E
Year: 2020
Journal: Nat Commun
Title: Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway.
Volume: 11
Issue: 1
Pages: 6339
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Publication
29937272 | J:277094
First Author: Kang R
Year: 2018
Journal: Cell Host Microbe
Title: Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis.
Volume: 24
Issue: 1
Pages: 97-108.e4
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Publication
34794077 | J:315052
 
First Author: Fradejas-Villar N
Year: 2021
Journal: Redox Biol
Title: Missense mutation in selenocysteine synthase causes cardio-respiratory failure and perinatal death in mice which can be compensated by selenium-independent GPX4.
Volume: 48
Pages: 102188
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Publication
18762024 | J:139668
First Author: Seiler A
Year: 2008
Journal: Cell Metab
Title: Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.
Volume: 8
Issue: 3
Pages: 237-48
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Publication
25824823 | J:222639
First Author: Matsushita M
Year: 2015
Journal: J Exp Med
Title: T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.
Volume: 212
Issue: 4
Pages: 555-68
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Publication
28627418 | J:244291
 
First Author: Schriever SC
Year: 2017
Journal: Neuroscience
Title: Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency.
Volume: 357
Pages: 241-254
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Publication
37219513 | J:341972
First Author: Lv Y
Year: 2023
Journal: FASEB J
Title: Estrogen deficiency accelerates postmenopausal atherosclerosis by inducing endothelial cell ferroptosis through inhibiting NRF2/GPX4 pathway.
Volume: 37
Issue: 6
Pages: e22992
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Strain
MGI:5491022 | B6.129P2-Gpx4<tm1Marc>/Ieg
Attribute String: targeted mutation, mutant strain, congenic
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Protein Coding Gene
MGP_CAROLIEiJ_G0015562 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017480 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017458 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017419 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017420 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017243 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_104767 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017874 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016810 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017215 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017321 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017315 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017392 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017341 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017915 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016591 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016870 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030975 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016380 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11344099 | J:69361
First Author: Pfeifer H
Year: 2001
Journal: FASEB J
Title: Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross-linking during sperm maturation.
Volume: 15
Issue: 7
Pages: 1236-8
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Publication
12745070 | J:83472
First Author: Imai H
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene.
Volume: 305
Issue: 2
Pages: 278-86
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Publication
14575705 | J:86228
First Author: Nakamura T
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and functional expression of nucleolar phospholipid hydroperoxide glutathione peroxidase in mammalian cells.
Volume: 311
Issue: 1
Pages: 139-48
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Publication
30226473 | J:271218
First Author: Anderson EJ
Year: 2018
Journal: J Clin Invest
Title: A carnosine analog mitigates metabolic disorders of obesity by reducing carbonyl stress.
Volume: 128
Issue: 12
Pages: 5280-5293
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Publication
38317225 | J:357626
First Author: Liddell JR
Year: 2024
Journal: Mol Neurodegener
Title: Microglial ferroptotic stress causes non-cell autonomous neuronal death.
Volume: 19
Issue: 1
Pages: 14
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Publication
16107710 | J:100525
First Author: Conrad M
Year: 2005
Journal: Mol Cell Biol
Title: The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability.
Volume: 25
Issue: 17
Pages: 7637-44
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Publication
20798033 | J:164380
First Author: Conrad M
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: 12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases.
Volume: 107
Issue: 36
Pages: 15774-9
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