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Search results 1 to 100 out of 1562 for Grb2

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
493492 | grb2
Type: gene
Organism: frog, western clawed
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Gene
2885 | GRB2
Type: gene
Organism: human
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Gene
81504 | Grb2
Type: gene
Organism: rat
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Gene
737245 | GRB2
Type: gene
Organism: chimpanzee
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Gene
483312 | GRB2
Type: gene
Organism: dog, domestic
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Gene
535298 | GRB2
Type: gene
Organism: cattle
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Gene
386572 | GRB2
Type: gene
Organism: chicken
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Gene
702041 | GRB2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR030219 | Grb2
Type: Family
Description: Growth factor receptor-bound protein 2 (Grb2) is an SH2 and SH3 domain-containing adaptor protein that links receptor tyrosine kinases to Ras signalling []. Grb2 interacts with the cytoplasmic tyrosine kinase ACK1 (activated Cdc42-associated kinase 1) and mediates its interaction with other receptor tyrosine kinases []. ACK1 is implicated in metastatic behaviour, cell spreading and migration, and epidermal growth factor receptor (EGFR) signalling [].
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Protein Coding Gene
MGI:95805 | Grb2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
1322798 | J:23345
First Author: Lowenstein EJ
Year: 1992
Journal: Cell
Title: The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
Volume: 70
Issue: 3
Pages: 431-42
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Publication
19815557 | -
First Author: Pao-Chun L
Year: 2009
Journal: J Biol Chem
Title: Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.
Volume: 284
Issue: 50
Pages: 34954-63
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Protein
B1AT95
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: true
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Publication
17363695 | J:134913
First Author: Proctor BM
Year: 2007
Journal: Arterioscler Thromb Vasc Biol
Title: Grb2 is required for atherosclerotic lesion formation.
Volume: 27
Issue: 6
Pages: 1361-7
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Gene
10750 | GRAP
Type: gene
Organism: human
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Publication
7529871 | J:200360
First Author: Ravichandran KS
Year: 1995
Journal: Mol Cell Biol
Title: Interaction of Shc with Grb2 regulates association of Grb2 with mSOS.
Volume: 15
Issue: 2
Pages: 593-600
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Publication
28964849 | J:255426
First Author: Frelin C
Year: 2017
Journal: Biochim Biophys Acta
Title: Grb2 regulates the proliferation of hematopoietic stem and progenitors cells.
Volume: 1864
Issue: 12
Pages: 2449-2459
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Publication
16436051 | J:111915
First Author: Honma M
Year: 2006
Journal: Genes Cells
Title: Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases.
Volume: 11
Issue: 2
Pages: 143-51
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Publication
12084912 | J:77353
First Author: Kessels HW
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Specificity and affinity motifs for Grb2 SH2-ligand interactions.
Volume: 99
Issue: 13
Pages: 8524-9
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Publication
11135575 | J:86374
First Author: Gong Q
Year: 2001
Journal: Nat Immunol
Title: Disruption of T cell signaling networks and development by Grb2 haploid insufficiency.
Volume: 2
Issue: 1
Pages: 29-36
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Publication
21427701 | J:171222
First Author: Ackermann JA
Year: 2011
Journal: EMBO J
Title: Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling.
Volume: 30
Issue: 8
Pages: 1621-33
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Publication
9865697 | J:51424
First Author: Cheng AM
Year: 1998
Journal: Cell
Title: Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.
Volume: 95
Issue: 6
Pages: 793-803
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Publication
37067793 | J:341962
 
First Author: Choi S
Year: 2023
Journal: J Exp Med
Title: GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1.
Volume: 220
Issue: 7
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Publication
37421147 | J:338808
 
First Author: Clark JF
Year: 2023
Journal: Biol Open
Title: FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development.
Volume: 12
Issue: 7
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Publication
28360125 | J:242308
First Author: Majumder P
Year: 2017
Journal: Dis Model Mech
Title: Cellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario.
Volume: 10
Issue: 5
Pages: 655-669
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Publication
18789888 | J:141241
First Author: Thornhill PB
Year: 2008
Journal: Biochem Biophys Res Commun
Title: The adaptor protein Grb2 regulates cell surface Fas ligand in Schwann cells.
Volume: 376
Issue: 2
Pages: 341-6
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Publication
20925113 | J:168655
First Author: Wang Y
Year: 2011
Journal: Dev Dyn
Title: Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation.
Volume: 240
Issue: 3
Pages: 566-76
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Publication
15539154 | J:93888
First Author: Stork B
Year: 2004
Journal: Immunity
Title: Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes.
Volume: 21
Issue: 5
Pages: 681-91
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Publication
8898205 | J:36244
First Author: Maina F
Year: 1996
Journal: Cell
Title: Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development.
Volume: 87
Issue: 3
Pages: 531-42
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Publication
23226445 | J:195444
First Author: Bisson N
Year: 2012
Journal: PLoS One
Title: The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier.
Volume: 7
Issue: 11
Pages: e50996
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Publication
12842846 | J:103043
First Author: Zhang S
Year: 2003
Journal: Arterioscler Thromb Vasc Biol
Title: Grb2 is required for the development of neointima in response to vascular injury.
Volume: 23
Issue: 10
Pages: 1788-93
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Publication
19240254 | J:148523
First Author: Liu X
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction.
Volume: 296
Issue: 5
Pages: E1067-75
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Publication
7478529 | J:29980
First Author: Huang L
Year: 1995
Journal: Oncogene
Title: GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase.
Volume: 11
Issue: 10
Pages: 2097-103
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Publication
15492213 | J:93530
First Author: Cully M
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice.
Volume: 101
Issue: 43
Pages: 15358-63
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Publication
26769899 | J:246102
First Author: Gingras J
Year: 2016
Journal: J Cell Sci
Title: Α-Dystrobrevin-1 recruits Grb2 and α-catulin to organize neurotransmitter receptors at the neuromuscular junction.
Volume: 129
Issue: 5
Pages: 898-911
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Publication
11551923 | J:72778
First Author: Otipoby KL
Year: 2001
Journal: J Biol Chem
Title: CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1.
Volume: 276
Issue: 47
Pages: 44315-22
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Publication
11707404 | J:73038
First Author: Ong SH
Year: 2001
Journal: EMBO J
Title: ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.
Volume: 20
Issue: 22
Pages: 6327-36
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Publication
27188442 | J:259331
First Author: Zvezdova E
Year: 2016
Journal: Sci Signal
Title: Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.
Volume: 9
Issue: 428
Pages: ra51
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Publication
16405865 | J:104992
First Author: Lim JY
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Merlin inhibits growth hormone-regulated Raf-ERKs pathways by binding to Grb2 protein.
Volume: 340
Issue: 4
Pages: 1151-7
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Publication
11823423 | J:335501
First Author: Waterman H
Year: 2002
Journal: EMBO J
Title: A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.
Volume: 21
Issue: 3
Pages: 303-13
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Publication
11567986 | J:72115
First Author: Tu Z
Year: 2001
Journal: Blood
Title: Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein.
Volume: 98
Issue: 7
Pages: 2028-38
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Publication
9199344 | J:326666
First Author: Harmer SL
Year: 1997
Journal: Mol Cell Biol
Title: Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes.
Volume: 17
Issue: 7
Pages: 4087-95
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Publication
11127814 | J:243545
First Author: Suzuki A
Year: 2000
Journal: Oncogene
Title: Meltrin alpha cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src.
Volume: 19
Issue: 51
Pages: 5842-50
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Publication
20398064 | J:169648
First Author: Murata Y
Year: 2010
Journal: Genes Cells
Title: Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn.
Volume: 15
Issue: 5
Pages: 513-24
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Publication
8816475 | J:200355
First Author: Schlaepfer DD
Year: 1996
Journal: Mol Cell Biol
Title: Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases.
Volume: 16
Issue: 10
Pages: 5623-33
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Publication
8798570 | J:35493
First Author: Stein E
Year: 1996
Journal: J Biol Chem
Title: Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.
Volume: 271
Issue: 38
Pages: 23588-93
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Publication
7689150 | J:14183
First Author: Suen KL
Year: 1993
Journal: Mol Cell Biol
Title: Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.
Volume: 13
Issue: 9
Pages: 5500-12
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Publication
8479540 | J:200364
First Author: Rozakis-Adcock M
Year: 1993
Journal: Nature
Title: The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.
Volume: 363
Issue: 6424
Pages: 83-5
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Publication
7706237 | J:24168
First Author: Jackman JK
Year: 1995
Journal: J Biol Chem
Title: Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells.
Volume: 270
Issue: 13
Pages: 7029-32
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Publication
20498059 | J:161294
First Author: Jang IK
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection.
Volume: 107
Issue: 23
Pages: 10620-5
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Publication
15301538 | J:201317
First Author: Lysek DA
Year: 2004
Journal: Biochemistry
Title: Prion protein interaction with the C-terminal SH3 domain of Grb2 studied using NMR and optical spectroscopy.
Volume: 43
Issue: 32
Pages: 10393-9
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Publication
21703542 | J:173993
First Author: Schnyder T
Year: 2011
Journal: Immunity
Title: B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster.
Volume: 34
Issue: 6
Pages: 905-18
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Publication
8479536 | J:326914
First Author: Egan SE
Year: 1993
Journal: Nature
Title: Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation.
Volume: 363
Issue: 6424
Pages: 45-51
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Publication
10930041 | J:64650
First Author: Diwan BA
Year: 2000
Journal: Toxicol Pathol
Title: Overexpression of Grb2 in inflammatory lesions and preneoplastic foci and tumors induced by N-nitrosodimethylamine in Helicobacter hepaticus-infected and -noninfected A/J mice.
Volume: 28
Issue: 4
Pages: 548-54
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Publication
18346204 | J:137323
First Author: Weinger JG
Year: 2008
Journal: J Neurochem
Title: In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation.
Volume: 106
Issue: 1
Pages: 134-46
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Gene
9402 | GRAP2
Type: gene
Organism: human
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Gene
2549 | GAB1
Type: gene
Organism: human
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Gene
9846 | GAB2
Type: gene
Organism: human
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Gene
139716 | GAB3
Type: gene
Organism: human
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Gene
202309 | GAPT
Type: gene
Organism: human
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Gene
400581 | GRAPL
Type: gene
Organism: human
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Gene
100652908 | LOC100652908
Type: gene
Organism: human
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Gene
6455 | SH3GL1
Type: gene
Organism: human
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Gene
6456 | SH3GL2
Type: gene
Organism: human
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Gene
6457 | SH3GL3
Type: gene
Organism: human
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Gene
51100 | SH3GLB1
Type: gene
Organism: human
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Gene
56904 | SH3GLB2
Type: gene
Organism: human
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Gene
128954 | GAB4
Type: gene
Organism: human
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Gene
150946 | GAREM2
Type: gene
Organism: human
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Gene
64762 | GAREM1
Type: gene
Organism: human
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Gene
390251 | LOC390251
Type: gene
Organism: human
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Gene
6458 | SH3GL1P1
Type: gene
Organism: human
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Gene
6459 | SH3GL1P2
Type: gene
Organism: human
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Gene
727736 | SH3GL1P3
Type: gene
Organism: human
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Publication
28250424 | J:258683
First Author: Choi S
Year: 2017
Journal: Nat Immunol
Title: THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.
Volume: 18
Issue: 4
Pages: 433-441
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Publication
9670936 | J:48581
First Author: Takemoto Y
Year: 1998
Journal: J Immunol
Title: Growth factor receptor-bound protein 2 (Grb2) association with hemopoietic specific protein 1: linkage between Lck and Grb2.
Volume: 161
Issue: 2
Pages: 625-30
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Publication
28355572 | J:254051
First Author: Caron E
Year: 2017
Journal: Cell Rep
Title: Precise Temporal Profiling of Signaling Complexes in Primary Cells Using SWATH Mass Spectrometry.
Volume: 18
Issue: 13
Pages: 3219-3226
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Publication
14722116 | J:159072
First Author: Koonpaew S
Year: 2004
Journal: J Biol Chem
Title: The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB.
Volume: 279
Issue: 12
Pages: 11229-35
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Publication
8923966 | J:36615
First Author: Zhang J
Year: 1996
Journal: Anal Biochem
Title: A yeast three-hybrid method to clone ternary protein complex components.
Volume: 242
Issue: 1
Pages: 68-72
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Publication
11551227 | J:213907
First Author: Oak SA
Year: 2001
Journal: Biochemistry
Title: Mouse alpha1-syntrophin binding to Grb2: further evidence of a role for syntrophin in cell signaling.
Volume: 40
Issue: 37
Pages: 11270-8
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Publication
24910098 | J:215321
First Author: Yasui N
Year: 2014
Journal: Mol Cell
Title: Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation.
Volume: 54
Issue: 6
Pages: 1034-41
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Publication
19528233 | J:151521
First Author: Kawada K
Year: 2009
Journal: Mol Cell Biol
Title: Cell migration is regulated by platelet-derived growth factor receptor endocytosis.
Volume: 29
Issue: 16
Pages: 4508-18
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Publication
19805304 | J:153235
First Author: Patrick MS
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes.
Volume: 106
Issue: 38
Pages: 16345-50
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Publication
12639989 | J:82523
First Author: Zhang S
Year: 2003
Journal: J Clin Invest
Title: The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis.
Volume: 111
Issue: 6
Pages: 833-41
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Publication
30183074 | J:267461
First Author: Willebrand R
Year: 2018
Journal: Eur J Immunol
Title: Murine eosinophil development and allergic lung eosinophilia are largely dependent on the signaling adaptor GRB2.
Volume: 48
Issue: 11
Pages: 1786-1795
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Publication
8955163 | J:37294
First Author: Sahni M
Year: 1996
Journal: J Biol Chem
Title: Identification of a novel 135-kDa Grb2-binding protein in osteoclasts.
Volume: 271
Issue: 51
Pages: 33141-7
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Publication
21508326 | J:172211
First Author: Jang IK
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction.
Volume: 108
Issue: 19
Pages: 7926-31
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Publication
32605923 | J:298032
First Author: Luo HC
Year: 2020
Journal: J Biol Chem
Title: Role of long noncoding RNA MEG3/miR-378/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke.
Volume: 295
Issue: 41
Pages: 14125-14139
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Publication
11571277 | J:72874
First Author: Spielhaupter C
Year: 2001
Journal: J Biol Chem
Title: PrPC directly interacts with proteins involved in signaling pathways.
Volume: 276
Issue: 48
Pages: 44604-12
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Publication
10744659 | J:76319
First Author: Goitsuka R
Year: 2000
Journal: Int Immunol
Title: A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation.
Volume: 12
Issue: 4
Pages: 573-80
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Publication
7806216 | J:19671
First Author: Yulug IG
Year: 1994
Journal: Genomics
Title: Mapping GRB2, a signal transduction gene in the human and the mouse.
Volume: 22
Issue: 2
Pages: 313-8
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Publication
10330178 | J:55014
First Author: Goyal RK
Year: 1999
Journal: Mol Cell Biol
Title: Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner.
Volume: 19
Issue: 6
Pages: 4379-89
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Publication
8262059 | J:177180
First Author: van der Geer P
Year: 1993
Journal: EMBO J
Title: Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts.
Volume: 12
Issue: 13
Pages: 5161-72
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Publication
16314834 | J:122429
First Author: Teal HE
Year: 2006
Journal: Oncogene
Title: GRB2-mediated recruitment of GAB2, but not GAB1, to SF-STK supports the expansion of Friend virus-infected erythroid progenitor cells.
Volume: 25
Issue: 17
Pages: 2433-43
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Publication
37777158 | J:342351
First Author: Li X
Year: 2023
Journal: J Biol Chem
Title: Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2-ERK depending on downregulation of proteasome-related genes.
Volume: 299
Issue: 11
Pages: 105301
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Publication
17673906 | J:200409
First Author: Lee MK
Year: 2007
Journal: EMBO J
Title: TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA.
Volume: 26
Issue: 17
Pages: 3957-67
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Publication
15314156 | J:92782
First Author: Higuchi T
Year: 2004
Journal: Mol Cell Biol
Title: MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met.
Volume: 24
Issue: 17
Pages: 7456-68
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Publication
16678776 | J:108748
First Author: Chazaud C
Year: 2006
Journal: Dev Cell
Title: Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway.
Volume: 10
Issue: 5
Pages: 615-24
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Publication
11173924 | J:338801
First Author: Goodearl A
Year: 2001
Journal: Dev Neurosci
Title: Neuregulin-induced association of Sos Ras exchange protein with HER2(erbB2)/HER3(erbB3) receptor complexes in Schwann cells through a specific Grb2-HER2(erbB2) interaction.
Volume: 23
Issue: 1
Pages: 25-30
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Publication
23452850 | J:206901
First Author: Findlay GM
Year: 2013
Journal: Cell
Title: Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.
Volume: 152
Issue: 5
Pages: 1008-20
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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