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Search results 1 to 100 out of 283 for Il21

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
59067 | IL21
Type: gene
Organism: human
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Gene
100145684 | il21
Type: gene
Organism: frog, western clawed
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Gene
365769 | Il21
Type: gene
Organism: rat
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Gene
442935 | IL21
Type: gene
Organism: dog, domestic
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Gene
471295 | IL21
Type: gene
Organism: chimpanzee
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Gene
378475 | IL21
Type: gene
Organism: cattle
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Gene
554218 | IL21
Type: gene
Organism: chicken
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Gene
100150203 | il21
Type: gene
Organism: zebrafish
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Gene
708125 | IL21
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1890474 | Il21
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
100996941 | IL21-AS1
Type: gene
Organism: human
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Publication
17918202 | J:126318
First Author: Allard EL
Year: 2007
Journal: Eur J Immunol
Title: Overexpression of IL-21 promotes massive CD8+ memory T cell accumulation.
Volume: 37
Issue: 11
Pages: 3069-77
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Protein
Q5SUE2
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: false
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Publication
11081504 | J:65629
First Author: Parrish-Novak J
Year: 2000
Journal: Nature
Title: Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.
Volume: 408
Issue: 6808
Pages: 57-63
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Publication
32122993 | J:318594
First Author: Koh CH
Year: 2020
Journal: Cancer Immunol Res
Title: GITR Agonism Triggers Antitumor Immune Responses through IL21-Expressing Follicular Helper T Cells.
Volume: 8
Issue: 5
Pages: 698-709
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Publication
23667536 | J:202181
First Author: Stumhofer JS
Year: 2013
Journal: PLoS One
Title: IL-21 is required for optimal antibody production and T cell responses during chronic Toxoplasma gondii infection.
Volume: 8
Issue: 5
Pages: e62889
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Publication
20639489 | J:162541
First Author: Chen G
Year: 2010
Journal: J Immunol
Title: Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel.
Volume: 185
Issue: 4
Pages: 2350-9
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Publication
22466669 | J:185372
First Author: Lüthje K
Year: 2012
Journal: Nat Immunol
Title: The development and fate of follicular helper T cells defined by an IL-21 reporter mouse.
Volume: 13
Issue: 5
Pages: 491-8
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Publication
17884812 | J:161016
First Author: Wei L
Year: 2007
Journal: J Biol Chem
Title: IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.
Volume: 282
Issue: 48
Pages: 34605-10
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Publication
33916486 | J:307072
 
First Author: Allred MG
Year: 2021
Journal: Int J Mol Sci
Title: Characterization of Type I Interferon-Associated Chemokines and Cytokines in Lacrimal Glands of Nonobese Diabetic Mice.
Volume: 22
Issue: 7
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Publication
26499265 | J:230488
First Author: Wichner K
Year: 2016
Journal: FASEB J
Title: Dysregulated development of IL-17- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORγt.
Volume: 30
Issue: 2
Pages: 761-74
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Publication
19880748 | J:154769
First Author: McGuire HM
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus.
Volume: 106
Issue: 46
Pages: 19438-43
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Publication
22019586 | J:178709
First Author: Liu SM
Year: 2011
Journal: J Clin Invest
Title: Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice.
Volume: 121
Issue: 11
Pages: 4303-10
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Publication
24973819 | J:259007
First Author: Végran F
Year: 2014
Journal: Nat Immunol
Title: The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells.
Volume: 15
Issue: 8
Pages: 758-66
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Publication
30059018 | J:266384
First Author: Hsu CY
Year: 2018
Journal: J Clin Invest
Title: SUMO-defective c-Maf preferentially transactivates Il21 to exacerbate autoimmune diabetes.
Volume: 128
Issue: 9
Pages: 3779-3793
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Publication
25763578 | J:244850
First Author: Pérez-Mazliah D
Year: 2015
Journal: PLoS Pathog
Title: Disruption of IL-21 signaling affects T cell-B cell interactions and abrogates protective humoral immunity to malaria.
Volume: 11
Issue: 3
Pages: e1004715
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Publication
27798619 | J:259397
First Author: Miyauchi K
Year: 2016
Journal: Nat Immunol
Title: Protective neutralizing influenza antibody response in the absence of T follicular helper cells.
Volume: 17
Issue: 12
Pages: 1447-1458
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Publication
22365664 | J:181626
First Author: Harada Y
Year: 2012
Journal: Immunity
Title: The 3' enhancer CNS2 is a critical regulator of interleukin-4-mediated humoral immunity in follicular helper T cells.
Volume: 36
Issue: 2
Pages: 188-200
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Publication
14679059 | J:86885
 
First Author: Ikegami H
Year: 2003
Journal: Ann N Y Acad Sci
Title: Congenic mapping and candidate sequencing of susceptibility genes for Type 1 diabetes in the NOD mouse.
Volume: 1005
Pages: 196-204
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Protein Coding Gene
MGP_CAROLIEiJ_G0024946 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027167 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027127 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027139 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026882 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1890474 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027585 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026335 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026859 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026993 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026961 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027105 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026980 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027644 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026068 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026409 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026386 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025880 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
15494482 | J:93740
First Author: Ozaki K
Year: 2004
Journal: J Immunol
Title: Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6.
Volume: 173
Issue: 9
Pages: 5361-71
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Publication
22829452 | J:208509
First Author: Mariño E
Year: 2012
Journal: Diabetes
Title: B-cell cross-presentation of autologous antigen precipitates diabetes.
Volume: 61
Issue: 11
Pages: 2893-905
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Publication
25351608 | J:246498
First Author: Lin PY
Year: 2015
Journal: Immunology
Title: Interleukin-21 suppresses the differentiation and functions of T helper 2 cells.
Volume: 144
Issue: 4
Pages: 668-76
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Publication
18390721 | J:134257
First Author: Clough LE
Year: 2008
Journal: J Immunol
Title: Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21.
Volume: 180
Issue: 8
Pages: 5393-401
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Publication
35801309 | J:333521
First Author: Dvorscek AR
Year: 2022
Journal: EMBO Rep
Title: IL-21 has a critical role in establishing germinal centers by amplifying early B cell proliferation.
Volume: 23
Issue: 9
Pages: e54677
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Publication
31383743 | J:286101
 
First Author: Yasmin S
Year: 2019
Journal: Infect Immun
Title: Interleukin-21 (IL-21) Downregulates Dendritic Cell Cytokine Responses to Helicobacter pylori and Modulates T Lymphocyte IL-17A Expression in Peyer's Patches during Infection.
Volume: 87
Issue: 11
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Publication
21987656 | J:178766
First Author: Stolfi C
Year: 2011
Journal: J Exp Med
Title: Involvement of interleukin-21 in the regulation of colitis-associated colon cancer.
Volume: 208
Issue: 11
Pages: 2279-90
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Publication
23607664 | J:200646
First Author: Chen XL
Year: 2013
Journal: Clin Exp Immunol
Title: Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8⁺ T cells.
Volume: 173
Issue: 2
Pages: 184-94
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Publication
24430438 | J:229296
First Author: Fabrizi M
Year: 2014
Journal: Diabetes
Title: IL-21 is a major negative regulator of IRF4-dependent lipolysis affecting Tregs in adipose tissue and systemic insulin sensitivity.
Volume: 63
Issue: 6
Pages: 2086-96
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Publication
24616379 | J:210825
First Author: Clarkson BD
Year: 2014
Journal: J Exp Med
Title: T cell-derived interleukin (IL)-21 promotes brain injury following stroke in mice.
Volume: 211
Issue: 4
Pages: 595-604
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Publication
25053783 | J:243886
First Author: Carbo A
Year: 2014
Journal: MBio
Title: Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection.
Volume: 5
Issue: 4
Pages: e01243-14
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Publication
17918200 | J:126320
First Author: Fantini MC
Year: 2007
Journal: Eur J Immunol
Title: IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells.
Volume: 37
Issue: 11
Pages: 3155-63
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Publication
12393685 | J:80779
First Author: Suto A
Year: 2002
Journal: Blood
Title: Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells.
Volume: 100
Issue: 13
Pages: 4565-73
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Publication
15240677 | J:91923
First Author: Moroz A
Year: 2004
Journal: J Immunol
Title: IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21.
Volume: 173
Issue: 2
Pages: 900-9
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Publication
15585879 | J:94854
First Author: Pelletier M
Year: 2004
Journal: J Immunol
Title: In vivo and in vitro roles of IL-21 in inflammation.
Volume: 173
Issue: 12
Pages: 7521-30
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Publication
17554014 | J:124239
First Author: Ostiguy V
Year: 2007
Journal: J Leukoc Biol
Title: IL-21 promotes T lymphocyte survival by activating the phosphatidylinositol-3 kinase signaling cascade.
Volume: 82
Issue: 3
Pages: 645-56
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Publication
19073938 | J:142658
First Author: D'Alise AM
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors.
Volume: 105
Issue: 50
Pages: 19857-62
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Publication
18515660 | J:143807
First Author: Castermans K
Year: 2008
Journal: Blood
Title: Angiostatic activity of the antitumor cytokine interleukin-21.
Volume: 112
Issue: 13
Pages: 4940-7
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Publication
17312126 | J:144112
First Author: Coquet JM
Year: 2007
Journal: J Immunol
Title: IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production.
Volume: 178
Issue: 5
Pages: 2827-34
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Publication
21911600 | J:179315
First Author: Magari M
Year: 2011
Journal: J Immunol
Title: IL-21-dependent B cell death driven by prostaglandin E2, a product secreted from follicular dendritic cells.
Volume: 187
Issue: 8
Pages: 4210-8
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Publication
28405614 | J:319264
First Author: Yuan Y
Year: 2017
Journal: JCI Insight
Title: IL-21 is required for CD4 memory formation in response to viral infection.
Volume: 2
Issue: 7
Pages: e90652
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Publication
29844233 | J:319465
 
First Author: Noguchi N
Year: 2018
Journal: Infect Immun
Title: Interleukin-21 Induces Short-Lived Effector CD8+ T Cells but Does Not Inhibit Their Exhaustion after Mycobacterium bovis BCG Infection in Mice.
Volume: 86
Issue: 8
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Publication
23992866 | J:318137
First Author: Phares TW
Year: 2013
Journal: J Neuroimmunol
Title: IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis.
Volume: 263
Issue: 1-2
Pages: 43-54
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GXD Expression
GXD Expression
   
Probe: MGI:7471160
Assay Type: RT-PCR
Annotation Date: 2023-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:7471189
Age: embryonic day 14.5
Image: 7
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7471160
Assay Type: RT-PCR
Annotation Date: 2023-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:7471189
Age: embryonic day 14.5
Image: 7
Specimen Label: KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691618
Age: postnatal adult
Image: UC Davis_1888028
Note: vas deferens
Specimen Label: UC Davis_1888028
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691618
Age: postnatal adult
Image: UC Davis_1888026
Specimen Label: UC Davis_1888026
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691618
Age: postnatal adult
Image: UC Davis_1888027
Specimen Label: UC Davis_1888027
Detected: true
Specimen Num: 2
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Publication
11970879 | J:76043
First Author: Kasaian MT
Year: 2002
Journal: Immunity
Title: IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity.
Volume: 16
Issue: 4
Pages: 559-69
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Publication
25586558 | J:338005
First Author: Cao AT
Year: 2015
Journal: Mucosal Immunol
Title: Interleukin (IL)-21 promotes intestinal IgA response to microbiota.
Volume: 8
Issue: 5
Pages: 1072-82
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Publication
21430227 | J:172862
First Author: Ramanathan S
Year: 2011
Journal: J Immunol
Title: Exposure to IL-15 and IL-21 enables autoreactive CD8 T cells to respond to weak antigens and cause disease in a mouse model of autoimmune diabetes.
Volume: 186
Issue: 9
Pages: 5131-41
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Publication
19915059 | J:157388
First Author: Søndergaard H
Year: 2009
Journal: J Immunol
Title: Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity.
Volume: 183
Issue: 11
Pages: 7326-36
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Publication
22120118 | J:178990
First Author: King IL
Year: 2011
Journal: Nat Immunol
Title: Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner.
Volume: 13
Issue: 1
Pages: 44-50
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Publication
19208913 | J:151122
First Author: Sutherland AP
Year: 2009
Journal: Diabetes
Title: Interleukin-21 is required for the development of type 1 diabetes in NOD mice.
Volume: 58
Issue: 5
Pages: 1144-55
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Publication
22723520 | J:189795
First Author: Nguyen V
Year: 2012
Journal: J Immunol
Title: IL-21 promotes lupus-like disease in chronic graft-versus-host disease through both CD4 T cell- and B cell-intrinsic mechanisms.
Volume: 189
Issue: 2
Pages: 1081-93
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Publication
35896116 | J:330818
First Author: Quast I
Year: 2022
Journal: Immunity
Title: Interleukin-21, acting beyond the immunological synapse, independently controls T follicular helper and germinal center B cells.
Volume: 55
Issue: 8
Pages: 1414-1430.e5
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Publication
21357471 | J:169677
First Author: McGuire HM
Year: 2011
Journal: Diabetes
Title: Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models.
Volume: 60
Issue: 3
Pages: 867-75
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Publication
23516660 | J:321299
First Author: Dorfmeier CL
Year: 2013
Journal: PLoS Negl Trop Dis
Title: Investigating the role for IL-21 in rabies virus vaccine-induced immunity.
Volume: 7
Issue: 3
Pages: e2129
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Publication
18773086 | J:143945
First Author: Datta S
Year: 2008
Journal: PLoS One
Title: IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms.
Volume: 3
Issue: 9
Pages: e3118
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Publication
26363366 | J:227006
First Author: Jain S
Year: 2015
Journal: Am J Pathol
Title: IL-21-driven neoplasms in SJL mice mimic some key features of human angioimmunoblastic T-cell lymphoma.
Volume: 185
Issue: 11
Pages: 3102-14
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Publication
22238461 | J:181192
First Author: Spolski R
Year: 2012
Journal: J Immunol
Title: IL-21 promotes the pathologic immune response to pneumovirus infection.
Volume: 188
Issue: 4
Pages: 1924-32
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Publication
34887406 | J:334641
First Author: Zotos D
Year: 2021
Journal: Nat Commun
Title: The concerted change in the distribution of cell cycle phases and zone composition in germinal centers is regulated by IL-21.
Volume: 12
Issue: 1
Pages: 7160
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Publication
18602282 | J:137867
First Author: Vogelzang A
Year: 2008
Journal: Immunity
Title: A fundamental role for interleukin-21 in the generation of T follicular helper cells.
Volume: 29
Issue: 1
Pages: 127-37
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Publication
23637417 | J:198436
First Author: Rasheed MA
Year: 2013
Journal: J Virol
Title: Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells.
Volume: 87
Issue: 13
Pages: 7737-46
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Publication
20926797 | J:165648
First Author: King IL
Year: 2010
Journal: J Immunol
Title: A nonredundant role for IL-21 receptor signaling in plasma cell differentiation and protective type 2 immunity against gastrointestinal helminth infection.
Volume: 185
Issue: 10
Pages: 6138-45
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Publication
18490706 | J:136354
First Author: Coquet JM
Year: 2008
Journal: J Immunol
Title: Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis.
Volume: 180
Issue: 11
Pages: 7097-101
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Publication
19168593 | J:149704
First Author: Seo GY
Year: 2009
Journal: J Leukoc Biol
Title: IL-21 ensures TGF-beta 1-induced IgA isotype expression in mouse Peyer's patches.
Volume: 85
Issue: 5
Pages: 744-50
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Publication
18981236 | J:143221
First Author: Odegard JM
Year: 2008
Journal: J Exp Med
Title: ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity.
Volume: 205
Issue: 12
Pages: 2873-86
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Publication
28798332 | J:250904
First Author: Haymaker C
Year: 2017
Journal: Nat Commun
Title: Absence of Grail promotes CD8+ T cell anti-tumour activity.
Volume: 8
Issue: 1
Pages: 239
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