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Search results 1 to 100 out of 2041 for Ins2

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Type Details Score
Gene
24506 | Ins2
Type: gene
Organism: rat
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Protein Coding Gene
MGI:96573 | Ins2
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
 
Probe: MGI:3820901
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3565022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825694
Age: embryonic day 14.5
Image: 5 Ins2
Specimen Label: 5 Ins2
Detected: true
Specimen Num: 1
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Publication
- | J:292865
     
First Author: King A
Year: 2020
Journal: MGI Direct Data Submission
Title: Ins2 Kings allele
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GXD Expression
GXD Expression
 
Probe: MGI:3820901
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3565022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825694
Age: embryonic day 14.5
Image: Additional file 4 Ins2
Specimen Label: Additional file 4 Ins2
Detected: true
Specimen Num: 2
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Publication
32994272 | J:300475
First Author: Austin ALF
Year: 2020
Journal: Diabetes
Title: The KINGS Ins2 +/G32S Mouse: A Novel Model of β-Cell Endoplasmic Reticulum Stress and Human Diabetes.
Volume: 69
Issue: 12
Pages: 2667-2677
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Allele
Ins2<Kings> | MGI:6236252
Name: insulin II; KCL Ins2 G32S
Allele Type: Spontaneous
Attribute String: Not Specified
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Publication
24258027 | J:321229
First Author: Murakami-Kawaguchi S
Year: 2014
Journal: Cell Tissue Res
Title: Expression of Ins1 and Ins2 genes in mouse fetal liver.
Volume: 355
Issue: 2
Pages: 303-14
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Publication
25428948 | J:228850
 
First Author: Wu X
Year: 2014
Journal: Physiol Rep
Title: Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation.
Volume: 2
Issue: 11
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Publication
19966211 | J:159429
First Author: Jarchum I
Year: 2010
Journal: J Immunol
Title: Ins2 deficiency augments spontaneous HLA-A*0201-restricted T cell responses to insulin.
Volume: 184
Issue: 2
Pages: 658-65
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Publication
18515593 | J:137045
First Author: Gastinger MJ
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic mice.
Volume: 49
Issue: 6
Pages: 2635-42
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Publication
9465295 | J:45695
First Author: Duvillié B
Year: 1998
Journal: Genomics
Title: Imprinting at the mouse Ins2 locus: evidence for cis- and trans-allelic interactions.
Volume: 47
Issue: 1
Pages: 52-7
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Publication
15567729 | J:94051
First Author: Deltour L
Year: 2004
Journal: Gene Expr Patterns
Title: Differential expression and imprinting status of Ins1 and Ins2 genes in extraembryonic tissues of laboratory mice.
Volume: 5
Issue: 2
Pages: 297-300
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Publication
26830324 | J:251799
 
First Author: Li L
Year: 2016
Journal: Sci Rep
Title: Knockin of Cre Gene at Ins2 Locus Reveals No Cre Activity in Mouse Hypothalamic Neurons.
Volume: 6
Pages: 20438
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Publication
25957229 | J:224619
First Author: Fang F
Year: 2015
Journal: Diabetologia
Title: Deletion of the gene for adiponectin accelerates diabetic nephropathy in the Ins2 (+/C96Y) mouse.
Volume: 58
Issue: 7
Pages: 1668-78
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Publication
15587270 | J:94589
First Author: Lamotte L
Year: 2004
Journal: Transgenic Res
Title: Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain.
Volume: 13
Issue: 5
Pages: 463-73
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Publication
29675273 | J:281951
 
First Author: Francis AW
Year: 2018
Journal: J Ophthalmol
Title: Assessment of Global and Local Alterations in Retinal Layer Thickness in Ins2 (Akita) Diabetic Mice by Spectral Domain Optical Coherence Tomography.
Volume: 2018
Pages: 7253498
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Publication
8835532 | J:31823
First Author: Pearce RB
Year: 1996
Journal: Mamm Genome
Title: Clarification of the Ins2 gene sequence: relevance to glucose intolerance in NON/Lt mice.
Volume: 7
Issue: 2
Pages: 143-4
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Publication
19684026 | J:153719
First Author: Lefebvre L
Year: 2009
Journal: Hum Mol Genet
Title: The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region.
Volume: 18
Issue: 22
Pages: 4255-67
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Publication
17303807 | J:122098
First Author: Herbach N
Year: 2007
Journal: Diabetes
Title: Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice.
Volume: 56
Issue: 5
Pages: 1268-76
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Publication
20520806 | J:160899
First Author: de Preux Charles AS
Year: 2010
Journal: PLoS One
Title: Global transcriptional programs in peripheral nerve endoneurium and DRG are resistant to the onset of type 1 diabetic neuropathy in Ins2 mice.
Volume: 5
Issue: 5
Pages: e10832
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Publication
27055260 | J:253547
First Author: Templeman NM
Year: 2016
Journal: PLoS One
Title: Hyper-Variability in Circulating Insulin, High Fat Feeding Outcomes, and Effects of Reducing Ins2 Dosage in Male Ins1-Null Mice in a Specific Pathogen-Free Facility.
Volume: 11
Issue: 4
Pages: e0153280
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Publication
34645928 | J:312429
First Author: Noguchi H
Year: 2021
Journal: Sci Rep
Title: In vivo evaluation of GG2-GG1/A2 element activity in the insulin promoter region using the CRISPR-Cas9 system.
Volume: 11
Issue: 1
Pages: 20290
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Regulatory Region
MGI:7338990 | Rr268
Type: enhancer
Organism: mouse, laboratory
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Publication
18563383 | J:138005
First Author: Pearson T
Year: 2008
Journal: Diabetologia
Title: A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
Volume: 51
Issue: 8
Pages: 1449-56
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Publication
15005713 | J:96748
First Author: Nozaki Ji
Year: 2004
Journal: Genes Cells
Title: The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells.
Volume: 9
Issue: 3
Pages: 261-70
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Publication
22522616 | J:203174
First Author: Schoeller EL
Year: 2012
Journal: Diabetes
Title: Insulin rescues impaired spermatogenesis via the hypothalamic-pituitary-gonadal axis in Akita diabetic mice and restores male fertility.
Volume: 61
Issue: 7
Pages: 1869-78
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Publication
26822858 | J:323080
 
First Author: Madonna R
Year: 2016
Journal: Cardiovasc Diabetol
Title: High glucose-induced hyperosmolarity contributes to COX-2 expression and angiogenesis: implications for diabetic retinopathy.
Volume: 15
Pages: 18
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Publication
23412636 | J:238044
First Author: Takeshita S
Year: 2012
Journal: Genes Genet Syst
Title: Diabetic modifier QTL, Dbm4, affecting elevated fasting blood glucose concentrations in congenic mice.
Volume: 87
Issue: 5
Pages: 341-6
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Publication
33852861 | J:308553
First Author: Akerman I
Year: 2021
Journal: Cell Rep
Title: Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene.
Volume: 35
Issue: 2
Pages: 108981
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Publication
22449801 | J:184712
First Author: Yeh CK
Year: 2012
Journal: Lab Invest
Title: Hyperglycemia and xerostomia are key determinants of tooth decay in type 1 diabetic mice.
Volume: 92
Issue: 6
Pages: 868-82
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Publication
33662611 | J:312118
 
First Author: Hu P
Year: 2021
Journal: Bone
Title: Type 1 diabetic Akita mice have low bone mass and impaired fracture healing.
Volume: 147
Pages: 115906
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Publication
21447785 | J:182074
First Author: Jun JY
Year: 2011
Journal: Am J Physiol Endocrinol Metab
Title: Spontaneously diabetic Ins2(+/Akita):apoE-deficient mice exhibit exaggerated hypercholesterolemia and atherosclerosis.
Volume: 301
Issue: 1
Pages: E145-54
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Publication
23019230 | J:190320
First Author: Vashistha H
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney.
Volume: 303
Issue: 12
Pages: F1629-40
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Publication
16604193 | J:108948
First Author: Kakoki M
Year: 2006
Journal: J Clin Invest
Title: Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors.
Volume: 116
Issue: 5
Pages: 1302-9
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Publication
16964447 | J:112869
First Author: Takeshita S
Year: 2006
Journal: Mamm Genome
Title: Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice.
Volume: 17
Issue: 9
Pages: 927-40
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Publication
34489701 | J:325385
 
First Author: Bucolo C
Year: 2021
Journal: Front Pharmacol
Title: Short-and Long-Term Expression of Vegf: A Temporal Regulation of a Key Factor in Diabetic Retinopathy.
Volume: 12
Pages: 707909
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Publication
29371604 | J:258611
First Author: Kang C
Year: 2018
Journal: Nat Commun
Title: SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia.
Volume: 9
Issue: 1
Pages: 367
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Publication
18219478 | J:137936
First Author: Liu Z
Year: 2008
Journal: Diabetologia
Title: Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation.
Volume: 51
Issue: 4
Pages: 623-31
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Publication
19955657 | J:156725
First Author: Matsuda T
Year: 2010
Journal: J Clin Invest
Title: Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice.
Volume: 120
Issue: 1
Pages: 115-26
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Publication
28102311 | J:272178
 
First Author: Chen E
Year: 2017
Journal: Sci Rep
Title: PLIN2 is a Key Regulator of the Unfolded Protein Response and Endoplasmic Reticulum Stress Resolution in Pancreatic β Cells.
Volume: 7
Pages: 40855
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Publication
32169892 | J:293276
First Author: Sharma I
Year: 2020
Journal: Diabetes
Title: Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes.
Volume: 69
Issue: 6
Pages: 1248-1263
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Publication
28069641 | J:278589
First Author: Bishop NH
Year: 2017
Journal: Diabetes
Title: Differential Impact of Chronic Hyperglycemia on Humoral Versus Cellular Primary Alloimmunity.
Volume: 66
Issue: 4
Pages: 981-986
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Publication
21576366 | J:174090
First Author: Jones MJ
Year: 2011
Journal: Mol Cell Biol
Title: An extended domain of Kcnq1ot1 silencing revealed by an imprinted fluorescent reporter.
Volume: 31
Issue: 14
Pages: 2827-37
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Publication
19778534 | J:154092
First Author: Jones MJ
Year: 2009
Journal: Dev Biol
Title: An imprinted GFP insertion reveals long-range epigenetic regulation in embryonic lineages.
Volume: 336
Issue: 1
Pages: 42-52
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Publication
19680229 | J:152798
First Author: Fan Y
Year: 2009
Journal: EMBO J
Title: Thymus-specific deletion of insulin induces autoimmune diabetes.
Volume: 28
Issue: 18
Pages: 2812-24
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Publication
9337391 | J:44024
First Author: Greally JM
Year: 1997
Journal: Mamm Genome
Title: Matrix-attachment regions in the mouse chromosome 7F imprinted domain.
Volume: 8
Issue: 11
Pages: 805-10
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Publication
21551953 | J:171567
First Author: Nakamura K
Year: 2011
Journal: Biomed Res
Title: Pancreatic β-cells are generated by neogenesis from non-β-cells after birth.
Volume: 32
Issue: 2
Pages: 167-74
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Publication
23217255 | J:194167
First Author: Mehran AE
Year: 2012
Journal: Cell Metab
Title: Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.
Volume: 16
Issue: 6
Pages: 723-37
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Publication
28700945 | J:255242
First Author: Templeman NM
Year: 2017
Journal: Cell Rep
Title: Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan.
Volume: 20
Issue: 2
Pages: 451-463
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Publication
7729600 | J:24370
First Author: Deltour L
Year: 1995
Journal: Dev Biol
Title: Tissue- and developmental stage-specific imprinting of the mouse proinsulin gene, Ins2.
Volume: 168
Issue: 2
Pages: 686-8
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Publication
32546815 | J:293751
First Author: Noguchi H
Year: 2020
Journal: Commun Biol
Title: Mutations in the C1 element of the insulin promoter lead to diabetic phenotypes in homozygous mice.
Volume: 3
Issue: 1
Pages: 309
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Strain
MGI:6449740 | C57BL/6J-Ins2<Kings>/Kcl
Attribute String: coisogenic, mutant strain, spontaneous mutation
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Publication
7534338 | J:23782
First Author: Ha JH
Year: 1995
Journal: J Neurochem
Title: Striatal met-enkephalin and substance P levels are decreased in mice infected with the LP-BM5 murine leukemia virus.
Volume: 64
Issue: 4
Pages: 1896-8
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Publication
38446901 | J:347026
First Author: Clotet-Freixas S
Year: 2024
Journal: Sci Transl Med
Title: Sex differences in kidney metabolism may reflect sex-dependent outcomes in human diabetic kidney disease.
Volume: 16
Issue: 737
Pages: eabm2090
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Publication
38142581 | J:344317
 
First Author: Aldoghachi AF
Year: 2024
Journal: Biochem Biophys Res Commun
Title: Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes.
Volume: 694
Pages: 149392
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Publication
37628852 | J:339659
 
First Author: Zerbini G
Year: 2023
Journal: Int J Mol Sci
Title: Progressive Thinning of Retinal Nerve Fiber Layer/Ganglion Cell Layer (RNFL/GCL) as Biomarker and Pharmacological Target of Diabetic Retinopathy.
Volume: 24
Issue: 16
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Publication
33069809 | J:299817
 
First Author: Otomo H
Year: 2020
Journal: Metabolism
Title: Sodium-glucose cotransporter 2 inhibition attenuates protein overload in renal proximal tubule via suppression of megalin O-GlcNacylation in progressive diabetic nephropathy.
Volume: 113
Pages: 154405
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Publication
29972779 | J:270881
First Author: Xu B
Year: 2018
Journal: Cell Rep
Title: Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes.
Volume: 24
Issue: 1
Pages: 181-196
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Publication
22653270 | J:186435
First Author: Liu GC
Year: 2012
Journal: Diabetologia
Title: Deletion of p47phox attenuates the progression of diabetic nephropathy and reduces the severity of diabetes in the Akita mouse.
Volume: 55
Issue: 9
Pages: 2522-32
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Publication
30019207 | J:269355
First Author: Hombrebueno JR
Year: 2018
Journal: Diabetologia
Title: Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes.
Volume: 61
Issue: 11
Pages: 2433-2446
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Publication
24163078 | J:207722
First Author: Rajab M
Year: 2013
Journal: Am J Physiol Heart Circ Physiol
Title: Increased inducibility of ventricular tachycardia and decreased heart rate variability in a mouse model for type 1 diabetes: effect of pravastatin.
Volume: 305
Issue: 12
Pages: H1807-16
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Publication
18558660 | J:145654
First Author: Kim ST
Year: 2008
Journal: Reproduction
Title: Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression.
Volume: 136
Issue: 3
Pages: 313-22
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Publication
28214591 | J:248726
 
First Author: Maresch CC
Year: 2017
Journal: Mol Cell Endocrinol
Title: Hyperglycemia is associated with reduced testicular function and activin dysregulation in the Ins2Akita+/- mouse model of type 1 diabetes.
Volume: 446
Pages: 91-101
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Publication
36809274 | J:335186
 
First Author: Kogot-Levin A
Year: 2023
Journal: JCI Insight
Title: Mapping the metabolic reprogramming induced by sodium-glucose cotransporter 2 inhibition.
Volume: 8
Issue: 7
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Publication
20042456 | J:157873
First Author: Gurley SB
Year: 2010
Journal: Am J Physiol Renal Physiol
Title: Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice.
Volume: 298
Issue: 3
Pages: F788-95
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Publication
22205225 | J:182441
First Author: Lo CS
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice.
Volume: 302
Issue: 7
Pages: F840-52
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Publication
21467180 | J:181425
First Author: Losiewicz MK
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Diabetes impairs the neuroprotective properties of retinal alpha-crystallins.
Volume: 52
Issue: 9
Pages: 5034-42
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Publication
17082643 | J:140617
First Author: Gyurko R
Year: 2006
Journal: J Immunol
Title: Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice.
Volume: 177
Issue: 10
Pages: 7250-6
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Publication
17334640 | J:125256
First Author: Asakawa A
Year: 2007
Journal: Int J Mol Med
Title: Ins2Akita mice exhibit hyperphagia and anxiety behavior via the melanocortin system.
Volume: 19
Issue: 4
Pages: 649-52
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Publication
21872588 | J:178385
First Author: Schmidt RE
Year: 2011
Journal: Exp Neurol
Title: Effect of insulin and an erythropoietin-derived peptide (ARA290) on established neuritic dystrophy and neuronopathy in Akita (Ins2 Akita) diabetic mouse sympathetic ganglia.
Volume: 232
Issue: 2
Pages: 126-35
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Publication
17585110 | J:141650
First Author: Martens GW
Year: 2007
Journal: Am J Respir Cell Mol Biol
Title: Tuberculosis susceptibility of diabetic mice.
Volume: 37
Issue: 5
Pages: 518-24
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Publication
11854314 | J:78863
First Author: Ron D
Year: 2002
Journal: J Clin Invest
Title: Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.
Volume: 109
Issue: 4
Pages: 443-5
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Publication
29304075 | J:257015
First Author: Choi J
Year: 2018
Journal: PLoS One
Title: β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice.
Volume: 13
Issue: 1
Pages: e0190863
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Publication
26597883 | J:228139
First Author: Venegas-Pino DE
Year: 2016
Journal: Am J Pathol
Title: Sex-Specific Differences in an ApoE(-/-):Ins2(+/Akita) Mouse Model of Accelerated Atherosclerosis.
Volume: 186
Issue: 1
Pages: 67-77
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Publication
25207540 | J:213912
First Author: Soto I
Year: 2014
Journal: PLoS One
Title: DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation.
Volume: 9
Issue: 9
Pages: e107291
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Publication
23404117 | J:214916
First Author: Murray AR
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model.
Volume: 54
Issue: 3
Pages: 1689-97
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Publication
30480744 | J:267368
First Author: You ZP
Year: 2018
Journal: Invest Ophthalmol Vis Sci
Title: Bioinformatics Analysis of Weighted Genes in Diabetic Retinopathy.
Volume: 59
Issue: 13
Pages: 5558-5563
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Publication
28324005 | J:246874
First Author: Ghosh A
Year: 2017
Journal: Endocrinology
Title: Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice.
Volume: 158
Issue: 4
Pages: 903-919
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Publication
23825921 | J:200768
 
First Author: Howell SJ
Year: 2013
Journal: Mol Vis
Title: Degeneration of retinal ganglion cells in diabetic dogs and mice: relationship to glycemic control and retinal capillary degeneration.
Volume: 19
Pages: 1413-21
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Publication
24247978 | J:217958
First Author: Chen H
Year: 2014
Journal: J Physiol
Title: Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse.
Volume: 592
Issue: 3
Pages: 505-21
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Publication
12630555 | J:107880
First Author: Haseyama T
Year: 2002
Journal: Tohoku J Exp Med
Title: Complications of IgA nephropathy in a non-insulin-dependent diabetes model, the Akita mouse.
Volume: 198
Issue: 4
Pages: 233-44
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Publication
16954344 | J:118086
First Author: Nasrallah R
Year: 2007
Journal: Am J Physiol Renal Physiol
Title: Renal prostaglandin E2 receptor (EP) expression profile is altered in streptozotocin and B6-Ins2Akita type I diabetic mice.
Volume: 292
Issue: 1
Pages: F278-84
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Publication
26203118 | J:290893
First Author: You YH
Year: 2016
Journal: J Am Soc Nephrol
Title: Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease.
Volume: 27
Issue: 2
Pages: 466-81
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Publication
18469181 | J:141696
First Author: Smith SB
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine.
Volume: 49
Issue: 9
Pages: 4154-61
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Publication
34680110 | J:312502
 
First Author: Juin SK
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