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Search results 1 to 100 out of 560 for Irf6

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Hits by Category

Hits by Strain

Type Details Score
Gene
3664 | IRF6
Type: gene
Organism: human
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Gene
594908 | irf6
Type: gene
Organism: frog, western clawed
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Gene
364081 | Irf6
Type: gene
Organism: rat
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Gene
480015 | IRF6
Type: gene
Organism: dog, domestic
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Gene
457701 | IRF6
Type: gene
Organism: chimpanzee
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Gene
614253 | IRF6
Type: gene
Organism: cattle
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Gene
419863 | IRF6
Type: gene
Organism: chicken
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Gene
393570 | irf6
Type: gene
Organism: zebrafish
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Gene
712958 | IRF6
Type: gene
Organism: macaque, rhesus
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Protein
Q9QZL7
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: true
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Protein Coding Gene
MGI:1859211 | Irf6
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
     
Probe: MGI:6781801
Assay Type: RT-PCR
Annotation Date: 2021-10-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752525
Stage: TS25
Assay Id: MGI:6781881
Age: embryonic day 17.5
Specimen Label: Irf6 WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6781801
Assay Type: RT-PCR
Annotation Date: 2021-10-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752525
Stage: TS25
Assay Id: MGI:6781881
Age: embryonic day 17.5
Specimen Label: Irf6 mutant
Detected: true
Specimen Num: 2
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Publication
28643456 | J:244349
First Author: Kousa YA
Year: 2017
Journal: Dev Dyn
Title: IRF6 expression in basal epithelium partially rescues Irf6 knockout mice.
Volume: 246
Issue: 9
Pages: 670-681
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Publication
29913133 | J:309667
First Author: Kousa YA
Year: 2018
Journal: J Invest Dermatol
Title: IRF6 and AP2A Interaction Regulates Epidermal Development.
Volume: 138
Issue: 12
Pages: 2578-2588
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Publication
22366192 | J:184926
First Author: Blackburn J
Year: 2012
Journal: Dev Biol
Title: The role of Irf6 in tooth epithelial invagination.
Volume: 365
Issue: 1
Pages: 61-70
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Publication
27927890 | J:289168
First Author: Tamasas B
Year: 2017
Journal: J Dent Res
Title: Massively Increased Caries Susceptibility in an Irf6 Cleft Lip/Palate Model.
Volume: 96
Issue: 3
Pages: 315-322
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Publication
17041603 | J:116077
First Author: Richardson RJ
Year: 2006
Journal: Nat Genet
Title: Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch.
Volume: 38
Issue: 11
Pages: 1329-34
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Publication
28732181 | J:255609
First Author: Kousa YA
Year: 2017
Journal: J Dent Res
Title: IRF6 and SPRY4 Signaling Interact in Periderm Development.
Volume: 96
Issue: 11
Pages: 1306-1313
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Publication
28769044 | J:267941
First Author: Fakhouri WD
Year: 2017
Journal: Sci Rep
Title: Intercellular Genetic Interaction Between Irf6 and Twist1 during Craniofacial Development.
Volume: 7
Issue: 1
Pages: 7129
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Publication
38809584 | J:358823
First Author: Antiguas A
Year: 2024
Journal: Mol Biol Cell
Title: A novel noncanonical function for IRF6 in the recycling of E-cadherin.
Volume: 35
Issue: 7
Pages: ar102
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Publication
- | J:94918
     
First Author: Schutte B
Year: 2005
Journal: MGI Direct Data Submission
Title: Mice that lack Irf6 exhibit skin, limb and craniofacial abnormalities
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Publication
28526834 | J:273515
First Author: Huang R
Year: 2017
Journal: Sci Rep
Title: The Transcription Factor IRF6 Co-Represses PPARγ-Mediated Cytoprotection in Ischemic Cerebrovascular Endothelial Cells.
Volume: 7
Issue: 1
Pages: 2150
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Publication
28645193 | J:246329
First Author: Li C
Year: 2017
Journal: Endocrinology
Title: IRF6 Regulates Alternative Activation by Suppressing PPARγ in Male Murine Macrophages.
Volume: 158
Issue: 9
Pages: 2837-2847
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Publication
24442519 | J:209153
First Author: Fakhouri WD
Year: 2014
Journal: Hum Mol Genet
Title: An etiologic regulatory mutation in IRF6 with loss- and gain-of-function effects.
Volume: 23
Issue: 10
Pages: 2711-20
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Publication
18836445 | J:181021
First Author: Rahimov F
Year: 2008
Journal: Nat Genet
Title: Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip.
Volume: 40
Issue: 11
Pages: 1341-7
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Publication
23451037 | J:199408
First Author: Goudy S
Year: 2013
Journal: PLoS One
Title: Cell-autonomous and non-cell-autonomous roles for IRF6 during development of the tongue.
Volume: 8
Issue: 2
Pages: e56270
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Publication
22113860 | J:333537
First Author: Fakhouri WD
Year: 2012
Journal: Dev Dyn
Title: MCS9.7 enhancer activity is highly, but not completely, associated with expression of Irf6 and p63.
Volume: 241
Issue: 2
Pages: 340-9
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Publication
27369589 | J:275989
First Author: Chu EY
Year: 2016
Journal: J Dent Res
Title: Full Spectrum of Postnatal Tooth Phenotypes in a Novel Irf6 Cleft Lip Model.
Volume: 95
Issue: 11
Pages: 1265-73
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Publication
26240017 | J:250738
 
First Author: Ke CY
Year: 2015
Journal: Sci Rep
Title: IRF6 is the mediator of TGFβ3 during regulation of the epithelial mesenchymal transition and palatal fusion.
Volume: 5
Pages: 12791
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Publication
31387937 | J:282087
 
First Author: Ke CY
Year: 2019
Journal: Sci Signal
Title: IRF6 and TAK1 coordinately promote the activation of HIPK2 to stimulate apoptosis during palate fusion.
Volume: 12
Issue: 593
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Publication
23029012 | J:192000
First Author: Letra A
Year: 2012
Journal: PLoS One
Title: Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.
Volume: 7
Issue: 9
Pages: e45441
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Publication
21909072 | J:180027
First Author: Restivo G
Year: 2011
Journal: EMBO J
Title: IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes.
Volume: 30
Issue: 22
Pages: 4571-85
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Publication
23406900 | J:194043
First Author: Iwata J
Year: 2013
Journal: Development
Title: Smad4-Irf6 genetic interaction and TGFβ-mediated IRF6 signaling cascade are crucial for palatal fusion in mice.
Volume: 140
Issue: 6
Pages: 1220-30
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Publication
20424327 | J:161459
First Author: Thomason HA
Year: 2010
Journal: J Clin Invest
Title: Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice.
Volume: 120
Issue: 5
Pages: 1561-9
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Publication
19439425 | J:150009
First Author: Richardson RJ
Year: 2009
Journal: Hum Mol Genet
Title: Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence.
Volume: 18
Issue: 14
Pages: 2632-42
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Publication
20424325 | J:161645
First Author: Moretti F
Year: 2010
Journal: J Clin Invest
Title: A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias.
Volume: 120
Issue: 5
Pages: 1570-7
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GXD Expression
GXD Expression
     
Probe: MGI:6781811
Assay Type: RT-PCR
Annotation Date: 2021-10-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752525
Stage: TS25
Assay Id: MGI:6781885
Age: embryonic day 17.5
Specimen Label: Irf6 WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6781811
Assay Type: RT-PCR
Annotation Date: 2021-10-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752525
Stage: TS25
Assay Id: MGI:6781885
Age: embryonic day 17.5
Specimen Label: Irf6 mutant
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6781812
Assay Type: RT-PCR
Annotation Date: 2021-10-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752525
Stage: TS25
Assay Id: MGI:6781884
Age: embryonic day 17.5
Specimen Label: Irf6 WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6781812
Assay Type: RT-PCR
Annotation Date: 2021-10-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752525
Stage: TS25
Assay Id: MGI:6781884
Age: embryonic day 17.5
Specimen Label: Irf6 mutant
Detected: true
Specimen Num: 2
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Publication
19036739 | J:153386
First Author: Little HJ
Year: 2009
Journal: Hum Mol Genet
Title: Missense mutations that cause Van der Woude syndrome and popliteal pterygium syndrome affect the DNA-binding and transcriptional activation functions of IRF6.
Volume: 18
Issue: 3
Pages: 535-45
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Publication
28481036 | J:242906
 
First Author: Smith AL
Year: 2017
Journal: Genesis
Title: Generation and characterization of a conditional allele of Interferon Regulatory Factor 6.
Volume: 55
Issue: 7
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Publication
22931925 | J:358654
First Author: de la Garza G
Year: 2013
Journal: J Invest Dermatol
Title: Interferon regulatory factor 6 promotes differentiation of the periderm by activating expression of Grainyhead-like 3.
Volume: 133
Issue: 1
Pages: 68-77
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Publication
24357509 | J:225262
First Author: Aerts A
Year: 2014
Journal: Am J Med Genet A
Title: Haploinsufficiency of interferon regulatory factor 6 alters brain morphology in the mouse.
Volume: 164A
Issue: 3
Pages: 655-60
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Publication
24777480 | J:214669
First Author: Biggs LC
Year: 2014
Journal: J Cell Sci
Title: Interferon regulatory factor 6 regulates keratinocyte migration.
Volume: 127
Issue: Pt 13
Pages: 2840-8
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Publication
20196077 | J:160190
First Author: Stottmann RW
Year: 2010
Journal: Genesis
Title: Identification of a Van der Woude syndrome mutation in the cleft palate 1 mutant mouse.
Volume: 48
Issue: 5
Pages: 303-8
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Publication
21918538 | J:180634
First Author: Biggs LC
Year: 2012
Journal: J Invest Dermatol
Title: Interferon regulatory factor 6 is necessary, but not sufficient, for keratinocyte differentiation.
Volume: 132
Issue: 1
Pages: 50-8
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Publication
38604478 | J:354752
First Author: Wright AP
Year: 2024
Journal: Mucosal Immunol
Title: Interferon regulatory factor 6 (IRF6) determines intestinal epithelial cell development and immunity.
Volume: 17
Issue: 4
Pages: 633-650
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Publication
18212048 | J:153307
First Author: Bailey CM
Year: 2008
Journal: Mol Cell Biol
Title: Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner.
Volume: 28
Issue: 7
Pages: 2235-43
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Publication
31724286 | J:286595
First Author: Rhea L
Year: 2020
Journal: Dev Dyn
Title: Interferon regulatory factor 6 is required for proper wound healing in vivo.
Volume: 249
Issue: 4
Pages: 509-522
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Publication
27035130 | J:249150
First Author: Joly S
Year: 2016
Journal: PLoS One
Title: Interferon Regulatory Factor 6 Has a Protective Role in the Host Response to Endotoxic Shock.
Volume: 11
Issue: 4
Pages: e0152385
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Publication
23008150 | J:202648
First Author: Leslie EJ
Year: 2012
Journal: Birth Defects Res A Clin Mol Teratol
Title: Expression and mutation analyses implicate ARHGAP29 as the etiologic gene for the cleft lip with or without cleft palate locus identified by genome-wide association on chromosome 1p22.
Volume: 94
Issue: 11
Pages: 934-42
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Publication
16245336 | J:108225
First Author: Knight AS
Year: 2006
Journal: Dev Dyn
Title: Developmental expression analysis of the mouse and chick orthologues of IRF6: the gene mutated in Van der Woude syndrome.
Volume: 235
Issue: 5
Pages: 1441-7
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Publication
17041601 | J:115343
First Author: Ingraham CR
Year: 2006
Journal: Nat Genet
Title: Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6).
Volume: 38
Issue: 11
Pages: 1335-40
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Publication
33234718 | J:301551
 
First Author: Carroll SH
Year: 2020
Journal: Development
Title: An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates.
Volume: 147
Issue: 24
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Publication
21982646 | J:178316
First Author: Ferretti E
Year: 2011
Journal: Dev Cell
Title: A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis.
Volume: 21
Issue: 4
Pages: 627-41
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Publication
24360809 | J:226218
First Author: Peyrard-Janvid M
Year: 2014
Journal: Am J Hum Genet
Title: Dominant mutations in GRHL3 cause Van der Woude Syndrome and disrupt oral periderm development.
Volume: 94
Issue: 1
Pages: 23-32
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Publication
30689861 | J:277917
First Author: Kousa YA
Year: 2019
Journal: Hum Mol Genet
Title: The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation.
Volume: 28
Issue: 10
Pages: 1726-1737
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Publication
31943082 | J:286649
First Author: Hall EG
Year: 2020
Journal: Hum Mol Genet
Title: SPECC1L regulates palate development downstream of IRF6.
Volume: 29
Issue: 5
Pages: 845-858
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Publication
16780827 | J:112634
First Author: Xu X
Year: 2006
Journal: Dev Biol
Title: Cell autonomous requirement for Tgfbr2 in the disappearance of medial edge epithelium during palatal fusion.
Volume: 297
Issue: 1
Pages: 238-48
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Publication
25387952 | J:321073
First Author: Mollo MR
Year: 2015
Journal: Exp Dermatol
Title: p63-dependent and independent mechanisms of nectin-1 and nectin-4 regulation in the epidermis.
Volume: 24
Issue: 2
Pages: 114-9
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Publication
30684382 | J:273627
First Author: Thompson J
Year: 2019
Journal: Dev Dyn
Title: A cleft lip and palate gene, Irf6, is involved in osteoblast differentiation of craniofacial bone.
Volume: 248
Issue: 3
Pages: 221-232
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Publication
21574244 | J:174238
First Author: Rorick NK
Year: 2011
Journal: Am J Med Genet A
Title: Genomic strategy identifies a missense mutation in WD-repeat domain 65 (WDR65) in an individual with Van der Woude syndrome.
Volume: 155A
Issue: 6
Pages: 1314-21
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Publication
31578523 | J:283325
First Author: Oberbeck N
Year: 2019
Journal: Nature
Title: The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function.
Volume: 574
Issue: 7777
Pages: 249-253
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Publication
27302476 | J:234343
First Author: Kawasaki M
Year: 2016
Journal: Dev Dyn
Title: Regional regulation of Filiform tongue papillae development by Ikkα/Irf6.
Volume: 245
Issue: 9
Pages: 937-46
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Protein Coding Gene
MGP_CAROLIEiJ_G0015065 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016958 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016937 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016902 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016895 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016719 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1859211 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017358 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016302 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016693 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016799 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016795 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016874 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016827 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017395 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016089 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016364 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028297 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015865 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:3815817
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Absent
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3816621
Age: postnatal
Specimen Label: Metaphase II
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3815817
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3816621
Age: embryonic day 1.5
Specimen Label: 2-cell embryo
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3815817
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:3816621
Age: embryonic day 2.0
Specimen Label: 4-cell embryo
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3815817
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:3816621
Age: embryonic day 2.5
Specimen Label: 8-cell embryo
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3815817
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:3816621
Age: embryonic day 3.0
Specimen Label: Morula
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:3815817
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:3816621
Age: embryonic day 3.5
Specimen Label: E3.5 blastocyst
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:3815817
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360465
Stage: TS05
Assay Id: MGI:3816621
Age: embryonic day 4.5
Specimen Label: E4.5 blastocyst
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:3815817
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160415
Stage: TS05
Assay Id: MGI:3816621
Age: embryonic day 4.5
Specimen Label: E4.5 inner cell mass
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:6198289
Assay Type: Western blot
Annotation Date: 2018-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752525
Stage: TS25
Assay Id: MGI:6198290
Age: embryonic day 17.5
Image: 2
Specimen Label: e17.5 skin
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6470013
Assay Type: RT-PCR
Annotation Date: 2020-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3639225
Stage: TS25
Assay Id: MGI:6470022
Age: embryonic day 17.5
Specimen Label: hyp/-
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6470013
Assay Type: RT-PCR
Annotation Date: 2020-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3639225
Stage: TS25
Assay Id: MGI:6470022
Age: embryonic day 17.5
Specimen Label: hyp/+
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6470013
Assay Type: RT-PCR
Annotation Date: 2020-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3639225
Stage: TS25
Assay Id: MGI:6470022
Age: embryonic day 17.5
Specimen Label: +/+
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6470013
Assay Type: RT-PCR
Annotation Date: 2020-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674825
Stage: TS25
Assay Id: MGI:6470037
Age: embryonic day 17.5
Specimen Label: WT
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6470013
Assay Type: RT-PCR
Annotation Date: 2020-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674825
Stage: TS25
Assay Id: MGI:6470037
Age: embryonic day 17.5
Specimen Label: Irf6neo/
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6781801
Assay Type: RT-PCR
Annotation Date: 2021-10-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:6781886
Age: embryonic day 7.0
Specimen Label: 7 dpc
Detected: true
Specimen Num: 2
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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