| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
There are two mammalian homologue of Drosophila tumor suppressor Lats (large tumor suppressor, also known as Warts): LATS1 and LATS2. Lats/Warts is a serine/threonine-protein kinase that negatively regulates YAP1 (Drosophila Yorkie (Yki) homologue) in the Hippo signaling pathway, which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis [, ]. This entry represents LATS1 from mammals. During cell division, LATS1 interacts with MOB1A and serves as a mitotic exit network kinase []. |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7408355 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2022-12-16 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689417 |
| Pattern: |
Punctate |
| Stage: |
TS17 |
| Assay Id: |
MGI:7408371 |
| Age: |
embryonic day 10.5 |
| Image: |
S1A Lats1 |
| Note: |
Expression in cranial neuroepithelium, more enriched than for Lats2. |
| Specimen Label: |
S1A Lats1 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hao Y |
| Year: |
2008 |
| Journal: |
J Biol Chem |
| Title: |
Tumor suppressor LATS1 is a negative regulator of oncogene YAP. |
| Volume: |
283 |
| Issue: |
9 |
| Pages: |
5496-509 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bothos J |
| Year: |
2005 |
| Journal: |
Cancer Res |
| Title: |
Human LATS1 is a mitotic exit network kinase. |
| Volume: |
65 |
| Issue: |
15 |
| Pages: |
6568-75 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1129
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
St John MA |
| Year: |
1999 |
| Journal: |
Nat Genet |
| Title: |
Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. |
| Volume: |
21 |
| Issue: |
2 |
| Pages: |
182-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huang J |
| Year: |
2005 |
| Journal: |
Cell |
| Title: |
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. |
| Volume: |
122 |
| Issue: |
3 |
| Pages: |
421-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang F |
| Year: |
2019 |
| Journal: |
Nat Commun |
| Title: |
LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
5755 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun T |
| Year: |
2015 |
| Journal: |
Biol Reprod |
| Title: |
Lats1 Deletion Causes Increased Germ Cell Apoptosis and Follicular Cysts in Mouse Ovaries. |
| Volume: |
93 |
| Issue: |
1 |
| Pages: |
22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yabuta N |
| Year: |
2013 |
| Journal: |
J Cell Sci |
| Title: |
N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instability. |
| Volume: |
126 |
| Issue: |
Pt 2 |
| Pages: |
508-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mohad V |
| Year: |
2021 |
| Journal: |
Dev Biol |
| Title: |
Inactivation of Lats1 and Lats2 highlights the role of hippo pathway effector YAP in larynx and vocal fold epithelium morphogenesis. |
| Volume: |
473 |
|
| Pages: |
33-49 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nezhad FY |
| Year: |
2022 |
| Journal: |
Transgenic Res |
| Title: |
Skeletal muscle phenotyping of Hippo gene-mutated mice reveals that Lats1 deletion increases the percentage of type I muscle fibers. |
| Volume: |
31 |
| Issue: |
2 |
| Pages: |
227-237 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Abou Nader N |
| Year: |
2024 |
| Journal: |
FASEB J |
| Title: |
Lats1 and Lats2 regulate YAP and TAZ activity to control the development of mouse Sertoli cells. |
| Volume: |
38 |
| Issue: |
9 |
| Pages: |
e23633 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Abou Nader N |
| Year: |
2022 |
| Journal: |
Int J Mol Sci |
| Title: |
Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate. |
| Volume: |
23 |
| Issue: |
21 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ménard A |
| Year: |
2020 |
| Journal: |
Endocrinology |
| Title: |
Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal Cortex Development and Alters Adrenocortical Cell Fate. |
| Volume: |
161 |
| Issue: |
5 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tsoi M |
| Year: |
2019 |
| Journal: |
FASEB J |
| Title: |
Lats1 and Lats2 are required for ovarian granulosa cell fate maintenance. |
| Volume: |
33 |
| Issue: |
10 |
| Pages: |
10819-10832 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
St-Jean G |
| Year: |
2019 |
| Journal: |
Development |
| Title: |
Lats1 and Lats2 are required for the maintenance of multipotency in the Müllerian duct mesenchyme. |
| Volume: |
146 |
| Issue: |
20 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Varelas X |
| Year: |
2010 |
| Journal: |
Dev Cell |
| Title: |
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. |
| Volume: |
19 |
| Issue: |
6 |
| Pages: |
831-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gan W |
| Year: |
2020 |
| Journal: |
Nat Cell Biol |
| Title: |
LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. |
| Volume: |
22 |
| Issue: |
2 |
| Pages: |
246-256 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chiyoda T |
| Year: |
2012 |
| Journal: |
J Cell Biol |
| Title: |
LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression. |
| Volume: |
197 |
| Issue: |
5 |
| Pages: |
625-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McPherson JP |
| Year: |
2004 |
| Journal: |
EMBO J |
| Title: |
Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. |
| Volume: |
23 |
| Issue: |
18 |
| Pages: |
3677-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pefani DE |
| Year: |
2014 |
| Journal: |
Nat Cell Biol |
| Title: |
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2. |
| Volume: |
16 |
| Issue: |
10 |
| Pages: |
962-71, 1-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rueda EM |
| Year: |
2019 |
| Journal: |
Cell Rep |
| Title: |
The Hippo Pathway Blocks Mammalian Retinal Müller Glial Cell Reprogramming. |
| Volume: |
27 |
| Issue: |
6 |
| Pages: |
1637-1649.e6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Choi S |
| Year: |
2024 |
| Journal: |
Nat Metab |
| Title: |
Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass. |
| Volume: |
6 |
| Issue: |
5 |
| Pages: |
847-860 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kern JG |
| Year: |
2022 |
| Journal: |
Nat Commun |
| Title: |
Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
7198 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eder N |
| Year: |
2020 |
| Journal: |
Nat Commun |
| Title: |
YAP1/TAZ drives ependymoma-like tumour formation in mice. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
2380 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xiao Y |
| Year: |
2018 |
| Journal: |
Dev Cell |
| Title: |
Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development. |
| Volume: |
45 |
| Issue: |
2 |
| Pages: |
153-169.e6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Szymaniak AD |
| Year: |
2017 |
| Journal: |
Elife |
| Title: |
The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland. |
| Volume: |
6 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park J |
| Year: |
2020 |
| Journal: |
Mol Cells |
| Title: |
WWC1 and NF2 Prevent the Development of Intrahepatic Cholangiocarcinoma by Regulating YAP/TAZ Activity through LATS in Mice. |
| Volume: |
43 |
| Issue: |
5 |
| Pages: |
491-499 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee DH |
| Year: |
2016 |
| Journal: |
Nat Commun |
| Title: |
LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development. |
| Volume: |
7 |
|
| Pages: |
11961 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nishiyama T |
| Year: |
2021 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Deficiency of large tumor suppressor kinase 1 causes congenital hearing loss associated with cochlear abnormalities in mice. |
| Volume: |
534 |
|
| Pages: |
921-926 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park J |
| Year: |
2020 |
| Journal: |
Cancer Res |
| Title: |
YAP and AP-1 Cooperate to Initiate Pancreatic Cancer Development from Ductal Cells in Mice. |
| Volume: |
80 |
| Issue: |
21 |
| Pages: |
4768-4779 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xiao Y |
| Year: |
2019 |
| Journal: |
Genes Dev |
| Title: |
Hippo pathway deletion in adult resting cardiac fibroblasts initiates a cell state transition with spontaneous and self-sustaining fibrosis. |
| Volume: |
33 |
| Issue: |
21-22 |
| Pages: |
1491-1505 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mei L |
| Year: |
2021 |
| Journal: |
Oncogene |
| Title: |
SUMOylation activates large tumour suppressor 1 to maintain the tissue homeostasis during Hippo signalling. |
| Volume: |
40 |
| Issue: |
35 |
| Pages: |
5357-5366 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MartÃnez Traverso IM |
| Year: |
2022 |
| Journal: |
Development |
| Title: |
LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation. |
| Volume: |
149 |
| Issue: |
18 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
McNeill H |
| Year: |
2017 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Lats1/2 Regulate Yap/Taz to Control Nephron Progenitor Epithelialization and Inhibit Myofibroblast Formation. |
| Volume: |
28 |
| Issue: |
3 |
| Pages: |
852-861 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun Z |
| Year: |
2018 |
| Journal: |
PLoS Genet |
| Title: |
FoxO6 regulates Hippo signaling and growth of the craniofacial complex. |
| Volume: |
14 |
| Issue: |
10 |
| Pages: |
e1007675 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Du X |
| Year: |
2018 |
| Journal: |
Nature |
| Title: |
Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells. |
| Volume: |
558 |
| Issue: |
7708 |
| Pages: |
141-145 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nantie LB |
| Year: |
2018 |
| Journal: |
Development |
| Title: |
Lats1/2 inactivation reveals Hippo function in alveolar type I cell differentiation during lung transition to air breathing. |
| Volume: |
145 |
| Issue: |
21 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yi J |
| Year: |
2016 |
| Journal: |
Hepatology |
| Title: |
Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. |
| Volume: |
64 |
| Issue: |
5 |
| Pages: |
1757-1772 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Turenchalk GS |
| Year: |
1999 |
| Journal: |
Biochim Biophys Acta |
| Title: |
The role of lats in cell cycle regulation and tumorigenesis. |
| Volume: |
1424 |
| Issue: |
2-3 |
| Pages: |
M9-M16 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5763420 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2016-04-28 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:360411 |
|
| Stage: |
TS01 |
| Assay Id: |
MGI:5763600 |
| Age: |
embryonic day 0.5 |
|
|
| Specimen Label: |
1-cell |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5763420 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2016-04-28 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:360422 |
|
| Stage: |
TS02 |
| Assay Id: |
MGI:5763600 |
| Age: |
embryonic day 1.0 |
|
|
| Specimen Label: |
2-cell |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5763420 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2016-04-28 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:360443 |
|
| Stage: |
TS03 |
| Assay Id: |
MGI:5763600 |
| Age: |
embryonic day 2.5 |
|
|
| Specimen Label: |
8c |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5763420 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2016-04-28 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:360453 |
|
| Stage: |
TS03 |
| Assay Id: |
MGI:5763600 |
| Age: |
embryonic day 3.0 |
|
|
| Specimen Label: |
morula |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5763420 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2016-04-28 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:360464 |
|
| Stage: |
TS04 |
| Assay Id: |
MGI:5763600 |
| Age: |
embryonic day 3.5 |
|
|
| Specimen Label: |
blastocyst |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5763420 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2016-04-28 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603915 |
|
| Stage: |
TS15 |
| Assay Id: |
MGI:5763600 |
| Age: |
embryonic day 9.5 |
|
|
| Specimen Label: |
E9.5 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7408367 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2022-12-16 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689417 |
|
| Stage: |
TS17 |
| Assay Id: |
MGI:7408397 |
| Age: |
embryonic day 10.5 |
| Image: |
S3 |
|
| Specimen Label: |
Control |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7408367 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2022-12-16 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689417 |
|
| Stage: |
TS17 |
| Assay Id: |
MGI:7408397 |
| Age: |
embryonic day 10.5 |
| Image: |
S3 |
|
| Specimen Label: |
DCKO |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7466189 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-04-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672827 |
|
| Stage: |
TS27 |
| Assay Id: |
MGI:7466418 |
| Age: |
postnatal day 2 |
| Image: |
3 |
|
| Specimen Label: |
Control |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7466189 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-04-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672827 |
|
| Stage: |
TS27 |
| Assay Id: |
MGI:7466418 |
| Age: |
postnatal day 2 |
| Image: |
3 |
|
| Specimen Label: |
cKO |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7466193 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-04-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672827 |
|
| Stage: |
TS27 |
| Assay Id: |
MGI:7466421 |
| Age: |
postnatal day 2 |
| Image: |
3 |
|
| Specimen Label: |
Control |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7466193 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-04-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672827 |
|
| Stage: |
TS27 |
| Assay Id: |
MGI:7466421 |
| Age: |
postnatal day 2 |
| Image: |
3 |
|
| Specimen Label: |
cKO |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7466189 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-04-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672824 |
|
| Stage: |
TS24 |
| Assay Id: |
MGI:7466425 |
| Age: |
embryonic day 16.5 |
| Image: |
3 |
|
| Specimen Label: |
Control |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7466189 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-04-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672824 |
|
| Stage: |
TS24 |
| Assay Id: |
MGI:7466425 |
| Age: |
embryonic day 16.5 |
| Image: |
3 |
|
| Specimen Label: |
cKO |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7466193 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-04-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672824 |
|
| Stage: |
TS24 |
| Assay Id: |
MGI:7466428 |
| Age: |
embryonic day 16.5 |
| Image: |
3 |
|
| Specimen Label: |
Control |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7466193 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-04-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672824 |
|
| Stage: |
TS24 |
| Assay Id: |
MGI:7466428 |
| Age: |
embryonic day 16.5 |
| Image: |
3 |
|
| Specimen Label: |
cKO |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7466189 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-04-27 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7466798 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
Control |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7466189 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-04-27 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7466798 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
cKO |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7466193 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-04-27 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7466800 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
Control |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7466193 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-04-27 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7466800 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
cKO |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7666546 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2024-07-22 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1608515 |
|
| Stage: |
TS15 |
| Assay Id: |
MGI:7666573 |
| Age: |
embryonic day 9.5 |
| Image: |
S6 |
|
| Specimen Label: |
+/+ |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7666546 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2024-07-22 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1608515 |
|
| Stage: |
TS15 |
| Assay Id: |
MGI:7666573 |
| Age: |
embryonic day 9.5 |
| Image: |
S6 |
|
| Specimen Label: |
gt/gt |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3505905 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2004-12-06 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1698217 |
| Pattern: |
Not Specified |
| Stage: |
TS17 |
| Assay Id: |
MGI:3510334 |
| Age: |
embryonic day 10.5 |
| Image: |
3B |
| Note: |
Neuroblast/VIII ganglion. |
| Specimen Label: |
3B |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4425739 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-09-12 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3271122 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:7525219 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
Supplementary table 2 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3505905 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2004-12-06 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1666917 |
| Pattern: |
Regionally restricted |
| Stage: |
TS17 |
| Assay Id: |
MGI:3510334 |
| Age: |
embryonic day 10.5 |
| Image: |
3B |
| Note: |
Otic vesicle; ventral and/or anteroventral restricted expression. |
| Specimen Label: |
3B |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4425739 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-09-12 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754722 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:7525219 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
Supplementary table 2 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3505905 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2004-12-06 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1699417 |
| Pattern: |
Not Specified |
| Stage: |
TS17 |
| Assay Id: |
MGI:3510334 |
| Age: |
embryonic day 10.5 |
| Image: |
3B |
| Note: |
Endolymphatic duct. |
| Specimen Label: |
3B |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou R |
| Year: |
2021 |
| Journal: |
PLoS Biol |
| Title: |
The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration. |
| Volume: |
19 |
| Issue: |
2 |
| Pages: |
e3001122 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carter P |
| Year: |
2021 |
| Journal: |
J Clin Invest |
| Title: |
Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma. |
| Volume: |
131 |
| Issue: |
11 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu LMN |
| Year: |
2022 |
| Journal: |
Sci Adv |
| Title: |
Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy. |
| Volume: |
8 |
| Issue: |
44 |
| Pages: |
eabo5442 |
|
•
•
•
•
•
|