Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Maf transcription factors form a distinct family of the basic leucine zipper (bZip) transcription factors. The Maf family is divided into two subclasses, large Mafs (c-maf, mafB, and mafA/L-maf, nrl) and small Mafs (MafF, MafK and MafG). Both subclasses contain leucine-zipper motifs, which allow homodimerisation as well as heterodimerisation with a variety of other bZip proteins. In contrast to the small Mafs, the large Maf proteins contain a transactivator domain in their amino terminus.MafB plays critical roles in a variety of cellular differentiation processes, including in kidney podocytes [], macrophages [, ], and pancreatic islet alpha and beta-cells, which are responsible for the production of the hormones glucagon and insulin respectively. MafB is also expressed in alpha-cells in adult pancreas and is important for their function [, , , ].Mutations in Maf gene cause multicentric carpotarsal osteolysis syndrome (MCTO), which is a rare skeletal disorder, usually presenting in early childhood with a clinical picture mimicking juvenile rheumatoid arthritis []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Artner I |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
MafB is required for islet beta cell maturation. |
Volume: |
104 |
Issue: |
10 |
Pages: |
3853-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aziz A |
Year: |
2006 |
Journal: |
Mol Cell Biol |
Title: |
Development of macrophages with altered actin organization in the absence of MafB. |
Volume: |
26 |
Issue: |
18 |
Pages: |
6808-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Artner I |
Year: |
2006 |
Journal: |
Diabetes |
Title: |
MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells. |
Volume: |
55 |
Issue: |
2 |
Pages: |
297-304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sarrazin S |
Year: |
2009 |
Journal: |
Cell |
Title: |
MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells. |
Volume: |
138 |
Issue: |
2 |
Pages: |
300-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Artner I |
Year: |
2010 |
Journal: |
Diabetes |
Title: |
MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. |
Volume: |
59 |
Issue: |
10 |
Pages: |
2530-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sadl V |
Year: |
2002 |
Journal: |
Dev Biol |
Title: |
The mouse Kreisler (Krml1/MafB) segmentation gene is required for differentiation of glomerular visceral epithelial cells. |
Volume: |
249 |
Issue: |
1 |
Pages: |
16-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hang Y |
Year: |
2011 |
Journal: |
Trends Endocrinol Metab |
Title: |
MafA and MafB activity in pancreatic β cells. |
Volume: |
22 |
Issue: |
9 |
Pages: |
364-73 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
168
 |
Fragment?: |
true |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6449791 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-08-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750321 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:6449814 |
Age: |
embryonic day 13.5 |
Image: |
S1 E13.5 MafB |
Note: |
Expression overlaps with that of Myt1. |
Specimen Label: |
S1 E13.5 MafB |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6449791 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-08-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3292723 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:6449814 |
Age: |
embryonic day 15.5 |
Image: |
S1 E15.5 MafB |
Note: |
Expression overlaps with that of Myt1. |
Specimen Label: |
S1 E15.5 MafB |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
323
 |
Fragment?: |
false |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5789283 |
Assay Type: |
RT-PCR |
Annotation Date: |
2016-08-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716320 |
|
Stage: |
TS20 |
Assay Id: |
MGI:5789315 |
Age: |
embryonic day 12.5 |
|
|
Specimen Label: |
mafB |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zankl A |
Year: |
2012 |
Journal: |
Am J Hum Genet |
Title: |
Multicentric carpotarsal osteolysis is caused by mutations clustering in the amino-terminal transcriptional activation domain of MAFB. |
Volume: |
90 |
Issue: |
3 |
Pages: |
494-501 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang K |
Year: |
2000 |
Journal: |
Gene |
Title: |
Molecular cloning and functional characterization of the mouse mafB gene. |
Volume: |
242 |
Issue: |
1-2 |
Pages: |
419-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moriguchi T |
Year: |
2006 |
Journal: |
Mol Cell Biol |
Title: |
MafB is essential for renal development and F4/80 expression in macrophages. |
Volume: |
26 |
Issue: |
15 |
Pages: |
5715-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blanchi B |
Year: |
2003 |
Journal: |
Nat Neurosci |
Title: |
MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth. |
Volume: |
6 |
Issue: |
10 |
Pages: |
1091-100 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park JG |
Year: |
2016 |
Journal: |
Am J Hum Genet |
Title: |
Loss of MAFB Function in Humans and Mice Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects. |
Volume: |
98 |
Issue: |
6 |
Pages: |
1220-1227 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishimura W |
Year: |
2008 |
Journal: |
Dev Biol |
Title: |
Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. |
Volume: |
314 |
Issue: |
2 |
Pages: |
443-56 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
384
 |
Fragment?: |
true |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6449762 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-08-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750321 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:6449800 |
Age: |
embryonic day 13.5 |
Image: |
S1 E13.5 MafB |
Note: |
Expression overlaps with expression of Mafb. |
Specimen Label: |
S1 E13.5 MafB |
Detected: |
true |
Specimen Num: |
22 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6449762 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-08-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3292723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:6449800 |
Age: |
embryonic day 15.5 |
Image: |
S1 E15.5 MafB |
|
Specimen Label: |
S1 E15.5 MafB |
Detected: |
true |
Specimen Num: |
26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim K |
Year: |
2007 |
Journal: |
Blood |
Title: |
MafB negatively regulates RANKL-mediated osteoclast differentiation. |
Volume: |
109 |
Issue: |
8 |
Pages: |
3253-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hamada M |
Year: |
2014 |
Journal: |
Nat Commun |
Title: |
MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. |
Volume: |
5 |
|
Pages: |
3147 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyai M |
Year: |
2016 |
Journal: |
J Invest Dermatol |
Title: |
Transcription Factor MafB Coordinates Epidermal Keratinocyte Differentiation. |
Volume: |
136 |
Issue: |
9 |
Pages: |
1848-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tran MT |
Year: |
2016 |
Journal: |
FEBS Open Bio |
Title: |
MafB deficiency accelerates the development of obesity in mice. |
Volume: |
6 |
Issue: |
6 |
Pages: |
540-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tran MTN |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
MafB is a critical regulator of complement component C1q. |
Volume: |
8 |
Issue: |
1 |
Pages: |
1700 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hashimoto D |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
Radiation inducible MafB gene is required for thymic regeneration. |
Volume: |
11 |
Issue: |
1 |
Pages: |
10439 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dieterich LC |
Year: |
2020 |
Journal: |
Angiogenesis |
Title: |
Lymphatic MAFB regulates vascular patterning during developmental and pathological lymphangiogenesis. |
Volume: |
23 |
Issue: |
3 |
Pages: |
411-423 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang K |
Year: |
1999 |
Journal: |
Hokkaido Igaku Zasshi |
Title: |
Cloning and characterization of promoter of the mouse mafB gene. |
Volume: |
74 |
Issue: |
6 |
Pages: |
419-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koshida R |
Year: |
2017 |
Journal: |
Biochem Biophys Res Commun |
Title: |
MafB is required for development of the hindbrain choroid plexus. |
Volume: |
483 |
Issue: |
1 |
Pages: |
288-293 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kanai M |
Year: |
2020 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Phenotypic analysis of mice carrying human-type MAFB p.Leu239Pro mutation. |
Volume: |
523 |
Issue: |
2 |
Pages: |
452-457 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rondon-Galeano M |
Year: |
2020 |
Journal: |
Dev Dyn |
Title: |
MAFB modulates the maturation of lymphatic vascular networks in mice. |
Volume: |
249 |
Issue: |
10 |
Pages: |
1201-1216 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tanahashi H |
Year: |
2010 |
Journal: |
Arch Biochem Biophys |
Title: |
MafB protein stability is regulated by the JNK and ubiquitin-proteasome pathways. |
Volume: |
494 |
Issue: |
1 |
Pages: |
94-100 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yadav MK |
Year: |
2024 |
Journal: |
Cell Rep |
Title: |
MAFB in macrophages regulates cold-induced neuronal density in brown adipose tissue. |
Volume: |
43 |
Issue: |
4 |
Pages: |
113978 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vo T |
Year: |
2022 |
Journal: |
Front Immunol |
Title: |
Case report: Mafb promoter activity may define the alveolar macrophage dichotomy. |
Volume: |
13 |
|
Pages: |
1050494 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato-Nishiwaki M |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Reduced number and morphofunctional change of alveolar macrophages in MafB gene-targeted mice. |
Volume: |
8 |
Issue: |
9 |
Pages: |
e73963 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hasegawa H |
Year: |
2016 |
Journal: |
Atherosclerosis |
Title: |
The role of macrophage transcription factor MafB in atherosclerotic plaque stability. |
Volume: |
250 |
|
Pages: |
133-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsushita S |
Year: |
2016 |
Journal: |
Endocrinology |
Title: |
Androgen Regulates Mafb Expression Through its 3'UTR During Mouse Urethral Masculinization. |
Volume: |
157 |
Issue: |
2 |
Pages: |
844-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim H |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
The transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophages. |
Volume: |
7 |
Issue: |
1 |
Pages: |
7591 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cui H |
Year: |
2023 |
Journal: |
Commun Biol |
Title: |
MafB regulates NLRP3 inflammasome activation by sustaining p62 expression in macrophages. |
Volume: |
6 |
Issue: |
1 |
Pages: |
1047 |
|
•
•
•
•
•
|
Publication |
First Author: |
Banerjee RR |
Year: |
2016 |
Journal: |
Diabetes |
Title: |
Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells. |
Volume: |
65 |
Issue: |
8 |
Pages: |
2331-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh T |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Loss of MafA and MafB expression promotes islet inflammation. |
Volume: |
9 |
Issue: |
1 |
Pages: |
9074 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takeuchi T |
Year: |
2009 |
Journal: |
Genes Cells |
Title: |
Neither MafA/L-Maf nor MafB is essential for lens development in mice. |
Volume: |
14 |
Issue: |
8 |
Pages: |
941-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiafukaiti G |
Year: |
2019 |
Journal: |
Mol Cell Biol |
Title: |
MafB Is Important for Pancreatic β-Cell Maintenance under a MafA-Deficient Condition. |
Volume: |
39 |
Issue: |
17 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Pajcini KV |
Year: |
2017 |
Journal: |
Sci Signal |
Title: |
MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia. |
Volume: |
10 |
Issue: |
505 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Alcantara MC |
Year: |
2022 |
Journal: |
iScience |
Title: |
Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice. |
Volume: |
25 |
Issue: |
12 |
Pages: |
105609 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yadav MK |
Year: |
2020 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Transcription factor MafB is a marker of tumor-associated macrophages in both mouse and humans. |
Volume: |
521 |
Issue: |
3 |
Pages: |
590-595 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sturgeon K |
Year: |
2011 |
Journal: |
Development |
Title: |
Cdx1 refines positional identity of the vertebrate hindbrain by directly repressing Mafb expression. |
Volume: |
138 |
Issue: |
1 |
Pages: |
65-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu J |
Year: |
2012 |
Journal: |
Oncogene |
Title: |
Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse. |
Volume: |
31 |
Issue: |
31 |
Pages: |
3647-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishimura W |
Year: |
2006 |
Journal: |
Dev Biol |
Title: |
A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. |
Volume: |
293 |
Issue: |
2 |
Pages: |
526-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamasaki A |
Year: |
2024 |
Journal: |
Commun Biol |
Title: |
IRF8 and MAFB drive distinct transcriptional machineries in different resident macrophages of the central nervous system. |
Volume: |
7 |
Issue: |
1 |
Pages: |
896 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato Y |
Year: |
2018 |
Journal: |
Kidney Int |
Title: |
A mutation in transcription factor MAFB causes Focal Segmental Glomerulosclerosis with Duane Retraction Syndrome. |
Volume: |
94 |
Issue: |
2 |
Pages: |
396-407 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katoh MC |
Year: |
2018 |
Journal: |
Mol Cell Biol |
Title: |
MafB Is Critical for Glucagon Production and Secretion in Mouse Pancreatic α Cells In Vivo. |
Volume: |
38 |
Issue: |
8 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wu X |
Year: |
2016 |
Journal: |
J Exp Med |
Title: |
Mafb lineage tracing to distinguish macrophages from other immune lineages reveals dual identity of Langerhans cells. |
Volume: |
213 |
Issue: |
12 |
Pages: |
2553-2565 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tozaki-Saitoh H |
Year: |
2019 |
Journal: |
Glia |
Title: |
Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development. |
Volume: |
67 |
Issue: |
4 |
Pages: |
729-740 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dieterich LC |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
DeepCAGE Transcriptomics Reveal an Important Role of the Transcription Factor MAFB in the Lymphatic Endothelium. |
Volume: |
13 |
Issue: |
7 |
Pages: |
1493-1504 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vicente-Dueñas C |
Year: |
2012 |
Journal: |
EMBO J |
Title: |
A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors. |
Volume: |
31 |
Issue: |
18 |
Pages: |
3704-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pai EL |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function. |
Volume: |
26 |
Issue: |
5 |
Pages: |
1157-1173.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shichita T |
Year: |
2017 |
Journal: |
Nat Med |
Title: |
MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. |
Volume: |
23 |
Issue: |
6 |
Pages: |
723-732 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki K |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Sexually dimorphic expression of Mafb regulates masculinization of the embryonic urethral formation. |
Volume: |
111 |
Issue: |
46 |
Pages: |
16407-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim H |
Year: |
2010 |
Journal: |
Nat Immunol |
Title: |
The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3. |
Volume: |
11 |
Issue: |
8 |
Pages: |
743-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paul BJ |
Year: |
2021 |
Journal: |
Dev Dyn |
Title: |
The Mafb cleft-associated variant H131Q is not required for palatogenesis in the mouse. |
Volume: |
250 |
Issue: |
10 |
Pages: |
1463-1476 |
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Publication |
First Author: |
Beaty TH |
Year: |
2010 |
Journal: |
Nat Genet |
Title: |
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. |
Volume: |
42 |
Issue: |
6 |
Pages: |
525-9 |
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Publication |
First Author: |
Chang YH |
Year: |
2020 |
Journal: |
Exp Anim |
Title: |
Uncovering the role of MAFB in glucagon production and secretion in pancreatic α-cells using a new α-cell-specific Mafb conditional knockout mouse model. |
Volume: |
69 |
Issue: |
2 |
Pages: |
178-188 |
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Publication |
First Author: |
Shawki HH |
Year: |
2018 |
Journal: |
PLoS One |
Title: |
MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice. |
Volume: |
13 |
Issue: |
1 |
Pages: |
e0190800 |
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Publication |
First Author: |
Li SY |
Year: |
2021 |
Journal: |
Biol Reprod |
Title: |
Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis†. |
Volume: |
105 |
Issue: |
4 |
Pages: |
958-975 |
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Publication |
First Author: |
Deng Z |
Year: |
2020 |
Journal: |
Int J Mol Sci |
Title: |
An Inducible Diabetes Mellitus Murine Model Based on MafB Conditional Knockout under MafA-Deficient Condition. |
Volume: |
21 |
Issue: |
16 |
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Publication |
First Author: |
Sultana DA |
Year: |
2009 |
Journal: |
Blood |
Title: |
Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development. |
Volume: |
113 |
Issue: |
13 |
Pages: |
2976-87 |
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Publication |
First Author: |
Cordes SP |
Year: |
1994 |
Journal: |
Cell |
Title: |
The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor. |
Volume: |
79 |
Issue: |
6 |
Pages: |
1025-34 |
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Publication |
First Author: |
Conrad E |
Year: |
2016 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells. |
Volume: |
310 |
Issue: |
1 |
Pages: |
E91-E102 |
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Publication |
First Author: |
Saul SM |
Year: |
2008 |
Journal: |
Mol Cell Neurosci |
Title: |
Math5 expression and function in the central auditory system. |
Volume: |
37 |
Issue: |
1 |
Pages: |
153-69 |
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Publication |
First Author: |
Smink JJ |
Year: |
2009 |
Journal: |
EMBO J |
Title: |
Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB. |
Volume: |
28 |
Issue: |
12 |
Pages: |
1769-81 |
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Publication |
First Author: |
Manzanares M |
Year: |
2002 |
Journal: |
EMBO J |
Title: |
Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain. |
Volume: |
21 |
Issue: |
3 |
Pages: |
365-76 |
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Publication |
First Author: |
Kawauchi S |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
Regulation of lens fiber cell differentiation by transcription factor c-Maf. |
Volume: |
274 |
Issue: |
27 |
Pages: |
19254-60 |
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Publication |
First Author: |
Pai EL |
Year: |
2020 |
Journal: |
Elife |
Title: |
Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation. |
Volume: |
9 |
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GXD Expression |
Probe: |
MGI:6193626 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2018-08-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3282013 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:6193660 |
Age: |
embryonic day 8.75 |
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Note: |
Expressed in rhombomere 5 and rhombomere 6. There was a gap between the posterior boundary of Mafb and the anterior boundary of Cdx1 expression. |
Specimen Label: |
not shown |
Detected: |
true |
Specimen Num: |
6 |
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Publication |
First Author: |
Kelly LM |
Year: |
2000 |
Journal: |
EMBO J |
Title: |
MafB is an inducer of monocytic differentiation. |
Volume: |
19 |
Issue: |
9 |
Pages: |
1987-97 |
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Publication |
First Author: |
Eichmann A |
Year: |
1997 |
Journal: |
Mech Dev |
Title: |
The expression pattern of the mafB/kr gene in birds and mice reveals that the kreisler phenotype does not represent a null mutant. |
Volume: |
65 |
Issue: |
1-2 |
Pages: |
111-22 |
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UniProt Feature |
Begin: |
1 |
Description: |
Transcription factor MafB |
Type: |
chain |
End: |
323 |
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Publication |
First Author: |
Tinsley C |
Year: |
2001 |
Journal: |
Curr Opin Microbiol |
Title: |
Meningococcal pathogenesis: at the boundary between the pre- and post-genomic eras. |
Volume: |
4 |
Issue: |
1 |
Pages: |
47-52 |
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Publication |
First Author: |
Jamet A |
Year: |
2015 |
Journal: |
PLoS Pathog |
Title: |
A new family of secreted toxins in pathogenic Neisseria species. |
Volume: |
11 |
Issue: |
1 |
Pages: |
e1004592 |
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Protein Domain |
Type: |
Family |
Description: |
MafB constitutes a family of secreted toxins in pathogenic Neisseria species, probably involved in interbacterial competition []. Genes immediately downstream of mafB encode a specific immunity protein (MafI). MafB proteins exhibit a signal peptide sequence, a N-terminal conserved domain and a C-terminal variable region. Toxic domains identified at the C terminus include , , , and .The genus Neisseria includes both commensal and pathogenic species. The pathogenic neisseriae are a small group of virulent bacteria that initiate infection at the human host mucosal membranes []. Neisseria gonorrhoeae is passed through sexual transmission and can cause renal failure in extreme cases. The more extreme Neisseria meningitidis is a usually commensal nasopharynx microbe that causes meningococcemia and acute bacterial meningitis, especially in young children and teenagers []. |
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Publication |
First Author: |
Mechta-Grigoriou F |
Year: |
2003 |
Journal: |
Dev Biol |
Title: |
c-jun regulation and function in the developing hindbrain. |
Volume: |
258 |
Issue: |
2 |
Pages: |
419-31 |
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Publication |
First Author: |
DEOL MS |
Year: |
1964 |
Journal: |
J Embryol Exp Morphol |
Title: |
THE ABNORMALITIES OF THE INNER EAR IN KREISLER MICE. |
Volume: |
12 |
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Pages: |
475-90 |
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Publication |
First Author: |
Ruben RJ |
Year: |
1973 |
Journal: |
Laryngoscope |
Title: |
Development and cell kinetics of the kreisler (kr-kr) mouse. |
Volume: |
83 |
Issue: |
9 |
Pages: |
1440-68 |
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Publication |
First Author: |
Adam J |
Year: |
1992 |
Journal: |
Hered Deaf News |
Title: |
The deaf kreisler mouse: a hindbrain segmentation mutant. |
Volume: |
8 |
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Pages: |
10-11 |
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Publication |
First Author: |
Voituron N |
Year: |
2011 |
Journal: |
Neuroscience |
Title: |
The kreisler mutation leads to the loss of intrinsically hypoxia-activated spots in the region of the retrotrapezoid nucleus/parafacial respiratory group. |
Volume: |
194 |
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Pages: |
95-111 |
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Publication |
First Author: |
Hertwig P |
Year: |
1944 |
Journal: |
Z Mensch Vererb Konst |
Title: |
Die Genese der Hirn- und Gehororganmissbildungen bei rontgenmutierten Kreisler-Mausen |
Volume: |
18 |
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Pages: |
327-54 |
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Publication |
First Author: |
McKay IJ |
Year: |
1997 |
Journal: |
Eur J Neurosci |
Title: |
Organization and development of facial motor neurons in the kreisler mutant mouse. |
Volume: |
9 |
Issue: |
7 |
Pages: |
1499-506 |
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