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Search results 1 to 100 out of 239 for Mdm4

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Hits by Pathway

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Hits by Strain

Type Details Score
Protein Domain
IPR015458 | MDM4
Type: Family
Description: MDM4, also known as MDMX, is a MDM2-related protein that has been shown to inhibit p53, although not as well as MDM2 [, ].
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Gene
4194 | MDM4
Type: gene
Organism: human
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Gene
304798 | Mdm4
Type: gene
Organism: rat
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Gene
478939 | MDM4
Type: gene
Organism: dog, domestic
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Gene
457658 | MDM4
Type: gene
Organism: chimpanzee
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Gene
514225 | MDM4
Type: gene
Organism: cattle
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Gene
334932 | mdm4
Type: gene
Organism: zebrafish
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Gene
699563 | MDM4
Type: gene
Organism: macaque, rhesus
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Gene
100216294 | mdm4
Type: gene
Organism: frog, western clawed
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Gene
419823 | MDM4
Type: gene
Organism: chicken
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Protein Coding Gene
MGI:107934 | Mdm4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O35618
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Publication
6163388 | -
First Author: Mero M
Year: 1980
Journal: Ann Chir Gynaecol
Title: Serum immunoreactive trypsin and trypsin inhibitors during acute pancreatitis.
Volume: 69
Issue: 6
Pages: 251-5
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Publication
16511572 | -
First Author: Jin Y
Year: 2006
Journal: EMBO J
Title: 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.
Volume: 25
Issue: 6
Pages: 1207-18
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Protein
A0A087WQP2
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Protein
A0A087WQ90
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: false
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Protein
A0A087WQ20
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Protein
A0A087WRX7
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: false
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Protein
Q99L86
Organism: Mus musculus/domesticus
Length: 490  
Fragment?: false
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Protein
Q3UTC9
Organism: Mus musculus/domesticus
Length: 490  
Fragment?: false
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Gene
100533712 | MDM4P1
Type: gene
Organism: human
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Publication
33688918 | J:343864
 
First Author: Qu J
Year: 2021
Journal: J Exp Med
Title: Targeting mechanosensitive MDM4 promotes lung fibrosis resolution in aged mice.
Volume: 218
Issue: 5
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Publication
23327795 | J:320712
First Author: Xiong S
Year: 2013
Journal: Chin J Cancer
Title: Mouse models of Mdm2 and Mdm4 and their clinical implications.
Volume: 32
Issue: 7
Pages: 371-5
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Publication
17533180 | J:137114
First Author: Xiong S
Year: 2007
Journal: Circulation
Title: Loss of Mdm4 results in p53-dependent dilated cardiomyopathy.
Volume: 115
Issue: 23
Pages: 2925-30
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Publication
22820643 | J:317304
First Author: Gembarska A
Year: 2012
Journal: Nat Med
Title: MDM4 is a key therapeutic target in cutaneous melanoma.
Volume: 18
Issue: 8
Pages: 1239-47
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Publication
17105817 | J:143668
First Author: Maetens M
Year: 2007
Journal: Blood
Title: Distinct roles of Mdm2 and Mdm4 in red cell production.
Volume: 109
Issue: 6
Pages: 2630-3
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Publication
17526734 | J:123661
First Author: Terzian T
Year: 2007
Journal: Mol Cell Biol
Title: Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development.
Volume: 27
Issue: 15
Pages: 5479-85
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Publication
18567799 | J:139880
First Author: Barboza JA
Year: 2008
Journal: Mol Cancer Res
Title: Mdm2 and Mdm4 loss regulates distinct p53 activities.
Volume: 6
Issue: 6
Pages: 947-54
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Publication
27925213 | J:241797
First Author: Xiong S
Year: 2017
Journal: J Pathol
Title: The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis.
Volume: 241
Issue: 4
Pages: 501-510
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Publication
32464196 | J:300508
 
First Author: Hilliard SA
Year: 2020
Journal: Mech Dev
Title: Mdm4 controls ureteric bud branching via regulation of p53 activity.
Volume: 163
Pages: 103616
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Publication
14712235 | J:88362
First Author: Steinman HA
Year: 2004
Journal: Oncogene
Title: Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth.
Volume: 23
Issue: 1
Pages: 303-6
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Publication
26527653 | J:230519
First Author: Tashakori M
Year: 2016
Journal: Mol Cancer Res
Title: p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis.
Volume: 14
Issue: 1
Pages: 56-65
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Publication
24285179 | J:318847
First Author: Pellegrino R
Year: 2014
Journal: Hepatology
Title: EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma.
Volume: 59
Issue: 5
Pages: 1886-99
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Publication
8895579 | J:36053
First Author: Shvarts A
Year: 1996
Journal: EMBO J
Title: MDMX: a novel p53-binding protein with some functional properties of MDM2.
Volume: 15
Issue: 19
Pages: 5349-57
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Publication
19371999 | J:149219
First Author: Valentin-Vega YA
Year: 2009
Journal: Differentiation
Title: Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities.
Volume: 77
Issue: 5
Pages: 442-9
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Publication
22262167 | J:318094
First Author: Yang H
Year: 2012
Journal: Cell Cycle
Title: Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection.
Volume: 11
Issue: 3
Pages: 582-93
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Publication
19521340 | J:150846
First Author: Mancini F
Year: 2009
Journal: EMBO J
Title: MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway.
Volume: 28
Issue: 13
Pages: 1926-39
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Publication
16492744 | J:120591
First Author: Francoz S
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.
Volume: 103
Issue: 9
Pages: 3232-7
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Publication
16027727 | J:103425
First Author: Steinman HA
Year: 2005
Journal: Oncogene
Title: Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.
Volume: 24
Issue: 53
Pages: 7935-40
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Publication
16492743 | J:107178
First Author: Xiong S
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development.
Volume: 103
Issue: 9
Pages: 3226-31
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Publication
30012555 | J:272583
First Author: Van Alstyne M
Year: 2018
Journal: Genes Dev
Title: Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy.
Volume: 32
Issue: 15-16
Pages: 1045-1059
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Publication
12101245 | J:77907
First Author: Migliorini D
Year: 2002
Journal: Mol Cell Biol
Title: Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.
Volume: 22
Issue: 15
Pages: 5527-38
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Publication
20855528 | J:317403
First Author: De Clercq S
Year: 2010
Journal: Mol Cell Biol
Title: Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivo.
Volume: 30
Issue: 22
Pages: 5394-405
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Publication
20697359 | J:170004
First Author: Giglio S
Year: 2010
Journal: Oncogene
Title: Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity.
Volume: 29
Issue: 44
Pages: 5935-45
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Publication
23474762 | J:212378
First Author: Fang M
Year: 2014
Journal: Oncogene
Title: Mdm4 loss in mice expressing a p53 hypomorph alters tumor spectrum without improving survival.
Volume: 33
Issue: 10
Pages: 1336-9
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Publication
16616333 | J:108183
First Author: Toledo F
Year: 2006
Journal: Cancer Cell
Title: A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.
Volume: 9
Issue: 4
Pages: 273-85
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Publication
25088193 | J:222536
First Author: Bardot B
Year: 2015
Journal: Oncogene
Title: Mice engineered for an obligatory Mdm4 exon skipping express higher levels of the Mdm4-S isoform but exhibit increased p53 activity.
Volume: 34
Issue: 22
Pages: 2943-8
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Publication
15361844 | J:93838
First Author: Iwakuma T
Year: 2004
Journal: Oncogene
Title: Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice.
Volume: 23
Issue: 46
Pages: 7644-50
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Publication
22821713 | J:188490
First Author: Zhang Q
Year: 2012
Journal: J Pathol
Title: Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development.
Volume: 228
Issue: 3
Pages: 416-28
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Publication
21730132 | J:174368
First Author: Pant V
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.
Volume: 108
Issue: 29
Pages: 11995-2000
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Publication
24013503 | J:201152
First Author: Bezzi M
Year: 2013
Journal: Genes Dev
Title: Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery.
Volume: 27
Issue: 17
Pages: 1903-16
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Publication
25961923 | J:346784
First Author: Mancini F
Year: 2016
Journal: Oncogene
Title: MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response.
Volume: 35
Issue: 2
Pages: 228-40
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Publication
- | J:272830
     
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for isla_nublar.
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Publication
- | J:265262
     
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for sun_island.
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Publication
20736370 | J:164225
First Author: Xiong S
Year: 2010
Journal: Cancer Res
Title: Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4.
Volume: 70
Issue: 18
Pages: 7148-54
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Protein
O35618-2
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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Publication
17128209 | J:120252
First Author: Toledo F
Year: 2006
Journal: Nat Rev Cancer
Title: Regulating the p53 pathway: in vitro hypotheses, in vivo veritas.
Volume: 6
Issue: 12
Pages: 909-23
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UniProt Feature
UniProt Feature
Begin: 1
Description: Protein Mdm4
Type: chain
End: 489
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Publication
28460439 | J:256595
First Author: Pant V
Year: 2017
Journal: Oncotarget
Title: Tumorigenesis promotes Mdm4-S overexpression.
Volume: 8
Issue: 16
Pages: 25837-25847
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Publication
20962274 | J:166152
First Author: Slee EA
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivo.
Volume: 107
Issue: 45
Pages: 19479-84
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Publication
17018606 | J:113394
First Author: Chandler DS
Year: 2006
Journal: Cancer Res
Title: Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.
Volume: 66
Issue: 19
Pages: 9502-8
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Publication
16729027 | J:132251
First Author: Boesten LS
Year: 2006
Journal: Cell Death Differ
Title: Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death.
Volume: 13
Issue: 12
Pages: 2089-98
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Publication
25144937 | J:223276
 
First Author: Xiong X
Year: 2014
Journal: Elife
Title: Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis.
Volume: 3
Pages: e02236
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Publication
30807606 | J:273775
First Author: Wakasugi T
Year: 2019
Journal: PLoS One
Title: Role of smooth muscle cell p53 in pulmonary arterial hypertension.
Volume: 14
Issue: 2
Pages: e0212889
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Publication
33667384 | J:305020
First Author: Ueda K
Year: 2021
Journal: Cancer Cell
Title: MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism.
Volume: 39
Issue: 4
Pages: 529-547.e7
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Publication
27364741 | J:235222
First Author: Livera G
Year: 2016
Journal: FEBS Lett
Title: Loss of oocytes due to conditional ablation of Murine double minute 2 (Mdm2) gene is p53-dependent and results in female sterility.
Volume: 590
Issue: 16
Pages: 2566-74
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Publication
11528400 | J:71532
First Author: Parant J
Year: 2001
Journal: Nat Genet
Title: Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53.
Volume: 29
Issue: 1
Pages: 92-5
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Publication
25981963 | J:242745
First Author: Joshi Y
Year: 2015
Journal: Brain
Title: The MDM4/MDM2-p53-IGF1 axis controls axonal regeneration, sprouting and functional recovery after CNS injury.
Volume: 138
Issue: Pt 7
Pages: 1843-62
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Publication
27912078 | J:240039
First Author: Zhang CX
Year: 2017
Journal: Am J Pathol
Title: Mouse Double Minute 2 Actively Suppresses p53 Activity in Oocytes during Mouse Folliculogenesis.
Volume: 187
Issue: 2
Pages: 339-351
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Publication
16354690 | J:104114
First Author: Grier JD
Year: 2006
Journal: Mol Cell Biol
Title: Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.
Volume: 26
Issue: 1
Pages: 192-8
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Publication
14695178 | J:87065
First Author: Chavez-Reyes A
Year: 2003
Journal: Cancer Res
Title: Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets.
Volume: 63
Issue: 24
Pages: 8664-9
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Publication
28049824 | J:239540
First Author: Zhang G
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: p53 pathway is involved in cell competition during mouse embryogenesis.
Volume: 114
Issue: 3
Pages: 498-503
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Publication
37612280 | J:339368
First Author: Yao F
Year: 2023
Journal: Cell Death Dis
Title: Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis.
Volume: 14
Issue: 8
Pages: 543
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Protein Coding Gene
MGP_CAROLIEiJ_G0014593 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016478 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016461 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016426 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016421 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016247 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_107934 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016882 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015827 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016219 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016326 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016325 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016397 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016350 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0016918 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015613 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015889 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027829 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015400 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
15916963 | J:197517
First Author: Meulmeester E
Year: 2005
Journal: Mol Cell
Title: Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2.
Volume: 18
Issue: 5
Pages: 565-76
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Publication
11404026 | J:70147
First Author: Parant JM
Year: 2001
Journal: Gene
Title: Organization, expression, and localization of the murine mdmx gene and pseudogene.
Volume: 270
Issue: 1-2
Pages: 277-83
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Publication
23303139 | J:193502
First Author: Wade M
Year: 2013
Journal: Nat Rev Cancer
Title: MDM2, MDMX and p53 in oncogenesis and cancer therapy.
Volume: 13
Issue: 2
Pages: 83-96
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Publication
26477779 | J:318332
 
First Author: Colacurcio DJ
Year: 2015
Journal: Neurosci Lett
Title: Caspase-dependent degradation of MDMx/MDM4 cell cycle regulatory protein in amyloid β-induced neuronal damage.
Volume: 609
Pages: 182-8
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GXD Expression
GXD Expression
     
Probe: MGI:2670381
Assay Type: Northern blot
Annotation Date: 2003-08-26
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2670382
Age: postnatal adult
Specimen Label: 1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2670381
Assay Type: Northern blot
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2670382
Age: postnatal adult
Specimen Label: 2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2670381
Assay Type: Northern blot
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:2670382
Age: embryonic day 18.5
Specimen Label: 3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2670381
Assay Type: Northern blot
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:2670382
Age: embryonic day 12.5
Specimen Label: 4
Detected: true
Specimen Num: 4
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