| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dmitriev RI |
| Year: |
2014 |
| Journal: |
J Cell Biochem |
| Title: |
Two distinct nuclear localization signals in mammalian MSL1 regulate its function. |
| Volume: |
115 |
| Issue: |
11 |
| Pages: |
1967-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MarĂn I |
| Year: |
2003 |
| Journal: |
J Mol Evol |
| Title: |
Evolution of chromatin-remodeling complexes: comparative genomics reveals the ancient origin of "novel" compensasome genes. |
| Volume: |
56 |
| Issue: |
5 |
| Pages: |
527-39 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6115782 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2018-02-13 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1603922 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:6115812 |
| Age: |
embryonic day 14.5 |
| Image: |
2 |
|
| Specimen Label: |
KO-M |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6115782 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2018-02-13 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1603922 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:6115812 |
| Age: |
embryonic day 14.5 |
| Image: |
2 |
|
| Specimen Label: |
WT-M |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6115782 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2018-02-13 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1603917 |
|
| Stage: |
TS17 |
| Assay Id: |
MGI:6115832 |
| Age: |
embryonic day 10.5 |
| Image: |
S1 |
|
| Specimen Label: |
WT-M |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6115782 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2018-02-13 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1603917 |
|
| Stage: |
TS17 |
| Assay Id: |
MGI:6115832 |
| Age: |
embryonic day 10.5 |
| Image: |
S1 |
|
| Specimen Label: |
KO-M |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6115782 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2018-02-13 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1603926 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6115845 |
| Age: |
embryonic day 18.5 |
| Image: |
S1 |
|
| Specimen Label: |
WT-M |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6115782 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2018-02-13 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1603926 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6115845 |
| Age: |
embryonic day 18.5 |
| Image: |
S1 |
|
| Specimen Label: |
KO-M |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6115782 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2018-02-13 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1603922 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:6115821 |
| Age: |
embryonic day 14.5 |
| Image: |
2 |
|
| Specimen Label: |
WT-F |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6115782 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2018-02-13 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1603922 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:6115821 |
| Age: |
embryonic day 14.5 |
| Image: |
2 |
|
| Specimen Label: |
KO-F |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6115782 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2018-02-13 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1603917 |
|
| Stage: |
TS17 |
| Assay Id: |
MGI:6115838 |
| Age: |
embryonic day 10.5 |
| Image: |
S1 |
|
| Specimen Label: |
WT-F |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6115782 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2018-02-13 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1603917 |
|
| Stage: |
TS17 |
| Assay Id: |
MGI:6115838 |
| Age: |
embryonic day 10.5 |
| Image: |
S1 |
|
| Specimen Label: |
KO-F |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6115782 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2018-02-13 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1603926 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6115844 |
| Age: |
embryonic day 18.5 |
| Image: |
S1 |
|
| Specimen Label: |
WT-F |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6115782 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2018-02-13 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1603926 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6115844 |
| Age: |
embryonic day 18.5 |
| Image: |
S1 |
|
| Specimen Label: |
KO-F |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3065018 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2022-02-01 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603920 |
|
| Stage: |
TS20 |
| Assay Id: |
MGI:6861825 |
| Age: |
embryonic day 12.5 |
| Image: |
2 |
|
| Specimen Label: |
Embryo |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3065018 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2022-02-01 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3187320 |
|
| Stage: |
TS20 |
| Assay Id: |
MGI:6861825 |
| Age: |
embryonic day 12.5 |
| Image: |
2 |
|
| Specimen Label: |
Placenta |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ye A |
| Year: |
2017 |
| Journal: |
PLoS One |
| Title: |
PEG3 control on the mammalian MSL complex. |
| Volume: |
12 |
| Issue: |
6 |
| Pages: |
e0178363 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dmitriev RI |
| Year: |
2009 |
| Journal: |
Cell Tissue Res |
| Title: |
Nuclear transport of protein TTC4 depends on the cell cycle. |
| Volume: |
336 |
| Issue: |
3 |
| Pages: |
521-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Deng X |
| Year: |
2013 |
| Journal: |
Dev Cell |
| Title: |
Mammalian X upregulation is associated with enhanced transcription initiation, RNA half-life, and MOF-mediated H4K16 acetylation. |
| Volume: |
25 |
| Issue: |
1 |
| Pages: |
55-68 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tanaka TS |
| Year: |
2000 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. |
| Volume: |
97 |
| Issue: |
16 |
| Pages: |
9127-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dmitriev RI |
| Year: |
2007 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Characterization of hampin/MSL1 as a node in the nuclear interactome. |
| Volume: |
355 |
| Issue: |
4 |
| Pages: |
1051-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wolstenholme JT |
| Year: |
2013 |
| Journal: |
Genes Brain Behav |
| Title: |
Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes. |
| Volume: |
12 |
| Issue: |
2 |
| Pages: |
166-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chelmicki T |
| Year: |
2014 |
| Journal: |
Elife |
| Title: |
MOF-associated complexes ensure stem cell identity and Xist repression. |
| Volume: |
3 |
|
| Pages: |
e02024 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ye A |
| Year: |
2016 |
| Journal: |
Epigenetics |
| Title: |
PEG3 binds to H19-ICR as a transcriptional repressor. |
| Volume: |
11 |
| Issue: |
12 |
| Pages: |
889-900 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom |
| Year: |
2023 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lennon G |
| Year: |
1999 |
| Journal: |
Database Download |
| Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
| Year: |
2014 |
| Journal: |
Database Release |
| Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
1670-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Helmholtz Zentrum Muenchen GmbH |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawai J |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Functional annotation of a full-length mouse cDNA collection. |
| Volume: |
409 |
| Issue: |
6821 |
| Pages: |
685-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGD Nomenclature Committee |
| Year: |
1995 |
|
| Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zambrowicz BP |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
| Pages: |
14109-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
|
| Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
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|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
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•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
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|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the N-terminal domain of the E3 ubiquitin-protein ligase Msl2. This domain binds Msl1 and exhibits ubiquitin E3 ligase activity towards H2B K34 []. |
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•
•
•
•
|
| Publication |
| First Author: |
Kadlec J |
| Year: |
2011 |
| Journal: |
Nat Struct Mol Biol |
| Title: |
Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. |
| Volume: |
18 |
| Issue: |
2 |
| Pages: |
142-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Morales V |
| Year: |
2004 |
| Journal: |
EMBO J |
| Title: |
Functional integration of the histone acetyltransferase MOF into the dosage compensation complex. |
| Volume: |
23 |
| Issue: |
11 |
| Pages: |
2258-68 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zheng S |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
Solution structure of MSL2 CXC domain reveals an unusual Zn3Cys9 cluster and similarity to pre-SET domains of histone lysine methyltransferases. |
| Volume: |
7 |
| Issue: |
9 |
| Pages: |
e45437 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the short coiled dimerisation domain of higher eukaryotic MSL1, part of the MSL or Male-Specific Lethal complex. This complex regulates the dosage compensation of the male X chromosome in Drosophila and other eukaryotes. The structure of the MSL1/MSL2 core shows that two MSL2 subunits bind to a dimer formed by two molecules of MSL1. MSL1 is a substrate for MSL2 E3 ubiquitin ligase activity []. |
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•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This domain was first identified in drosophila MSL1 (male-specific lethal 1) []. In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3) [, ]. This domain can also be found in KAT8 regulatory NSL complex subunit 1 (KANSL1 or NSL1), which is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription []. |
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•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Male-specific lethal 3 homolog (MSL3) is a component of the MSL complex []. MSL3 has a chromodomain by which it interacts with DNA [, ]and an MRG domain with which it interacts with MSL1 [].The male-specific lethal (MSL) complex is a histone acetyltransferase with specificity for histone H4 'lysine-16' in chromatin. The complex consists of MOF, MSL1, MSL2, and MSL3 []. The complex was first identified in Drosophila. |
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•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1036
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
991
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1099
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
647
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
947
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hallacli E |
| Year: |
2012 |
| Journal: |
Mol Cell |
| Title: |
Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila. |
| Volume: |
48 |
| Issue: |
4 |
| Pages: |
587-600 |
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•
•
•
•
•
|