Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
sheep |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This domain is found in eukaryotes, is approximately 70 amino acids in length, and contains a conserved CSD sequence motif. It is found in association with , . This domain is found in Myogenic factor 5 (Myf5) and Myoblast determination protein 1 (MyoD1). Myf5 is responsible for directing cells to the skeletal myocyte lineage during development []. Myf5 is likely to act in a similar way to the other MRF4 proteins such as MyoD which perform the same function []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6504943 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-02-04 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640619 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6504946 |
Age: |
embryonic day 11.5 |
Image: |
6(II) Myf5 FL Six1-/- |
Note: |
Expression absent in Six1-/- FL. |
Specimen Label: |
6(II) Myf5 FL Six1-/- |
Detected: |
false |
Specimen Num: |
19 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6504943 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-02-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1745820 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:6504946 |
Age: |
embryonic day 12.5 |
Image: |
6(III) Myf5 PHL Six1-/- |
Note: |
Expression detected dorsally. |
Specimen Label: |
6(III) Myf5 PHL Six1-/- |
Detected: |
true |
Specimen Num: |
23 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6504943 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-02-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1745820 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:6504946 |
Age: |
embryonic day 12.5 |
Image: |
6(III) Myf5 DHL wt |
Note: |
Expression detectable at 500 mm from tip of limb. |
Specimen Label: |
6(III) Myf5 DHL wt |
Detected: |
true |
Specimen Num: |
24 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6504943 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-02-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1745820 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:6504946 |
Age: |
embryonic day 12.5 |
Image: |
6(III) Myf5 DHL Six1-/- |
Note: |
Expression detectable at 900 mm from tip of limb. |
Specimen Label: |
6(III) Myf5 DHL Six1-/- |
Detected: |
true |
Specimen Num: |
25 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6504943 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-02-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1745820 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:6504946 |
Age: |
embryonic day 12.5 |
Image: |
6(III) Myf5 PHL wt |
|
Specimen Label: |
6(III) Myf5 PHL wt |
Detected: |
true |
Specimen Num: |
22 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6504943 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-02-04 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1677919 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:6504946 |
Age: |
embryonic day 11.5 |
Image: |
6(II) Myf5 PHL Six1-/- |
Note: |
Weak expressin in ventral aspect. |
Specimen Label: |
6(II) Myf5 PHL Six1-/- |
Detected: |
true |
Specimen Num: |
16 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6504943 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-02-04 |
Strength: |
Trace |
Sex: |
Not Specified |
Emaps: |
EMAPS:1677919 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6504946 |
Age: |
embryonic day 11.5 |
Image: |
6(II) Myf5 PHL Six1-/-Six4-/+ |
Note: |
Expression barely detectable. |
Specimen Label: |
6(II) Myf5 PHL Six1-/-Six4-/+ |
Detected: |
true |
Specimen Num: |
17 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6504943 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-02-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741220 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:6504946 |
Age: |
embryonic day 12.5 |
Image: |
6(III) Myf5 FL wt |
|
Specimen Label: |
6(III) Myf5 FL wt |
Detected: |
true |
Specimen Num: |
20 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6504943 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-02-04 |
Strength: |
Trace |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741220 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:6504946 |
Age: |
embryonic day 12.5 |
Image: |
6(III) Myf5 FL Six1-/- |
Note: |
Most expression lost except in posterior aspect. |
Specimen Label: |
6(III) Myf5 FL Six1-/- |
Detected: |
true |
Specimen Num: |
21 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6504943 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-02-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640619 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6504946 |
Age: |
embryonic day 11.5 |
Image: |
6(II) Myf5 FL wt |
|
Specimen Label: |
6(II) Myf5 FL wt |
Detected: |
true |
Specimen Num: |
18 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6504943 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-02-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1677919 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6504946 |
Age: |
embryonic day 11.5 |
Image: |
6(II) Myf5 PHL wt |
|
Specimen Label: |
6(II) Myf5 PHL wt |
Detected: |
true |
Specimen Num: |
15 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5141239 |
Assay Type: |
RT-PCR |
Annotation Date: |
2011-08-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3275713 |
|
Stage: |
TS13 |
Assay Id: |
MGI:5141287 |
Age: |
embryonic day 8.5 |
Image: |
S1 |
|
Specimen Label: |
Myf5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5141239 |
Assay Type: |
RT-PCR |
Annotation Date: |
2011-08-29 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3185813 |
|
Stage: |
TS13 |
Assay Id: |
MGI:5141287 |
Age: |
embryonic day 8.5 |
Image: |
S1 |
|
Specimen Label: |
Myf5 |
Detected: |
false |
Specimen Num: |
8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ye HQ |
Year: |
2007 |
Journal: |
Comp Biochem Physiol B Biochem Mol Biol |
Title: |
Molecular cloning and characterization of the Myf5 gene in sea perch (Lateolabrax japonicus). |
Volume: |
147 |
Issue: |
3 |
Pages: |
452-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Londhe P |
Year: |
2011 |
Journal: |
Skelet Muscle |
Title: |
Sequential association of myogenic regulatory factors and E proteins at muscle-specific genes. |
Volume: |
1 |
Issue: |
1 |
Pages: |
14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
1996 |
Journal: |
Nature |
Title: |
Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin. |
Volume: |
379 |
Issue: |
6568 |
Pages: |
823-5 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
318
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
255
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
159
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
255
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Borycki AG |
Year: |
1999 |
Journal: |
Development |
Title: |
Sonic hedgehog controls epaxial muscle determination through Myf5 activation. |
Volume: |
126 |
Issue: |
18 |
Pages: |
4053-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Edwards JG |
Year: |
1996 |
Journal: |
Circ Res |
Title: |
Cardiomyopathy in transgenic myf5 mice. |
Volume: |
78 |
Issue: |
3 |
Pages: |
379-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Valdez MR |
Year: |
2000 |
Journal: |
Dev Biol |
Title: |
Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4. |
Volume: |
219 |
Issue: |
2 |
Pages: |
287-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Borello U |
Year: |
2006 |
Journal: |
Development |
Title: |
The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. |
Volume: |
133 |
Issue: |
18 |
Pages: |
3723-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kablar B |
Year: |
2003 |
Journal: |
Dev Biol |
Title: |
Myf5 and MyoD activation define independent myogenic compartments during embryonic development. |
Volume: |
258 |
Issue: |
2 |
Pages: |
307-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
1997 |
Journal: |
Development |
Title: |
Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently. |
Volume: |
124 |
Issue: |
13 |
Pages: |
2507-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Perez-Ruiz A |
Year: |
2007 |
Journal: |
Cell Signal |
Title: |
Control of Myf5 activation in adult skeletal myonuclei requires ERK signalling. |
Volume: |
19 |
Issue: |
8 |
Pages: |
1671-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ancel S |
Year: |
2023 |
Journal: |
bioRxiv |
Title: |
A Dual Color Pax7 and Myf5 In Vivo Reporter to Investigate Muscle Stem Cell Heterogeneity in Regeneration and Aging |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gayraud-Morel B |
Year: |
2012 |
Journal: |
J Cell Sci |
Title: |
Myf5 haploinsufficiency reveals distinct cell fate potentials for adult skeletal muscle stem cells. |
Volume: |
125 |
Issue: |
Pt 7 |
Pages: |
1738-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beauchamp JR |
Year: |
2000 |
Journal: |
J Cell Biol |
Title: |
Expression of CD34 and Myf5 defines the majority of quiescent adult skeletal muscle satellite cells. |
Volume: |
151 |
Issue: |
6 |
Pages: |
1221-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haldar M |
Year: |
2008 |
Journal: |
Dev Cell |
Title: |
Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis. |
Volume: |
14 |
Issue: |
3 |
Pages: |
437-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Biressi S |
Year: |
2013 |
Journal: |
Dev Biol |
Title: |
Myf5 expression during fetal myogenesis defines the developmental progenitors of adult satellite cells. |
Volume: |
379 |
Issue: |
2 |
Pages: |
195-207 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sanchez-Gurmaches J |
Year: |
2012 |
Journal: |
Cell Metab |
Title: |
PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors. |
Volume: |
16 |
Issue: |
3 |
Pages: |
348-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gayraud-Morel B |
Year: |
2007 |
Journal: |
Dev Biol |
Title: |
A role for the myogenic determination gene Myf5 in adult regenerative myogenesis. |
Volume: |
312 |
Issue: |
1 |
Pages: |
13-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pan H |
Year: |
2011 |
Journal: |
Dev Biol |
Title: |
A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis. |
Volume: |
351 |
Issue: |
1 |
Pages: |
120-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ustanina S |
Year: |
2007 |
Journal: |
Stem Cells |
Title: |
The myogenic factor Myf5 supports efficient skeletal muscle regeneration by enabling transient myoblast amplification. |
Volume: |
25 |
Issue: |
8 |
Pages: |
2006-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hadchouel J |
Year: |
2000 |
Journal: |
Development |
Title: |
Modular long-range regulation of Myf5 reveals unexpected heterogeneity between skeletal muscles in the mouse embryo. |
Volume: |
127 |
Issue: |
20 |
Pages: |
4455-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Panda AC |
Year: |
2016 |
Journal: |
Nucleic Acids Res |
Title: |
Novel RNA-binding activity of MYF5 enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis. |
Volume: |
44 |
Issue: |
5 |
Pages: |
2393-408 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hung CM |
Year: |
2014 |
Journal: |
Cell Rep |
Title: |
Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease. |
Volume: |
8 |
Issue: |
1 |
Pages: |
256-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Daubas P |
Year: |
2000 |
Journal: |
Development |
Title: |
Myf5 is a novel early axonal marker in the mouse brain and is subjected to post-transcriptional regulation in neurons. |
Volume: |
127 |
Issue: |
2 |
Pages: |
319-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giordani J |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs. |
Volume: |
104 |
Issue: |
27 |
Pages: |
11310-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tekko T |
Year: |
2022 |
Journal: |
Dev Dyn |
Title: |
Assessing Myf5 and Lbx1 contribution to carapace development by reproducing their turtle-specific signatures in mouse embryos. |
Volume: |
251 |
Issue: |
10 |
Pages: |
1698-1710 |
|
•
•
•
•
•
|
Publication |
First Author: |
Daubas P |
Year: |
2015 |
Journal: |
Biol Open |
Title: |
Fine-tuning the onset of myogenesis by homeobox proteins that interact with the Myf5 limb enhancer. |
Volume: |
4 |
Issue: |
12 |
Pages: |
1614-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Daubas P |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
The regulatory mechanisms that underlie inappropriate transcription of the myogenic determination gene Myf5 in the central nervous system. |
Volume: |
327 |
Issue: |
1 |
Pages: |
71-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ribas R |
Year: |
2011 |
Journal: |
Dev Biol |
Title: |
Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments. |
Volume: |
355 |
Issue: |
2 |
Pages: |
372-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bajard L |
Year: |
2006 |
Journal: |
Genes Dev |
Title: |
A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb. |
Volume: |
20 |
Issue: |
17 |
Pages: |
2450-64 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178603 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
|
Stage: |
TS21 |
Assay Id: |
MGI:6190834 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Myf5 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178603 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
|
Stage: |
TS24 |
Assay Id: |
MGI:6190834 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Myf5 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178603 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190834 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Myf5 |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178603 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190834 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Myf5 |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178603 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6190834 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Myf5 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178603 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6190834 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Myf5 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178603 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190834 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Myf5 |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu B |
Year: |
2016 |
Journal: |
Exp Neurol |
Title: |
Myf5 and Myogenin in the development of thymic myoid cells - Implications for a murine in vivo model of myasthenia gravis. |
Volume: |
277 |
|
Pages: |
76-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Summerbell D |
Year: |
2002 |
Journal: |
Mech Dev |
Title: |
Expression of the myogenic regulatory factor Mrf4 precedes or is contemporaneous with that of Myf5 in the somitic bud. |
Volume: |
117 |
Issue: |
1-2 |
Pages: |
331-5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1341128 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-08-10 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:2969517 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:1341130 |
Age: |
embryonic day 10.5 |
Image: |
1C |
Note: |
Myf5 transcription is high in the myotome. |
Specimen Label: |
1C |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1929240 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:2969515 |
Pattern: |
Regionally restricted |
Stage: |
TS15 |
Assay Id: |
MGI:1930195 |
Age: |
embryonic day 9.5 |
Image: |
5A |
Note: |
Myf5 transcripts were restricted to the myotome. |
Specimen Label: |
5A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1341128 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-08-10 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:2969517 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:1341130 |
Age: |
embryonic day 10.5 |
Image: |
1F |
Note: |
Myf5 transcription is high in the myotome. |
Specimen Label: |
1F |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Summerbell D |
Year: |
2000 |
Journal: |
Development |
Title: |
The expression of Myf5 in the developing mouse embryo is controlled by discrete and dispersed enhancers specific for particular populations of skeletal muscle precursors. |
Volume: |
127 |
Issue: |
17 |
Pages: |
3745-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Daubas P |
Year: |
2013 |
Journal: |
Dev Biol |
Title: |
Direct molecular regulation of the myogenic determination gene Myf5 by Pax3, with modulation by Six1/4 factors, is exemplified by the -111 kb-Myf5 enhancer. |
Volume: |
376 |
Issue: |
2 |
Pages: |
236-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stuelsatz P |
Year: |
2014 |
Journal: |
Dev Biol |
Title: |
Ancestral Myf5 gene activity in periocular connective tissue identifies a subset of fibro/adipogenic progenitors but does not connote a myogenic origin. |
Volume: |
385 |
Issue: |
2 |
Pages: |
366-79 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4849948 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2003-02-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640818 |
Pattern: |
Not Specified |
Stage: |
TS18 |
Assay Id: |
MGI:2449197 |
Age: |
embryonic day 10.5 |
Image: |
3K,L |
Note: |
The majority of Myf5 expressing cells express alpha5. |
Specimen Label: |
3K,L |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haldar M |
Year: |
2014 |
Journal: |
Dev Cell |
Title: |
Response: Contributions of the Myf5-independent lineage to myogenesis. |
Volume: |
31 |
Issue: |
5 |
Pages: |
539-41 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1929240 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:2969515 |
Pattern: |
Regionally restricted |
Stage: |
TS15 |
Assay Id: |
MGI:1930195 |
Age: |
embryonic day 9.5 |
Image: |
5B |
Note: |
Myf5 transcripts were restricted to the myotome, but were absent in the lateral myotome. |
Specimen Label: |
5B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7430743 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-01-31 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1612816 |
Pattern: |
Regionally restricted |
Stage: |
TS16 |
Assay Id: |
MGI:7430770 |
Age: |
embryonic day 10.0 |
Image: |
2K |
Note: |
Co-expression of Myf5 and Pitx2 (beta-gal) was detected in the first branchial arch muscle anlagen. |
Specimen Label: |
2K |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang W |
Year: |
1995 |
Journal: |
Genes Dev |
Title: |
Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies. |
Volume: |
9 |
Issue: |
11 |
Pages: |
1388-99 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1341128 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-08-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1626220 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1341130 |
Age: |
embryonic day 12.5 |
Image: |
2C |
Note: |
The expression domains of M-twist and myf5 are mutually exclusive in the developing branchial arches, where myf5 is observed in the anlagen of the jaw muscles. |
Specimen Label: |
2C |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Patapoutian A |
Year: |
1995 |
Journal: |
Development |
Title: |
Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome. |
Volume: |
121 |
Issue: |
10 |
Pages: |
3347-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rawls A |
Year: |
1998 |
Journal: |
Development |
Title: |
Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice. |
Volume: |
125 |
Issue: |
13 |
Pages: |
2349-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tallquist MD |
Year: |
2000 |
Journal: |
Development |
Title: |
Early myotome specification regulates PDGFA expression and axial skeleton development. |
Volume: |
127 |
Issue: |
23 |
Pages: |
5059-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sweetman D |
Year: |
2008 |
Journal: |
Dev Biol |
Title: |
Specific requirements of MRFs for the expression of muscle specific microRNAs, miR-1, miR-206 and miR-133. |
Volume: |
321 |
Issue: |
2 |
Pages: |
491-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sambasivan R |
Year: |
2009 |
Journal: |
Dev Cell |
Title: |
Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates. |
Volume: |
16 |
Issue: |
6 |
Pages: |
810-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Floss T |
Year: |
1996 |
Journal: |
Dev Biol |
Title: |
Myf-5(m1)/Myf-6(m1) compound heterozygous mouse mutants down-regulate Myf-5 expression and exert rib defects: evidence for long-range cis effects on Myf-5 transcription. |
Volume: |
174 |
Issue: |
1 |
Pages: |
140-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reddy T |
Year: |
2004 |
Journal: |
Dev Dyn |
Title: |
Evidence for the involvement of neurotrophins in muscle transdifferentiation and acetylcholine receptor transformation in the esophagus of Myf5(-/-):MyoD(-/-) and NT-3(-/-) embryos. |
Volume: |
231 |
Issue: |
4 |
Pages: |
683-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vincent SD |
Year: |
2012 |
Journal: |
Mol Biol Evol |
Title: |
Non conservation of function for the evolutionarily conserved prdm1 protein in the control of the slow twitch myogenic program in the mouse embryo. |
Volume: |
29 |
Issue: |
10 |
Pages: |
3181-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Braun T |
Year: |
1995 |
Journal: |
EMBO J |
Title: |
Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle development. |
Volume: |
14 |
Issue: |
6 |
Pages: |
1176-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moncaut N |
Year: |
2012 |
Journal: |
Development |
Title: |
Musculin and TCF21 coordinate the maintenance of myogenic regulatory factor expression levels during mouse craniofacial development. |
Volume: |
139 |
Issue: |
5 |
Pages: |
958-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kablar B |
Year: |
2005 |
Journal: |
Dev Dyn |
Title: |
Presence of neurotrophic factors in skeletal muscle correlates with survival of spinal cord motor neurons. |
Volume: |
234 |
Issue: |
3 |
Pages: |
659-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilson-Rawls J |
Year: |
1999 |
Journal: |
Development |
Title: |
Differential regulation of epaxial and hypaxial muscle development by paraxis. |
Volume: |
126 |
Issue: |
23 |
Pages: |
5217-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaul A |
Year: |
2000 |
Journal: |
Cell |
Title: |
Myf-5 revisited: loss of early myotome formation does not lead to a rib phenotype in homozygous Myf-5 mutant mice. |
Volume: |
102 |
Issue: |
1 |
Pages: |
17-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wood WM |
Year: |
2020 |
Journal: |
Dev Biol |
Title: |
Development and patterning of rib primordia are dependent on associated musculature. |
Volume: |
468 |
Issue: |
1-2 |
Pages: |
133-145 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu Q |
Year: |
2021 |
Journal: |
Cell Death Dis |
Title: |
KDM4A regulates myogenesis by demethylating H3K9me3 of myogenic regulatory factors. |
Volume: |
12 |
Issue: |
6 |
Pages: |
514 |
|
•
•
•
•
•
|
Publication |
First Author: |
Olson EN |
Year: |
1996 |
Journal: |
Cell |
Title: |
Know your neighbors: three phenotypes in null mutants of the myogenic bHLH gene MRF4. |
Volume: |
85 |
Issue: |
1 |
Pages: |
1-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang NC |
Year: |
2018 |
Journal: |
Cell Stem Cell |
Title: |
The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment. |
Volume: |
22 |
Issue: |
5 |
Pages: |
755-768.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garry DJ |
Year: |
1997 |
Journal: |
Dev Biol |
Title: |
Persistent expression of MNF identifies myogenic stem cells in postnatal muscles. |
Volume: |
188 |
Issue: |
2 |
Pages: |
280-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lynes MD |
Year: |
2015 |
Journal: |
Endocrinology |
Title: |
Disruption of insulin signaling in Myf5-expressing progenitors leads to marked paucity of brown fat but normal muscle development. |
Volume: |
156 |
Issue: |
5 |
Pages: |
1637-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ignacio DL |
Year: |
2017 |
Journal: |
Thyroid |
Title: |
Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function. |
Volume: |
27 |
Issue: |
4 |
Pages: |
577-586 |
|
•
•
•
•
•
|
Publication |
First Author: |
Braun T |
Year: |
1992 |
Journal: |
Cell |
Title: |
Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death. |
Volume: |
71 |
Issue: |
3 |
Pages: |
369-82 |
|
•
•
•
•
•
|