Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Lei Y |
Year: |
2015 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Aqueous Humor Outflow Physiology in NOS3 Knockout Mice. |
Volume: |
56 |
Issue: |
8 |
Pages: |
4891-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ichinose F |
Year: |
2004 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency. |
Volume: |
286 |
Issue: |
3 |
Pages: |
H1070-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nadeau M |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation. |
Volume: |
107 |
Issue: |
45 |
Pages: |
19356-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song M |
Year: |
2017 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Genetic Deletion of the NOS3 Gene in CAV1-/- Mice Restores Aqueous Humor Outflow Function. |
Volume: |
58 |
Issue: |
12 |
Pages: |
4976-4987 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luiking YC |
Year: |
2005 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
The role of NOS2 and NOS3 in renal protein and arginine metabolism during early endotoxemia in mice. |
Volume: |
288 |
Issue: |
4 |
Pages: |
F816-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang Z |
Year: |
2015 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Plasma gelsolin improves lung host defense against pneumonia by enhancing macrophage NOS3 function. |
Volume: |
309 |
Issue: |
1 |
Pages: |
L11-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bastian C |
Year: |
2018 |
Journal: |
J Neurosci |
Title: |
NOS3 Inhibition Confers Post-Ischemic Protection to Young and Aging White Matter Integrity by Conserving Mitochondrial Dynamics and Miro-2 Levels. |
Volume: |
38 |
Issue: |
28 |
Pages: |
6247-6266 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang CH |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy. |
Volume: |
108 |
Issue: |
5 |
Pages: |
2070-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luiking YC |
Year: |
2005 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
NOS3 is involved in the increased protein and arginine metabolic response in muscle during early endotoxemia in mice. |
Volume: |
288 |
Issue: |
6 |
Pages: |
E1258-64 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179179 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190915 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Nos3 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179179 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190915 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Nos3 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179179 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190915 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Nos3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179179 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190915 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Nos3 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179179 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190915 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Nos3 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179179 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190915 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Nos3 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179179 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190915 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Nos3 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6277918 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-02-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3284724 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6277922 |
Age: |
embryonic day 16.5 |
|
Note: |
Author report first expression for Nos3 is detectable. |
Specimen Label: |
E16 not shown |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peterson JC |
Year: |
2018 |
Journal: |
Dis Model Mech |
Title: |
Bicuspid aortic valve formation: Nos3 mutation leads to abnormal lineage patterning of neural crest cells and the second heart field. |
Volume: |
11 |
Issue: |
10 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Pike D |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
The effect of endothelial nitric oxide synthase on the hemodynamics and wall mechanics in murine arteriovenous fistulas. |
Volume: |
9 |
Issue: |
1 |
Pages: |
4299 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dick BP |
Year: |
2020 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Hematopoietic Cell-Expressed Endothelial Nitric Oxide Protects the Liver From Insulin Resistance. |
Volume: |
40 |
Issue: |
3 |
Pages: |
670-681 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohashi Y |
Year: |
1998 |
Journal: |
J Clin Invest |
Title: |
Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase. |
Volume: |
102 |
Issue: |
12 |
Pages: |
2061-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamashita T |
Year: |
2001 |
Journal: |
Nitric Oxide |
Title: |
Role of endogenous nitric oxide generation in the regulation of vascular tone and reactivity in small vessels as investigated in transgenic mice using synchrotron radiation microangiography. |
Volume: |
5 |
Issue: |
5 |
Pages: |
494-503 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jones SP |
Year: |
2004 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury. |
Volume: |
286 |
Issue: |
1 |
Pages: |
H276-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Turer E |
Year: |
2019 |
Journal: |
MGI Direct Data Submission |
Title: |
Mutagenetix entry for Peter. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Duranski MR |
Year: |
2006 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury. |
Volume: |
291 |
Issue: |
6 |
Pages: |
H2980-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nagasu H |
Year: |
2012 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Endothelial dysfunction promotes the transition from compensatory renal hypertrophy to kidney injury after unilateral nephrectomy in mice. |
Volume: |
302 |
Issue: |
11 |
Pages: |
F1402-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sansbury BE |
Year: |
2012 |
Journal: |
Circ Res |
Title: |
Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype. |
Volume: |
111 |
Issue: |
9 |
Pages: |
1176-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Haperen R |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Reduction of blood pressure, plasma cholesterol, and atherosclerosis by elevated endothelial nitric oxide. |
Volume: |
277 |
Issue: |
50 |
Pages: |
48803-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mees B |
Year: |
2011 |
Journal: |
Am J Pathol |
Title: |
Endothelial nitric oxide synthase overexpression restores the efficiency of bone marrow mononuclear cell-based therapy. |
Volume: |
178 |
Issue: |
1 |
Pages: |
55-60 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
178
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
van Deel ED |
Year: |
2015 |
Journal: |
J Mol Cell Cardiol |
Title: |
Normal and high eNOS levels are detrimental in both mild and severe cardiac pressure-overload. |
Volume: |
88 |
|
Pages: |
145-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang Z |
Year: |
2014 |
Journal: |
Elife |
Title: |
Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target. |
Volume: |
3 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kim TK |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
2'-5' oligoadenylate synthetase‑like 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability. |
Volume: |
13 |
Issue: |
1 |
Pages: |
6647 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chiossi G |
Year: |
2011 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Effect of age and gender on the progression of adult vascular dysfunction in a mouse model of fetal programming lacking endothelial nitric oxide synthase. |
Volume: |
301 |
Issue: |
2 |
Pages: |
H297-305 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao Y |
Year: |
2016 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Collecting duct-specific knockout of nitric oxide synthase 3 impairs water excretion in a sex-dependent manner. |
Volume: |
311 |
Issue: |
5 |
Pages: |
F1074-F1083 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chavez GG |
Year: |
2017 |
Journal: |
Nitric Oxide |
Title: |
The temporal expression profile of a Nos3-related natural antisense RNA in the brain suggests a possible role in neurogenesis. |
Volume: |
71 |
|
Pages: |
27-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ichinose F |
Year: |
2007 |
Journal: |
Circ Res |
Title: |
Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock. |
Volume: |
100 |
Issue: |
1 |
Pages: |
130-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pallares P |
Year: |
2008 |
Journal: |
Reproduction |
Title: |
Disruption of the endothelial nitric oxide synthase gene affects ovulation, fertilization and early embryo survival in a knockout mouse model. |
Volume: |
136 |
Issue: |
5 |
Pages: |
573-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Champion HC |
Year: |
2004 |
Journal: |
Circ Res |
Title: |
Modulation of in vivo cardiac function by myocyte-specific nitric oxide synthase-3. |
Volume: |
94 |
Issue: |
5 |
Pages: |
657-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Campbell KA |
Year: |
2015 |
Journal: |
J Mol Cell Cardiol |
Title: |
Nos3-/- iPSCs model concordant signatures of in utero cardiac pathogenesis. |
Volume: |
87 |
|
Pages: |
228-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang H |
Year: |
2008 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Endothelial nitric oxide synthase decreases beta-adrenergic responsiveness via inhibition of the L-type Ca2+ current. |
Volume: |
294 |
Issue: |
3 |
Pages: |
H1473-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Neilan TG |
Year: |
2007 |
Journal: |
Circulation |
Title: |
Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin. |
Volume: |
116 |
Issue: |
5 |
Pages: |
506-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Caporarello N |
Year: |
2020 |
Journal: |
Aging Cell |
Title: |
Vascular dysfunction in aged mice contributes to persistent lung fibrosis. |
|
|
Pages: |
e13196 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vaporidi K |
Year: |
2010 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Nitric oxide synthase 3 contributes to ventilator-induced lung injury. |
Volume: |
299 |
Issue: |
2 |
Pages: |
L150-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takimoto E |
Year: |
2005 |
Journal: |
J Clin Invest |
Title: |
Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load. |
Volume: |
115 |
Issue: |
5 |
Pages: |
1221-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Buys ES |
Year: |
2007 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload. |
Volume: |
293 |
Issue: |
1 |
Pages: |
H620-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Steudel W |
Year: |
1998 |
Journal: |
J Clin Invest |
Title: |
Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. |
Volume: |
101 |
Issue: |
11 |
Pages: |
2468-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao Y |
Year: |
2018 |
Journal: |
J Am Heart Assoc |
Title: |
Nephron-Specific Disruption of Nitric Oxide Synthase 3 Causes Hypertension and Impaired Salt Excretion. |
Volume: |
7 |
Issue: |
14 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Tempfer C |
Year: |
2000 |
Journal: |
Fertil Steril |
Title: |
Genetic contributions of the endothelial nitric oxide synthase gene to ovulation and menopause in a mouse model. |
Volume: |
73 |
Issue: |
5 |
Pages: |
1025-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vandecasteele G |
Year: |
1999 |
Journal: |
Nat Med |
Title: |
Muscarinic and beta-adrenergic regulation of heart rate, force of contraction and calcium current is preserved in mice lacking endothelial nitric oxide synthase. |
Volume: |
5 |
Issue: |
3 |
Pages: |
331-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baltazar S |
Year: |
2023 |
Journal: |
Sci Rep |
Title: |
Effects of endothelial nitric oxide synthase on mouse arteriovenous fistula hemodynamics. |
Volume: |
13 |
Issue: |
1 |
Pages: |
22786 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elrod JW |
Year: |
2006 |
Journal: |
Circ Res |
Title: |
eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling. |
Volume: |
99 |
Issue: |
1 |
Pages: |
78-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qi W |
Year: |
2017 |
Journal: |
Nat Med |
Title: |
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. |
Volume: |
23 |
Issue: |
6 |
Pages: |
753-762 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Nitric oxide synthase-3 promotes embryonic development of atrioventricular valves. |
Volume: |
8 |
Issue: |
10 |
Pages: |
e77611 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wetzel MD |
Year: |
2021 |
Journal: |
Physiol Rep |
Title: |
Homoarginine ameliorates diabetic nephropathy independent of nitric oxide synthase-3. |
Volume: |
9 |
Issue: |
5 |
Pages: |
e14766 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takimoto E |
Year: |
2005 |
Journal: |
Circ Res |
Title: |
cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism. |
Volume: |
96 |
Issue: |
1 |
Pages: |
100-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakayama H |
Year: |
2009 |
Journal: |
J Clin Invest |
Title: |
alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice. |
Volume: |
119 |
Issue: |
12 |
Pages: |
3787-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Varghese P |
Year: |
2000 |
Journal: |
J Clin Invest |
Title: |
beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility. |
Volume: |
106 |
Issue: |
5 |
Pages: |
697-703 |
|
•
•
•
•
•
|
Publication |
First Author: |
Menon RT |
Year: |
2020 |
Journal: |
Am J Pathol |
Title: |
Adrenomedullin Is Necessary to Resolve Hyperoxia-Induced Experimental Bronchopulmonary Dysplasia and Pulmonary Hypertension in Mice. |
Volume: |
190 |
Issue: |
3 |
Pages: |
711-722 |
|
•
•
•
•
•
|
Publication |
First Author: |
Robb GB |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Post-transcriptional regulation of endothelial nitric-oxide synthase by an overlapping antisense mRNA transcript. |
Volume: |
279 |
Issue: |
36 |
Pages: |
37982-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
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Am J Physiol Regul Integr Comp Physiol |
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J Mol Cell Cardiol |
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J Mol Cell Cardiol |
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Year: |
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Journal: |
Eur Heart J |
Title: |
Nitric oxide synthase-3 deficiency results in hypoplastic coronary arteries and postnatal myocardial infarction. |
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Mol Genet Metab |
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Year: |
2017 |
Journal: |
Endocrinology |
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Markers of Islet Endothelial Dysfunction Occur in Male B6.BKS(D)-Leprdb/J Mice and May Contribute to Reduced Insulin Release. |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
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•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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