Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Neurotrophins are a family of secreted proteins that regulate development, maintenance and function of vertebrate nervous systems. They act via two different classes of receptor: p75NTR (a member of the TNF receptor superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also known as tropomyosin-related kinases (Trks) []. NTRKs are multi-domain, transmembrane proteins - in addition to their cytoplasmic kinase domains, members of the family possess a number of extracellular leucine-rich repeat (LRR) and Ig-like C2-type regions. Ligand binding induces them to dimerise, resulting in activation of their cytoplasmic tyrosine kinase domains. The activated receptors couple to a variety of intracellular signalling cascades, including the Ras, phosphatidylinositol-3-kinase (PI-3 kinase), mitogen-activated protein (MAP) kinase, and phospholipase C (PLC)-gamma pathways []. NTRK3 (also termed TrkC) is a high-affinity receptor for neurotrophin-3 (NT-3). The receptor is widely expressed in the developing nervous system, and is also found in many non-neuronal tissues []. In addition to roles in peripheral nerve cell myelination, mediating the inhibitory effects of NT-3 on this process []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Tessarollo L |
Year: |
1993 |
Journal: |
Development |
Title: |
trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. |
Volume: |
118 |
Issue: |
2 |
Pages: |
463-75 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Cosgaya JM |
Year: |
2002 |
Journal: |
Science |
Title: |
The neurotrophin receptor p75NTR as a positive modulator of myelination. |
Volume: |
298 |
Issue: |
5596 |
Pages: |
1245-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
86
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
82
 |
Fragment?: |
true |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271120 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk3 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex. |
Specimen Label: |
Ntrk3 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk3 - E14.5 |
Note: |
There is very strong staining in the postmitotic neurons in the cortical plate of the cerebral cortex. |
Specimen Label: |
Ntrk3 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271124 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk3 - E16.5 |
Note: |
There is very strong staining in the postmitotic neurons in the cortical plate of the cerebral cortex. |
Specimen Label: |
Ntrk3 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271220 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk3 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
Specimen Label: |
Ntrk3 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271222 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk3 - E14.5 |
Note: |
There is very strong staining in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
Specimen Label: |
Ntrk3 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271224 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk3 - E16.5 |
Note: |
There is very strong staining in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
Specimen Label: |
Ntrk3 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754320 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk3 - E12.5 |
Note: |
There is very strong staining in the ventricular zone of the prethalamus. Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus. |
Specimen Label: |
Ntrk3 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754322 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk3 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus and prethalamus. |
Specimen Label: |
Ntrk3 - E14.5 |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754324 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk3 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus and prethalamus. |
Specimen Label: |
Ntrk3 - E16.5 |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753720 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk3 - E12.5 |
Note: |
There is strong staining in the mantle zone of the dorsal and ventral POAs, PVH nucleus and the AVH and weak staining in the anterior and posterior IDs and VMH nucleus. Staining is either absent or ubiquitous in the mantle zone of the ARH nucleus. |
Specimen Label: |
Ntrk3 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753722 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk3 - E14.5 |
Note: |
There is very strong staining in the mantle zone of the AVH, strong staining in the anterior and posterior IDs and VMH nucleus, moderate staining in the dorsal and ventral POAs and weak staining in the PVH and ARH nuclei. |
Specimen Label: |
Ntrk3 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753724 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk3 - E16.5 |
Note: |
There is strong staining in the MZ of the dorsal POA & VMH nucleus, moderate staining in the AVH, DAH & PH, & the SCH nucleus & weak staining in the PVH nucleus. Staining is either absent or ubiquitous in the MZ of the ventral POA & DMH & ARH nuclei. |
Specimen Label: |
Ntrk3 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691319 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 11.5 |
Image: |
Ntrk3 - E11.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex and the ganglionic eminences. |
Specimen Label: |
Ntrk3 - E11.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271820 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk3 - E12.5 |
Note: |
There is strong staining in the mantle zone of the supramam zone and moderate staining in the mam zone. Staining is either absent or ubiquitous in the mantle zone of the premam zone and the TT. |
Specimen Label: |
Ntrk3 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271822 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk3 - E14.5 |
Note: |
There is strong staining in the mantle zone of the premam, mam and supramam zones and the TT. |
Specimen Label: |
Ntrk3 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271824 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk3 - E16.5 |
Note: |
There is weak staining in the mantle zone of the premam zone. |
Specimen Label: |
Ntrk3 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690819 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 11.5 |
Image: |
Ntrk3 - E11.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus, the prethalamus, dorsal and ventral POAs, the PVH and VMH nuclei, the AVH and anterior and posterior IDs. |
Specimen Label: |
Ntrk3 - E11.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753920 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk3 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs. |
Specimen Label: |
Ntrk3 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753922 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk3 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs. |
Specimen Label: |
Ntrk3 - E14.5 |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753924 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk3 - E16.5 |
Note: |
There is moderate staining in the ventricular zone of the ventral POA. Staining is either absent or ubiquitous in the ventricular zone of the dorsal POA, the PVH, SCH, DMH, VMH and ARH nuclei, the AVH, the DAH and the PH. |
Specimen Label: |
Ntrk3 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691119 |
Pattern: |
Non-Uniform |
Stage: |
TS19 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 11.5 |
Image: |
Ntrk3 - E11.5 |
Note: |
There is strong staining in the mantle zone of the ganglionic eminences. Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone and cortical plate of the cerebral cortex. |
Specimen Label: |
Ntrk3 - E11.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754720 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk3 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex. |
Specimen Label: |
Ntrk3 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk3 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex. |
Specimen Label: |
Ntrk3 - E14.5 |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754724 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk3 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex. |
Specimen Label: |
Ntrk3 - E16.5 |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271020 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk3 - E12.5 |
Note: |
There is weak staining in the ventricular zone of the premam zone. Staining is either absent or ubiquitous in the ventricular zone of the mam and supramam zones and the TT. |
Specimen Label: |
Ntrk3 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271022 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk3 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the premam, mam and supramam zones and the TT. |
Specimen Label: |
Ntrk3 - E14.5 |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271024 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk3 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the premam zone. |
Specimen Label: |
Ntrk3 - E16.5 |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266520 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk3 - E12.5 |
Note: |
There is very strong staining in the mantle zone of the ganglionic eminences. Staining is either absent or ubiquitous in the ventricular zone of the ganglionic eminences. |
Specimen Label: |
Ntrk3 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266522 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk3 - E14.5 |
Note: |
There is very strong staining in the mantle zone of the ganglionic eminences. Staining is either absent or ubiquitous in the ventricular zone of the ganglionic eminences. |
Specimen Label: |
Ntrk3 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266524 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk3 - E16.5 |
Note: |
There is strong staining in the mantle zone of the ganglionic eminences. Staining is either absent or ubiquitous in the ventricular zone of the ganglionic eminences. |
Specimen Label: |
Ntrk3 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690619 |
Pattern: |
Non-Uniform |
Stage: |
TS19 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 11.5 |
Image: |
Ntrk3 - E11.5 |
Note: |
There is strong staining in the MZ of the PVH nucleus & AVH, moderate staining in the prethalamus & weak staining in anterior & posterior IDs. Staining is either absent or ubiquitous in the MZ of the dorsal thalamus, dorsal & ventral POAs & VMH nucleus. |
Specimen Label: |
Ntrk3 - E11.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754120 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk3 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus and prethalamus. |
Specimen Label: |
Ntrk3 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754122 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk3 - E14.5 |
Note: |
There is moderate staining in the mantle zone of the prethalamus and weak staining in the dorsal thalamus. |
Specimen Label: |
Ntrk3 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442672 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754124 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450882 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk3 - E16.5 |
Note: |
There is very strong staining in the mantle zone of the dorsal thalamus and strong staining in the prethalamus. |
Specimen Label: |
Ntrk3 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
825
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Bothwell M |
Year: |
1995 |
Journal: |
Annu Rev Neurosci |
Title: |
Functional interactions of neurotrophins and neurotrophin receptors. |
Volume: |
18 |
|
Pages: |
223-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang EJ |
Year: |
2001 |
Journal: |
Annu Rev Neurosci |
Title: |
Neurotrophins: roles in neuronal development and function. |
Volume: |
24 |
|
Pages: |
677-736 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
864
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
839
 |
Fragment?: |
false |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5544467 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-08-18 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1797220 |
|
Stage: |
TS20 |
Assay Id: |
MGI:7519006 |
Age: |
embryonic day 12.5 |
|
Note: |
Authors report no specific expression pattern was seen. |
Specimen Label: |
Ntrk3 not shown |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179394 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190980 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Ntrk3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179394 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190980 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Ntrk3 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179394 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190980 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Ntrk3 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179394 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190980 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Ntrk3 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179394 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190980 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Ntrk3 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179394 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190980 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Ntrk3 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179394 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190980 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Ntrk3 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gorokhova S |
Year: |
2014 |
Journal: |
PLoS Genet |
Title: |
Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor. |
Volume: |
10 |
Issue: |
2 |
Pages: |
e1004081 |
|
•
•
•
•
•
|
Publication |
First Author: |
Santos M |
Year: |
2013 |
Journal: |
J Neurosci |
Title: |
Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model. |
Volume: |
33 |
Issue: |
38 |
Pages: |
15259-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moqrich A |
Year: |
2004 |
Journal: |
Nat Neurosci |
Title: |
Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. |
Volume: |
7 |
Issue: |
8 |
Pages: |
812-8 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Menn B |
Year: |
1998 |
Journal: |
J Comp Neurol |
Title: |
Differential expression of TrkC catalytic and noncatalytic isoforms suggests that they act independently or in association. |
Volume: |
401 |
Issue: |
1 |
Pages: |
47-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fünfschilling U |
Year: |
2004 |
Journal: |
J Comp Neurol |
Title: |
TrkC kinase expression in distinct subsets of cutaneous trigeminal innervation and nonneuronal cells. |
Volume: |
480 |
Issue: |
4 |
Pages: |
392-414 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klein R |
Year: |
1994 |
Journal: |
Nature |
Title: |
Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. |
Volume: |
368 |
Issue: |
6468 |
Pages: |
249-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuo S |
Year: |
2000 |
Journal: |
Neuroscience |
Title: |
Proprioceptive afferents survive in the masseter muscle of trkC knockout mice. |
Volume: |
95 |
Issue: |
1 |
Pages: |
209-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Botchkareva NV |
Year: |
1999 |
Journal: |
J Invest Dermatol |
Title: |
Retardation of hair follicle development by the deletion of TrkC, high-affinity neurotrophin-3 receptor. |
Volume: |
113 |
Issue: |
3 |
Pages: |
425-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Youn YH |
Year: |
2003 |
Journal: |
Mol Cell Neurosci |
Title: |
Neural crest stem cell and cardiac endothelium defects in the TrkC null mouse. |
Volume: |
24 |
Issue: |
1 |
Pages: |
160-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brahimi F |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS. |
Volume: |
11 |
Issue: |
10 |
Pages: |
e0162307 |
|
•
•
•
•
•
|
Publication |
First Author: |
Closser M |
Year: |
2022 |
Journal: |
Neuron |
Title: |
An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity. |
Volume: |
110 |
Issue: |
1 |
Pages: |
70-85.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bai Y |
Year: |
2010 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
In glaucoma the upregulated truncated TrkC.T1 receptor isoform in glia causes increased TNF-alpha production, leading to retinal ganglion cell death. |
Volume: |
51 |
Issue: |
12 |
Pages: |
6639-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Forooghian F |
Year: |
2000 |
Journal: |
J Mol Neurosci |
Title: |
Molecular analysis of trkC in the cat visual cortex. |
Volume: |
14 |
Issue: |
1-2 |
Pages: |
39-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lamballe F |
Year: |
1994 |
Journal: |
J Neurosci |
Title: |
Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system. |
Volume: |
14 |
Issue: |
1 |
Pages: |
14-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wyatt S |
Year: |
1999 |
Journal: |
J Neurosci |
Title: |
Selective regulation of trkC expression by NT3 in the developing peripheral nervous system. |
Volume: |
19 |
Issue: |
15 |
Pages: |
6559-70 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2684741 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-01-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679716 |
|
Stage: |
TS16 |
Assay Id: |
MGI:2684748 |
Age: |
embryonic day 10.0 |
Image: |
1 |
|
Specimen Label: |
E10 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2684741 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-01-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679718 |
|
Stage: |
TS18 |
Assay Id: |
MGI:2684748 |
Age: |
embryonic day 11.0 |
Image: |
1 |
|
Specimen Label: |
E11 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2684741 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-01-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679720 |
|
Stage: |
TS20 |
Assay Id: |
MGI:2684748 |
Age: |
embryonic day 12.0 |
Image: |
1 |
|
Specimen Label: |
E12 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2684741 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-01-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679721 |
|
Stage: |
TS21 |
Assay Id: |
MGI:2684748 |
Age: |
embryonic day 13.0 |
Image: |
1 |
|
Specimen Label: |
E13 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|